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1. 发明申请

US20050222539A1 Automatic injection device 审中-公开
标题翻译：自动注射装置
公开(公告)号：US20050222539A1
公开(公告)日：2005-10-06
申请号：US10817224
申请日：2004-04-02
申请人： Gilbert Gonzales , Matthew Huddleston , Kenneth Hughes
发明人： Gilbert Gonzales , Matthew Huddleston , Kenneth Hughes
IPC分类号： A61M5/00 , A61M5/20 , A61M5/31 , A61M5/32
CPC分类号： A61M5/2033 , A61M5/3129 , A61M5/3157 , A61M5/326 , A61M5/3271 , A61M2005/2013 , A61M2005/206 , A61M2005/2073 , A61M2205/583
摘要： An injector device comprising a body containing a syringe with a needle and plunger, a drive spring coupled with the syringe and operable, when released, to drive the syringe forward to inject the needle and subsequently to dispense a dosage from the syringe, a housing containing the body and drive spring, and a release apparatus coupled with the housing. The drive spring is initially locked in an unreleased position, and the body is slidable with respect to the housing and configured for sliding upward in the housing when the injector device is pressed down at an injection site to engage the release apparatus and release the drive spring for delivering a dosage.
摘要翻译：一种注射器装置，其包括具有针和柱塞的注射器的主体，与注射器联接的驱动弹簧，当释放时可驱动注射器向前注射针头，随后从注射器分配剂量，主体和驱动弹簧以及与壳体联接的释放装置。驱动弹簧最初被锁定在未释放位置，并且主体可相对于壳体滑动并且构造成当喷射器装置在注射位置处向下滑动以接合释放装置并释放驱动弹簧用于递送剂量。

2. 发明申请

US20050136112A1 Oral medicament delivery system 审中-公开
标题翻译：口服药物输送系统
公开(公告)号：US20050136112A1
公开(公告)日：2005-06-23
申请号：US10741873
申请日：2003-12-19
申请人： Gilbert Gonzales , Kenneth Hughes , Sofia Gonzales
发明人： Gilbert Gonzales , Kenneth Hughes , Sofia Gonzales
IPC分类号： A61K9/00 , A61K9/20 , A61K9/70 , A61K9/24 , A61K9/14
CPC分类号： A61K9/0095 , A61K9/0056 , A61K9/006 , A61K9/2086
摘要： Oral medicament delivery system comprising a pharmaceutical composition comprising a flexible matrix, said matrix formed of a plurality of fibers comprising a collagen-based carrier and a medicament, the composition orally dissolvable to deliver a unit dose of the medicament to a patient. The flexible composition can be dose titrated and co-administered with a second pharmaceutical formulation.
摘要翻译：口服药物递送系统，其包含药物组合物，其包含柔性基质，所述基质由包含基于胶原的载体的多种纤维和药物形成，所述组合物可口服溶解以将单位剂量的药物递送至患者。柔性组合物可以被剂量滴定并与第二种药物制剂共同施用。

3. 发明申请

US20050226770A1 Apparatus and methods for automated handling and embedding of tissue samples 有权
标题翻译：用于自动处理和嵌入组织样本的装置和方法
公开(公告)号：US20050226770A1
公开(公告)日：2005-10-13
申请号：US11010773
申请日：2004-12-13
申请人： Douglas Allen , Dominic DiNovo , Matthew Huddleston , Kenneth Hughes , George Keller , Keith Kuisick , Rebeccah Quam , Cecil Robinson , Jonathan Turner , Ernest VanHoose , Thomas Ward , Warren Williamson
发明人： Douglas Allen , Dominic DiNovo , Matthew Huddleston , Kenneth Hughes , George Keller , Keith Kuisick , Rebeccah Quam , Cecil Robinson , Jonathan Turner , Ernest VanHoose , Thomas Ward , Warren Williamson
IPC分类号： G01N1/36 , G01N35/00 , B01L3/00
CPC分类号： G01N1/36 , G01N35/00732 , G01N2001/366 , Y10T436/2525 , Y10T436/2575
摘要： An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports after the tissue embedding operation. A cooling unit is configured to hold at least one of the microtome sectionable supports during the tissue embedding operation. A motorized carrier assembly is mounted for movement and configured to hold at least one of the microtome sectionable supports. The carrier assembly moves the support from the input member to the cooling unit and, finally, to the output member. A dispensing device dispenses an embedding material onto the microtome sectionable support and at least one tissue sample carried by the microtome sectionable support during the embedding operation.
摘要翻译：一种用于处理和嵌入包含在切片机可切片支架上的组织样本的自动化机器。该机器包括一个输入构件，构造成在组织嵌入操作之前保持多个切片机可切割支架。输出构件被配置为在组织嵌入操作之后保持多个切片机可切割支撑件。冷却单元构造成在组织嵌入操作期间保持切片机可分段支撑件中的至少一个。安装电动载体组件用于移动并且构造成保持切片机可分段支撑件中的至少一个。托架组件将支撑件从输入构件移动到冷却单元，最后移动到输出构件。分配装置在嵌入操作期间将嵌入材料分配到切片机可切片支撑件和由切片机可切割支撑件携带的至少一个组织样本。

