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1. 发明授权

US09034844B2 6′-sialyllactose salts and process for their synthesis and for the synthesis of other alpha-sialyloligosaccharides 有权
标题翻译： 6'-唾液酸乳糖盐及其合成和合成其它α-唾液酸低聚糖的方法
公开(公告)号：US09034844B2
公开(公告)日：2015-05-19
申请号：US13260221
申请日：2010-04-06
申请人： Giancarlo Tamerlani , Ilaria Lombardi , Debora Bartalucci , Andrea Danesi , Liana Salsini , Marco Manoni , Giovanni Cipolletti
发明人： Giancarlo Tamerlani , Ilaria Lombardi , Debora Bartalucci , Andrea Danesi , Liana Salsini , Marco Manoni , Giovanni Cipolletti
IPC分类号： C07H13/04 , C07H15/04 , C07H23/00 , C07H13/06
CPC分类号： C07H13/06 , A23G2200/06 , C07H13/04 , C07H15/04 , C07H23/00
摘要： The present invention relates to a process of synthesis of α-sialyl oligosaccharides and in particular of 6′-sialyllactose and its salts comprising a step of coupling by Koenigs-Knorr reaction under conditions that allow its use on an industrial scale.
摘要翻译：本发明涉及α-唾液酸寡糖，特别是6'-唾液乳糖及其盐的合成方法，其包括在允许其在工业规模上使用的条件下通过Koenigs-Knorr反应偶联的步骤。

2. 发明申请

US20120071441A1 6'-SIALYLLACTOSE SALTS AND PROCESS FOR THEIR SYNTHESIS AND FOR THE SYNTHESIS OF OTHER ALPHA-SIALYLOLIGOSACCHARIDES 有权
标题翻译： 6'-SIALYLLACTOSE SALTS及其合成和合成其他α-淀粉胆固醇的方法
公开(公告)号：US20120071441A1
公开(公告)日：2012-03-22
申请号：US13260221
申请日：2010-04-06
申请人： Giancarlo Tamerlani , Ilaria Lombardi , Debora Bartalucci , Andrea Danesi , Liana Salsini , Marco Manoni , Giovanni Cipolletti
发明人： Giancarlo Tamerlani , Ilaria Lombardi , Debora Bartalucci , Andrea Danesi , Liana Salsini , Marco Manoni , Giovanni Cipolletti
IPC分类号： A61K31/702 , A23L1/09 , A23L1/304 , C07H5/06
CPC分类号： C07H13/06 , A23G2200/06 , C07H13/04 , C07H15/04 , C07H23/00
摘要： The present invention relates to a process of synthesis of α-sialyl oligosaccharides and in particular of 6′-sialyllactose and its salts comprising a step of coupling by Koenigs-Knorr reaction under conditions that allow its use on an industrial scale.
摘要翻译：本发明涉及α-唾液酸寡糖，特别是6'-唾液乳糖及其盐的合成方法，其包括在允许其在工业规模上使用的条件下通过Koenigs-Knorr反应偶联的步骤。

3. 发明授权

US06891036B2 Process for the preparation of ribofuranose derivatives 失效
标题翻译：制备呋喃核糖衍生物的方法
公开(公告)号：US06891036B2
公开(公告)日：2005-05-10
申请号：US10447167
申请日：2003-05-27
申请人： Giancarlo Tamerlani , Liana Salsini , Ilaria Lombardi , Debora Bartalucci , Giovanni Cipolletti
发明人： Giancarlo Tamerlani , Liana Salsini , Ilaria Lombardi , Debora Bartalucci , Giovanni Cipolletti
IPC分类号： C07H3/00 , C07H13/04 , C07H13/08
CPC分类号： C07H3/00
摘要： The present invention relates to a new process in 3 steps starting from 2-C-methyl-D-ribopentono-1,4-lactone for the preparation of tetra-acyl ribofuranose derivatives of formula (I): useful in the synthesis of nucleotides.
摘要翻译：本发明涉及从2- C-methyl-D-ribopentono-1,4-内酯开始制备用于合成核苷酸的式（I）的四酰基呋喃核糖衍生物的3个步骤的新方法。

4. 发明授权

US08124758B2 Process for the preparation of N-Acetyl-D-mannosamine monohydrate 有权
标题翻译： N-乙酰基-D-甘露糖胺一水合物的制备方法
公开(公告)号：US08124758B2
公开(公告)日：2012-02-28
申请号：US12227423
申请日：2007-05-18
申请人： Giovanni Cipolletti , Giancarlo Tamerlani , Ilaria Lombardi , Debora Bartalucci
发明人： Giovanni Cipolletti , Giancarlo Tamerlani , Ilaria Lombardi , Debora Bartalucci
IPC分类号： C07H1/06
CPC分类号： C07H1/00 , C07H13/04
摘要： A process is described for the preparation of N-Acetyl-D-mannosamine monohydrate of formula (I) a specific intermediate in the synthesis of N-Acetyl-neuraminic acid, that is an important starting product for the synthesis of various pharmaceutically active products.
摘要翻译：描述了用于制备式（I）的N-乙酰基-D-甘露糖胺一水合物的方法，其是合成N-乙酰神经氨酸的特定中间体，其是用于合成各种药学活性产物的重要起始产物。

