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1. 发明申请

US20080015345A1 COMPOSITIONS AND PROCESSES FOR PREPARING 13-DEOXY-ANTHRACYCLINES 有权
标题翻译：用于制备13-去氧 - 蒽醌的组合物和方法
公开(公告)号：US20080015345A1
公开(公告)日：2008-01-17
申请号：US11777057
申请日：2007-07-12
申请人： Gerald Walsh , Richard Olson
发明人： Gerald Walsh , Richard Olson
IPC分类号： C07H15/00
CPC分类号： C07H15/24
摘要： 13-benzenesulfonylhydrazone anthracyclines useful in producing improved yields in the synthesis 13-deoxyanthrcyclines, and an improved method of reducing 13-benzene-sulfonylhydrazone anthracyclines to 13-deoxyanthrcyclines wherein the reduction reaction is maintained at temperatures of about 55° C. to 64° C. without stirring or agitation. The reaction is completed with the addition of aqueous bicarbonate which forms the 13-deoxyanthracycline and precipitates. The precipitates are filtered and the precipitate and filtrate are extracted separately with organic solvents. The crude 13-deoxy anthracycline can be converted to 5-imino-13-deoxy anthracycline by reaction with methanolic ammonia. The reaction can also be performed with an acidic pyridinium salt instead of a strong acid so that neutralization of the reaction or extraction of the product is not necessary, thereby facilitating purification.
摘要翻译：可用于在合成13-脱氧肾上腺素中产生改善产量的13-苯磺酰腙蒽环类抗生素，以及将13-苯磺酰腙蒽环类抗生素还原为13-脱氧肾上腺素的改进方法，其中还原反应保持在约55℃至64℃ ，不搅拌或搅拌。反应完成，加入形成13-脱氧蒽环并沉淀的碳酸氢盐水溶液。将沉淀物过滤，并将沉淀物和滤液用有机溶剂分开萃取。粗制的13-脱氧蒽环霉素可以通过与甲醇氨反应而转化成5-亚氨基-13-脱氧蒽环霉素。该反应也可以用酸性吡啶鎓盐代替强酸进行，从而不需要中和反应或提取产物，从而有助于纯化。

2. 发明申请

US20060100421A1 Compositions and processes for preparing 13-deoxy-anthracyclines 有权
标题翻译：用于制备13-脱氧蒽环类药物的组合物和方法
公开(公告)号：US20060100421A1
公开(公告)日：2006-05-11
申请号：US10982873
申请日：2004-11-08
申请人： Gerald Walsh , Richard Olson
发明人： Gerald Walsh , Richard Olson
IPC分类号： C07H15/24
CPC分类号： C07H15/24
摘要： 13-benzenesulfonylhydrazone anthracyclines useful in producing improved yields in the synthesis 13-deoxyanthrcyclines, and an improved method of reducing 13-benzene-sulfonylhydrazone anthracyclines to 13-deoxyanthrcyclines wherein the reduction reaction is maintained at temperatures of about 55° C. to 64° C. without stirring or agitation. The reaction is completed with the addition of aqueous bicarbonate which forms the 13-deoxyanthracycline and precipitates. The precipitates are filtered and the precipitate and filtrate are extracted separately with organic solvents. The crude 13-deoxy anthracycline can be converted to 5-imino-13-deoxy anthracycline by reaction with methanolic ammonia. The reaction can also be performed with an acidic pyridinium salt instead of a strong acid so that neutralization of the reaction or extraction of the product is not necessary, thereby facilitating purification.
摘要翻译：可用于在合成13-脱氧肾上腺素中产生改善产量的13-苯磺酰腙蒽环类抗生素，以及将13-苯磺酰腙蒽环类抗生素还原为13-脱氧肾上腺素的改进方法，其中还原反应保持在约55℃至64℃ ，不搅拌或搅拌。反应完成，加入形成13-脱氧蒽环并沉淀的碳酸氢盐水溶液。将沉淀物过滤，并将沉淀物和滤液用有机溶剂分开萃取。粗制的13-脱氧蒽环霉素可以通过与甲醇氨反应而转化成5-亚氨基-13-脱氧蒽环霉素。该反应也可以用酸性吡啶鎓盐代替强酸进行，从而不需要中和反应或提取产物，从而有助于纯化。

