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1. 发明授权

US06780508B1 Powder particles with smooth surface for use in inhalation therapy 有权
标题翻译：具有光滑表面的粉末颗粒用于吸入治疗
公开(公告)号：US06780508B1
公开(公告)日：2004-08-24
申请号：US10030686
申请日：2002-04-16
申请人： Giovanni Caponetti , Pier Luigi Catellani , Ruggero Bettini , Paolo Colombo , Paolo Ventura
发明人： Giovanni Caponetti , Pier Luigi Catellani , Ruggero Bettini , Paolo Colombo , Paolo Ventura
IPC分类号： B32B516
CPC分类号： A61K9/0075 , A61K9/145 , A61K9/1623 , Y10T428/2991 , Y10T428/2998
摘要： Carriers for use in the preparation of mixtures for inhalation powders intended for pulmonary administration of micronized drugs by means of a dry powder inhaler and the method for their preparation are described.
摘要翻译：描述了用于制备用于通过干粉吸入器肺部给予微粉化药物的吸入粉末的混合物的载体及其制备方法。

2. 发明授权

US07399528B2 Powder particles with smooth surface for use in inhalation therapy 有权
标题翻译：具有光滑表面的粉末颗粒用于吸入治疗
公开(公告)号：US07399528B2
公开(公告)日：2008-07-15
申请号：US10806240
申请日：2004-03-23
申请人： Giovanni Caponetti , Pier Luigi Catellani , Ruggero Bettini , Paolo Colombo , Paolo Ventura
发明人： Giovanni Caponetti , Pier Luigi Catellani , Ruggero Bettini , Paolo Colombo , Paolo Ventura
IPC分类号： B32B5/16 , A61K9/14
CPC分类号： A61K9/0075 , A61K9/145 , A61K9/1623 , Y10T428/2991 , Y10T428/2998
摘要： Carrier particles, for use in the preparation of powdery mixtures for administration by inhalation, and having a median diameter of greater than 90 microns and a surface rugosity expressed as the fractal dimension of less than or equal to 1.1, may be prepared by subjecting particles having a median diameter of greater than 90 microns to repeated stages of wetting with a solvent and drying.
摘要翻译：用于制备用于通过吸入给药的粉末混合物并且具有大于90微米的中值粒径和表示为小于或等于1.1的分形维数的表面粗糙度的载体颗粒可以通过使具有中等直径大于90微米，重复使用溶剂润湿阶段并进行干燥。

3. 发明申请

US20050118113A1 Powder particles with smooth surface for use in inhalation therapy 有权
标题翻译：具有光滑表面的粉末颗粒用于吸入治疗
公开(公告)号：US20050118113A1
公开(公告)日：2005-06-02
申请号：US10806240
申请日：2004-03-23
申请人： Giovanni Caponetti , Pier Catellani , Ruggero Bettini , Paolo Colombo , Paolo Ventura
发明人： Giovanni Caponetti , Pier Catellani , Ruggero Bettini , Paolo Colombo , Paolo Ventura
IPC分类号： A61K9/00 , A61K9/14 , A61K9/16 , A61K9/72 , A61K47/26 , A61K47/40 , A61K31/4745 , A61L9/04
CPC分类号： A61K9/0075 , A61K9/145 , A61K9/1623 , Y10T428/2991 , Y10T428/2998
摘要： Carrier particles, for use in the preparation of powdery mixtures for administration by inhalation, and having a median diameter of greater than 90 microns and a surface rugosity expressed as the fractal dimension of less than or equal to 1.1, may be prepared by subjecting particles having a median diameter of greater than 90 microns to repeated stages of wetting with a solvent and drying.
摘要翻译：用于制备用于通过吸入给药的粉末混合物并且具有大于90微米的中值粒径和表示为小于或等于1.1的分形维数的表面粗糙度的载体颗粒可以通过使具有中等直径大于90微米，重复使用溶剂润湿阶段并干燥。

4. 发明授权

US08545883B2 Modular systems for the controlled release of a substance with space and time control 有权
标题翻译：用于控制释放具有空间和时间控制的物质的模块化系统
公开(公告)号：US08545883B2
公开(公告)日：2013-10-01
申请号：US13410560
申请日：2012-03-02
申请人： Paolo Colombo , Ruggero Bettini , Patrizia Santi , Pier Luigi Catellani
发明人： Paolo Colombo , Ruggero Bettini , Patrizia Santi , Pier Luigi Catellani
IPC分类号： A61K9/20
CPC分类号： A61K9/0065 , A61K9/2009 , A61K9/2054 , A61K9/2072 , A61K9/2086
摘要： An innovative pharmaceutical form for controlled drug release relates to systems obtained by the assembly of individual release modules, of which the capacity to release the drug in time and in space depends on the way in which the modules have been assembled. The modular structure offers high reproducibility of manufacture and flexibility of release.
摘要翻译：用于受控药物释放的创新药物形式涉及通过组装各个释放模块获得的系统，其中在时间和空间中释放药物的能力取决于模块组装的方式。模块化结构提供了很高的制造再现性和释放的灵活性。

