专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080280305A1 Assays for Detecting Hiv-1 Tat Protein in Hiv-1 Infection 审中-公开
标题翻译：检测Hiv-1 Tat蛋白在Hiv-1感染中的检测
公开(公告)号：US20080280305A1
公开(公告)日：2008-11-13
申请号：US11795671
申请日：2006-02-13
申请人： Gideon Goldstein
发明人： Gideon Goldstein
IPC分类号： G01N33/53
CPC分类号： G01N33/56988
摘要： A method for detecting or measuring HIV-1 Transactivating (Tat) protein in a biological sample comprising contacting the biological sample with an amount of a basic protein effective to reduce interference with binding between anti-HIV-1 Tat Epitope 2 ligand and Tat that is caused by acidic components within the sample or reagents. A more accurate detection and measurement of the amount of HIV-1 Tat in the sample is obtained by binding between the anti-Epitope 2 antibody and the Tat in the sample when the interference is neutralized. A diagnostic kit for use in practicing the method contains these components.
摘要翻译：一种用于检测或测量生物样品中HIV-1反式激活（Tat）蛋白的方法，包括使生物样品与一定量的碱性蛋白质接触，所述碱性蛋白质有效减少抗HIV-1 Tat表位2配体与Tat之间的结合的干扰，由样品或试剂中的酸性成分引起。当干扰被中和时，样品中HIV-1 Tat的量的更准确的检测和测量是通过结合抗Epitope 2抗体和样品中的Tat获得的。用于实施该方法的诊断试剂盒包含这些组分。

2. 发明申请

US20060258594A1 Methods and compositions for impairing multiplication of HIV-1 审中-公开
公开(公告)号：US20060258594A1
公开(公告)日：2006-11-16
申请号：US11491755
申请日：2006-07-24
申请人： Gideon Goldstein
发明人： Gideon Goldstein
IPC分类号： A61K38/10
CPC分类号： C07K14/005 , A61K38/10 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/545 , A61K2039/55566 , A61K2039/6037 , C07K16/1072 , C07K2317/34 , C07K2319/60 , C12N2740/15022 , C12N2740/16322 , C12N2740/16334
摘要： A composition which elicits antibodies to greater than 95%, and even greater than 99%, of the known variants of HIV-1 Tat protein contains at least one peptide or polypeptide of the formula of Epitope I (based on amino acids 2-10 of HIV-1 Tat consensus sequence) and optionally one or more of a peptide or polypeptide of Epitope II (based on amino acids 41 to 51 of that sequence), of Epitope III (based on amino acids 52-62 of that sequence), or of Epitope IV (based on amino acids 62 through 72 of that sequence with a C-terminal Pro). Vaccinal and pharmaceutical compositions can contain the antibodies induced by the peptide compositions for use in passive therapy. Diagnostic compositions and uses are described for assessing the immune status of vaccinated patients.

3. 发明授权

US5891994A Methods and compositions for impairing multiplication of HIV-1 失效
标题翻译：减少HIV-1增殖的方法和组合物
公开(公告)号：US5891994A
公开(公告)日：1999-04-06
申请号：US893853
申请日：1997-07-11
申请人： Gideon Goldstein
发明人： Gideon Goldstein
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/395 , A61P31/18 , C07K1/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K14/16 , C07K16/00 , C07K17/00 , C12N1/21 , C12N5/10 , C12N7/00 , C12P21/08 , C12Q1/70 , G01N33/53 , A61K38/04
CPC分类号： C07K14/005 , A61K38/10 , A61K39/12 , A61K39/21 , C07K16/1072 , A61K2039/545 , A61K2039/55566 , A61K2039/6037 , A61K39/00 , C07K2317/34 , C07K2319/60 , C12N2740/15022 , C12N2740/16322 , C12N2740/16334
摘要： A composition is provided which contains a non-naturally occurring peptide or polypeptide comprising at least two or more, and preferably all four amino acid sequences -Asp-Pro-Arg-Leu-Glu-Pro- SEQ ID NO: 6; -Asp-Pro-Lys-Leu-Glu-Pro- SEQ ID NO: 7; -Asp-Pro-Ser-Leu-Glu-Pro- SEQ ID NO: 8; and -Asp-Pro-Asn-Leu-Glu-Pro- SEQ ID NO: 9. This composition, including a number of additional optional peptides or polypeptides, and in a variety of forms, demonstrates a biological activity of inducing antibodies that react with most HIV-1 Tat proteins and impairing the multiplication of HIV-1. Also provided are synthetic genes encoding these peptides, recombinant viruses and commensal bacterium carrying these genes, transfected host cells, and polyclonal or other types of antibodies produced by immunizing other mammals with these aforementioned compositions. Methods for making and using such compositions to lower the viral level of HIV-1 are described.
摘要翻译：提供了包含非天然存在的肽或多肽的组合物，其包含至少两个或更多个，优选全部四个氨基酸序列-Asp-Pro-Arg-Leu-Glu-Pro-SEQ ID NO：6; -Asp-Pro-Lys-Leu-Glu-Pro-SEQ ID NO：7; -Asp-Pro-Ser-Leu-Glu-Pro-SEQ ID NO：8; 和-Asp-Pro-Asn-Leu-Glu-Pro-SEQ ID NO：9。这种组合物，包括许多其它任选的肽或多肽，并且以多种形式，表现出诱导与大多数HIV-1 Tat蛋白并且损害HIV-1的增殖。还提供了编码这些肽的合成基因，携带这些基因的重组病毒和共生细菌，转染的宿主细胞，以及通过用上述组合物免疫其它哺乳动物产生的多克隆或其他类型的抗体。描述了制备和使用这些组合物降低HIV-1病毒水平的方法。

