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1. 发明申请

US20090208456A1 Imidazo[4,5-d]pyrimidines, their uses and methods of preparation 审中-公开
标题翻译：咪唑并[4,5-d]嘧啶，其用途和制备方法
公开(公告)号：US20090208456A1
公开(公告)日：2009-08-20
申请号：US11658625
申请日：2005-07-26
申请人： Gerhard Puerstinger , Choung U. Kim , Johan Neyts , David A. Oare
发明人： Gerhard Puerstinger , Choung U. Kim , Johan Neyts , David A. Oare
IPC分类号： A61K38/21 , C12Q1/70 , A61K31/708 , A61K31/52 , A61K31/437 , C07D473/00 , C07D471/00
CPC分类号： C07D471/04 , C07D473/00 , C07D473/30
摘要： The present invention relates to pharmaceutical compositions for the treatment of prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyrimidine having the general formula (A), wherein the substituents are described in the specification. The invention also relates to processes for the preparation of compounds according to the invention having above mentioned general formula, their pharmaceutically acceptable formulations and their use as a medicine or to treat or prevent viral infections.
摘要翻译：本发明涉及用于治疗预防病毒感染的药物组合物，其包含作为活性成分的至少一种具有通式（A）的咪唑并[4,5-c]嘧啶，其中取代基在说明书中描述。本发明还涉及制备具有上述通式的本发明化合物及其药学上可接受的制剂及其作为药物的用途或用于治疗或预防病毒感染的化合物的方法。

2. 发明授权

US07790730B2 Imidazo[4,5-d]pyrimidines, their uses and methods of preparation 有权
标题翻译：咪唑并[4,5-d]嘧啶，其用途和制备方法
公开(公告)号：US07790730B2
公开(公告)日：2010-09-07
申请号：US11190751
申请日：2005-07-26
申请人： Choung U. Kim , Johan Neyts , David A. Oare , Gerhard Puerstinger
发明人： Choung U. Kim , Johan Neyts , David A. Oare , Gerhard Puerstinger
IPC分类号： C07D473/02 , A61P31/14 , A61K31/52 , C07D471/04 , A61K31/4745 , C07D261/08
CPC分类号： C07D471/04 , C07D473/00 , C07D473/30
摘要： The present invention relates to pharmaceutical compositions for the treatment or prevention of viral infections comprising as an active principle at least one compound having the general formula (A): wherein U is N or C; X is selected from C1-C10 alkylene, C2-10 alkenylene or C2-10 alkynylene, where each may include one or more intrachain heteroatoms selected from O, S, or NR11, provided any such heteroatom is not adjacent to the N in the ring; R3 is selected from aryl, aryloxy, arylthio, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl-N(R10)—, or heterocycle, where each said substituent is optionally substituted with at least one R17, provided that for cycloalkenyl the double bond is not adjacent to a nitrogen; and the other substituents are described in the specification. The invention also relates to processes for the preparation of compounds according to the invention having above mentioned general formula, their pharmaceutically acceptable formulations and their use as a medicine or to treat or prevent viral infections.
摘要翻译：本发明涉及用于治疗或预防病毒感染的药物组合物，其包含至少一种具有通式（A）的化合物作为活性成分：其中U为N或C; X选自C1-C10亚烷基，C2-10亚烯基或C2-10亚炔基，其中每个可以包括一个或多个选自O，S或NR 11的链内杂原子，条件是任何这样的杂原子不与环中的N相邻 ; R 3选自芳基，芳氧基，芳硫基，环烷基，环烯基，环炔基，芳基-N（R 10） - 或杂环，其中每个所述取代基任选被至少一个R 17取代，条件是对于环烯基，双键不相邻到氮气并且其它取代基在说明书中描述。本发明还涉及制备具有上述通式的本发明化合物及其药学上可接受的制剂及其作为药物的用途或用于治疗或预防病毒感染的化合物的方法。

3. 发明授权

US07648998B2 Imidazo 4,5-c pyridine compounds and methods of antiviral treatment 有权
标题翻译：咪唑4,5-C吡啶化合物和抗病毒治疗方法
公开(公告)号：US07648998B2
公开(公告)日：2010-01-19
申请号：US10583814
申请日：2004-12-21
申请人： Steven S. Bondy , Eric Davis Dowdy , Choung U. Kim , David A. Oare , Johan Neyts , Vahid Zia , Gerhard Pürstinger
发明人： Steven S. Bondy , Eric Davis Dowdy , Choung U. Kim , David A. Oare , Johan Neyts , Vahid Zia , Gerhard Pürstinger
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention relates to a pharmaceutical composition for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine prodrug having the general Formula (A) wherein the substituents are described in the specification. The invention also relates to processes for the preparation and screening ofcompounds according to the invention having above mentioned general Formula and their use in the treatment or prophylaxis of viral infections.
摘要翻译：本发明涉及用于治疗或预防病毒感染的药物组合物，其包含作为活性成分的至少一种具有通式（A）的咪唑并[4,5-c]吡啶前药，其中取代基在说明书中描述。本发明还涉及根据具有上述通式的本发明的化合物的制备和筛选方法及其在治疗或预防病毒感染中的用途。

