专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5008273A Amino acid derivatives and their pharmaceutical use 失效
标题翻译：氨基酸衍生物及其药物用途
公开(公告)号：US5008273A
公开(公告)日：1991-04-16
申请号：US403628
申请日：1989-09-06
申请人： Gerd Schnorrenberg , Otto Roos , Walter Losel , Ingrid Wiedemann , Wolfram Gaida , Wolfgang Hoefke , Dietrich Arndts , Ilse Streller
发明人： Gerd Schnorrenberg , Otto Roos , Walter Losel , Ingrid Wiedemann , Wolfram Gaida , Wolfgang Hoefke , Dietrich Arndts , Ilse Streller
IPC分类号： C07K14/81 , A61K31/198 , A61K31/381 , A61K31/435 , A61K38/00 , A61K38/55 , A61P9/00 , A61P9/12 , A61P43/00 , C07D471/04 , C07D491/048 , C07D495/04 , C07K1/113 , C07K5/02 , C07K5/06
CPC分类号： C07K5/0222 , C07K5/06086 , A61K38/00
摘要： Amino acid derivatives of general formula ##STR1## (the definitions of the various symbols being explained in the specification) are suitable for treating high blood pressure and for cardioprotection. The new compounds are prepared and used in the usual way.
摘要翻译：通式（I）的氨基酸衍生物（说明书中解释的各种符号的定义）适用于治疗高血压和心脏保护。新化合物以常规方式制备和使用。

2. 发明授权

US4766129A Pyrrolo[2,3-C]pyridines and their use as anti-hypertensive agents 失效
标题翻译：吡咯并[2,3-C]吡啶及其作为抗高血压药的用途
公开(公告)号：US4766129A
公开(公告)日：1988-08-23
申请号：US47417
申请日：1987-05-06
申请人： Gerd Schnorrenberg , Otto Roos , Walter Losel , Ingrid Wiedemann , Wolfram Gaida , Wolfgang Hoefke
发明人： Gerd Schnorrenberg , Otto Roos , Walter Losel , Ingrid Wiedemann , Wolfram Gaida , Wolfgang Hoefke
IPC分类号： A61K31/435 , A61K38/00 , A61P7/10 , A61P9/12 , C07D471/04 , C07D495/04 , C07K5/02 , A61K31/40
CPC分类号： C07D471/04 , C07D495/04 , C07K5/0222 , A61K38/00
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 6 carbon atoms or phenyl(alkyl of 1 to 6 carbon atoms);R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms or phenyl(alkyl of 1 to 6 carbon atoms);R.sub.3 is hydrogen or alkyl of 1 to 6 carbon atoms;n and m are each independently 0, 1 or 2, the sum of n and m being 1 or 2;X, Y and Z are each independently oxygen, sulfur, --NR.sub.4 --, .dbd.CR.sub.5 --, --CHR.sub.5 --, ##STR2## provided that only one of X, Y and Z is O, S, ##STR3## and one or two of X, Y and Z are --R.sub.4 --; R.sub.4 is hydrogen or alkyl of 1 to 4 carbon atoms; andR.sub.5 is hydrogen or, together with a vicinal radical R.sub.5, a phenyl ring, or when m and n are both 1, the dihydro form with its double bond in conjugation with the C-terminal carboxylic group;or a non-toxic, pharmacologically acceptable salt thereof. The compounds as well as their salts are useful as antihypertensives.
摘要翻译：其中R 1是氢，1至6个碳原子的烷基或苯基（1至6个碳原子的烷基）的式 R2是氢，1至4个碳原子的烷基或苯基（1至6个碳原子的烷基）; R3是氢或1至6个碳原子的烷基; n和m各自独立地为0,1或2，n和m的和为1或2; X，Y和Z各自独立地为氧，硫，-NR4-，= CR5-，-CHR5-，，条件是X，Y和Z中只有一个是O，S，，一个或两个 X，Y和Z为-R4-; R4是氢或1-4个碳原子的烷基; 并且R 5是氢或与连位基R5一起为苯环，或者当m和n均为1时，与C末端羧基共轭的双键形式的二氢形式; 或其无毒的药理学上可接受的盐。化合物及其盐可用作抗高血压药。

