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1. 发明授权

US4861807A Radiation-crosslinkable compositions 失效
标题翻译：辐射交联组合物
公开(公告)号：US4861807A
公开(公告)日：1989-08-29
申请号：US137897
申请日：1987-12-28
申请人： Gerhard Preiner , Friedrich Hockemeyer , Christa Burger
发明人： Gerhard Preiner , Friedrich Hockemeyer , Christa Burger
IPC分类号： B05D3/06 , C08L83/04 , C08L83/07 , C08L83/08 , C09J7/02
CPC分类号： C08L83/08
摘要： Compositions which may be crosslinked to form adhesive-repellent coatings having increased separation values, comprising organopolysiloxanes in which at least 95 mol percent of the siloxane units have the formulaHR.sup.1 C.dbd.CR.sup.2 COOR.sup.3 SiR.sub.2 O.sub.1/2,where R is a monovalent hydrocarbon radical or a halogenated monovalent hydrocarbon radical, R.sup.1 is hydrogen or a halogenated phenyl radical, R.sup.2 is hydrogen or an alkyl radical having from 1 to 4 carbon atoms, R.sup.3 is a divalent hydrocarbon radical or a halogenated divalent hydrocarbon radical, in which the organopolysiloxanes also contain siloxane units of the formulasHSR.sup.4 SiRO and R.sub.2.sup.5 SiOin which R is the same as above, R.sup.4 is a divalent hydrocarbon radical, R.sup.5 is the same as R or a hydrocarbon radical substituted with the HR.sup.1 C.dbd.CR.sup.2 COO group, where R.sup.1 and R.sup.2 are the same as above, and at least 95 percent of the silicon-bonded oxygen atoms in the siloxane units having the HS group are present in the .tbd.SiOSi.tbd. group, and at least one organopolysiloxane having units of the formulasR.sub.3.sup.6 SiO.sub.178 and R.sup.6 SiO.sub.3/2 and/or SiO.sub.4/2in which 0.5 to 50 percent of the R.sup.6 radicals are those of the formulaHSR.sup.4 --where R.sup.4 is the same as above and the remaining R.sup.6 radicals are the same or different monovalent hydrocarbon radicals, halogenated monovalent hydrocarbon radicals or hydrocarbon radicals which are substituted by a group of the formula HR.sup.1 C.dbd.CR.sup.2 COO--, where R.sup.1 and R.sup.2 are the same as above.
摘要翻译：可以交联以形成具有增加的分离值的粘合剂拒斥涂层的组合物，其包含有机聚硅氧烷，其中至少95mol％的硅氧烷单元具有式HR1C = CR2COOR3SiR2O1 / 2，其中R是单价烃基或卤代一价烃基，R 1为氢或卤代苯基，R 2为氢或具有1至4个碳原子的烷基，R 3为二价烃基或卤代二价烃基，其中有机聚硅氧烷还含有式为HSR4SiRO和R25SiO，其中R为上述相同，R4为二价烃基，R5为R或与HR1C = CR2COO基取代的烃基，其中R1和R2与上述相同，在具有HS基团的硅氧烷单元中的与硅键合的氧原子的至少95％存在于3BOND SiOSi 3BOND基团中，并且至少一种有机聚硅氧烷其具有式R36SiO178和R6SiO3 / 2和/或SiO4 / 2的单元，其中0.5％至50％的R6基团是式HSR4的那些，其中R 4与上述相同，并且其余的R6基团是相同的或不同的一价烃基，卤代一价烃基或烃基，其被式HR1C = CR2COO-取代，其中R1和R2与上述相同。