3. 发明申请

US20070249547A1 Anticancer treatment with a combination of taxanes and 13-deoxyanthracyclines 有权
标题翻译：用紫杉烷类和13-脱氧蒽环类药物组合进行抗癌治疗
公开(公告)号：US20070249547A1
公开(公告)日：2007-10-25
申请号：US11408000
申请日：2006-04-21
申请人： Richard Olson , Gerald Walsh
发明人： Richard Olson , Gerald Walsh
IPC分类号： A61K31/704 , A61K31/337
CPC分类号： A61K31/337 , A61K31/704 , A61K2300/00
摘要： A 13-deoxy anthracycline and a taxane can be administered to a patient simultaneously, separately, sequentially, or consecutively to produce a therapeutic anticancer effect with reduced toxicity and side effect profile, compared to the administration of equieffective amounts of either compound alone. A composition or preparation of a 13-deoxy anthracyclines and a taxane for producing a potent anticancer therapeutic effect is also provided.
摘要翻译：与单独施用任一化合物的等效量相比，可以同时，分别，依次或连续地向患者施用13-脱氧蒽环类抗生素和紫杉烷类，以产生具有降低的毒性和副作用特征的治疗性抗癌作用。还提供了用于产生有效的抗癌治疗效果的13-脱氧蒽环类抗生素和紫杉烷的组合物或制剂。

4. 发明授权

US08685074B2 Balloon catheter 有权
标题翻译：气球导管
公开(公告)号：US08685074B2
公开(公告)日：2014-04-01
申请号：US11282252
申请日：2005-11-18
申请人： Tracee Eidenschink , Richard Olson
发明人： Tracee Eidenschink , Richard Olson
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61M2025/0058 , A61M2025/1004
摘要： A catheter system comprises a catheter, an inner shaft, an expandable balloon, and an elongate advancement member. The expandable balloon has an unwrapped state and rewrapped state and the advancement member has a first state and a second state. When the advancement member is in the first state the expandable balloon is in the unwrapped state, and when the advancement member is in the second state the expandable balloon is in the rewrapped state. The unwrapped state has a first length and a first diameter, the rewrapped state has a second length and a second diameter, the second length is equal to or greater than the first length, and the second diameter is less than first diameter. The advancement member in the second state extends through the interior region defined by the expandable balloon.
摘要翻译：导管系统包括导管，内轴，可膨胀气囊和细长推进构件。可膨胀气囊具有展开状态和再包裹状态，并且前进构件具有第一状态和第二状态。当推进构件处于第一状态时，可膨胀气囊处于展开状态，并且当推进构件处于第二状态时，可膨胀气囊处于重新包裹状态。展开状态具有第一长度和第一直径，再包裹状态具有第二长度和第二直径，第二长度等于或大于第一长度，并且第二直径小于第一直径。第二状态的前进构件延伸穿过由可膨胀气囊限定的内部区域。

5. 发明授权

US07575568B2 Catheter distal tip 有权
标题翻译：导管远端
公开(公告)号：US07575568B2
公开(公告)日：2009-08-18
申请号：US10732983
申请日：2003-12-10
申请人： Thomas J. Holman , Daniel K. Tomaschko , Leo M. Klisch , Richard Olson , Joseph M Lyver , Richard Dunn , David Griswold , Nie Tang , Lixiao Wang
发明人： Thomas J. Holman , Daniel K. Tomaschko , Leo M. Klisch , Richard Olson , Joseph M Lyver , Richard Dunn , David Griswold , Nie Tang , Lixiao Wang
IPC分类号： A61M29/00
CPC分类号： A61M25/1034 , A61M25/0069 , A61M25/104 , A61M2025/1093
摘要： The present invention is directed to distal tip designs for catheter, wherein distal tip material is positioned about an inner shaft. The distal tip material may also be used as a tie layer for thermally bonding two incompatible materials together, such as a waist portion of a balloon to the inner shaft.
摘要翻译：本发明涉及用于导管的远侧末端设计，其中远侧末端材料围绕内部轴定位。远侧末端材料也可以用作将两个不相容材料（例如球囊的腰部部分）一起热粘合到内轴的连接层。