3. 发明授权

US4683238A 2,3,4,9-tetrahydro beta carboline derivatives, useful as antihypertensive agents 失效
标题翻译： 2,3,4,9-四氢β-咔啉衍生物，可用作抗高血压药
公开(公告)号：US4683238A
公开(公告)日：1987-07-28
申请号：US749473
申请日：1985-06-27
申请人： Gerd Schnorrenberg , Otto Roos , Walter Losel , Ingrid Wiedemann , Wolfram Gaida , Wolfgang Hoefke
发明人： Gerd Schnorrenberg , Otto Roos , Walter Losel , Ingrid Wiedemann , Wolfram Gaida , Wolfgang Hoefke
IPC分类号： A61K31/435 , A61K38/00 , A61P7/10 , A61P9/12 , C07D471/04 , C07D495/04 , C07K5/02 , A61K31/40
CPC分类号： C07D471/04 , C07D495/04 , C07K5/0222 , A61K38/00
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 6 carbon atoms or phenyl(alkyl of 1 to 6 carbon atoms);R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms or phenyl(alkyl of 1 to 6 carbon atoms);R.sub.3 is hydrogen or alkyl of 1 to 6 carbon atoms;n and m are each independently 0, 1 or 2, the sum of n and m being 1 or 2;X, Y and Z are each independently oxygen, sulfur, --NR.sub.4 --, .dbd.CR.sub.5 --, --CHR.sub.5 --, ##STR2## provided that only one of X, Y and Z is O, S ##STR3## and one or two of X, Y and Z are --NR.sub.4 --; R.sub.4 is hydrogen or alkyl of 1 to 4 carbon atoms; andR.sub.5 is hydrogen or, together with a vicinal radical R.sub.5, a phenyl ring, or when m and n are both 1, the dihydro form with its double bond in conjugation with the C-terminal carboxylic group;or a non-toxic, pharmacologically acceptable salt thereof. The compounds as well as their salts are useful as antihypertensives.
摘要翻译：其中R 1是氢，1至6个碳原子的烷基或苯基（1至6个碳原子的烷基）的式 R2是氢，1至4个碳原子的烷基或苯基（1至6个碳原子的烷基）; R3是氢或1至6个碳原子的烷基; n和m各自独立地为0,1或2，n和m的和为1或2; X，Y和Z各自独立地为氧，硫，-NR4-，= CR5-，-CHR5-，，条件是X，Y和Z中只有一个是O，S 和X中的一个或两个，Y和Z是-NR 4 - ; R4是氢或1-4个碳原子的烷基; 并且R 5是氢或与连位基R5一起为苯环，或者当m和n均为1时，与C末端羧基共轭的双键形式的二氢形式; 或其无毒的药理学上可接受的盐。化合物及其盐可用作抗高血压药。

4. 发明授权

US4826855A Thieno pyridines and their use as anti-hypertensive agents 失效
标题翻译：噻吩并吡啶类作为抗高血压药物
公开(公告)号：US4826855A
公开(公告)日：1989-05-02
申请号：US199121
申请日：1988-05-26
申请人： Gerd Schnorrenberg , Otto Roos , Walter Losel , Ingrid Wiedemann , Wolfram Gaida , Wolfgang Hoefke
发明人： Gerd Schnorrenberg , Otto Roos , Walter Losel , Ingrid Wiedemann , Wolfram Gaida , Wolfgang Hoefke
IPC分类号： A61K31/435 , A61K38/00 , A61P7/10 , A61P9/12 , C07D471/04 , C07D495/04 , C07K5/02 , A61K31/38 , C07D513/02
CPC分类号： C07D471/04 , C07D495/04 , C07K5/0222 , A61K38/00
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 6 carbon atoms, or phenyl(alkyl of 1 to 6 carbon atoms);R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms or phenyl(alkyl of 1 to 6 carbon atoms);R.sub.3 is hydrogen or alkyl of 1 to 6 carbon atoms;n and m are each independently 0, 1 or 2, the sum of n and m being 1 or 2;X, Y and Z are each independently oxygen, sulfur, --NR.sub.4 --, .dbd.CR.sub.5 --, --CHR.sub.5 --, ##STR2## provided that only one of X, Y and Z is O, S, ##STR3## and one or two of X, Y and Z are --NR.sub.4 --; R.sub.4 is hydrogen or alkyl of 1 to 4 carbon atoms; andR.sub.5 is hydrogen or, together with a vicinal radical R.sub.5, a phenyl ring, or when m and n are both 1, the dihydro form with its double bond in conjugation with the C-term=inal carboxylic group;or a non-toxic, pharmacologically acceptable salt thereof. The compounds as well as their salts are useful as antihypertensives.
摘要翻译：其中R 1是氢，1至6个碳原子的烷基或苯基（1至6个碳原子的烷基）的式 R2是氢，1至4个碳原子的烷基或苯基（1至6个碳原子的烷基）; R3是氢或1至6个碳原子的烷基; n和m各自独立地为0,1或2，n和m的和为1或2; X，Y和Z各自独立地为氧，硫，-NR4-，= CR5-，-CHR5-，，条件是X，Y和Z中只有一个是O，S，，一个或两个 X，Y和Z是-NR 4 - ; R4是氢或1-4个碳原子的烷基; 并且R 5是氢或与连位基R 5一起成为苯环，或者当m和n均为1时，其双键与C-term =内接羧基共轭的二氢形式; 或其无毒的药理学上可接受的盐。化合物及其盐可用作抗高血压药。