4. 发明授权

US08329727B2 Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment 有权
标题翻译：咪唑并[4,5-c]吡啶化合物和抗病毒治疗方法
公开(公告)号：US08329727B2
公开(公告)日：2012-12-11
申请号：US12577865
申请日：2009-10-13
申请人： Steven S. Bondy , Eric Davis Dowdy , Choung U. Kim , David A. Oare , Johan Neyts , Vahid Zia , Gerhard Pürstinger
发明人： Steven S. Bondy , Eric Davis Dowdy , Choung U. Kim , David A. Oare , Johan Neyts , Vahid Zia , Gerhard Pürstinger
IPC分类号： A61K31/437 , A61K38/21 , A61K31/708 , C07D471/04 , A61P3/12
CPC分类号： C07D471/04
摘要： The present invention relates to pharmaceutical compositions for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine prodrug having the general Formula (A) wherein the substituents are described in the specification. The invention also relates to processes for the preparation and screening of compounds according to the invention having above mentioned general Formula and their use in the treatment or prophylaxis of viral infections.
摘要翻译：本发明涉及用于治疗或预防病毒感染的药物组合物，其包含作为活性成分的至少一种具有通式（A）的咪唑并[4,5-c]吡啶前药，其中取代基在说明书中描述。本发明还涉及制备和筛选具有上述通式的本发明化合物及其在治疗或预防病毒感染中的用途的方法。

5. 发明申请

US20100028301A1 IMIDAZO[4,5-c]PYRIDINE COMPOUNDS AND METHODS OF ANTIVIRAL TREATMENT 有权
标题翻译：咪唑并[4,5-c]吡啶化合物和抗病毒治疗方法
公开(公告)号：US20100028301A1
公开(公告)日：2010-02-04
申请号：US12577865
申请日：2009-10-13
申请人： Steven S. Bondy , Eric Davis Dowdy , Choung U. Kim , David A. Oare , Johan Neyts , Vahid Zia , Gerhard Pürstinger
发明人： Steven S. Bondy , Eric Davis Dowdy , Choung U. Kim , David A. Oare , Johan Neyts , Vahid Zia , Gerhard Pürstinger
IPC分类号： A61K31/437 , C07D471/04 , A61P3/12 , A61K38/21 , A61K31/708
CPC分类号： C07D471/04
摘要： The present invention relates to pharmaceutical compositions for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine prodrug having the general Formula (A) wherein the substituents are described in the specification. The invention also relates to processes for the preparation and screening of compounds according to the invention having above mentioned general Formula and their use in the treatment or prophylaxis of viral infections.
摘要翻译：本发明涉及用于治疗或预防病毒感染的药物组合物，其包含作为活性成分的至少一种具有通式（A）的咪唑并[4,5-c]吡啶前药，其中取代基在说明书中描述。本发明还涉及制备和筛选具有上述通式的本发明化合物及其在治疗或预防病毒感染中的用途的方法。

6. 发明授权

US07645747B2 Therapeutic phosphonate compounds 有权
标题翻译：治疗性膦酸酯化合物
公开(公告)号：US07645747B2
公开(公告)日：2010-01-12
申请号：US11258621
申请日：2005-10-25
申请人： Constantine G. Boojamra , Carina E. Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Manoj Desai , Maria Fardis , Craig S. Gibbs , Ralph F. Hirschmann , Alan X. Huang , Haolun Jin , Choung U. Kim , Thorsten A. Kirschberg , Steven Krawczyk , Christopher P. Lee , William A. Lee , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Peter H. Nelson , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang , Lijun Zhang
发明人： Constantine G. Boojamra , Carina E. Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Manoj Desai , Maria Fardis , Craig S. Gibbs , Ralph F. Hirschmann , Alan X. Huang , Haolun Jin , Choung U. Kim , Thorsten A. Kirschberg , Steven Krawczyk , Christopher P. Lee , William A. Lee , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Peter H. Nelson , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang , Lijun Zhang
IPC分类号： A61K31/661 , A61K31/662 , C07F9/06 , C07F9/28
CPC分类号： C07F9/65616 , C07F9/4006 , C07F9/4465 , C07F9/5304 , C07F9/650952 , C07F9/653 , C07F9/65507 , C07F9/65515 , C07F9/65517 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要： The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.
摘要翻译：本发明涉及磷取代的治疗剂，含有这种磷取代剂的组合物，以及包括施用这种磷取代剂的治疗方法，以及可用于制备这种药剂的方法和中间体。