5. 发明申请

US20050019411A1 Powder for nasal administration of drugs 审中-公开
标题翻译：用于鼻内给药的粉剂
公开(公告)号：US20050019411A1
公开(公告)日：2005-01-27
申请号：US10492816
申请日：2002-10-17
申请人： Paolo Colombo , Patrizia Santi , Ruggero Bettini , Pier Luigi Catellani , Mariella Artusi , Cecilia Sacchetti
发明人： Paolo Colombo , Patrizia Santi , Ruggero Bettini , Pier Luigi Catellani , Mariella Artusi , Cecilia Sacchetti
IPC分类号： A61K9/00 , A61K9/16 , A61K9/14 , D04H1/00
CPC分类号： A61K9/0043 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1652
摘要： The present invention concerns drug formulae for nasal administration and insufflators filled with said formula. The present invention also concerns methods for making said formulae available as well as primary particles for obtaining chimerical agglomerates that can be used in said formulae.
摘要翻译：本发明涉及用于鼻腔给药的药物配方和填充有所述配方的吹入器。本发明还涉及使所述配方可用的方法以及用于获得可用于所述配方中的嵌合共聚物的初级颗粒。

6. 发明申请

US20100008972A1 Film for active ingredients dermal and transdermal administration 审中-公开
标题翻译：用于活性成分的皮肤皮肤和透皮给药
公开(公告)号：US20100008972A1
公开(公告)日：2010-01-14
申请号：US12459361
申请日：2009-06-30
申请人： Paolo Colombo , Pier Luigi Catellani , Cristina Padula , Patrizia Santi , Gaia Colombo
发明人： Paolo Colombo , Pier Luigi Catellani , Cristina Padula , Patrizia Santi , Gaia Colombo
IPC分类号： A61K9/70 , A61P43/00
CPC分类号： A61K9/0009 , A61K9/7007 , A61K9/7015
摘要： Single-layer film for active ingredients dermal and transdermal administration containing at least an active ingredient, a film-forming agent, and a hydrophilic adhesive polymer.
摘要翻译：含有至少活性成分，成膜剂和亲水性粘合剂聚合物的用于活性成分的皮肤和透皮给药的单层膜。

7. 发明申请

US20100074926A1 MODULES, NEW ASSEMBLAGE KITS AND NEW ASSEMBLES FOR THE CONTROLLED RELEASE OF SUBSTANCES 审中-公开
标题翻译：用于控制释放物质的模块，新组装工具和新组件
公开(公告)号：US20100074926A1
公开(公告)日：2010-03-25
申请号：US12312831
申请日：2006-12-05
申请人： Paolo Colombo , Patrizia Santi , Ruggero Bettini , Orazio Luca Strusi , Fabio Sonvico , Gaia Colombo
发明人： Paolo Colombo , Patrizia Santi , Ruggero Bettini , Orazio Luca Strusi , Fabio Sonvico , Gaia Colombo
IPC分类号： A61K9/00 , A61J3/10
CPC分类号： A61K9/2072 , A61K9/0065
摘要： A module which is destroyed in the presence of water solution, composed of a compressed powdery mixture, the said powdery mixture comprising a matrix building component, suitable to release an optionally included active substance into a surrounding aqueous liquid, and one or more tabletting aids chosen from the group consisting of lubricants, glidants, and anti-adherent agents, the said module being provided with particular male topological features allowing its connection to a corresponding female module, giving raise to an assembly that can be safely handled on industrial scale, wherein, in the composition of the male module, the percentage ratio between the tabletting aid and the matrix building component is comprised between 1:2.5 and 1:999. The module can be employed to convey pharmaceuticals, nutraceuticals, agrochemicals or other active principles to the intended site of action.
摘要翻译：在水溶液存在下被破坏的模块，由压缩的粉末混合物组成，所述粉末混合物包含基质构建组分，其适于将任选包含的活性物质释放到周围的水性液体中，并且选择一种或多种压片助剂从由润滑剂，助流剂和抗粘附剂组成的组中，所述模块具有特定的男性拓扑特征，允许其连接到相应的阴模块，从而提高可以以工业规模安全地处理的组件，其中，在阳模组合物中，压片助剂和基质构成成分之间的百分比为1:2.5至1:9999。该模块可用于将药物，营养品，农用化学品或其他活性成分输送到预期的作用位置。