4. 发明申请

US20060289349A1 Composite materials for fluid treatment 审中-公开
标题翻译：用于流体处理的复合材料
公开(公告)号：US20060289349A1
公开(公告)日：2006-12-28
申请号：US11175986
申请日：2005-07-06
申请人： Kenneth Hughes
发明人： Kenneth Hughes
IPC分类号： B01D24/00
CPC分类号： B01J20/261 , A23L2/39 , A23L27/74 , A61L2/0082 , A61L2/16 , A61L12/08 , B01D35/02 , B01D53/02 , B01D53/1493 , B01D53/84 , B01D53/86 , B01D53/94 , B01D61/145 , B01D61/147 , B01D61/16 , B01D69/02 , B01D69/141 , B01D2311/04 , B01J20/02 , B01J20/0211 , B01J20/0218 , B01J20/0222 , B01J20/0229 , B01J20/0233 , B01J20/0237 , B01J20/0244 , B01J20/0248 , B01J20/0277 , B01J20/0281 , B01J20/0292 , B01J20/043 , B01J20/045 , B01J20/048 , B01J20/06 , B01J20/103 , B01J20/12 , B01J20/16 , B01J20/18 , B01J20/20 , B01J20/24 , B01J20/262 , B01J20/28042 , B01J2220/44 , B01J2220/46 , C02F1/003 , C02F1/28 , C02F1/288 , C02F1/50 , C02F1/52 , C02F1/66 , C02F1/70 , C02F1/72 , C02F1/76 , C02F1/766 , C02F1/78 , C02F2303/02 , C02F2305/04 , C02F2305/14 , Y02A50/2358 , B01D2311/12 , B01D2311/2688
摘要： This invention relates generally to composite materials and to devices which may alter fluid parameters. Devices incorporating the composite materials of the invention are used to deliver, remove, and generate, fluid treatment agents, and combinations thereof. These materials and devices are applicable to many different fluid processing situations including drinking water treatment, wastewater treatment, emission treatment, pollution cleanup, and sensing fluid composition. In its more particular aspects, the invention relates to the field of composites that may be widely tailored for many different treatment applications.
摘要翻译：本发明一般涉及复合材料和可改变流体参数的装置。结合本发明的复合材料的装置用于输送，除去和产生流体处理剂及其组合。这些材料和装置适用于许多不同的流体处理情况，包括饮用水处理，废水处理，排放处理，污染清理和传感液组成。在其更具体的方面，本发明涉及可以广泛地针对许多不同处理应用定制的复合材料领域。

5. 发明申请

US20060111403A1 Cyano anthranilamide insecticides 有权
标题翻译：氰基邻氨基苯甲酰胺杀虫剂
公开(公告)号：US20060111403A1
公开(公告)日：2006-05-25
申请号：US10540966
申请日：2004-01-21
申请人： Kenneth Hughes , George Lahm , Thomas Selby , Thomas Stevenson
发明人： Kenneth Hughes , George Lahm , Thomas Selby , Thomas Stevenson
IPC分类号： C07D403/02 , A01N43/40
CPC分类号： A01N43/56 , A01N43/16 , A01N43/24 , A01N43/54 , A01N43/707 , A01N43/84 , A01N43/88 , A01N57/14 , A01N57/28 , A01N59/02 , A01N59/20 , A01N63/00 , A01N63/02 , C07D401/04 , Y02A50/322 , Y02A50/326 , Y02A50/352 , Y02A50/356 , Y02A50/371 , Y02A50/373 , Y02A50/375
摘要： This invention provides compounds of Formula (I), N-oxides and suitable salts thereof INSERT FORMULA I HERE wherein R1 is Me, Cl, Br or F; R2 is F, Cl, Br, C1-C4 haloalkyl or C1-C4 haloalkoxy; R3 is F, Cl or Br; R4 is H or C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, C3-C5 cycloalkyl, or C4-C6 cycloalkylalkyl, each optionally substituted with one substituent selected from the group consisting of halogen, CN, SMe S(O)Me, S(O)2Me and OMe; R5 is H or Me; R6 is H, F or Cl; and R7 is H, F or Cl. Also disclosed are methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of Formula (I), an N-oxide thereof or a suitable salt of the compound (e.g., as a composition described herein). This invention also pertains to a composition for controlling an invertebrate pest comprising a biologically effective amount of a compound of Formula (I), an N-oxide thereof or a suitable salt of the compound and at least one additional component selected from the group consisting of a surfactant, a solid diluent and a liquid diluent.
摘要翻译：本发明提供了式（I）的化合物，N-氧化物及其合适的盐，其中R 1是Me，Cl，Br或F; R 2是F，Cl，Br，C 1 -C 4卤代烷基或C 1 -C 3 > 4卤代烷氧基; R 3是F，Cl或Br; R 4是H或C 1 -C 4烷基，C 3 -C 4烷基，C 3 -C 4烷基，C 3 -C 4烷基，亚烷基，C 3 -C 4炔基，C 3 -C 5环烷基或C