5. 发明申请

US20110245488A1 PROCESS FOR THE SYNTHESIS OF L-FUCOSYL DI- OR OLIGO-SACCHARIDES AND NOVEL 2,3,4 TRIBENZYL-FUCOSYL DERIVATIVES INTERMEDIATES THEREOF 审中-公开
标题翻译：合成L-赖氨酸对 - 或寡糖和新型2,3,4三苯并呋喃衍生物的方法中间体
公开(公告)号：US20110245488A1
公开(公告)日：2011-10-06
申请号：US13140815
申请日：2009-12-18
申请人： Liana Salsini , Marco Manoni , Giovanni Cipolletti
发明人： Liana Salsini , Marco Manoni , Giovanni Cipolletti
IPC分类号： C07H3/06 , C07H1/00 , C07H3/04
CPC分类号： C07H1/00 , C07H3/06
摘要： The present invention relates to a process for the synthesis of L-fucosyl di- or oligosaccharides and their novel 2,3,4-tri-O-benzyl-fucosyl synthetic intermediates derivatives of easy crystallization. In particular the present invention relates to a process applicable to industrial scale for the synthesis of 2′O-fucosyl lactose.
摘要翻译：本发明涉及一种合成L-岩藻糖基二糖或寡糖的方法及其新颖的2,3,4-三-O-苄基 - 岩藻糖基合成中间体易结晶的衍生物。特别地，本发明涉及适用于合成2'O-岩藻糖基乳糖的工业规模的方法。

6. 发明申请

US20070042993A1 Polysaccharides derivatives with high antithrombotic activity in plasma 失效
标题翻译：血浆中具有高抗血栓活性的多糖衍生物
公开(公告)号：US20070042993A1
公开(公告)日：2007-02-22
申请号：US10557584
申请日：2004-07-07
申请人： Marco Manoni , Liana Salsini , Jacopo Chini , Giovanni Cipolletti
发明人： Marco Manoni , Liana Salsini , Jacopo Chini , Giovanni Cipolletti
IPC分类号： A61K31/727 , C08B37/08
CPC分类号： C08B37/0063 , C08B37/00 , C08B37/006 , C08B37/0075 , Y10S435/849
摘要： The present invention relates to a process for the preparation of sulphated glycosaminoglycans derived from N-acetylheparosan which comprises: a) N-deacetylation and N-sulphation of the N-acetylheparosan polysaccharide prepared from natural or recombinant bacterial strain, preferably K5 E. coli, b) enzymatic epimerization with the glucuronyl C5-epimerase enzyme, c) partial O-sulphation followed by a partial O-desulphation, d) partial 6-0-sulphation, e) N-sulphation and an intermediate step of controlled depolimerization characterised by the fact that both 0-sulphations (0-sulphation and 60-sulphation) are partial. Furthermore the invention relates to the products obtained according to the process which show a ratio between the anti-Xa activity and anti-Ila activity equal to or higher than 1 and to compositions comprising said products in combination with suitable and pharmaceutically acceptable excipients and/or diluent.
摘要翻译：本发明涉及一种用于制备源自N-乙酰基异烟芽孢杆菌的硫酸化葡糖胺聚糖的方法，其包括：a）由天然或重组细菌菌株，优选K5大肠杆菌制备的N-乙酰基异烟芽孢杆菌多糖的N-脱乙酰和N-硫酸化， b）用葡糖醛酸C5-差向异构酶进行酶促差向异构化，c）部分O-硫酸化，然后是部分O-脱硫，d）部分6-0-硫酸化，e）N-硫酸化和中间步骤，事实上，0-硫酸化（O-硫酸化和60-硫酸化）都是部分的。此外，本发明涉及根据显示抗Xa活性和等于或高于1的抗Ila活性之间的比例的方法获得的产品和包含所述产品的组合物与合适的和药学上可接受的赋形剂和/或冲淡。