4. 发明授权

US5196310A Hybrid cell line for producing monoclonal antibody to a human monocyte antigen, antibody, and methods 失效
标题翻译：用于产生人单核细胞抗原的单克隆抗体的杂交细胞系，抗体和方法
公开(公告)号：US5196310A
公开(公告)日：1993-03-23
申请号：US389246
申请日：1989-08-03
申请人： Patrick C. Kung , Gideon Goldstein
发明人： Patrick C. Kung , Gideon Goldstein
IPC分类号： A61K38/00 , C07K16/28
CPC分类号： C07K16/28 , A61K38/00
摘要： Hybrid cell line for production of monoclonal antibody to an antigen found on normal human monocytes and granulocytes. The hybrid is formed by fusing splenocytes from immunized BALB/cJ mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
摘要翻译：用于在正常人单核细胞和粒细胞上发现的抗原的单克隆抗体的杂交细胞系。通过将来自免疫的BALB / cJ小鼠的脾细胞与P3X63Ag8U1骨髓瘤细胞融合来形成杂交体。还公开了单克隆抗体的诊断和治疗用途。

5. 再颁专利

USRE34165E Potent thymopentin analogs 失效
公开(公告)号：USRE34165E
公开(公告)日：1993-01-19
申请号：US514184
申请日：1990-04-25
申请人： Gideon Goldstein , George Heavner , Daniel Kroon , Tapan Audhya
发明人： Gideon Goldstein , George Heavner , Daniel Kroon , Tapan Audhya
IPC分类号： A61K38/22 , A61K38/00 , A61P37/04 , C07K7/06 , C07K14/66
CPC分类号： C07K14/662 , A61K38/00 , Y10S930/18
摘要： Immunoregulating peptides are disclosed which are more potent than thymopentin or splenin and are useful for their effects on the immune system, especially the treatment of thymic deficiencies.

6. 发明授权

US4798806A Compositions and methods using a monoclonal antibody to a human T cell antigen 失效
标题翻译：使用单克隆抗体对人T细胞抗原的组合物和方法
公开(公告)号：US4798806A
公开(公告)日：1989-01-17
申请号：US892019
申请日：1986-08-01
申请人： Patrick C. Kung , Gideon Goldstein
发明人： Patrick C. Kung , Gideon Goldstein
IPC分类号： A61K38/00 , C07K16/28 , G01N33/569 , G01N33/54
CPC分类号： C07K16/2806 , G01N33/56972 , A61K38/00
摘要： Hybrid cell line for production of monoclonal antibody to an antigen found on essentially all normal human T cells and on approximately 95% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
摘要翻译：用于在基本上所有正常人T细胞和大约95％正常人胸腺细胞上发现的抗原的单克隆抗体的杂交细胞系。通过将来自免疫的CAF1小鼠的脾细胞与P3X63Ag8U1骨髓瘤细胞融合来形成杂交体。还公开了单克隆抗体的诊断和治疗用途。

