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1. 发明授权

US5780044A Liquid delivery compositions 失效
标题翻译：控制释放递送组合物
公开(公告)号：US5780044A
公开(公告)日：1998-07-14
申请号：US761015
申请日：1996-12-05
申请人： Gerald L. Yewey , Nancy L. Krinick , Richard L. Dunn , Michael L. Radomsky , Gerbrand Brouwer , Arthur J. Tipton
发明人： Gerald L. Yewey , Nancy L. Krinick , Richard L. Dunn , Michael L. Radomsky , Gerbrand Brouwer , Arthur J. Tipton
IPC分类号： A61K9/00 , A61K9/08 , A61K9/20 , A61K9/22 , A61K9/70 , A61K47/48 , A61K49/00 , A61L15/44 , A61F2/00 , A61K9/127 , A61K9/52
CPC分类号： A61K9/0024 , A61K31/4439 , A61K31/485 , A61K31/704 , A61K38/09 , A61K38/27 , A61K47/34 , A61K47/48176 , A61K47/48192 , A61K47/482 , A61K47/48784 , A61K47/48853 , A61K49/0017 , A61K49/0036 , A61K49/0054 , A61K49/0063 , A61K49/0091 , A61K9/10 , A61K9/146 , A61K9/5026 , A61K9/5047 , A61L26/0019 , A61L26/0066 , A61L26/0085 , A61L27/18 , A61L27/56 , A61L31/06 , A61L31/146 , A61L31/16 , A61K47/42 , A61L2300/604 , A61L2300/62 , A61L2400/06 , Y10S514/90 , Y10S525/937 , Y10S977/774 , Y10S977/783 , Y10S977/906 , Y10S977/907 , Y10S977/915 , Y10S977/918
摘要： Improved biocompatible liquid delivery compositions, which are useful for the formation of sustained release delivery systems for active agents, are provided. The compositions include liquid formulations of a biocompatible polymer or prepolymer in combination with a controlled release component. The controlled release component includes an active agent. These compositions may be introduced into the body of a subject in liquid form which then solidify or cure in situ to form a controlled release implant or a film dressing. The liquid delivery compositions may also be employed ex situ to produce a controlled release implant. Methods of forming a controlled release implant and employing the liquid formulations in the treatment of a subject are also provided.
摘要翻译：提供改进的生物相容性液体递送组合物，其可用于形成活性剂的缓释递送系统。组合物包括与受控释放组分组合的生物相容性聚合物或预聚物的液体制剂。受控释放组分包括活性剂。这些组合物可以以液体形式引入受试者的身体，其然后在现场固化或固化以形成控释植入物或膜敷料。液体递送组合物也可以非原位地用于产生控释植入物。还提供了形成受控释放植入物并使用液体制剂治疗受试者的方法。

2. 发明授权

US5759563A Liquid delivery compositions 失效
标题翻译：液体输送组合物
公开(公告)号：US5759563A
公开(公告)日：1998-06-02
申请号：US486262
申请日：1995-06-07
申请人： Gerald L. Yewey , Nancy L. Krinick , Richard L. Dunn , Michael L. Radomsky , Gerbrand Brouwer , Arthur J. Tipton
发明人： Gerald L. Yewey , Nancy L. Krinick , Richard L. Dunn , Michael L. Radomsky , Gerbrand Brouwer , Arthur J. Tipton
IPC分类号： A61K9/00 , A61K9/08 , A61K9/20 , A61K9/22 , A61K9/70 , A61K47/48 , A61K49/00 , A61L15/44 , A61K9/127 , A61F13/00
CPC分类号： A61K9/0024 , A61K31/4439 , A61K31/485 , A61K31/704 , A61K38/09 , A61K38/27 , A61K47/34 , A61K47/48176 , A61K47/48192 , A61K47/482 , A61K47/48784 , A61K47/48853 , A61K49/0017 , A61K49/0036 , A61K49/0054 , A61K49/0063 , A61K49/0091 , A61K9/10 , A61K9/146 , A61K9/5026 , A61K9/5047 , A61L26/0019 , A61L26/0066 , A61L26/0085 , A61L27/18 , A61L27/56 , A61L31/06 , A61L31/146 , A61L31/16 , A61K47/42 , A61L2300/604 , A61L2300/62 , A61L2400/06 , Y10S514/90 , Y10S525/937 , Y10S977/774 , Y10S977/783 , Y10S977/906 , Y10S977/907 , Y10S977/915 , Y10S977/918
摘要： Improved biocompatible liquid delivery compositions, which are useful for the formation of sustained release delivery systems for active agents, are provided. The compositions include liquid formulations of a biocompatible polymer or prepolymer in combination with a controlled release component. The controlled release component includes an active agent. These compositions may be introduced into the body of a subject in liquid form which then solidify or cure in situ to form a controlled release implant or a film dressing. The liquid delivery compositions may also be employed ex situ to produce a controlled release implant. Methods of forming a controlled release implant and employing the liquid formulations in the treatment of a subject are also provided.
摘要翻译：提供改进的生物相容性液体递送组合物，其可用于形成活性剂的缓释递送系统。组合物包括与受控释放组分组合的生物相容性聚合物或预聚物的液体制剂。受控释放组分包括活性剂。这些组合物可以以液体形式引入受试者的身体，其然后在现场固化或固化以形成控释植入物或膜敷料。液体递送组合物也可以非原位地用于产生控释植入物。还提供了形成受控释放植入物并使用液体制剂治疗受试者的方法。