8. 发明申请

US20050008700A1 Modular systems for the controlled release of a substance with space and time control 审中-公开
标题翻译：用于控制释放具有空间和时间控制的物质的模块化系统
公开(公告)号：US20050008700A1
公开(公告)日：2005-01-13
申请号：US10496327
申请日：2002-11-20
申请人： Paolo Colombo , Ruggero Bettini , Patrizia Santi , Pier Catellani
发明人： Paolo Colombo , Ruggero Bettini , Patrizia Santi , Pier Catellani
IPC分类号： A61K9/00 , A61K9/20 , A61K9/22
CPC分类号： A61K9/0065 , A61K9/2009 , A61K9/2054 , A61K9/2072 , A61K9/2086
摘要： The present invention concerns an innovative pharmaceutical form for controlled drug release. In particular, the present invention refers to systems obtained by the assembly of individual release modules, of which the capacity to release the drug in time and in space depends on the way in which the modules have been assembled. The modular structure offers high reproducibility of manufacture and flexibility of release.
摘要翻译：本发明涉及用于受控药物释放的创新药物形式。特别地，本发明涉及通过组装各个释放模块获得的系统，其中在时间和空间上释放药物的能力取决于模块组装的方式。模块化结构提供了很高的制造再现性和释放的灵活性。

9. 发明授权

US07625865B2 Insulin highly respirable microparticles 有权
标题翻译：胰岛素高度可呼吸的微粒
公开(公告)号：US07625865B2
公开(公告)日：2009-12-01
申请号：US10593861
申请日：2004-03-26
申请人： Paolo Colombo , Stefano Cagnani , Paolo Ventura
发明人： Paolo Colombo , Stefano Cagnani , Paolo Ventura
IPC分类号： A61K38/28 , A61K51/12
CPC分类号： A61K9/0075 , A61K9/1688 , A61K38/28
摘要： The invention describes novel dried powders of peptide therapeutic agent useful for producing highly respirable aerosols and the methods for their manufacture. Insulin is the peptide therapeutic agent in the preferred embodiment. The powders of insulin prepared for pulmonary administration are characterized by the peculiar structure and shape of the microparticles that allow the powder to flow and to be easy aerosolized. Typical dry powder of insulin described in this patent show corrugated, nonagglomerated microparticles with a low tapped density. The mean geometric diameter (particle size) ranges between 1.0 and 10.0 micron and the mass median aerodynamic diameter (MMAD) ranges between 1.0 and 4.0 micron. These insulin pulmonary powders exhibit in vitro a very high respirable fraction (>75%).
摘要翻译：本发明描述了用于生产高吸入性气溶胶的肽治疗剂的新颖干粉及其制备方法。胰岛素是优选实施方案中的肽治疗剂。制备用于肺部给药的胰岛素粉末的特征在于允许粉末流动并易于雾化的微粒的特殊结构和形状。在该专利中描述的典型的胰岛素干粉末显示具有低抽头密度的波纹状，非团聚微粒。平均几何直径（粒径）在1.0和10.0微米之间，质量中值空气动力学直径（MMAD）在1.0和4.0微米之间。这些胰岛素肺粉末在体外表现出非常高的可呼吸分数（> 75％）。

10. 发明申请

US20070154404A1 Insulin highly respirable microparticles 有权
标题翻译：胰岛素高度可呼吸的微粒
公开(公告)号：US20070154404A1
公开(公告)日：2007-07-05
申请号：US10593861
申请日：2004-03-26
申请人： Paolo Colombo , Stefano Cagnani , Paolo Ventura
发明人： Paolo Colombo , Stefano Cagnani , Paolo Ventura
IPC分类号： A61K38/28 , A61K9/14
CPC分类号： A61K9/0075 , A61K9/1688 , A61K38/28
摘要： The invention describes novel dried powders of peptide therapeutic agent useful for producing highly respirable aerosols and the methods for their manufacture. Insulin is the peptide therapeutic agent in the preferred embodiment. The powders of insulin prepared for pulmonary administration are characterized by the peculiar structure and shape of the microparticles that allow the powder to flow and to be easy aerosolized. Typical dry powder of insulin described in this patent show corrugated, nonagglomerated microparticles with a low tapped density. The mean geometric diameter (particle size) ranges between 1.0 and 10.0 micron and the mass median aerodynamic diameter (MMAD) ranges between 1.0 and 4.0 micron. These insulin pulmonary powders exhibit in vitro a very high respirable fraction (>75%).
摘要翻译：本发明描述了用于生产高吸入性气溶胶的肽治疗剂的新颖干粉及其制备方法。胰岛素是优选实施方案中的肽治疗剂。制备用于肺部给药的胰岛素粉末的特征在于允许粉末流动并易于雾化的微粒的特殊结构和形状。在该专利中描述的典型的胰岛素干粉末显示具有低抽头密度的波纹状，非团聚微粒。平均几何直径（粒径）在1.0和10.0微米之间，质量中值空气动力学直径（MMAD）在1.0和4.0微米之间。这些胰岛素肺粉末在体外表现出非常高的可呼吸分数（> 75％）。

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