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1. 发明申请

US20080234831A1 Bioresorbable Stent and Method of Making 审中-公开
标题翻译：生物可吸收支架和制作方法
公开(公告)号：US20080234831A1
公开(公告)日：2008-09-25
申请号：US11688427
申请日：2007-03-20
申请人： Gerry Clarke , Hilda Mulvihill , Angela Duffy
发明人： Gerry Clarke , Hilda Mulvihill , Angela Duffy
IPC分类号： A61F2/04 , B29C39/00
CPC分类号： A61F2/90 , A61F2210/0004 , A61F2240/001 , B29C45/263 , B29C45/33 , B29L2031/753
摘要： A method of making a polymeric stent includes providing a molding apparatus including a central core pin and a plurality of slides, wherein each of the slides includes grooves on an inner surface the slide, wherein the grooves are formed in the shape of the stent. A molten polymer is injected into the grooves and allowed to solidify. The slides are moves away from the central core pin and the solidified polymer, in the shape of a stent, is removed. The central core also may or may not include corresponding grooves depending on the desired cross section of struts and crowns of the stent.
摘要翻译：制造聚合物支架的方法包括提供包括中心芯销和多个滑块的成型设备，其中每个滑块在滑动件的内表面上包括凹槽，其中所述凹槽形成为支架的形状。将熔融的聚合物注入槽中并使其固化。滑块移动远离中心芯销，固定的聚合物以支架的形状被移除。中心芯还可以包括或可以不包括取决于支架的支柱和冠部的期望横截面的相应的凹槽。

2. 发明授权

US08628513B2 Cell reservoirs created by polymer plugs 有权
标题翻译：由聚合物塞产生的电池槽
公开(公告)号：US08628513B2
公开(公告)日：2014-01-14
申请号：US12755470
申请日：2010-04-07
申请人： Angela Duffy , Brendan Hanley , Padraic Curran , Michael Benz
发明人： Angela Duffy , Brendan Hanley , Padraic Curran , Michael Benz
IPC分类号： A61M31/00
CPC分类号： A61M25/003 , A61B18/1492 , A61K31/00 , A61L27/14 , A61L27/38 , A61L2400/06 , A61M25/0067 , A61M25/007 , A61M2025/0004 , A61M2025/0036 , A61M2025/0037
摘要： Described herein generally are catheter systems used to deliver cells and other bioactive materials to a target location within the vascular system of the human body, and methods of delivering cells and other bioactive materials to such target locations.
摘要翻译：本文描述的通常是用于将细胞和其他生物活性物质递送到人体血管系统内的目标位置的导管系统，以及将细胞和其它生物活性物质递送到这些目标位置的方法。

3. 发明申请

US20100150877A1 Osteopontin for the Prediction and Treatment of Cardiovascular Diseases 有权
标题翻译：骨桥蛋白预测和治疗心血管疾病
公开(公告)号：US20100150877A1
公开(公告)日：2010-06-17
申请号：US12528610
申请日：2008-03-03
申请人： Timothy O'Brien , Frank Barry , Aaron Liew Yie Loong , Afshin Samali , Angela Duffy
发明人： Timothy O'Brien , Frank Barry , Aaron Liew Yie Loong , Afshin Samali , Angela Duffy
IPC分类号： A61K38/17 , C12N5/074 , C07K14/46 , C07H21/04 , A61K35/12 , A61K31/7088 , C12Q1/02 , C07K16/18 , A61P9/00
CPC分类号： A61K35/28 , A61K35/44
摘要： Osteopontin for the prediction and treatment of cardiovascular diseases The present invention relates to the use of endothelial progenitor cells (EPCs) and osteopontin for the treatment of cardiovascular diseases or complications. The invention also relates to the use of EPC osteopontin levels as a marker of the risk of the development of these cardiovascular complications. In particular, the invention provides compositions and methods based on osteopontin and the genes encoding osteopontin.
摘要翻译：用于预测和治疗心血管疾病的骨桥蛋白本发明涉及内皮祖细胞（EPCs）和骨桥蛋白用于治疗心血管疾病或并发症的用途。本发明还涉及使用EPC骨桥蛋白水平作为发展这些心血管并发症风险的标志物。特别地，本发明提供了基于骨桥蛋白和编码骨桥蛋白的基因的组合物和方法。

4. 发明授权

US08323968B2 Osteopontin for the prediction and treatment of cardiovascular diseases 有权
标题翻译：骨桥蛋白预测和治疗心血管疾病
公开(公告)号：US08323968B2
公开(公告)日：2012-12-04
申请号：US12528610
申请日：2008-03-03
申请人： Timothy O'Brien , Frank Barry , Aaron Yie Loong Liew , Afshin Samali , Angela Duffy
发明人： Timothy O'Brien , Frank Barry , Aaron Yie Loong Liew , Afshin Samali , Angela Duffy
IPC分类号： C12N15/63 , C12N5/00 , C12N5/08 , C07K1/00
CPC分类号： A61K35/28 , A61K35/44
摘要： Osteopontin for the prediction and treatment of cardiovascular diseases The present invention relates to the use of endothelial progenitor cells (EPCs) and osteopontin for the treatment of cardiovascular diseases or complications. The invention also relates to the use of EPC osteopontin levels as a marker of the risk of the development of these cardiovascular complications. In particular, the invention provides compositions and methods based on osteopontin and the genes encoding osteopontin.
摘要翻译：用于预测和治疗心血管疾病的骨桥蛋白本发明涉及内皮祖细胞（EPCs）和骨桥蛋白用于治疗心血管疾病或并发症的用途。本发明还涉及使用EPC骨桥蛋白水平作为发展这些心血管并发症风险的标志物。特别地，本发明提供了基于骨桥蛋白和编码骨桥蛋白的基因的组合物和方法。

