专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050014768A1 Use of 4-oxobutanoic acid derivatives in the treatment of inflammation 失效
标题翻译：使用4-氧代丁酸衍生物治疗炎症
公开(公告)号：US20050014768A1
公开(公告)日：2005-01-20
申请号：US10497491
申请日：2002-11-06
申请人： Gerard Moinet , Dominique Marais , Philippe Maizeray
发明人： Gerard Moinet , Dominique Marais , Philippe Maizeray
IPC分类号： A61P3/10 , A61K31/192 , A61K31/36 , A61P9/10 , A61P9/12 , A61P11/00 , A61P19/00 , A61P19/02 , A61P25/00 , A61P25/04 , A61P29/00 , A61P43/00 , A61K31/505 , A61K31/401 , A61K31/445
CPC分类号： A61K31/36
摘要： The present invention relates to the use of a 4-oxobutanoic acid derivative for the preparation of a pharmaceutical composition for treating inflammation.
摘要翻译：本发明涉及4-氧代丁酸衍生物在制备用于治疗炎症的药物组合物中的用途。

2. 发明授权

US07897644B2 Use of 4-oxobutanoic acid derivatives in the treatment of inflammation 失效
标题翻译：使用4-氧代丁酸衍生物治疗炎症
公开(公告)号：US07897644B2
公开(公告)日：2011-03-01
申请号：US10497491
申请日：2002-11-06
申请人： Gérard Moinet , Dominique Marais , Philippe Maizeray
发明人： Gérard Moinet , Dominique Marais , Philippe Maizeray
IPC分类号： A01N37/00 , A61K31/185
CPC分类号： A61K31/36
摘要： The present invention relates to the use of a 4-oxobutanoic acid derivative for the preparation of a pharmaceutical composition for treating inflammation.
摘要翻译：本发明涉及4-氧代丁酸衍生物在制备用于治疗炎症的药物组合物中的用途。

3. 发明授权

US08329738B2 Use of AMPK-activating imidazole derivatives, preparation process therefor and pharmaceutical compositions comprising them 有权
标题翻译：使用AMPK活化的咪唑衍生物，其制备方法和包含它们的药物组合物
公开(公告)号：US08329738B2
公开(公告)日：2012-12-11
申请号：US12373310
申请日：2007-06-12
申请人： Gerard Moinet , Dominique Marais , Sophie Hallakou-Bozec , Christine Charon
发明人： Gerard Moinet , Dominique Marais , Sophie Hallakou-Bozec , Christine Charon
IPC分类号： A01N43/50 , A01N47/28 , A01N31/14 , A61K31/415 , A61K31/17 , A61K31/08
CPC分类号： C07D233/90
摘要： The invention relates to the use of imidazole derivatives of the formula (1): in which A, R′1, R′2 and R′3 are as defined in the description, as AMPK activators. The invention also relates to processes for the preparation of the said compounds, to their uses for the preparation of medicaments for the treatment of insulin resistance, diabetes and related pathologies, and also obesity, and to the pharmaceutical compositions comprising them.Certain compounds of the formula (1) are novel and, in this respect, also form part of the invention.
摘要翻译：本发明涉及式（1）的咪唑衍生物的用途：其中A，R'1，R'2和R'3如说明书中所定义，作为AMPK活化剂。本发明还涉及制备所述化合物的方法，其制备用于治疗胰岛素抵抗的药物，糖尿病和相关病症以及肥胖症的用途，以及包含它们的药物组合物。某些式（1）化合物是新颖的，在这方面也是本发明的一部分。

4. 发明申请

US20060142358A1 Kynurenine 3-hydroxylase inhibitors for the treatment of diabetes 失效
标题翻译：用于治疗糖尿病的Kynurenine 3-羟化酶抑制剂
公开(公告)号：US20060142358A1
公开(公告)日：2006-06-29
申请号：US10541377
申请日：2003-12-18
申请人： Valerie Autier , Annick Arbellot De Vacqueur , Micheline Kergoat , Gerard Moinet , Dominique Marais , Catherine Kargar
发明人： Valerie Autier , Annick Arbellot De Vacqueur , Micheline Kergoat , Gerard Moinet , Dominique Marais , Catherine Kargar
IPC分类号： A61K31/426 , A61K31/198 , A61K31/192 , A61K31/19
CPC分类号： A61K45/06 , A61K31/00 , A61K31/06 , A61K31/19 , A61K31/192 , A61K31/194 , A61K31/216 , A61K31/22 , A61K31/235 , A61K31/426 , A61K31/55 , A61K2300/00
摘要： The present invention relates to the use of at least one compound with inhibitory activity on kynurenine 3-hydroxylase for the preparation of a medicament for the prevention and/or treatment of diabetes.
摘要翻译：本发明涉及至少一种具有抑制活性的化合物对犬尿氨酸3-羟化酶的用途，用于制备用于预防和/或治疗糖尿病的药物。

