专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06384912B1 Measuring device and the use thereof 有权
公开(公告)号：US06384912B1
公开(公告)日：2002-05-07
申请号：US09742391
申请日：2000-12-22
申请人： Gerolf Kraus , Michael Pawlak , Gert Ludwig Duveneck , Peter Oroszlan , Andreas Helg , Alfredo Emilio Bruno-Raimondi
发明人： Gerolf Kraus , Michael Pawlak , Gert Ludwig Duveneck , Peter Oroszlan , Andreas Helg , Alfredo Emilio Bruno-Raimondi
IPC分类号： G01N110
摘要： A device has a planar optical waveguide, including a transparent carrier (40) and a wave-guiding layer (41), wherein the waveguide at least has a diffractive element (42) for coupling excitation radiation into the wave-guiding layer. Located on the wave-guiding layer is a further, tightly sealing layer (43) made from a material which, at least at the support surface, is transparent both to the excitation radiation and to the evanescently excited radiation at least to the penetration depth of the evanescent field, and which, for an analysis sample, has, at least in a partial region of the guided excitation radiation, a cavity (45) which is open to the upper side or a cavity (6) which is closed to the upper side and connected by means of an inlet channel (2) and an outlet channel (3). The depth of the cavity corresponds at least to the penetration depth of the evanescent field, and the diffractive element (42) is fully covered by the material of the layer (43) at least in the coupling-in region of the excitation radiation.

2. 发明授权

US06198869B1 Measuring device and its use 有权
标题翻译：测量装置及其用途
公开(公告)号：US06198869B1
公开(公告)日：2001-03-06
申请号：US09308096
申请日：1999-05-17
申请人： Gerolf Kraus , Michael Pawlak , Gert Ludwig Duveneck , Peter Oroszlan , Andreas Helg , Alfredo Emilio Bruno-Raimondi
发明人： Gerolf Kraus , Michael Pawlak , Gert Ludwig Duveneck , Peter Oroszlan , Andreas Helg , Alfredo Emilio Bruno-Raimondi
IPC分类号： G01N2100
CPC分类号： G01N21/648 , G01N21/05 , G01N21/7703 , G01N2021/0346
摘要： A device comprising a planar optical waveguide, consisting of a transparent carrier (40) and a wave-guiding layer (41), wherein the waveguide at least has a diffractive element (42) for coupling excitation radiation into the wave-guiding layer, and there is located on the wave-guiding layer a further, tightly sealing layer (43) made from a material which, at least at the support surface, is transparent both to the excitation radiation and to the evanescently excited radiation at least to the penetration depth of the evanescent field, and which, for an analysis sample, has, at least in a partial region of the guided excitation radiation, a cavity (45) which is open to the upper side or a cavity (6) which is closed to the upper side and connected by means of an inflow channel (2) and an outflow channel (3), the depth of the cavity corresponding at least to the penetration depth of the evanescent field, and wherein the diffractive element (42) is fully covered by the material of the layer (43) at least in the coupling-in region of the excitation radiation.
摘要翻译：一种包括由透明载体（40）和波导层（41）组成的平面光波导的装置，其中所述波导至少具有用于将激发辐射耦合到波导层中的衍射元件（42），以及位于波导层上的另一紧密密封层（43）由材料制成，所述材料至少在支撑表面上对于激发辐射和至少到穿透深度的消逝的辐射是透明的，并且对于分析样本，至少在被引导的激发辐射的部分区域中具有向上侧敞开的空腔（45）或与所述空腔（6）关闭的空腔（6），所述空腔上侧并且通过流入通道（2）和流出通道（3）连接，所述空腔的深度至少对应于所述ev逝场的穿透深度，并且其中所述衍射元件（42）完全被层的材料（43）至少在激发辐射的耦合区域中。