6. 发明授权

US10350223B2 Compositions and methods for treating ocular diseases 有权
公开(公告)号：US10350223B2
公开(公告)日：2019-07-16
申请号：US15555527
申请日：2016-03-03
申请人： Richard W. Yee , Kenneth Hughes
发明人： Richard W. Yee , Kenneth Hughes
IPC分类号： A61K9/00 , A61K45/06 , A61K47/10 , A61K47/38 , A61K31/136 , A61K31/145 , A61K31/585
摘要： The compositions and methods disclosed herein provide for treatments of ocular disorders of the eye, such as ocular surface diseases as well as those associated with inflammation of internal cells and cell layers of the eye. The methods disclosed herein describe methods for treating ocular disorders, particularly dry eye disorders, comprising topically administering to an ocular region of a subject a composition comprising a pharmaceutically effective amount of at least one aldosterone antagonist or salt thereof and a pharmaceutically acceptable carrier. Included is a method for treating dry eye comprising topically administering to an ocular region of a subject a composition comprising spironolactone and hydroxypropyl methylcellulose; and reducing or preventing one or more symptoms or causes of dry eye.

7. 发明授权

US07270990B2 Virus production 有权
标题翻译：病毒生产
公开(公告)号：US07270990B2
公开(公告)日：2007-09-18
申请号：US10871768
申请日：2004-06-18
申请人： Gregory V. Williams , Kenneth Hughes
发明人： Gregory V. Williams , Kenneth Hughes
IPC分类号： C12P21/04 , C12P19/34 , C12N7/02 , C12N5/06 , C12N5/00
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , C12N2760/16034 , C12N2760/16051
摘要： An improved process for recovery of virus from allantoic fluid of virus-infected chick embryos. Virus associated with granular and fibrous debris in the allantoic fluid can be disassociated from the debris and recovered, thereby increasing viral yield. Dissociation can be achieved by subjecting the virus-debris complex to conditions of increased salt concentrations, e.g., 0.5 M or greater.
摘要翻译：一种用于从病毒感染的鸡胚胎的尿囊液中回收病毒的改进方法。与尿囊液中的颗粒状和纤维碎片相关的病毒可与碎片分离并回收，从而增加病毒产量。可以通过使病毒碎片复合物进入增加的盐浓度，例如0.5M或更大的条件来实现解离。