7. 发明授权

US07687249B2 Polysaccharide derivatives with high antithrombotic activity in plasma 失效
标题翻译：血浆中具有高抗血栓活性的多糖衍生物
公开(公告)号：US07687249B2
公开(公告)日：2010-03-30
申请号：US10557584
申请日：2004-07-07
申请人： Marco Manoni , Liana Salsini , Jacopo Chini , Giovanni Cipolletti
发明人： Marco Manoni , Liana Salsini , Jacopo Chini , Giovanni Cipolletti
IPC分类号： C12P1/00 , C12P19/00 , C12P19/04 , A01N41/08 , A61K31/70 , A61K31/715 , A61K31/726 , A61K31/727 , C07H5/06 , C07H5/04 , C08B37/08
CPC分类号： C08B37/0063 , C08B37/00 , C08B37/006 , C08B37/0075 , Y10S435/849
摘要： The present invention relates to a process for the preparation of sulphated glycosaminoglycans derived from N— acetylheparosan which comprises: a) N-deacetylation and N-sulphation of the N-acetylheparosan polysaccharide prepared from natural or recombinant bacterial strain, preferably K5 E. coli, b) enzymatic epimerization with the glucuronyl C5-epimerase enzyme, c) partial O-sulphation followed by a partial O-desulphation, d) partial 6-O-sulphation, e) N-sulphation and an intermediate step of controlled depolimerization characterised by the fact that both O-sulphations (O-sulphation and 6O-sulphation) are partial.Furthermore the invention relates to the products obtained according to the process which show a ratio between the anti-Xa activity and anti-IIa activity equal to or higher than 1 and to compositions comprising said products in combination with suitable and pharmaceutically acceptable excipients and/or diluent.
摘要翻译：本发明涉及一种制备衍生自N-乙酰胆碱硫酸的硫酸化糖胺聚糖的方法，其包括：a）由天然或重组细菌菌株，优选K5大肠杆菌制备的N-乙酰基黑色素多糖的N-脱乙酰和N-硫酸化， b）用葡糖醛酸C5-差向异构酶进行酶促差向异构化，c）部分O-硫酸化，然后是部分O-脱硫，d）部分6-O-硫酸化，e）N-硫酸化和中间步骤，事实上，O-硫酸化（O-硫酸化和60-硫酸化）都是部分的。此外，本发明涉及根据该方法获得的产品，其显示抗-a活性与等于或高于1的抗IIa活性之间的比例以及包含所述产品的组合物与合适的和药学上可接受的赋形剂和/或冲淡。

8. 发明申请

US20090131654A1 Process for the preparation of n-acetyl-d-mannosamine monohydrate 有权
标题翻译：制备正乙酰基-d-甘露糖胺一水合物的方法
公开(公告)号：US20090131654A1
公开(公告)日：2009-05-21
申请号：US12227423
申请日：2007-05-18
申请人： Giovanni Cipolletti , Giancarlo Tamerlani , Ilaria Lombardi , Debor Bartalucci
发明人： Giovanni Cipolletti , Giancarlo Tamerlani , Ilaria Lombardi , Debor Bartalucci
IPC分类号： C07H1/06
CPC分类号： C07H1/00 , C07H13/04
摘要： A process is described for the preparation of N-Acetyl-D-mannosamine monohydrate of formula (I) a specific intermediate in the synthesis of N-Acetyl-neuraminic acid, that is an important starting product for the synthesis of various pharmaceutically active products.
摘要翻译：描述了用于制备式（I）的N-乙酰基-D-甘露糖胺一水合物的方法，其是合成N-乙酰神经氨酸的特定中间体，其是用于合成各种药学活性产物的重要起始产物。

9. 发明授权

US09200303B2 Process for the production of ultrapure galacto-oligosaccharides 有权
标题翻译：制备超纯低聚半乳糖的方法
公开(公告)号：US09200303B2
公开(公告)日：2015-12-01
申请号：US13388721
申请日：2010-08-06
申请人： Silvia Giacomelli , Marco Manoni , Giovanni Cipolletti , Silvia Biagiolini , Luana Vagnoli , Jacopo Chini
发明人： Silvia Giacomelli , Marco Manoni , Giovanni Cipolletti , Silvia Biagiolini , Luana Vagnoli , Jacopo Chini
IPC分类号： C12N1/00 , C12P19/04
CPC分类号： C12P19/04 , A23L33/21 , A23V2002/00 , A61K31/7016 , A61K31/702 , A61K31/715 , Y02A50/473
摘要： The present invention describes a process for preparing ultrapure (≧95%) galacto-oligosaccharides (GOS), starting from GOS at lower purities by using sequential microbiological purifications involving Saccharomyces cerevisiae and Streptococcus thermophilics.
摘要翻译：本发明描述了通过使用涉及酿酒酵母和嗜热链球菌的连续微生物纯化从较低纯度的GOS开始制备超纯（≥95％）半乳寡聚糖（GOS）的方法。

10. 发明申请

US20050234014A1 O-sulphated bacterial polysaccharides and their use 审中-公开
公开(公告)号：US20050234014A1
公开(公告)日：2005-10-20
申请号：US11131636
申请日：2005-05-17
申请人： Marco Manoni , Sandro Miletti , Giovanni Cipolletti , Rosanna Abbate , Maria Gori
发明人： Marco Manoni , Sandro Miletti , Giovanni Cipolletti , Rosanna Abbate , Maria Gori
IPC分类号： A61K31/715 , A61P29/00 , C08B37/00 , A61K31/737
CPC分类号： A61K31/715 , C08B37/0063 , C08B37/0075 , Y02A50/411
摘要： The present invention refers to the preparation of O-sulphated, N-sulphatated or N-acetylated derivatives, both epimerised or non epimerised, of K5, K4, and optionally defructosilated K4 and K40 polysaccharides and to their use as antiinflammatory agents in chronic and acute inflammations.

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