2. 发明授权

US09527850B2 Benzyl piperidine compounds as lysophosphatidic acid (LPA) receptor antagonist 有权
标题翻译：苄基哌啶化合物作为溶血磷脂酸（LPA）受体拮抗剂
公开(公告)号：US09527850B2
公开(公告)日：2016-12-27
申请号：US14344267
申请日：2012-09-07
申请人： Kai Schiemann , Wolfgang Staehle , Michael Busch , Dirk Wienke , Oliver Poeschke , Christa Burger
发明人： Kai Schiemann , Wolfgang Staehle , Michael Busch , Dirk Wienke , Oliver Poeschke , Christa Burger
IPC分类号： C07D401/14 , A61K31/45 , C07D487/04 , C07D403/04 , C07D471/04 , A61K31/4525 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/4985 , C07D401/04 , C07D405/04 , C07D409/04
CPC分类号： C07D487/04 , A61K31/4525 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/4985 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D409/04 , C07D471/04
摘要： The invention provides novel substituted benzyl piperidine compounds according to Formula (I) as lysophosphatidic acid (LPA) receptor antagonists, their manufacture and use for the treatment of proliferative or inflammatory diseases, such as cancer, fibrosis or arthritis.
摘要翻译：本发明提供了作为溶血磷脂酸（LPA）受体拮抗剂的式（I）的新型取代的苄基哌啶化合物，其用于治疗增殖性或炎性疾病如癌症，纤维化或关节炎的制备和用途。

3. 发明授权

US07091321B2 Enhancing the circulating half-life of antibody-based fusion proteins 有权
公开(公告)号：US07091321B2
公开(公告)日：2006-08-15
申请号：US09780668
申请日：2001-02-09
申请人： Stephen D. Gillies , Christa Burger , Kin-Ming Lo
发明人： Stephen D. Gillies , Christa Burger , Kin-Ming Lo
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K5/1013 , A61K47/6813 , A61K47/6851 , A61K2039/505 , C07K14/525 , C07K14/55 , C07K16/00 , C07K16/30 , C07K19/00 , C07K2317/24 , C07K2317/52 , C07K2317/73 , C07K2319/00
摘要： Disclosed are compositions and methods for enhancing the circulating half-life of antibody-based fusion proteins. Disclosed methods and compositions rely on altering the amino acid sequence of the junction region between the antibody moiety and the fused protein moiety in an antibody-based fusion protein. An antibody-based fusion protein with an altered amino acid sequence in the junction region has a greater circulating half-life when administered to a mammal. Disclosed methods and compositions are particularly useful for reducing tumor size and metastasis in a mammal.

4. 发明申请

US20050112744A1 Glucose dehydrogenase fusion proteins and their use in expression systems 审中-公开
标题翻译：葡萄糖脱氢酶融合蛋白及其在表达系统中的应用
公开(公告)号：US20050112744A1
公开(公告)日：2005-05-26
申请号：US10681207
申请日：2003-10-09
申请人： Winfried Linxweiler , Christa Burger , Oliver Poeschke , Uwe Hofmann , Andrea Wolf
发明人： Winfried Linxweiler , Christa Burger , Oliver Poeschke , Uwe Hofmann , Andrea Wolf
IPC分类号： G01N33/483 , C07K14/815 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N9/04 , C12N15/09 , C12Q1/32 , G01N27/447 , G01N33/52 , G01N33/573 , G01N33/68 , C07H21/04
CPC分类号： C12N9/0004 , C07K14/815 , C07K2319/00 , C12N2799/021
摘要： The invention relates to novel recombinant fusion proteins containing a protein sequence having the biological activity of glucose dehydrogenase as one of its constituents and to their utilization for simple and efficient detection of any type of proteins/polypeptides in SDS-Page gels and for quick optimization of expression systems that can express the above-mentioned proteins/polypeptides.
摘要翻译：本发明涉及含有具有葡萄糖脱氢酶作为其成分之一的生物活性的蛋白质序列的新型重组融合蛋白，以及其用于简单且有效地检测SDS-PAGE凝胶中任何类型的蛋白质/多肽的快速优化可表达上述蛋白质/多肽的表达系统。