3. 发明授权

US5744153A Liquid delivery compositions 失效
公开(公告)号：US5744153A
公开(公告)日：1998-04-28
申请号：US871492
申请日：1997-06-09
申请人： Gerald L. Yewey , Nancy L. Krinick , Richard L. Dunn , Michael L. Radomsky , Gerbrand Brouwer , Arthur J. Tipton
发明人： Gerald L. Yewey , Nancy L. Krinick , Richard L. Dunn , Michael L. Radomsky , Gerbrand Brouwer , Arthur J. Tipton
IPC分类号： A61K9/00 , A61K9/08 , A61K9/20 , A61K9/22 , A61K9/70 , A61K47/48 , A61K49/00 , A61L15/44 , A61F2/00 , A61K9/127 , A61K9/52
CPC分类号： A61K9/0024 , A61K31/4439 , A61K31/485 , A61K31/704 , A61K38/09 , A61K38/27 , A61K47/34 , A61K47/48176 , A61K47/48192 , A61K47/482 , A61K47/48784 , A61K47/48853 , A61K49/0017 , A61K49/0036 , A61K49/0054 , A61K49/0063 , A61K49/0091 , A61K9/10 , A61K9/146 , A61K9/5026 , A61K9/5047 , A61L26/0019 , A61L26/0066 , A61L26/0085 , A61L27/18 , A61L27/56 , A61L31/06 , A61L31/146 , A61L31/16 , A61K47/42 , A61L2300/604 , A61L2300/62 , A61L2400/06 , Y10S514/90 , Y10S525/937 , Y10S977/774 , Y10S977/783 , Y10S977/906 , Y10S977/907 , Y10S977/915 , Y10S977/918
摘要： Improved biocompatible liquid delivery compositions, which are useful for the formation of sustained release delivery systems for active agents, are provided. The compositions include liquid formulations of a biocompatible polymer or prepolymer in combination with a controlled release component. The controlled release component includes an active agent. These compositions may be introduced into the body of a subject in liquid form which then solidify or cure in situ to form a controlled release implant or a film dressing. The liquid delivery compositions may also be employed ex situ to produce a controlled release implant. Methods of forming a controlled release implant and employing the liquid formulations in the treatment of a subject are also provided.

4. 发明授权

US5258453A Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light 失效
标题翻译：用于同时递送通过酶和光激活的药物的药物递送系统
公开(公告)号：US5258453A
公开(公告)日：1993-11-02
申请号：US822924
申请日：1992-01-21
申请人： Jindrich Kopecek , Nancy L. Krinick
发明人： Jindrich Kopecek , Nancy L. Krinick
IPC分类号： A61K41/00 , A61K47/48 , C08F20/04 , C08F20/52 , C08F20/56 , C08F120/04 , C08G63/48 , C08G63/91 , A61L9/01
CPC分类号： A61K47/48176 , A61K41/0071 , Y10S530/811 , Y10S530/812 , Y10S530/815 , Y10S530/816
摘要： Compositions for the treatment of cancerous tissues in warm-blooded animals containing both an anticancer drug and a photoactivatable drug attached to copolymeric carriers are made up of a member selected from the group consisting of (a) a copolymeric carrier having attached thereto both an anticancer drug and a photoactivatable drug, (b) a mixture of copolymeric carriers wherein one copolymeric carrier has attached an anticancer drug and the other copolymeric carrier has attached a photoactivatable drug and (c) a combination of (a) and (b). The anticancer drug is attached to the polymeric carrier by side-chains which are stable in the blood stream of the warm-blooded animal but susceptible to hydrolysis by lysosomal enzymes intracellularly. The photoactivatable drug is attached by either the same degradable side-chain or by a non-degradable attachment. The polymer carrier may optionally contain a targeting moiety. Upon administration polymeric macromolecules enter targeted cancer cells by pinocytosis which reduces the side effects normally elicited by the free drugs. A time lag is allowed following administration for optimal uptake of the copolymers in the cancerous tissue for the anticancer agent to begin to take effect. Then a light sources of the appropriate wavelength and energy is to activate the photoactivatable drug. The combined effect of the anticancer agent and photoactivatable drug provides greater cell destruction at reduced dosages and side effects.
摘要翻译：用于治疗包含附着在共聚载体上的抗癌药物和可光活化药物的温血动物中的癌组织的组合物由选自以下的成员组成：（a）与抗癌药物和可光活化药物，（b）共聚载体的混合物，其中一种共聚载体已经附着有抗癌药物，另一种共聚载体附着有可光活化药物，和（c）（a）和（b）的组合。抗癌药物通过在温血动物的血液中稳定但易于细胞内溶酶体酶水解的侧链的侧链连接到聚合物载体上。可光活化药物通过相同的可降解侧链或不可降解的附着物连接。聚合物载体可任选地含有靶向部分。在施用聚合物大分子时，通过胞饮作用进入靶向的癌细胞，其减少通常由游离药物引起的副作用。给药后允许时间延迟以使抗癌剂的癌组织中的共聚物的最佳摄取开始起作用。那么合适的波长和能量的光源就是激活可光活化的药物。抗癌剂和可光活化药物的组合效果在降低的剂量和副作用下提供更大的细胞破坏。

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