5. 发明申请

US20110098671A1 Over-The-WIre Balloon Catheter for Efficient Targeted Cell Delivery 有权
标题翻译：用于有效靶向细胞传递的超过-Everre气球导管
公开(公告)号：US20110098671A1
公开(公告)日：2011-04-28
申请号：US12606481
申请日：2009-10-27
申请人： Angela Duffy , Padraic Curran
发明人： Angela Duffy , Padraic Curran
IPC分类号： A61M31/00 , A61M29/00
CPC分类号： A61M25/10 , A61M25/0068
摘要： A method for delivering a therapeutic substance to a treatment site within a body lumen includes advancing a balloon catheter to the treatment site. A balloon of the balloon catheter is inflated and while the balloon is inflated, a primer that coats the treatment site and attracts the therapeutic substance thereto is delivered through a first fluid delivery lumen of the balloon catheter. The balloon of the balloon catheter is deflated for a predetermined period of time. The balloon of the balloon catheter is reinflated and while the balloon is reinflated, the therapeutic substance is delivered through a second fluid delivery lumen of the balloon catheter. The primer improves adherence of the therapeutic substance to the treatment site.
摘要翻译：用于将治疗物质输送到体腔内的治疗部位的方法包括将气囊导管推进到治疗部位。气囊导管的气囊膨胀，并且当气囊膨胀时，将涂覆治疗部位并吸引治疗物质的底漆通过气囊导管的第一流体输送腔输送。气囊导管的气囊放气预定的时间。球囊导管的球囊被重新充气，并且当球囊被重新充气时，治疗物质通过气囊导管的第二流体输送腔输送。引物改善了治疗物质对治疗部位的依从性。

6. 发明申请

US20110251545A1 Cell Reservoirs Created by Polymer Plugs 有权
标题翻译：由聚合物塞创建的细胞储库
公开(公告)号：US20110251545A1
公开(公告)日：2011-10-13
申请号：US12755470
申请日：2010-04-07
申请人： Angela Duffy , Brendan Hanley , Padraic Curran , Michael Benz
发明人： Angela Duffy , Brendan Hanley , Padraic Curran , Michael Benz
IPC分类号： A61M25/14 , A61K35/12 , A61B18/18
CPC分类号： A61M25/003 , A61B18/1492 , A61K31/00 , A61L27/14 , A61L27/38 , A61L2400/06 , A61M25/0067 , A61M25/007 , A61M2025/0004 , A61M2025/0036 , A61M2025/0037
摘要： Described herein generally are catheter systems used to deliver cells and other bioactive materials to a target location within the vascular system of the human body, and methods of delivering cells and other bioactive materials to such target locations.
摘要翻译：本文描述的通常是用于将细胞和其他生物活性物质递送到人体血管系统内的目标位置的导管系统，以及将细胞和其它生物活性物质递送到这些目标位置的方法。

7. 发明授权

US08372054B2 Over-the-wire balloon catheter for efficient targeted cell delivery 有权
标题翻译：用于有效靶向细胞递送的超线球囊导管
公开(公告)号：US08372054B2
公开(公告)日：2013-02-12
申请号：US12606481
申请日：2009-10-27
申请人： Angela Duffy , Padraic Curran
发明人： Angela Duffy , Padraic Curran
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61M25/0068
摘要： A method for delivering a therapeutic substance to a treatment site within a body lumen includes advancing a balloon catheter to the treatment site. A balloon of the balloon catheter is inflated and while the balloon is inflated, a primer that coats the treatment site and attracts the therapeutic substance thereto is delivered through a first fluid delivery lumen of the balloon catheter. The balloon of the balloon catheter is deflated for a predetermined period of time. The balloon of the balloon catheter is reinflated and while the balloon is reinflated, the therapeutic substance is delivered through a second fluid delivery lumen of the balloon catheter. The primer improves adherence of the therapeutic substance to the treatment site.
摘要翻译：用于将治疗物质输送到体腔内的治疗部位的方法包括将气囊导管推进到治疗部位。气囊导管的气囊膨胀，并且当气囊膨胀时，将涂覆治疗部位并吸引治疗物质的底漆通过气囊导管的第一流体输送腔输送。气囊导管的气囊放气预定的时间。球囊导管的球囊被重新充气，并且当球囊被重新充气时，治疗物质通过气囊导管的第二流体输送腔输送。引物改善了治疗物质对治疗部位的依从性。

8. 发明申请

US20100125265A1 Cell Delivery System to Induce Cell Growth and Angiogenesis 审中-公开
标题翻译：细胞递送系统诱导细胞生长和血管发生
公开(公告)号：US20100125265A1
公开(公告)日：2010-05-20
申请号：US12274803
申请日：2008-11-20
申请人： Noreen Moloney , Angela Duffy
发明人： Noreen Moloney , Angela Duffy
IPC分类号： A61M25/00
CPC分类号： A61M25/007 , A61K35/44 , A61K35/545 , A61M5/31511 , A61M2210/125
摘要： Systems and methods that allow the local delivery of stem cells and/or endothelial progenitor cells to a treatment site. More particularly, this disclosure provides cell delivery systems used to induce cell growth and angiogenesis at a treatment site.
摘要翻译：允许将干细胞和/或内皮祖细胞局部递送至治疗部位的系统和方法。更具体地，本公开提供用于在治疗部位诱导细胞生长和血管生成的细胞递送系统。

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