5. 发明授权

US4555511A Thieno [3,2,C]pyridines useful as antihypertensives 失效
标题翻译：噻吩并[3,2，C]吡啶可用作抗高血压药
公开(公告)号：US4555511A
公开(公告)日：1985-11-26
申请号：US572179
申请日：1984-01-19
申请人： Gerd Schnorrenberg , Otto Roos , Walter Losel , Ingrid Wiedemann , Wolfram Gaida , Wolfgang Hoefke
发明人： Gerd Schnorrenberg , Otto Roos , Walter Losel , Ingrid Wiedemann , Wolfram Gaida , Wolfgang Hoefke
IPC分类号： A61K31/435 , A61K38/00 , A61P7/10 , A61P9/12 , C07D471/04 , C07D495/04 , C07K5/02 , C07D513/02
CPC分类号： C07D471/04 , C07D495/04 , C07K5/0222 , A61K38/00
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 6 carbon atoms or phenyl (alkyl of 1 to 6 carbon atoms);R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms or phenyl (alkyl of 1 to 6 carbon atoms);R.sub.3 is hydrogen or alkyl of 1 to 6 carbon atoms; and their use as antihypertensives.
摘要翻译：其中R 1是氢，1至6个碳原子的烷基或苯基（1至6个碳原子的烷基）的式 R2是氢，1至4个碳原子的烷基或苯基（1至6个碳原子的烷基）; R3是氢或1至6个碳原子的烷基; 并将其用作抗高血压药。