5. 发明申请

US20060052456A1 Kynurenine 3-hydroxylase inhibitors for the treatment of diabetes by increasing the number of islets of langerhans cells 审中-公开
标题翻译： Kynurenine 3-羟化酶抑制剂，用于通过增加朗格汉斯细胞的胰岛数量来治疗糖尿病
公开(公告)号：US20060052456A1
公开(公告)日：2006-03-09
申请号：US10541493
申请日：2003-12-18
申请人： Valerie Autier , Annick Arbellot De Vacqueur , Micheline Kergoat , Gerard Moinet , Dominique Marais , Catherine Kargar
发明人： Valerie Autier , Annick Arbellot De Vacqueur , Micheline Kergoat , Gerard Moinet , Dominique Marais , Catherine Kargar
IPC分类号： A61K31/192 , A61K31/19
CPC分类号： A61K45/06 , A61K31/00 , A61K31/06 , A61K31/19 , A61K31/192 , A61K31/194 , A61K31/216 , A61K31/22 , A61K31/235 , A61K31/426 , A61K31/55 , A61K2300/00
摘要： The present invention relates to the use of at least one compound with inhibitory activity on kynurenine 3-hydroxylase, for the preparation of a medica ment for increasing the number of islets of Langerhans cells, which is intended especially for the prevention and/or treatment of diabetes.
摘要翻译：本发明涉及至少一种具有抑制活性的化合物对犬尿氨酸3-羟化酶的用途，用于制备用于增加朗格汉斯细胞胰岛数量的药物，其特别用于预防和/或治疗糖尿病。

6. 发明申请

US20050070553A1 Pharmaceutical composition comprising an alpha-glucosidase inhibitor and a 4-oxobutanoic acid, and the use thereof for treating diabetes 审中-公开
标题翻译：包含α-葡糖苷酶抑制剂和4-氧代丁酸的药物组合物及其用于治疗糖尿病的用途
公开(公告)号：US20050070553A1
公开(公告)日：2005-03-31
申请号：US10500335
申请日：2002-12-07
申请人： Gerard Moinet , Dominique Marais
发明人： Gerard Moinet , Dominique Marais
IPC分类号： A61K45/00 , A61K31/192 , A61K31/445 , A61K31/70 , A61K31/7036 , A61K45/06 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/12 , A61P43/00 , A61K31/505 , A61K31/19 , A61K31/34 , A61K31/381 , A61K31/40 , A61K31/44
CPC分类号： A61K45/06 , A61K31/445 , A61K31/70 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition comprising, as active principles, a 4-oxobutanoic acid and an α-glucosidase inhibitor, in combination with one or more pharmaceutically acceptable excipients. These compositions are particularly suitable for treating diabetes.
摘要翻译：本发明涉及药物组合物，其包含与一种或多种药学上可接受的赋形剂组合的4-氧代丁酸和α-葡糖苷酶抑制剂作为活性成分。这些组合物特别适用于治疗糖尿病。

7. 发明申请

US20090253764A1 USE OF AMPK-ACTIVATING IMIDAZOLE DERIVATIVES, PREPARATION PROCESS THEREFOR AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM 有权
标题翻译： AMPK活化咪唑衍生物的使用，其制备方法及包含它们的药物组合物
公开(公告)号：US20090253764A1
公开(公告)日：2009-10-08
申请号：US12373310
申请日：2007-06-12
申请人： Gerard Moinet , Dominique Marais , Sophie Hallakou-Bozec , Christine Charon
发明人： Gerard Moinet , Dominique Marais , Sophie Hallakou-Bozec , Christine Charon
IPC分类号： A61K31/4178 , A61K31/4164 , C07D233/22 , A61P3/04 , A61P3/10 , A61P9/00
CPC分类号： C07D233/90
摘要： The invention relates to the use of imidazole derivatives of the formula (1): in which A, R′1, R′2 and R′3 are as defined in the description, as AMPK activators.The invention also relates to processes for the preparation of the said compounds, to their uses for the preparation of medicaments for the treatment of insulin resistance, diabetes and related pathologies, and also obesity, and to the pharmaceutical compositions comprising them.Certain compounds of the formula (1) are novel and, in this respect, also form part of the invention.
摘要翻译：本发明涉及式（1）的咪唑衍生物的用途：其中A，R'1，R'2和R'3如说明书中所定义，作为AMPK活化剂。本发明还涉及制备所述化合物的方法，其制备用于治疗胰岛素抵抗的药物，糖尿病和相关病症以及肥胖症的用途，以及包含它们的药物组合物。某些式（1）化合物是新颖的，在这方面也是本发明的一部分。

