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1. 发明授权

US5648467A Natural killer cell stimulatory factor 失效
标题翻译：自然杀伤细胞刺激因子
公开(公告)号：US5648467A
公开(公告)日：1997-07-15
申请号：US403013
申请日：1995-03-13
申请人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi , Stanley F. Wolf
发明人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi , Stanley F. Wolf
IPC分类号： A61K38/00 , A61K38/22 , A61K39/395 , A61P31/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/04 , A61P43/00 , C07K1/16 , C07K1/20 , C07K1/22 , C07K14/00 , C07K14/435 , C07K14/52 , C07K14/54 , C07K16/24 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/19 , C12N15/26 , C12P21/00 , C12P21/02 , C12R1/19 , C12R1/91 , G01N33/53 , A61K38/20
CPC分类号： C07K14/5434 , A61K38/00 , Y10S435/803 , Y10S514/885
摘要： A novel homogeneous human cytokine, Natural Killer Stimulatory Factor, having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing it.
摘要翻译：具有诱导在人外周血淋巴细胞体外产生γ干扰素的能力的新型均质人细胞因子，天然杀伤刺激因子，以及含有它的药物制剂。

2. 发明授权

US5569454A Methods of treating infection using natural killer stimulatory factor 失效
标题翻译：使用自然杀伤刺激因子治疗感染的方法
公开(公告)号：US5569454A
公开(公告)日：1996-10-29
申请号：US403086
申请日：1995-03-13
申请人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi , Stanley F. Wolf
发明人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi , Stanley F. Wolf
IPC分类号： A61K38/00 , A61K38/22 , A61K39/395 , A61P31/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/04 , A61P43/00 , C07K1/16 , C07K1/20 , C07K1/22 , C07K14/00 , C07K14/435 , C07K14/52 , C07K14/54 , C07K16/24 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/19 , C12N15/26 , C12P21/00 , C12P21/02 , C12R1/19 , C12R1/91 , G01N33/53 , A61K38/20
CPC分类号： C07K14/5434 , A61K38/00 , Y10S435/803 , Y10S514/885
摘要： Methods of treating an infection using Natural Killer Stimulatory Factor (NKSF) are disclosed.
摘要翻译：公开了使用天然杀伤刺激因子（NKSF）治疗感染的方法。

3. 发明授权

US07122633B2 Natural killer stimulatory factor 失效
标题翻译：自然杀伤刺激因子
公开(公告)号：US07122633B2
公开(公告)日：2006-10-17
申请号：US10358395
申请日：2003-02-05
申请人： Giorgio Trinchieri , Bice Perussia , Stanley F. Wolf , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi
发明人： Giorgio Trinchieri , Bice Perussia , Stanley F. Wolf , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi
IPC分类号： C07K14/64
CPC分类号： C07K14/5434 , A61K38/00 , C07K14/52
摘要： This application relates to antibodies reactive with a novel homogenous human cytokine, Natural Killer Stimulator Factor (NKSF), having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.
摘要翻译：本申请涉及与人外周血淋巴细胞体外诱导γ干扰素生成能力的新型均质人细胞因子天然杀伤剂刺激因子（NKSF）反应的抗体，以及含有该抗体的药物制剂。

4. 发明授权

US5811523A Antibodies to natural killer stimulatory factor 失效
公开(公告)号：US5811523A
公开(公告)日：1998-09-22
申请号：US956240
申请日：1997-10-22
申请人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi , Stanley F. Wolf
发明人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi , Stanley F. Wolf
IPC分类号： A61K38/00 , C07K14/54 , C07K16/24
CPC分类号： C07K14/5434 , C07K14/52 , A61K38/00
摘要： A novel homogeneous human cytokine, Natural Killer Stimulatory Factor, having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing it.

5. 发明授权

US06555658B2 Antibodies to natural killer stimulatory factor 失效
标题翻译：抗自然杀伤刺激因子的抗体
公开(公告)号：US06555658B2
公开(公告)日：2003-04-29
申请号：US09924703
申请日：2001-08-09
申请人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi
发明人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi
IPC分类号： C07K1624
CPC分类号： C07K14/5434 , A61K38/00 , C07K14/52
摘要： This application relates to antibodies reactive with a novel homogenous human cytokine, Natural Killer Stimulator Factor (NKSF), having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.
摘要翻译：本申请涉及与人外周血淋巴细胞体外诱导γ干扰素生成能力的新型均质人细胞因子天然杀伤剂刺激因子（NKSF）反应的抗体，以及含有该抗体的药物制剂。

6. 发明授权

US06300478B1 Antibodies to natural killer stimulatory factor 失效
标题翻译：抗自然杀伤刺激因子的抗体
公开(公告)号：US06300478B1
公开(公告)日：2001-10-09
申请号：US09325958
申请日：1999-06-04
申请人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi
发明人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi
IPC分类号： C07K1624
CPC分类号： C07K14/5434 , A61K38/00 , C07K14/52
摘要： Antibodies reactive with a novel homogeneous human cytokine, Natural Killer Stimulatory Factor, (NKSF), NKSF having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.
摘要翻译：与人外周血淋巴细胞体外诱导γ干扰素生成能力的新型均质人细胞因子，天然杀伤刺激因子（NKSF），NKSF反应的抗体以及含有该抗体的药物制剂。