6. 发明申请

US20080207595A9 Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin 有权
标题翻译：芳基和杂芳基取代的四氢苯并氮杂及其用于阻断去甲肾上腺素，多巴胺和5-羟色胺的再摄取
公开(公告)号：US20080207595A9
公开(公告)日：2008-08-28
申请号：US11487884
申请日：2006-07-17
申请人： Bruce Molino , Shuang Liu , Aruna Sambandam , Peter Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David Manning , Matthew Isherwood , Kristen Fleming , Wenge Cui , Richard Olson
发明人： Bruce Molino , Shuang Liu , Aruna Sambandam , Peter Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David Manning , Matthew Isherwood , Kristen Fleming , Wenge Cui , Richard Olson
IPC分类号： A61K31/55 , C07D487/02 , C07D403/02
CPC分类号： C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04
摘要： The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
摘要翻译：本发明的化合物由以下芳基 - 和杂芳基取代的四氢苯并吖庚因和具有式I（AE）和式（II）的二氢苯并氮杂衍生物表示：其中指定为*的碳原子为R或S构型， X和R 1 -R 9如本文所定义。

7. 发明申请

US20060064152A1 Stent delivery system loading tool 审中-公开
公开(公告)号：US20060064152A1
公开(公告)日：2006-03-23
申请号：US11267421
申请日：2005-11-04
申请人： Richard Olson
发明人： Richard Olson
IPC分类号： A61F2/06
CPC分类号： A61F2/95 , A61F2002/9522
摘要： A removable loading tool for use with a catheter assembly wherein the loading tool comprises a body which defines a substantially hollow chamber. The substantially hollow chamber has a first portion and a second portion. The first portion has a first diameter sized to contain at least a portion of the catheter assembly having a stent mounted thereon. The second portion has a second diameter less than that of the first diameter. The body constructed and arranged to protect the at least a portion of the catheter assembly and the stent from undesired contact or damage during loading of a guide wire into the catheter assembly.

8. 发明申请

US20060025005A1 Pin Shroud 失效
标题翻译：针罩
公开(公告)号：US20060025005A1
公开(公告)日：2006-02-02
申请号：US10901338
申请日：2004-07-28
申请人： Richard Olson , Jill Quinn , Stacy Fraker , Jeffrey Deeney , Joseph Dutson
发明人： Richard Olson , Jill Quinn , Stacy Fraker , Jeffrey Deeney , Joseph Dutson
IPC分类号： H01R13/62
CPC分类号： H01R13/5213
摘要： A shroud for a circuit board having a raised pin platform and a pin array projecting from the raised pin platform. A spacer extending from a side wall of the shroud engages a side of the raised pin platform, thereby accurately aligning the shroud with the pin platform
摘要翻译：一种用于电路板的护罩，其具有凸起销平台和从凸起销平台突出的销阵列。从护罩的侧壁延伸的间隔件接合凸起销平台的侧面，从而将护罩与销平台精确对准

9. 外观设计

USD402689S Inkjet printer 失效
公开(公告)号：USD402689S
公开(公告)日：1998-12-15
申请号：US071903
申请日：1997-05-27
申请人： Stephen G Brown , Michael K. Bowen , Richard Olson , Michael S Millman , Robert M Yraceburu , Michael W Munro , Dean A Gaylor
设计人： Stephen G Brown , Michael K. Bowen , Richard Olson , Michael S Millman , Robert M Yraceburu , Michael W Munro , Dean A Gaylor

10. 发明申请

US20090299284A1 Balloon Catheter Tip Design 有权
标题翻译：气球导管尖端设计
公开(公告)号：US20090299284A1
公开(公告)日：2009-12-03
申请号：US12537324
申请日：2009-08-07
申请人： Thomas J. Holman , Daniel Keith Tomaschko , Leo M. Klisch , Richard Olson , Joseph M. Lyver , Richard Dunn , David Griswold , Nie Tang , Lixiao Wang
发明人： Thomas J. Holman , Daniel Keith Tomaschko , Leo M. Klisch , Richard Olson , Joseph M. Lyver , Richard Dunn , David Griswold , Nie Tang , Lixiao Wang
IPC分类号： A61M25/10 , A61M25/16
CPC分类号： A61M25/1034 , A61M25/0069 , A61M25/104 , A61M2025/1093
摘要： The present invention is directed to distal tip designs for catheter, wherein distal tip material is positioned about an inner shaft. The distal tip material may also be used as a tie layer for thermally bonding two incompatible materials together, such as a waist portion of a balloon to the inner shaft.
摘要翻译：本发明涉及用于导管的远侧末端设计，其中远侧末端材料围绕内部轴定位。远侧末端材料也可以用作将两个不相容材料（例如球囊的腰部部分）一起热粘合到内轴的连接层。

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