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1. 发明授权

US5576219A Standard solutions for determination of thyroxine-binding capacity in serum 失效
标题翻译：测定血清中甲状腺素结合能力的标准溶液
公开(公告)号：US5576219A
公开(公告)日：1996-11-19
申请号：US190705
申请日：1994-02-02
申请人： Gerhard Bienhaus , Helmut Jering
发明人： Gerhard Bienhaus , Helmut Jering
IPC分类号： G01N33/78 , G01N33/96
CPC分类号： G01N33/78 , Y10S435/967
摘要： The present invention provides a process for the determination of the thyroxine-binding capacity in serum, wherein, for the calibration, there are used at least two different standard solutions which contain substantially the same amount of thyroxine-binding globulin but a differing content of thyroxine.The present invention also provides a standard solution for the determination of the thyroxine-binding capacity containing thyroxine-binding globulin dissolved in a buffer system.
摘要翻译：本发明提供了测定血清中甲状腺素结合能力的方法，其中，对于校准，使用至少两种不同的标准溶液，其含有基本相同量的甲状腺素结合球蛋白，但甲状腺素含量不同。本发明还提供了用于测定溶解在缓冲系统中的含有甲状腺素结合球蛋白的甲状腺素结合能力的标准溶液。

2. 发明授权

US06919175B1 System for releasing and isolating nucleic acids 失效
标题翻译：释放和分离核酸的系统
公开(公告)号：US06919175B1
公开(公告)日：2005-07-19
申请号：US09558038
申请日：2000-04-26
申请人： Gerhard Bienhaus , Ulrich Schubert , Uwe Kolb , Burkhard Stolz , Manfred Pasch
发明人： Gerhard Bienhaus , Ulrich Schubert , Uwe Kolb , Burkhard Stolz , Manfred Pasch
IPC分类号： C07H21/04 , C12N1/20 , C12N15/00 , C12N15/10 , C12N15/63 , C12Q1/68
CPC分类号： C12N15/1013
摘要： A procedure for the release and isolation of nucleic acids from biological compartments of a sample always uses an instrument that can hold one or more sample processsing vessels, maintain the sample processing vessels at a constant temperature, shake the sample processing vessels and separate magnetic particles by means of magnetic force. This system greatly simplifies the isolation of nucleic acids.
摘要翻译：用于从样品的生物室释放和分离核酸的程序总是使用可以容纳一个或多个样品处理容器的仪器，将样品处理容器保持在恒定温度，摇动样品处理容器并将磁性颗粒分开磁力手段该系统大大简化了核酸的分离。

3. 发明授权

US5957822A Lid for closing vessels 失效
标题翻译：盖封船
公开(公告)号：US5957822A
公开(公告)日：1999-09-28
申请号：US617657
申请日：1996-04-01
申请人： Gerhard Bienhaus , Michael Fritz , Jurgen Schwab , Edda Geisler , Herbert Harttig , Heinz Macho
发明人： Gerhard Bienhaus , Michael Fritz , Jurgen Schwab , Edda Geisler , Herbert Harttig , Heinz Macho
IPC分类号： G01N35/02 , B01L3/14 , B65D39/16 , B65D51/16 , B65D51/24 , G01N1/34 , B31B1/74
CPC分类号： G01N1/405 , B01L3/5082 , B01L3/50825 , B65D39/16 , B65D51/1616 , B65D51/24 , Y10T29/49876
摘要： A lid for closing an opening of a vessel includes a lid body configured to engage the opening, with the vessel having a defined shape. The lid body includes an engagement part which engages a corresponding surface of the vessel, thereby closing the opening. A handling element is disposed on an outer portion of the lid, with the handling element extending in parallel with an axis of the vessel. The handling element is for handling the lid for opening and closing the vessel.
摘要翻译：用于关闭容器的开口的盖包括构造成接合开口的盖体，容器具有限定的形状。盖体包括与容器的相应表面接合的接合部分，从而封闭开口。处理元件设置在盖的外部部分上，处理元件与容器的轴线平行延伸。处理元件用于处理用于打开和关闭容器的盖子。

4. 发明授权

US5846489A System for opening closures of vessels and for the contamination-free operation of reaction sequences 失效
标题翻译：用于打开船只关闭和反应序列无污染操作的系统
公开(公告)号：US5846489A
公开(公告)日：1998-12-08
申请号：US834043
申请日：1997-04-11
申请人： Gerhard Bienhaus , Hans Lange
发明人： Gerhard Bienhaus , Hans Lange
IPC分类号： G01N35/02 , B01L3/14 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N35/00 , G01N35/04 , G01N1/00 , G01N35/10
CPC分类号： B01L3/50825 , G01N35/0099 , G01N2035/00287 , G01N2035/0405 , Y10T436/11 , Y10T436/25
摘要： System for the automatic operation of reactions using several vessels which can be closed by individual closures using a device for automatically opening the closures.
摘要翻译：使用几个容器进行反应的自动操作的系统，该容器可以通过使用用于自动打开盖子的装置的单独闭合来关闭。