7. 发明授权

US4680383A Monoclonal antibody to human T cells 失效
标题翻译：对人T细胞的单克隆抗体
公开(公告)号：US4680383A
公开(公告)日：1987-07-14
申请号：US639563
申请日：1984-08-10
申请人： Patrick C. Kung , Gideon Goldstein
发明人： Patrick C. Kung , Gideon Goldstein
IPC分类号： A61K38/00 , C07K16/28 , C07K16/30 , G01N33/569 , C07K15/00 , A61K39/395
CPC分类号： G01N33/56972 , C07K16/28 , C07K16/3061 , A61K38/00
摘要： Hybrid cell line for producing of monoclonal antibody to an antigen found on all normal human T cells. The hybrid is formed by fusing splenocytes from immunized Balb/cJ mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
摘要翻译：用于产生针对所有正常人T细胞上发现的抗原的单克隆抗体的杂交细胞系。通过将来自免疫Balb / cJ小鼠的脾细胞与P3X63Ag8U1骨髓瘤细胞融合形成杂交体。还公开了单克隆抗体的诊断和治疗用途。

8. 发明授权

US4637983A Hybrid cell line for producing monoclonal antibody to human cytotoxic and suppressor T cells, antibody, and methods 失效
标题翻译：用于产生人细胞毒性和抑制T细胞的单克隆抗体的杂交细胞系，抗体和方法
公开(公告)号：US4637983A
公开(公告)日：1987-01-20
申请号：US432455
申请日：1982-10-04
申请人： Patric C. Kung , Gideon Goldstein
发明人： Patric C. Kung , Gideon Goldstein
IPC分类号： A61K38/00 , C07K16/28 , C12P21/08 , G01N33/569 , C12N5/00 , C12N15/00 , C12P21/00 , C12R1/91
CPC分类号： C07K16/28 , G01N33/56972 , A61K38/00 , Y10S435/948
摘要： Hybrid cell line for production of monoclonal antibody to an antigen found on normal human cytotoxic and suppressor T cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
摘要翻译：用于在正常人细胞毒和抑制T细胞上发现的抗原的单克隆抗体的杂交细胞系。通过将来自免疫的CAF1小鼠的脾细胞与P3X63Ag8U1骨髓瘤细胞融合来形成杂交体。还公开了单克隆抗体的诊断和治疗用途。

9. 发明授权

US4547489A Conformationally restricted thymopentin-like compounds 失效
标题翻译：构象上限制的胸腺五肽样化合物
公开(公告)号：US4547489A
公开(公告)日：1985-10-15
申请号：US618968
申请日：1984-06-11
申请人： Gideon Goldstein , George Heavner , Tapan Audhya , Foe-Siong Tjoeng
发明人： Gideon Goldstein , George Heavner , Tapan Audhya , Foe-Siong Tjoeng
IPC分类号： C07K7/54 , A61K38/00 , A61K38/22 , A61P37/00 , C07K7/64 , C07K14/66 , A61K37/00
CPC分类号： C07K14/66 , A61K38/00 , Y10S930/18 , Y10S930/27
摘要： Immunoregulating peptides are disclosed which are cyclic peptides similar to thymopentin. These peptides are useful for their effects on the immune system, especially the treatment of thymic deficiencies.
摘要翻译：公开了与胸腺五肽相似的环肽的免疫调节肽。这些肽可用于对免疫系统的影响，特别是对胸腺缺陷的治疗。

10. 发明授权

US4381295A Monoclonal antibody to human helper T cells and methods of preparing same 失效
标题翻译：人辅助T细胞的单克隆抗体及其制备方法
公开(公告)号：US4381295A
公开(公告)日：1983-04-26
申请号：US33639
申请日：1979-04-26
申请人： Patrick C. Kung , Gideon Goldstein
发明人： Patrick C. Kung , Gideon Goldstein
IPC分类号： A61K39/395 , A61K38/00 , A61P37/00 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/28 , C07K16/30 , C12N5/00 , C12N5/10 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577 , C12N5/02 , C12N15/00 , C12Q1/00 , G01N33/48 , G01N33/68 , G01N33/96
CPC分类号： C07K16/3061 , C07K16/2812 , A61K38/00 , Y10S435/966 , Y10S530/808
摘要： Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human helper T cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
摘要翻译：用于在所有正常人辅助T细胞上发现的抗原的单克隆抗体的杂交细胞系。通过将来自免疫的CAF1小鼠的脾细胞与P3X63Ag8U1骨髓瘤细胞融合来形成杂交体。还公开了单克隆抗体的诊断和治疗用途。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式