6. 发明授权

US4341778A 3,1 Benzoxazin-2-ones and use thereof 失效
标题翻译： 3，苯并恶嗪-2-酮及其用途
公开(公告)号：US4341778A
公开(公告)日：1982-07-27
申请号：US280349
申请日：1981-07-06
申请人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Wolfgang Hoefke , Wolfram Gaida , Ilse Streller , Armin Fugner
发明人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Wolfgang Hoefke , Wolfram Gaida , Ilse Streller , Armin Fugner
IPC分类号： C07D265/16 , A61K31/535 , A61K31/536 , A61P9/00 , A61P9/08 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , C07D265/18 , C07D265/22
CPC分类号： C07D265/18
摘要： The invention relates to compounds of general formula I ##STR1## (wherein R.sub.1 and R.sub.2, which may be the same or different, each represents a hydrogen atom or a (C.sub.1 -C.sub.4) alkyl group;R.sub.3 and R.sub.4, which may be the same or different, each represents a hydrogen, fluorine or chlorine atom or a hydroxy, methyl, ethyl or (C.sub.1 -C.sub.4) alkoxy group, or R.sub.3 together with R.sub.4 represents a methylenedioxy group;R.sub.5 and R.sub.6, which may be the same or different, each represents a hydrogen atom or a methyl group;R.sub.7 represents a group of formula ##STR2## R represents a hydrogen atom or a (C.sub.1 -C.sub.4) alkyl group; R.sub.8 represents a fluorine or chlorine atom or a (C.sub.1 -C.sub.4) alkyl, (C.sub.1 -C.sub.4) alkylthio, hydroxymethyl, CONHR.sub.11, SO.sub.2 NHR.sub.11, OR.sub.12, methoxycarbonyl, ethoxycarbonyl or NHSO.sub.2 CH.sub.3 group;R.sub.9 represents a hydrogen, fluorine or chlorine atom or a OR.sub.12 group;R.sub.10 represents a hydrogen or chlorine atom or an amino, methyl or methoxy group;R.sub.11 represents a hydrogen atom or a methyl, ethyl or hydroxyethyl group;R.sub.12 represents a hydrogen atom or a (C.sub.1 -C.sub.4) alkyl, (C.sub.1 -C.sub.4) alkyl-CO, aryl-CH.sub.2 or aryl-CO group; andn represents 1, 2 or 3) and acid addition salts thereof as well as to processes for their preparation and pharmaceutical compositions containing them. The compounds of the invention possess interesting pharmacological properties in particular displaying hypotensive and selective tocolytic effects.
摘要翻译：本发明涉及通式I（I）的化合物（其中R 1和R 2可以相同或不同，各自表示氢原子或（C 1 -C 4）烷基; R 3和R 4可以相同或不同，各自表示氢，氟或氯原子或羟基，甲基，乙基或（C1-C4）烷氧基，或R3与R4一起代表亚甲二氧基; R5和R6可以相同或不同的，各自表示氢原子或甲基; R 7表示下式的基团：R表示氢原子或（C 1 -C 4）烷基; R 8表示氟或氯原子或（C 1 -C 4））烷基，（C1-C4）烷硫基，羟甲基，CONHR11，SO2NHR11，OR12，甲氧基羰基，乙氧基羰基或NHSO2CH3基; R9表示氢，氟或氯原子或OR12基团; R10表示氢或氯原子或氨基，甲基或甲氧基; R11表示氢原子或甲基，乙基或羟乙基; R12表示a 氢原子或（C 1 -C 4）烷基，（C 1 -C 4）烷基-CO，芳基-CH 2或芳基-CO基团; 和n表示1,2或3）及其酸加成盐以及其制备方法和含有它们的药物组合物。本发明的化合物具有特别显示降血压和选择性溶瘤作用的有趣的药理学性质。

7. 发明授权

US4997833A Aryloxy-aminoalkanes, and antihypertensive use thereof 失效
标题翻译：芳氧基 - 氨基烷烃及其抗高血压药物
公开(公告)号：US4997833A
公开(公告)日：1991-03-05
申请号：US375658
申请日：1989-07-05
申请人： KoHerbert , Franz Esser , Wolfram Gaida , Wolfgang Hoefke , Georg Speck
发明人： KoHerbert , Franz Esser , Wolfram Gaida , Wolfgang Hoefke , Georg Speck
IPC分类号： A61K31/54 , A61K31/5415 , A61P9/12 , C07D285/24 , C07D285/26 , C07D285/30 , C07D417/12
CPC分类号： C07D417/12 , C07D285/24 , C07D285/30
摘要： Aryloxy-aminoalkanes useful as antihypertensive agents are described and disclosed.
摘要翻译：描述和公开了可用作抗高血压剂的芳氧基 - 氨基烷烃。

8. 发明授权

US4594344A 1-aryloxypropanolamines 失效
标题翻译： 1-芳氧基丙醇胺
公开(公告)号：US4594344A
公开(公告)日：1986-06-10
申请号：US755044
申请日：1985-07-15
申请人： Herbert Koppe , Wolfgang Abele, deceased , Franz Esser , Wolfram Gaida , Wolfgang Hoefke
发明人： Herbert Koppe , Wolfgang Abele, deceased , Franz Esser , Wolfram Gaida , Wolfgang Hoefke
IPC分类号： A61K31/54 , A61P9/12 , C07D285/30 , C07D417/12
CPC分类号： C07D285/30
摘要： Disclosed are novel compounds having the formula ##STR1## wherein R.sub.1 is a hydrogen or halogen atom, a lower alkyl, lower alkoxy, lower alkoxy lower alkyl, lower alkenyl, lower alkenyl oxy, cyano, hydroxy, trifluoromethyl, nitro, amino, aminocarbonylmethyl, lower monoalkylamino, lower dialkylamino group;R.sub.2 is a hydrogen or halogen atom, cyano, lower alkyl or lower alkoxy or acylamino group;R.sub.3 is a hydrogen or halogen atom, a lower alkyl or lower alkoxy group, while R.sub.2 and R.sub.3 together can also be a butadienyl or methylene dioxy group;R.sub.4 is a hydrogen atom or a lower alkyl group;R.sub.5 is a chlorine atom or a trifluoromethyl group;X is an alkylene group;and the non-toxic, pharmaceutically acceptable acid addition salts thereof.The compounds are suitable for treatment and prophylaxis of hypertension.
摘要翻译：公开了具有下式的新化合物：其中R1是氢或卤原子，低级烷基，低级烷氧基，低级烷氧基低级烷基，低级烯基，低级烯基氧基，氰基，羟基，三氟甲基，硝基，氨基，氨基羰基甲基，低级单烷基氨基，低级二烷基氨基; R2是氢或卤素原子，氰基，低级烷基或低级烷氧基或酰氨基; R3是氢或卤素原子，低级烷基或低级烷氧基，R2和R3一起也可以是丁二烯基或亚甲基二氧基; R4是氢原子或低级烷基; R5是氯原子或三氟甲基; X是亚烷基; 和其无毒的药学上可接受的酸加成盐。该化合物适用于治疗和预防高血压。