5. 发明授权

US5932415A Processes and agents for detecting listerias 失效
标题翻译：用于检测李斯特菌的方法和试剂
公开(公告)号：US5932415A
公开(公告)日：1999-08-03
申请号：US456670
申请日：1995-06-01
申请人： Peter Schubert , Siegfried Neumann , Martina Pawelzik , Winfried Linxweiler , Christa Burger , Gottfried Hofmann , Andreas Bubert , Werner Goebel , Stefan Kohler
发明人： Peter Schubert , Siegfried Neumann , Martina Pawelzik , Winfried Linxweiler , Christa Burger , Gottfried Hofmann , Andreas Bubert , Werner Goebel , Stefan Kohler
IPC分类号： C07K7/06 , C07K7/08 , C07K14/00 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/12 , C12N15/02 , C12N15/09 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/53 , G01N33/569 , C07H21/04 , C12P19/34
CPC分类号： C07K14/195 , C07K16/1296 , C12Q1/689 , Y10S435/975
摘要： The invention relates to agents and processes for detecting bacteria of the genus Listeria, in particular L. monocytogenes. The agents according to the invention include primers whose sequence is selected from the iap gene of L. monocytogenes. In addition, the agents according to the invention include peptides whose sequence is selected from the p60 protein and which are suitable for producing specific antibodies for the immunological detection of L. monocytogenes.
摘要翻译：本发明涉及用于检测利斯特氏菌属细菌，特别是单核细胞增生李斯特菌的细菌的试剂和方法。根据本发明的试剂包括其序列选自单核细胞增生李斯特氏菌的iap基因的引物。此外，根据本发明的药剂包括其序列选自p60蛋白并且适合于产生用于免疫学检测单核细胞增生李斯特菌的特异性抗体的肽。

6. 发明申请

US20060036074A1 Bromodomain protein 审中-公开
标题翻译：溴结构域蛋白
公开(公告)号：US20060036074A1
公开(公告)日：2006-02-16
申请号：US10240771
申请日：2001-04-04
申请人： Klaus Ducker , Christa Burger , Oliver Wilbert
发明人： Klaus Ducker , Christa Burger , Oliver Wilbert
IPC分类号： C07K14/705 , C07K16/28 , G01N33/53 , C07H21/04 , C12P21/06
CPC分类号： C07K14/4702 , C07K14/47 , C07K2319/00
摘要： Hupolybromo1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hupolybromo1 polypeptides and polynucleotides in diagnostic assays.
摘要翻译：公开了通过重组技术生产此类多肽的多聚溴代多肽和多核苷酸和方法。还公开了在诊断测定中利用多聚溴代多肽和多核苷酸的方法。

7. 发明授权

US06951925B1 Processes and agents for detecting Listerias 失效
标题翻译：检测李斯特菌的过程和试剂
公开(公告)号：US06951925B1
公开(公告)日：2005-10-04
申请号：US09372036
申请日：1999-08-11
申请人： Peter Schubert , Siegfried Neumann , Martina Pawelzik , Winfried Linxweiler , Christa Burger , Andreas Bubert , Werner Goebel , Stefan Köhler
发明人： Peter Schubert , Siegfried Neumann , Martina Pawelzik , Winfried Linxweiler , Christa Burger , Andreas Bubert , Werner Goebel , Stefan Köhler
IPC分类号： C07K16/00 , C07K16/12 , C12P19/34 , G01N33/53 , G01N33/569
CPC分类号： G01N33/56911 , C07K16/1296 , Y10S435/975
摘要： The invention relates to agents and processes for detecting bacteria of the genus Listeria, in particular L. monocytogenes. The agents according to the invention include primers whose sequence is selected from the iap gene of L. monocytogenes. In addition, the agents according to the invention include peptides whose sequence is selected from the p60 protein and which are suitable for producing specific antibodies for the immunological detection of L. monocytogenes.
摘要翻译：本发明涉及用于检测利斯特氏菌属细菌，特别是单核细胞增生李斯特菌的细菌的试剂和方法。根据本发明的试剂包括其序列选自单核细胞增生李斯特氏菌的iap基因的引物。此外，根据本发明的药剂包括其序列选自p60蛋白并且适合于产生用于免疫学检测单核细胞增生李斯特菌的特异性抗体的肽。