3. 发明申请

US20100130370A1 FLOW CELL ARRAY AND THE UTILIZATION THEREOF FOR MULTIANALYTE DETERMINATION 有权
标题翻译：流量池阵列及其多用途测定的应用
公开(公告)号：US20100130370A1
公开(公告)日：2010-05-27
申请号：US12695553
申请日：2010-01-28
申请人： Eveline Schurmann-Mader , Andreas Peter Abel , Martin Andreas Bopp , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Mtthias Kresbach , Michael Pawlak , Nania Graciela Scharer-Hernandez , Eginhard Schick
发明人： Eveline Schurmann-Mader , Andreas Peter Abel , Martin Andreas Bopp , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Mtthias Kresbach , Michael Pawlak , Nania Graciela Scharer-Hernandez , Eginhard Schick
IPC分类号： C40B30/00 , C40B60/12
CPC分类号： B01L3/5025 , G01N21/05 , G01N21/253 , G01N2021/0346
摘要： A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents. An arrangement of one or more sample compartments includes a base plate and a body combined with the base plate in such a way that one or more recesses for generation of one or more flow cells fluidically sealed against one another, each with at least one inlet and one outlet, are formed between the base plate and the body, wherein at least one outlet of each flow cell is joined with a reservoir fluidically connected with the flow cell, the reservoir being operable to receive liquid exiting the flow cell, besides methods for its manufacturing and their use.
摘要翻译：提供了流动池的一维或二维布置，作为样品室阵列的一部分，每个样品室的至少一个入口和出口由基板和主体形成，具有空间凹陷的布置对应于样品室的（几何）布置，与基板结合。该装置允许从样品室供应或从样品室中取出，样品室可以大量排列在小的基底区域上，甚至是非常少量的样品或试剂。一个或多个样品室的布置包括基板和与基板组合的主体，使得一个或多个凹槽用于产生流体密封的一个或多个流动池，每个具有至少一个入口和一个出口形成在基板和主体之间，其中每个流动池的至少一个出口与与流动池流体连接的储存器连接，储存器可操作以接收离开流动池的液体，除了其用于其的方法制造及其使用。

4. 发明授权

US07678565B2 Flow cell array and the utilization thereof for multianalyte determination 失效
标题翻译：流量池阵列及其在多分辨率测定中的应用
公开(公告)号：US07678565B2
公开(公告)日：2010-03-16
申请号：US12071526
申请日：2008-02-21
申请人： Eveline Schürmann-Mader , Andreas Peter Abel , Martin Andreas Bopp , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Michael Pawlak , Nania Graciela Schärer-Hernández , Eginhard Schick
发明人： Eveline Schürmann-Mader , Andreas Peter Abel , Martin Andreas Bopp , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Michael Pawlak , Nania Graciela Schärer-Hernández , Eginhard Schick
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： B01L3/5025 , G01N21/05 , G01N21/253 , G01N2021/0346
摘要： A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents. An arrangement of one or more sample compartments includes a base plate and a body combined with the base plate in such a way that one or more recesses for generation of one or more flow cells fluidically sealed against one another, each with at least one inlet and one outlet, are formed between the base plate and the body, wherein at least one outlet of each flow cell is joined with a reservoir fluidically connected with the flow cell, the reservoir being operable to receive liquid exiting the flow cell, besides methods for its manufacturing and their use.
摘要翻译：提供了流动池的一维或二维布置，作为样品室阵列的一部分，每个样品室的至少一个入口和出口由基板和主体形成，具有空间凹陷的布置对应于样品室的（几何）布置，与基板结合。该装置允许从样品室供应或从样品室中取出，样品室可以大量排列在小的基底区域上，甚至是非常少量的样品或试剂。一个或多个样本室的布置包括基板和与基板结合的主体，使得一个或多个凹槽用于产生流体密封的一个或多个流动池，每个具有至少一个入口和一个出口形成在基板和主体之间，其中每个流动池的至少一个出口与与流动池流体连接的储存器连接，储存器可操作以接收离开流动池的液体，除了其用于其的方法制造及其使用。