9. 发明授权

US4361575A Substituted 2-phenylamino-2-imidazolines and salts thereof 失效
标题翻译：取代的2-苯基氨基-2-咪唑啉及其盐
公开(公告)号：US4361575A
公开(公告)日：1982-11-30
申请号：US276703
申请日：1981-06-23
申请人： Helmut Stahle , Herbert Koppe , Werner Kummer , Walter Kobinger , Christian Lillie , Ludwig Pichler , Wolfgang Hoefke , Wolfram Gaida
发明人： Helmut Stahle , Herbert Koppe , Werner Kummer , Walter Kobinger , Christian Lillie , Ludwig Pichler , Wolfgang Hoefke , Wolfram Gaida
IPC分类号： A61K31/415 , A61P9/06 , C07D233/50 , C07D233/52 , C07D233/06
CPC分类号： C07D233/50
摘要： Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3, which may be identical to or different from each other, are each hydrogen, fluorine, chlorine, bromine, methyl, trifluoromethyl, hydroxyl or amino;R.sub.4 is straight or branched alkyl of 1 to 5 carbon atoms, allyl or benzyl;R.sub.5 is methyl, ethyl or 2-dimethylamino-ethyl; andn is 0 or 1;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as bradycardiacs.
摘要翻译：其中R 1，R 2和R 3可以相同或不同，可以是氢，氟，氯，溴，甲基，三氟甲基，羟基或氨基; R4是1至5个碳原子的直链或支链烷基，烯丙基或苄基; R5是甲基，乙基或2-二甲基氨基 - 乙基; 并且n为0或1; 和无毒的，药学上可接受的酸加成盐。化合物及其盐可用作心动过缓。

10. 发明授权

US4259346A Bradycardiac pharmaceutical compositions and method of use 失效
标题翻译：心动过缓药物组合物和使用方法
公开(公告)号：US4259346A
公开(公告)日：1981-03-31
申请号：US103584
申请日：1979-12-14
申请人： Helmut Stahle , Herbert Koppe , Werner Kummer , Walter Kobinger , Christian Lillie , Ludwig Pichler , Wolfgang Hoefke , Wolfram Gaida
发明人： Helmut Stahle , Herbert Koppe , Werner Kummer , Walter Kobinger , Christian Lillie , Ludwig Pichler , Wolfgang Hoefke , Wolfram Gaida
IPC分类号： A61K31/415 , A61P9/06 , A61P9/10 , C07D233/52
CPC分类号： C07D233/52
摘要： Pharmaceutical compositions containing as an active ingredient a compound of the formula ##STR1## wherein R.sub.1 is hydrogen or lower alkyl,R.sub.2 is hydrogen, lower alkyl, hydroxy-lower alkyl, chloro-hydroxy-propyl, 2,3-epoxy-propyl, alkoxyalkyl, aminoalkyl, N-substituted aminoalkyl, benzyl or phenethyl,R.sub.3 is hydrogen or halogen, andR.sub.4 is halogen or methyl, or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as bradycardiacs.
摘要翻译：其中R 1为氢或低级烷基，R 2为氢，低级烷基，羟基 - 低级烷基，氯 - 羟基 - 丙基，2,3-环氧丙基，烷氧基烷基，氨基烷基，N-取代的氨基烷基，苄基或苯乙基，R3是氢或卤素，R4是卤素或甲基，或其无毒的药学上可接受的酸加成盐; 以及使用其作为心动过缓的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式