8. 发明授权

US07507412B2 Glycoprotein VI fusion proteins 失效
标题翻译：糖蛋白VI融合蛋白
公开(公告)号：US07507412B2
公开(公告)日：2009-03-24
申请号：US10483810
申请日：2002-07-12
申请人： Christa Burger , Johannes Gleitz , Mathias Frech
发明人： Christa Burger , Johannes Gleitz , Mathias Frech
IPC分类号： A61K39/00
CPC分类号： C07K14/70503 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to Glycoprotein VI (GPVI) fusion proteins (GPVI-fusion proteins) comprising a tag like myc, GST, HA, FLAG, STREP but preferably a Immunoglobulin molecule (Ig), more preferably a Fc portion of said Ig and a protein or oligopeptide having the biological activity of GPVI (GPVI-like protein) which is binding to collagen and their use in methods and kits for the screening of potential agonists or antagonists for GPVI-colagen and/or platelet-collagen interaction is disclosed. Further, pharmaaceutical compositions and therapeutic methods are provided comprising such GPVI-fusion proteins for the treatment of thrombotic and cardiovascular events and disorders related to GPVI-collagen and/or platelet-collagen interactions.
摘要翻译：本发明涉及包含标签如myc，GST，HA，FLAG，STREP但优选免疫球蛋白分子（Ig），更优选所述Ig的Fc部分的糖蛋白VI（GPVI）融合蛋白（GPVI-融合蛋白）公开了具有与胶原结合的GPVI（GPVI样蛋白）的生物学活性的蛋白质或寡肽及其在用于筛选GPVI-胶原和/或血小板 - 胶原相互作用的潜在激动剂或拮抗剂的方法和试剂盒中的用途。此外，提供了药物组合物和治疗方法，其包括用于治疗血栓形成和心血管事件以及与GPVI-胶原和/或血小板 - 胶原相互作用相关的病症的GPVI融合蛋白。

9. 发明授权

US07507406B2 Enhancing the circulating half-life of antibody-based fusion proteins 有权
公开(公告)号：US07507406B2
公开(公告)日：2009-03-24
申请号：US11268191
申请日：2005-11-07
申请人： Stephen D. Gillies , Christa Burger , Kin-Ming Lo
发明人： Stephen D. Gillies , Christa Burger , Kin-Ming Lo
IPC分类号： A61K39/00
CPC分类号： C07K5/1013 , A61K47/6813 , A61K47/6851 , A61K2039/505 , C07K14/525 , C07K14/55 , C07K16/00 , C07K16/30 , C07K19/00 , C07K2317/24 , C07K2317/52 , C07K2317/73 , C07K2319/00
摘要： Disclosed are compositions and methods for enhancing the circulating half-life of antibody-based fusion proteins. Disclosed methods and compositions rely on altering the amino acid sequence of the junction region between the antibody moiety and the fused protein moiety in an antibody-based fusion protein. An antibody-based fusion protein with an altered amino acid sequence in the junction region has a greater circulating half-life when administered to a mammal. Disclosed methods and compositions are particularly useful for reducing tumor size and metastasis in a mammal.

10. 发明申请

US20080206247A1 Glycoprotein VI fusion proteins 审中-公开
标题翻译：糖蛋白VI融合蛋白
公开(公告)号：US20080206247A1
公开(公告)日：2008-08-28
申请号：US11987079
申请日：2007-11-27
申请人： Christa Burger , Johannes Gleitz , Mathias Frech
发明人： Christa Burger , Johannes Gleitz , Mathias Frech
IPC分类号： A61K39/395 , A61K38/14 , A61P9/00
CPC分类号： C07K14/70503 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to Glycoprotein VI (GPVI) fusion proteins (GPVI-fusion proteins) comprising a tag like myc, GST, HA, FLAG, STREP but preferably a Immunoglobulin molecule (Ig), more preferably a Fc portion of said Ig and a protein or oligopeptide having the biological activity of GPVI (GPVI-like protein) which is binding to collagen and their use in methods and kits for the screening of potential agonists or antagonists for GPVI-collagen and/or platelet-collagen interaction is disclosed.Further, pharmaceutical compositions and therapeutic methods are provided comprising such GPVI-fusion proteins for the treatment of thrombotic and cardiovascular events and disorders related to GPVI-collagen and/or platelet-collagen interactions.
摘要翻译：本发明涉及包含标签如myc，GST，HA，FLAG，STREP但优选免疫球蛋白分子（Ig），更优选所述Ig的Fc部分的糖蛋白VI（GPVI）融合蛋白（GPVI-融合蛋白）公开了具有与胶原结合的GPVI（GPVI样蛋白）的生物学活性的蛋白质或寡肽及其在用于筛选GPVI-胶原和/或血小板 - 胶原相互作用的潜在激动剂或拮抗剂的方法和试剂盒中的用途。此外，提供药物组合物和治疗方法，其包括用于治疗血栓形成和心血管事件以及与GPVI-胶原和/或血小板 - 胶原相互作用相关的病症的GPVI-融合蛋白。

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