5. 发明申请

US20090224173A1 Grating waveguide structure for reinforcing an excitation field and use thereof 审中-公开
标题翻译：用于加强激励场的光栅波导结构及其用途
公开(公告)号：US20090224173A1
公开(公告)日：2009-09-10
申请号：US12318568
申请日：2008-12-31
申请人： Gert Ludwig Duveneck , Martin Andreas Bopp , Michael Pawlak , Markus Ehrat , Gerd Marowsky
发明人： Gert Ludwig Duveneck , Martin Andreas Bopp , Michael Pawlak , Markus Ehrat , Gerd Marowsky
IPC分类号： G01J1/58 , G02F1/01
CPC分类号： G01N21/648 , G01N21/6428 , G01N21/774 , G01N2021/6419 , G01N2021/7786 , G02B6/124
摘要： The invention relates to a variable embodiment of a grating waveguide structure, based on a planar thin-film waveguide with a first optically transparent layer (a) on a second optically transparent layer (b) having a lower refractive index than layer (a), and a grating structure (c) modulated in layer (a), wherein the intensity of an excitation light irradiated at the resonance angle for incoupling into layer (a) is enhanced by at least a factor of 100 on layer (a) and within layer (a), at least in the region of the grating structure (c), in comparison with the intensity of said excitation light on a substrate surface without incoupling of the excitation light. The invention also relates to an optical system with an excitation light source and an embodiment of a grating waveguide structure according to the invention, and to a method for enhancing an excitation light intensity, and to the use thereof in bioanalytical detection processes, in non-linear optics or in telecommunications or communications industry.
摘要翻译：本发明涉及一种基于具有比层（a）折射率低的第二光学透明层（b）上具有第一光学透明层（a）的平面薄膜波导的光栅波导结构的可变实施例，以及在层（a）中调制的光栅结构（c），其中以共耦合角度照射到层（a）中的激发光的强度在层（a）上至少增加100倍，并且在层（a），至少在光栅结构（c）的区域中，与衬底表面上的所述激发光的强度相比较，而不会激发激发光的耦合。本发明还涉及具有激发光源和根据本发明的光栅波导结构的实施例的光学系统，以及用于增强激发光强度的方法及其在生物分析检测过程中的用途，线性光学或电信或通信行业。

6. 发明申请

US20090054263A1 Grating waveguide structure for multi-analyte determinations and the use thereof 审中-公开
标题翻译：用于多分析物测定的光栅波导结构及其用途
公开(公告)号：US20090054263A1
公开(公告)日：2009-02-26
申请号：US12222212
申请日：2008-08-05
申请人： Michael Pawlak , Markus Ehrat , Gert Ludwig Duveneck , Martin Andreas Bopp
发明人： Michael Pawlak , Markus Ehrat , Gert Ludwig Duveneck , Martin Andreas Bopp
IPC分类号： C40B30/10 , C40B60/12
CPC分类号： G01N21/7743 , G01N33/54373
摘要： The invention relates to variable embodiments of a grating waveguide structure which enables to determine locally resolved changes of the resonance conditions for the incoupling of an excitation light into the waveguiding layer (a) of a stratified optical waveguide by means of a grating structure (c) modulated in said layer (a) or for outcoupling of a light guided in layer (a). The inventive system comprises arrays of measurement areas produced on the grating waveguide structure having different immobilized biological or biochemical or synthetic recognition elements for simultaneously binding and determining one or more analytes, wherein said excitation light is simultaneously irradiated onto an entire array of measurement areas, and the degree of satisfaction of the resonance condition for the incoupling of light into the layer (a) towards said measurement areas is simultaneously measured. The invention also relates to an optical system comprising at least one excitation light source and at least one locally resolving detector and, optionally, positioning elements for altering the angle of incidence of the excitation light onto the inventive grating waveguide structure. The invention additionally relates to a corresponding measuring method and to the use thereof. Surprisingly, it has been found that the inventive method is well-suited as an imaging detection method with high local resolution and sensitivity.
摘要翻译：本发明涉及光栅波导结构的可变实施例，其能够通过光栅结构（c）确定激发光进入分层光波导的波导层（a）的谐振条件的局部解析变化，在所述层（a）中调制或者在层（a）中引导的光的外耦合。本发明的系统包括在光栅波导结构上产生的具有不同的固定的生物或生物化学或合成识别元件的测量区域的阵列，用于同时结合和确定一种或多种分析物，其中所述激发光同时照射到整个测量区域阵列上，以及同时测量对于朝向所述测量区域将光耦合到层（a）中的共振条件的满足程度。本发明还涉及一种光学系统，其包括至少一个激发光源和至少一个局部分辨检测器以及可选地用于将激发光的入射角改变到本发明的光栅波导结构上的定位元件。本发明还涉及相应的测量方法及其用途。令人惊讶的是，已经发现本发明的方法非常适合作为具有高的局部分辨率和灵敏度的成像检测方法。