7. 发明授权

US07429565B2 Antiviral phosphonate analogs 有权
标题翻译：抗病毒膦酸酯类似物
公开(公告)号：US07429565B2
公开(公告)日：2008-09-30
申请号：US10832815
申请日：2004-04-26
申请人： Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Haolun Jin , Ralph F. Hirschmann , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Christopher P. Lee , William A. Lee , Richard L. Mackman , David Y. Markevitch , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang
发明人： Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Haolun Jin , Ralph F. Hirschmann , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Christopher P. Lee , William A. Lee , Richard L. Mackman , David Y. Markevitch , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang
IPC分类号： A61K38/00 , C07D267/22
CPC分类号： C07F9/65616 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K47/548 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/4075 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/65031 , C07F9/650905 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655354 , C07F9/6561 , C07H15/00 , C07H17/00 , C07H19/056 , C07H19/10 , C07H19/20 , C07H21/00 , Y02A50/393 , Y02A50/465
摘要： The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译：本发明涉及具有抗病毒活性的磷取代的化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

8. 发明申请

US20100022467A1 ANTI-CANCER PHOSPHONATE ANALOGS 审中-公开
标题翻译：抗癌剂磷酸酯类似物
公开(公告)号：US20100022467A1
公开(公告)日：2010-01-28
申请号：US12202719
申请日：2008-09-02
申请人： Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher P. Lee , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Peter H. Nelson , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang , Lijun Zhang
发明人： Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher P. Lee , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Peter H. Nelson , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang , Lijun Zhang
IPC分类号： A61K31/7076 , C07H19/20 , A61P35/00
CPC分类号： A61K31/7076 , A61K31/675 , A61K31/7072 , A61K47/548 , C07H19/04
摘要： The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译：本发明涉及磷取代的抗癌化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

9. 发明授权

US08022083B2 Antiviral phosphonate analogs 有权
标题翻译：抗病毒膦酸酯类似物
公开(公告)号：US08022083B2
公开(公告)日：2011-09-20
申请号：US12166076
申请日：2008-07-01
申请人： Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Haolun Jin , Ralph F. Hirschmann , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Christopher P. Lee , William A. Lee , Richard L. Mackman , David Y. Markevitch , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang
发明人： Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Haolun Jin , Ralph F. Hirschmann , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Christopher P. Lee , William A. Lee , Richard L. Mackman , David Y. Markevitch , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang
IPC分类号： A61K31/44 , C07D487/00
CPC分类号： C07F9/65616 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K47/548 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/4075 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/65031 , C07F9/650905 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655354 , C07F9/6561 , C07H15/00 , C07H17/00 , C07H19/056 , C07H19/10 , C07H19/20 , C07H21/00 , Y02A50/393 , Y02A50/465
摘要： The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译：本发明涉及具有抗病毒活性的磷取代的化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

10. 发明授权

US07842672B2 Phosphonate inhibitors of HCV 有权
标题翻译： HCV磷酸抑制剂
公开(公告)号：US07842672B2
公开(公告)日：2010-11-30
申请号：US11825395
申请日：2007-07-06
申请人： Constantine G. Boojamra , James M. Chen , Alan X. Huang , Choung U. Kim , Kuei-Ying Lin , Richard L. Mackman , David A. Oare , Jason K. Perry , Oliver L. Saunders , Sundaramoorthi Swaminathan , Lijun Zhang
发明人： Constantine G. Boojamra , James M. Chen , Alan X. Huang , Choung U. Kim , Kuei-Ying Lin , Richard L. Mackman , David A. Oare , Jason K. Perry , Oliver L. Saunders , Sundaramoorthi Swaminathan , Lijun Zhang
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： C07H19/00
摘要： A compound of Formula I, Formula II, Formula III, or Formula IV: or a pharmaceutically acceptable salt, solvate, and/or ester thereof, therapeutic compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
摘要翻译：式I，式II，式III或式IV化合物或其药学上可接受的盐，溶剂化物和/或酯，含有这些化合物的治疗组合物，以及包括施用这些化合物的治疗方法。

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