5. 发明授权

US07537935B2 System for providing biological materials 有权
标题翻译：提供生物材料的系统
公开(公告)号：US07537935B2
公开(公告)日：2009-05-26
申请号：US10694136
申请日：2003-10-27
申请人： Gerhard Bienhaus , Michael Fritz , Jurgen Schwab , Thomas Walter
发明人： Gerhard Bienhaus , Michael Fritz , Jurgen Schwab , Thomas Walter
IPC分类号： B01D15/08 , G01N33/53 , G01N1/18
CPC分类号： B01L3/50853 , B01L3/5025 , B01L3/50255 , B01L3/50825 , G01N2035/00752 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： A process and closure arrangement is provided for isolating purified biological material. The process includes placing biological materials in separate lysis vessels, adding lysis liquids to the biological materials in the lysis vessels, and transferring the liquids in the lysis vessels into a matrix unit. The liquids in the matrix vessels of the matrix unit are extracted through outlet openings during which the liquids flow through matrices and the matrix unit is placed on a collecting unit with collecting vessels which are arranged such that at least the outlet openings of the matrix vessels extend into the collecting vessels. The matrix vessels are with elution fluid and elution fluids from the matrix vessels are extracted through their outlet openings during which the elution fluids flow through the matrices and the elution fluids which are enriched with biological material are collected in the collecting vessels.
摘要翻译：提供了一种用于分离纯化的生物材料的方法和封闭装置。该方法包括将生物材料放置在分离的裂解容器中，向裂解容器中的生物材料中加入裂解液，并将裂解容器中的液体转移到基质单元中。基质单元的基质容器中的液体通过出口开口被抽出，在此期间液体流过基质，矩阵单元被放置在具有收集容器的收集单元上，收集容器布置成使得至少矩阵容器的出口开口延伸进入收集船。基质容器具有洗脱液，来自基质容器的洗脱液通过其出口开口提取，在洗涤流体中流过基质，富集有生物材料的洗脱液被收集在收集容器中。

6. 发明授权

US6017698A Method of binding a biological material 失效
标题翻译：结合生物材料的方法
公开(公告)号：US6017698A
公开(公告)日：2000-01-25
申请号：US617698
申请日：1996-04-01
申请人： Gerhard Bienhaus , Michael Fritz , Jurgen Schwab , Edda Geisler , Herbert Harttig , Heinz Macho
发明人： Gerhard Bienhaus , Michael Fritz , Jurgen Schwab , Edda Geisler , Herbert Harttig , Heinz Macho
IPC分类号： G01N33/48 , B01L3/14 , B65D39/16 , B65D51/16 , G01N1/00 , G01N1/28 , G01N1/34 , C12Q1/68 , G01N21/00 , G01N33/543 , G01N33/548
CPC分类号： G01N1/405 , B01L3/5082 , B01L3/50825 , B65D39/16 , B65D51/1616 , Y10S435/969 , Y10S436/807
摘要： Subject matter of the invention is a method of binding a biological material to a solid phase by providing a sample liquid containing the biological material in a sample vessel (A) having an inner contour (A17); then a hollow body (C) which has a contour (C12) that matches the inner contour (A17) is introduced into the sample vessel (A) while being closed with respect to the sample vessel by means of a porous matrix (C11); the sample liquid can enter the structural form (C) through the porous matrix (C11). This method is easy to automate and reduces the generation of aerosols.
摘要翻译：本发明的主题是通过在具有内轮廓（A17）的样品容器（A）中提供含有生物材料的样品液体将生物材料与固相结合的方法; 然后将具有与内部轮廓（A17）相匹配的轮廓（C12）的中空体（C）通过多孔基体（C11）相对于样品容器关闭而导入样品容器（A）中。样品液体可以通过多孔基质（C11）进入结构形式（C）。这种方法很容易自动化，减少了气溶胶的产生。