7. 发明申请

US20080299008A1 Flow cell array and the utilization thereof for multianalyte determination 失效
公开(公告)号：US20080299008A1
公开(公告)日：2008-12-04
申请号：US12071526
申请日：2008-02-21
申请人： Eveline Schurmann-Mader , Andreas Peter Abel , Martin Andreas Bopp , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Michael Pawlak , Nania Graciela Scharer-Hernandez , Eginhard Schick
发明人： Eveline Schurmann-Mader , Andreas Peter Abel , Martin Andreas Bopp , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Michael Pawlak , Nania Graciela Scharer-Hernandez , Eginhard Schick
IPC分类号： G01N21/00 , B01L3/00 , B01J19/00 , G01N25/00 , G01N27/00 , C12M1/34
CPC分类号： B01L3/5025 , G01N21/05 , G01N21/253 , G01N2021/0346
摘要： A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents. An arrangement of one or more sample compartments includes a base plate and a body combined with the base plate in such a way that one or more recesses for generation of one or more flow cells fluidically sealed against one another, each with at least one inlet and one outlet, are formed between the base plate and the body, wherein at least one outlet of each flow cell is joined with a reservoir fluidically connected with the flow cell, the reservoir being operable to receive liquid exiting the flow cell, besides methods for its manufacturing and their use.

8. 发明授权

US08053225B2 Flow cell array and the utilization thereof for multianalyte determination 有权
标题翻译：流量池阵列及其在多分辨率测定中的应用
公开(公告)号：US08053225B2
公开(公告)日：2011-11-08
申请号：US12695553
申请日：2010-01-28
申请人： Eveline Schürmann-Mader , Andreas Peter Abel , Martin Andreas Bopp , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Michael Pawlak , Nania Graciela Schärer-Hernández , Eginhard Schick
发明人： Eveline Schürmann-Mader , Andreas Peter Abel , Martin Andreas Bopp , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Michael Pawlak , Nania Graciela Schärer-Hernández , Eginhard Schick
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： B01L3/5025 , G01N21/05 , G01N21/253 , G01N2021/0346
摘要： A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents. An arrangement of one or more sample compartments includes a base plate and a body combined with the base plate in such a way that one or more recesses for generation of one or more flow cells fluidically sealed against one another, each with at least one inlet and one outlet, are formed between the base plate and the body, wherein at least one outlet of each flow cell is joined with a reservoir fluidically connected with the flow cell, the reservoir being operable to receive liquid exiting the flow cell, besides methods for its manufacturing and their use.
摘要翻译：提供了流动池的一维或二维布置，作为样品室阵列的一部分，每个样品室的至少一个入口和出口由基板和主体形成，具有空间凹陷的布置对应于样品室的（几何）布置，与基板结合。该装置允许从样品室供应或从样品室中取出，样品室可以大量排列在小的基底区域上，甚至是非常少量的样品或试剂。一个或多个样本室的布置包括基板和与基板结合的主体，使得一个或多个凹槽用于产生流体密封的一个或多个流动池，每个具有至少一个入口和一个出口形成在基板和主体之间，其中每个流动池的至少一个出口与与流动池流体连接的储存器连接，储存器可操作以接收离开流动池的液体，除了其用于其的方法制造及其使用。