8. 发明申请

US20070264299A1 Cyano anthranilamide insecticides 有权
标题翻译：氰基邻氨基苯甲酰胺杀虫剂
公开(公告)号：US20070264299A1
公开(公告)日：2007-11-15
申请号：US11811105
申请日：2007-06-08
申请人： Kenneth Hughes , George Lahm , Thomas Selby , Thomas Stevenson
发明人： Kenneth Hughes , George Lahm , Thomas Selby , Thomas Stevenson
IPC分类号： A01N25/08 , A01M5/00 , A61K31/44 , C07D401/06
CPC分类号： A01N43/56 , A01N43/16 , A01N43/24 , A01N43/54 , A01N43/707 , A01N43/84 , A01N43/88 , A01N57/14 , A01N57/28 , A01N59/02 , A01N59/20 , A01N63/00 , A01N63/02 , C07D401/04 , Y02A50/322 , Y02A50/326 , Y02A50/352 , Y02A50/356 , Y02A50/371 , Y02A50/373 , Y02A50/375
摘要： This invention provides compounds of Formula 1, N-oxides and suitable salts thereof wherein R1 is Me, Cl, Br or F; R2 is F, Cl, Br, C1-C4 haloalkyl or C1-C4 haloalkoxy; R3 is F, Cl or Br; R4 is H; C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, C3-C5 cycloalkyl, or C4-C6 cycloalkylalkyl, each optionally substituted with one substituent selected from the group consisting of halogen, CN, SMe, S(O)Me, S(O)2Me, and OMe; R5 is H or Me; R6is H, F or Cl; and R7is H, F or Cl. Also disclosed are methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of Formula 1, an N-oxide thereof or a suitable salt of the compound (e.g., as a composition described herein). This invention also pertains to a composition for controlling an invertebrate pest comprising a biologically effective amount of a compound of Formula 1, an N-oxide thereof or a suitable salt of the compound and at least one additional component selected from the group consisting of a surfactant, a solid diluent and a liquid diluent.
摘要翻译：本发明提供了其中R 1为Me，Cl，Br或F的式1化合物，N-氧化物及其合适的盐; R 2是F，Cl，Br，C 1 -C 4卤代烷基或C 1 -C 3 > 4卤代烷氧基; R 3是F，Cl或Br; R 4是H; C 1 -C 4烷基，C 3〜C 4链烯基，C 3

9. 发明申请

US20060168356A1 Method and system for transmitting data for a shared application 有权
公开(公告)号：US20060168356A1
公开(公告)日：2006-07-27
申请号：US10859640
申请日：2004-06-03
申请人： Christopher Mairs , Anthony Downes , Roderick MacFarquhar , Kenneth Hughes , Alex Pollitt , John Batty , Mark Berry
发明人： Christopher Mairs , Anthony Downes , Roderick MacFarquhar , Kenneth Hughes , Alex Pollitt , John Batty , Mark Berry
IPC分类号： G06F3/00
CPC分类号： G06F3/1462 , G06T9/005
摘要： A method and system for compressing bitmap data in a system for sharing an application running on a host computer with a remote computer, wherein the shared application's screen output is simultaneously displayed on both computers. Simultaneous display of screen output is achieved by efficiently transmitting display data between the host computer and the remote computer. When a font used by the host computer for displaying text is not available on the remote computer, the host computer sends a bitmap representation of the text for display, rather than the text itself. Bitmap representations are cached by the remote computer, so that the same bitmap representation need not be repeatedly transmitted from the host computer to the remote computer. Bitmap representations are compressed by the host computer prior to transmission, transmitted, then decompressed by the computer.

10. 发明申请

US20060014808A1 Novel anthranilamide insecticides 失效
标题翻译：新型邻氨基苯甲酰胺杀虫剂
公开(公告)号：US20060014808A1
公开(公告)日：2006-01-19
申请号：US10529612
申请日：2003-11-12
申请人： Kenneth Hughes , Thomas Selby , George Lahm
发明人： Kenneth Hughes , Thomas Selby , George Lahm
IPC分类号： A01N43/40 , A01N43/64 , A01N25/08
CPC分类号： C07D401/04 , A01N43/56 , C07D231/14 , C07D401/14
摘要： This invention provides compounds of Formula I, N-oxides and suitable salts thereof (INSERT FORMULA I HERE) wherein Y and V are each independently N or CR4a; W is N, CH or CR6; and R1 through R6, and n are as defined in the disclosure. This invention also pertains to a composition for controlling an invertebrate pest comprising a biologically effective amount of a compound of Formula I, an N-oxide thereof or an agronomic or nonagronomic suitable salt of the compound and at least one additional component selected from the group consisting of a surfactant, a solid diluent and a liquid diluent, and optionally further comprising an effective amount of at least one additional biologically active compound or agent. Also disclosed are methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of Formula I, an N-oxide thereof or an agronomic or nonagronomic suitable salt of the compound or with the composition described herein.
摘要翻译：本发明提供式I化合物，N-氧化物及其合适的盐（其中Y和V各自独立地为N或CR 4a）; W是N，CH或CR 6; 和R 1至R 6，并且n如本公开所定义。本发明还涉及用于控制无脊椎害虫的组合物，其包含生物学有效量的式I化合物，其N-氧化物或化合物的农艺或非农学上合适的盐和至少一种选自以下的另外的组分：表面活性剂，固体稀释剂和液体稀释剂，并且任选地还包含有效量的至少一种另外的生物活性化合物或试剂。还公开了用于控制无脊椎害虫的方法，包括使无脊椎害虫或其环境与生物有效量的式I化合物，其N-氧化物或化合物的农艺或非农业合适的盐或与本文所述的组合物接触。

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