8. 发明申请

US20050020609A1 Pharmaceutical composition comprising a combination of metformin and a 4-oxobutanoic acid, and the use thereof for treating diabetes 审中-公开
标题翻译：包含二甲双胍和4-氧代丁酸的组合的药物组合物及其用于治疗糖尿病的用途
公开(公告)号：US20050020609A1
公开(公告)日：2005-01-27
申请号：US10497145
申请日：2002-11-06
申请人： Gerald Moinet , Dominique Marais
发明人： Gerald Moinet , Dominique Marais
IPC分类号： C07D317/60 , A61K31/155 , A61K31/19 , A61K31/192 , A61K31/33 , A61K31/337 , A61K31/36 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , A61P9/12 , A61P13/00 , A61P25/02 , A61P27/00 , A61P43/00 , C07D307/16 , A61K31/505 , A61K31/34 , A61K31/35 , A61K31/381 , A61K31/44 , A61K31/445
CPC分类号： A61K31/19 , A61K31/33 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition comprising, as active principles, metformin, optionally in the form of one of it its pharmaceutically acceptable salts, and a 4-oxobutanoic acid, in combination with one or more pharmaceutically acceptable excipients. These compositions are particularly suitable for treating non-insulin-dependent diabetes.
摘要翻译：本发明涉及药物组合物，其包含作为活性成分的二甲双胍，任选以其药学上可接受的盐之一形式的二甲双胍和与一种或多种药学上可接受的赋形剂组合的4-氧代丁酸。这些组合物特别适用于治疗非胰岛素依赖性糖尿病。

9. 发明授权

US06376495B1 Antidiabetic piperazine derivatives, processes for their preparation and compositions containing them 失效
标题翻译：抗糖尿病哌嗪衍生物，其制备方法和含有它们的组合物
公开(公告)号：US06376495B1
公开(公告)日：2002-04-23
申请号：US09744693
申请日：2001-01-29
申请人： Gérard Moinet , Dominique Marais , Didier Mesangeau , Liliane Doare , Micheline Kergoat
发明人： Gérard Moinet , Dominique Marais , Didier Mesangeau , Liliane Doare , Micheline Kergoat
IPC分类号： A61K31495
CPC分类号： C07D239/42 , C07D213/74 , C07D277/82 , C07D295/088
摘要： Piperazine derivatives of formula (I) wherein Z, X, n, Ar and i have the meanings defined herein are usefull in the treatment of pathologies associated with insulin-resistance syndrome.
摘要翻译：式（I）的哌嗪衍生物其中Z，X，n，Ar和i具有本文定义的含义，可用于治疗与胰岛素抵抗综合征相关的病理学。

10. 发明授权

US5087334A Continuous process for the manufacture of potassium chlorate by coupling with a sodium chlorate production plant 失效
标题翻译：通过与氯酸钠生产厂联合制造氯酸钾的连续工艺
公开(公告)号：US5087334A
公开(公告)日：1992-02-11
申请号：US340090
申请日：1989-04-18
申请人： Dominique Marais , Jesus Collantes
发明人： Dominique Marais , Jesus Collantes
IPC分类号： C01B11/14 , C25B1/26
CPC分类号： C01B11/14 , C25B1/265
摘要： The present invention relates to a continuous process for the manufacture of potassium chlorate by coupling with a plant for the production of sodium chlorate by electrolysis, the said plant comprising a source of NaCl solution, (1), a loop for purification of the said solution (2--2', 3), an electrolysis device (4), a storage tank (5), if appropriate, and a crystallizer (6) in which the crystallization and the separation of NaClO.sub.3 crystals are preferably carried out, wherein circulating liquid is removed downstream of the said electrolysis device (4), a concentrated solution of potassium chloride is added to said liquid, precipitation (11) of the potassium chlorate is caused by any known means, the said potassium chlorate is separated off and the mother liquor from crystallization of the said potassium chlorate is recycled into the said purification loop (2--2', 3) of the sodium chlorate production plant.
摘要翻译：本发明涉及通过与用于通过电解生产氯酸钠的设备耦合来制造氯酸钾的连续方法，所述植物包含NaCl溶液源，（1），用于纯化所述溶液的环（2-2'，3），电解装置（4），储存罐（5）以及结晶器（6），其中优选进行NaClO 3晶体的结晶和分离，其中循环液在所述电解装置（4）的下游除去，向所述液体中加入浓氯化钾溶液，氯化钾的沉淀（11）是以任何已知方法引起的，所述氯酸钾被分离出，母液从所述氯酸钾的结晶中再循环到氯酸钠生产设备的所述纯化回路（2-2'，3）中。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式