7. 发明授权

US5648072A Methods of inducing gamma interferon and stimulating blood cell populations using natural killer stimulatory factor 失效
标题翻译：使用自然杀伤刺激因子诱导γ干扰素和刺激血细胞群的方法
公开(公告)号：US5648072A
公开(公告)日：1997-07-15
申请号：US402667
申请日：1995-03-13
申请人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Michiko Kobayashi , Gordon G. Wong , Rodney Hewick , Stanley F. Wolf
发明人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Michiko Kobayashi , Gordon G. Wong , Rodney Hewick , Stanley F. Wolf
IPC分类号： A61K38/00 , A61K38/22 , A61K39/395 , A61P31/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/04 , A61P43/00 , C07K1/16 , C07K1/20 , C07K1/22 , C07K14/00 , C07K14/435 , C07K14/52 , C07K14/54 , C07K16/24 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/19 , C12N15/26 , C12P21/00 , C12P21/02 , C12R1/19 , C12R1/91 , G01N33/53 , A61K45/05 , A61K39/00 , C07K1/00
CPC分类号： C07K14/5434 , A61K38/00 , Y10S435/803 , Y10S514/885
摘要： Methods of inducing gamma interferon production and stimulating lymphocyte populations using Natural Killer Stimulatory Factor (NKSF) are disclosed.
摘要翻译：公开了使用自然杀伤刺激因子（NKSF）诱导γ干扰素产生和刺激淋巴细胞群体的方法。

8. 发明授权

US5457038A Natural killer stimulatory factor 失效
标题翻译：自然杀伤刺激因子
公开(公告)号：US5457038A
公开(公告)日：1995-10-10
申请号：US584941
申请日：1990-09-18
申请人： Giorgio Trinchieri , Bice Perussia , Michiko Kobayashi , Steven C. Clark , Gordon G. Wong , Rodney Hewick
发明人： Giorgio Trinchieri , Bice Perussia , Michiko Kobayashi , Steven C. Clark , Gordon G. Wong , Rodney Hewick
IPC分类号： A61K38/00 , A61K38/22 , A61K39/395 , A61P31/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/04 , A61P43/00 , C07K1/16 , C07K1/20 , C07K1/22 , C07K14/00 , C07K14/435 , C07K14/52 , C07K14/54 , C07K16/24 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/19 , C12N15/26 , C12P21/00 , C12P21/02 , C12R1/19 , C12R1/91 , G01N33/53 , C07K1/00 , C12N1/16 , C12N1/18 , C12N7/00 , C12P19/34
CPC分类号： C07K14/5434 , A61K38/00 , Y10S435/803 , Y10S514/885
摘要： A novel homogeneous human cytokine, Natural Killer Stimulatory Factor, having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing it.
摘要翻译：具有诱导在人外周血淋巴细胞体外产生γ干扰素的能力的新型均质人细胞因子，天然杀伤刺激因子，以及含有它的药物制剂。

9. 发明授权

US4675285A Method for identification and isolation of DNA encoding a desired protein 失效
标题翻译：用于鉴定和分离编码所需蛋白质的DNA的方法
公开(公告)号：US4675285A
公开(公告)日：1987-06-23
申请号：US652316
申请日：1984-09-19
申请人： Steven C. Clark , Randal J. Kaufman , Gordon G. Wong
发明人： Steven C. Clark , Randal J. Kaufman , Gordon G. Wong
IPC分类号： C07K14/53 , C12N15/10 , C12N15/85 , C12Q1/68 , C12N5/00 , C12N15/00 , C12P21/00
CPC分类号： C12N15/1086 , C07K14/53 , C12N15/85
摘要： A method for identifying and isolating clones containing DNA coding for a desired protein is described. DNA prepared from a cell that expresses the desired protein is inserted into an isolation expression vector having means for replication (as a means of producing DNA) and a suitable promoter for expression of said DNA in a predetermined mammalian host cell as well as means for replication in a bacterial cell. The transient expression vector is then inserted into a bacterial cell for replication of the DNA. Pools of DNA, prepared from a predetermined number of bacterial clones so that the nucleic acids (DNA and RNA) is substantially free of other bacterial contaminants are transfected or microinjected into mammalian host cells and conditioned medium from growing such cells is tested for the presence of the desired protein. Positive pools are selected and the clones used to make the pool are screened to identify and isolate the clone containing the desired DNA.
摘要翻译：描述了鉴定和分离含有编码所需蛋白质的DNA的克隆的方法。将从表达所需蛋白质的细胞制备的DNA插入具有复制方式的分离表达载体（作为生产DNA的手段）和用于在预定哺乳动物宿主细胞中表达所述DNA的合适启动子以及复制手段在细菌细胞中。然后将瞬时表达载体插入用于DNA复制的细菌细胞中。从预定数量的细菌克隆制备DNA，使得核酸（DNA和RNA）基本上不含其它细菌污染物的DNA转染或显微注射到哺乳动物宿主细胞中，并测试来自培养这样的细胞的条件培养基的存在所需蛋白质。选择阳性池，筛选用于制备池的克隆以鉴定并分离含有所需DNA的克隆。

10. 发明授权

US06284237B1 Methods of treatment using IL-6 失效
标题翻译：使用IL-6治疗方法
公开(公告)号：US06284237B1
公开(公告)日：2001-09-04
申请号：US08224985
申请日：1994-04-06
申请人： Steven C. Clark , Gordon G. Wong , Paul Schendel , John McCoy
发明人： Steven C. Clark , Gordon G. Wong , Paul Schendel , John McCoy
IPC分类号： A61K3820
CPC分类号： C07K14/5412 , A61K38/2013 , A61K38/204 , A61K38/217 , A61K39/395 , Y10S514/885 , A61K2300/00
摘要： IL-6 is produced via recombinant DNA techniques. The peptide is useful in the treatment of disorders characterized by deficiencies in hematopoietic cells and in combination with other hematopoietins in cancer therapies.
摘要翻译：通过重组DNA技术产生IL-6。该肽可用于治疗以造血细胞缺陷为特征的疾病，并与癌症治疗中的其它造血素组合。

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