9. 发明授权

US07396675B2 Kit and method for determining a plurality of analytes 有权
标题翻译：用于确定多种分析物的试剂盒和方法
公开(公告)号：US07396675B2
公开(公告)日：2008-07-08
申请号：US10296851
申请日：2001-05-25
申请人： Michael Pawlak , Eginhard Schick , Andreas Peter Abel , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Eveline Schürmann-Mader , Martin Andreas Bopp
发明人： Michael Pawlak , Eginhard Schick , Andreas Peter Abel , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Eveline Schürmann-Mader , Martin Andreas Bopp
IPC分类号： G01N33/543 , G01N33/551
CPC分类号： G01N21/6452 , B01L3/5085 , G01N21/648 , G01N33/54373 , G01N2021/6441 , G01N2021/6482 , Y10S435/808 , Y10S435/975 , Y10S436/805 , Y10S436/808
摘要： The invention is related to different embodiments of a kit for the simultaneous qualitative and/or quantitative determination of a multitude of analytes comprising a sensor platform comprising an optical thin-film waveguide with a layer (a) transparent at least at an excitation wavelength on a layer (b) with lower refractive index than layer (a), also transparent at least at said excitation wavelength, and at least one grating structure (c) modulated in said layer (a), for the incoupling of said excitation light into layer (a), at least one array of biological or biochemical or synthetic recognition elements immobilized in discrete measurement areas (d) directly or by means of an adhesion-promoting layer on layer (a), for specific recognition and/or binding of said analytes and/or for specific interaction with said analytes, means for laterally resolved referencing of the excitation light intensity available in the measurement areas, and optionally means for the calibration of one or more luminescences generated in the near-field of layer (a) as a consequence of the binding of one or more analytes or of the specific interaction with one or more analytes, wherein a liquid sample to be analyzed for said analytes is brought into contact with said measurement areas on said sensor platform either directly or after mixture with further reagents. The invention is also related to analytical systems based on a kit according to the invention and to methods for the determination of one or more analytes, based on said kit, and to use thereof.
摘要翻译：本发明涉及用于同时定性和/或定量测定大量分析物的试剂盒的不同实施方案，其包括传感器平台，所述传感器平台包括具有至少在激发波长上透明的层（a）的光学薄膜波导至少在所述激发波长下透明的至少一个光栅结构（c），用于将所述激发光转换成层（a）的至少一个光栅结构（c） a），直接或通过层（a）上的粘附促进层固定在离散测量区域（d）中的生物或生化或合成识别元件的至少一个阵列，用于特异性识别和/或结合所述分析物和 /或用于与所述分析物的特异性相互作用，用于横向分辨参考测量区域中可用的激发光强度的装置，以及可选地用于校准一个或多个由于一种或多种分析物的结合或与一种或多种分析物的特异性相互作用的结合而在层（a）的近场产生的矿物发光，其中待分析的液体样品与所述分析物接触所述测量区域在所述传感器平台上直接或与其它试剂混合之后。本发明还涉及基于根据本发明的试剂盒的分析系统和基于所述试剂盒测定一种或多种分析物的方法及其用途。

10. 发明授权

US06289144B1 Sensor platform and method for the parallel detection of a plurality of analytes using evanescently excited luminescence 有权
标题翻译：用于使用ev逝激发光的并行检测多个分析物的传感器平台和方法
公开(公告)号：US06289144B1
公开(公告)日：2001-09-11
申请号：US09487560
申请日：2000-01-19
申请人： Dieter Neuschäfer , Gert Ludwig Duveneck , Michael Pawlak , Uwe Pieles , Wolfgang Budach
发明人： Dieter Neuschäfer , Gert Ludwig Duveneck , Michael Pawlak , Uwe Pieles , Wolfgang Budach
IPC分类号： G02B600
CPC分类号： G01N21/648 , G01N21/05 , G01N21/6452 , G01N21/7703 , G01N2021/0346 , G01N2021/7786 , G01N2021/7793
摘要： The invention relates to a sensor platform based on at least two planar, separate, inorganic dielectric waveguiding regions on a common substrate and to a method for the parallel evanescent excitation and detection of the luminescence of identical or different analytes. The invention relates also to a modified sensor platform that consists of the sensor platform having the planar, separate, inorganic dielectric waveguiding regions and one or more organic phases immobilised thereon. A further subject of the invention is the use of the sensor platform or of the modified sensor platform in a luminescence detection method for quantitative affinity sensing and for the selective quantitative determination of luminescent constituents of optically opaque solutions.
摘要翻译：本发明涉及一种基于公共衬底上的至少两个平面，分离的无机介电波导区域的传感器平台，以及用于平行ev逝激发和检测相同或不同分析物的发光的方法。本发明还涉及一种由传感器平台组成的改进的传感器平台，传感器平台具有平面，分离的无机介质波导区域和固定在其上的一个或多个有机相。本发明的另一个主题是在用于定量亲和力感测的发光检测方法中以及用于选择性定量确定光学不透明溶液的发光成分的传感器平台或修改的传感器平台的使用。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式