7. 发明授权

US5837144A Method of magnetically separating liquid components 失效
标题翻译：液体成分的磁分离方法
公开(公告)号：US5837144A
公开(公告)日：1998-11-17
申请号：US490986
申请日：1995-06-15
申请人： Gerhard Bienhaus , Burkhard Stolz , Ulrich Schubert
发明人： Gerhard Bienhaus , Burkhard Stolz , Ulrich Schubert
IPC分类号： B03C1/28 , G01N33/543 , B01D35/06
CPC分类号： G01N33/54326 , B03C1/284
摘要： Method of separating a component of a liquid from other components by immobilizing the component to suspended magnetic particles in a vessel, immersing a magnetic device into the vessel while the device is separated from the liquid by means of a protective sleeve made of a non-magnetic material. Then the non-immobilized components are removed. The invention also addresses a device suitable for implementing this method. With said method and device, resuspension is achieved in a simple and efficient manner.
摘要翻译：通过将组件固定在容器中的悬浮磁性颗粒上来将液体的组分与其它组分分离的方法，当通过非磁性的保护套将装置与液体分离时，将磁性装置浸入容器中材料。然后除去非固定化组分。本发明还涉及适用于实现该方法的装置。利用所述方法和装置，以简单和有效的方式实现再悬浮。

8. 发明授权

US06258531B1 Method of isolating a biological material 失效
标题翻译：分离生物材料的方法
公开(公告)号：US06258531B1
公开(公告)日：2001-07-10
申请号：US08622016
申请日：1996-03-26
申请人： Gerhard Bienhaus , Michael Fritz , Jürgen Schwab , Edda Geisler , Herbert Harttig , Heinz Macho
发明人： Gerhard Bienhaus , Michael Fritz , Jürgen Schwab , Edda Geisler , Herbert Harttig , Heinz Macho
IPC分类号： C12Q168
CPC分类号： B01D15/00 , B01D15/3804 , G01N33/54306 , Y10S436/807
摘要： A method of isolating a biological material by a) providing a biological material which is bound to a porous matrix (C11), and b) compressing the matrix under conditions where the biological material is released from the surface of the matrix into an elution liquid. brings about the advantage that the emission of aerosols into the environment is greatly reduced. It is also possible to obtain highly concentrated and minute amounts of solution. The method is also easy to automate.
摘要翻译：一种分离生物材料的方法，包括：提供与多孔基体结合的生物材料（C11），和b）在将生物材料从基质表面释放到洗脱液中的条件下压缩基质。将气溶胶排放到环境中的优势大大降低。也可以获得高浓度和微量的溶液。该方法也很容易自动化。

9. 发明授权

US6117398A System for releasing and isolating nucleic acids 失效
标题翻译：释放和分离核酸的系统
公开(公告)号：US6117398A
公开(公告)日：2000-09-12
申请号：US930247
申请日：1998-02-17
申请人： Gerhard Bienhaus , Ulrich Schubert , Uwe Kolb , Burkhard Stolz , Manfred Pasch
发明人： Gerhard Bienhaus , Ulrich Schubert , Uwe Kolb , Burkhard Stolz , Manfred Pasch
IPC分类号： G01N33/50 , C12M1/00 , C12N15/10 , C12Q1/68 , G01N1/04 , G01N35/04 , B01L11/00
CPC分类号： G01N35/0098 , C12N15/1013 , C12Q1/6804
摘要： An instrument that can hold one or more sample processsing vessels, maintain the sample processing vessels at a constant temperature, shake the sample processing vessels and separate magnetic particles by means of magnetic force. This system greatly simplifies the isolation of nucleic acids.
摘要翻译： PCT No.PCT / EP96 / 01368 Sec。 371日期1998年2月17日 102（e）日期1998年2月17日PCT 1996年3月28日PCT公布。公开号WO96 / 31781 日期1996年10月10日可以容纳一个或多个样品处理容器的仪器，将样品处理容器保持在恒定温度，摇动样品处理容器并通过磁力分离磁性颗粒。该系统大大简化了核酸的分离。

10. 发明授权

US5919622A System for the temperature adjustment treatment of liquid samples 失效
标题翻译：液体样品温度调节处理系统
公开(公告)号：US5919622A
公开(公告)日：1999-07-06
申请号：US715890
申请日：1996-09-19
申请人： Heinz Macho , Gerhard Bienhaus
发明人： Heinz Macho , Gerhard Bienhaus
IPC分类号： C12N15/09 , B01L7/00 , C07H21/04 , C12M1/00 , C12Q1/68 , B01J19/08 , C12P19/34 , G05D23/00
CPC分类号： B01L7/52
摘要： A system for the temperature adjustment treatment of liquids, especially during the isolation and amplification of nucleic acids with a reusable thermostat element and a disposable heating element has the advantage of a particularly simple means of conducting temperature adjustment treatments. This system facilitates the execution of sample preparation and amplification in a single vessel.
摘要翻译：用于温度调节处理液体的系统，特别是在用可重复使用的恒温元件和一次性加热元件分离和扩增核酸期间具有进行温度调节处理的特别简单的方法的优点。该系统便于在单个容器中执行样品制备和扩增。

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