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1. 发明授权

US08227574B2 Collagen materials, films and methods of making same 有权
标题翻译：胶原材料，胶片及其制作方法
公开(公告)号：US08227574B2
公开(公告)日：2012-07-24
申请号：US11951324
申请日：2007-12-05
申请人： Mikhail Vitoldovich Paukshto , David Harwood McMurtry , Gerald G. Fuller , Yuri Alexandrovich Bobrov , John E. Kirkwood
发明人： Mikhail Vitoldovich Paukshto , David Harwood McMurtry , Gerald G. Fuller , Yuri Alexandrovich Bobrov , John E. Kirkwood
IPC分类号： A61K38/17
CPC分类号： C07K14/78 , Y10T428/24479 , Y10T428/24612
摘要： In general, the present invention is related to collagen compositions and thin films, and to methods of making and using the same. In some embodiments, the present invention is directed to “woven pattern” or “basket pattern” collagen compositions and thin films, and methods of making.
摘要翻译：通常，本发明涉及胶原组合物和薄膜，以及制造和使用它们的方法。在一些实施方案中，本发明涉及“编织图案”或“筐形图案”胶原组合物和薄膜以及制备方法。

2. 发明授权

US08329246B2 Oriented collagen gel 有权
标题翻译：定向胶原凝胶
公开(公告)号：US08329246B2
公开(公告)日：2012-12-11
申请号：US12660702
申请日：2010-03-02
申请人： Gerald G. Fuller , John E. Kirkwood
发明人： Gerald G. Fuller , John E. Kirkwood
IPC分类号： A61L33/14
CPC分类号： B05D5/00 , A61L27/24 , A61L27/50 , C08J5/00 , C08J2389/00 , C08L89/06
摘要： Techniques for the production of flow-oriented collagen gels using hydrodynamics to influence the assembly of collagen fibers. Highly concentrated monomeric solutions of collagen are subjected to shear and extensional flow as they are drawn onto a substrate to induce fibrillogenesis under a high Ph buffer. The produced gel captures the flow induced ordering of molecular collagen upon fibril formation. The depositing or the induction of fibrillogenosis occurs without the application of a magnetic field to the concentration of collagen. These highly oriented 3D scaffolds are capable inducing contact guidance and guiding mammalian cell growth. The collagen fibers mimic the construction of in vivo fibers with the characteristic D-periodicity and the integrin receptors on the fibroblasts respond to this organization. The industrial applications of three-dimensional collagen gels as a biomaterial are widespread from drug delivery to burn repair or tissue engineering system.
摘要翻译：使用流体动力学制造流动性胶原凝胶来影响胶原纤维的组装的技术。胶体的高度浓缩的单体溶液经受剪切和拉伸流动，因为它们被吸引到基底上以在高Ph缓冲液下诱导原纤维生成。所产生的凝胶捕获原纤维形成时分子胶原的流动引发排序。原发性纤维化的沉积或诱导发生在没有对胶原浓度施加磁场的情况下。这些高度定向的3D支架能够诱导接触引导和引导哺乳动物细胞生长。胶原纤维模拟具有特征性D周期的体内纤维的构建，并且成纤维细胞上的整联蛋白受体对该组织作出反应。三维胶原凝胶作为生物材料的工业应用从药物输送到烧伤修复或组织工程系统是广泛的。

3. 发明申请

US20110151563A1 Collagen Materials, Films and Methods of Making Same 有权
标题翻译：胶原材料，薄膜及其制作方法
公开(公告)号：US20110151563A1
公开(公告)日：2011-06-23
申请号：US11951324
申请日：2007-12-05
申请人： Mikhail Vitoldovich Paukshto , David Harwood McMurtry , Gerald G. Fuller , Yuri Alexandrovich Bobrov , John E. Kirkwood
发明人： Mikhail Vitoldovich Paukshto , David Harwood McMurtry , Gerald G. Fuller , Yuri Alexandrovich Bobrov , John E. Kirkwood
IPC分类号： C12N5/00 , B32B3/30 , B29C39/04 , B82Y5/00
CPC分类号： C07K14/78 , Y10T428/24479 , Y10T428/24612
摘要： In general, the present invention is related to collagen compositions and thin films, and to methods of making and using the same. In some embodiments, the present invention is directed to “woven pattern” or “basket pattern” collagen compositions and thin films, and methods of making.
摘要翻译：通常，本发明涉及胶原组合物和薄膜，以及制造和使用它们的方法。在一些实施方案中，本发明涉及“编织图案”或“筐形图案”胶原组合物和薄膜以及制备方法。

4. 发明申请

US20100227043A1 Oriented collagen gel 有权
标题翻译：定向胶原凝胶
公开(公告)号：US20100227043A1
公开(公告)日：2010-09-09
申请号：US12660702
申请日：2010-03-02
申请人： Gerald G. Fuller , John E. Kirkwood
发明人： Gerald G. Fuller , John E. Kirkwood
IPC分类号： A61L33/14
CPC分类号： B05D5/00 , A61L27/24 , A61L27/50 , C08J5/00 , C08J2389/00 , C08L89/06
摘要： Techniques for the production of flow-oriented collagen gels using hydrodynamics to influence the assembly of collagen fibers. Highly concentrated monomeric solutions of collagen are subjected to shear and extensional flow as they are drawn onto a substrate to induce fibrillogenesis under a high Ph buffer. The produced gel captures the flow induced ordering of molecular collagen upon fibril formation. The depositing or the induction of fibrillogenosis occurs without the application of a magnetic field to the concentration of collagen. These highly oriented 3D scaffolds are capable inducing contact guidance and guiding mammalian cell growth. The collagen fibers mimic the construction of in vivo fibers with the characteristic D-periodicity and the integrin receptors on the fibroblasts respond to this organization. The industrial applications of three-dimensional collagen gels as a biomaterial are widespread from drug delivery to burn repair or tissue engineering system.
摘要翻译：使用流体动力学制造流动性胶原凝胶来影响胶原纤维的组装的技术。胶体的高度浓缩的单体溶液经受剪切和拉伸流动，因为它们被吸引到基底上以在高Ph缓冲液下诱导原纤维生成。所产生的凝胶捕获原纤维形成时分子胶原的流动引发排序。原发性纤维化的沉积或诱导发生在没有对胶原浓度施加磁场的情况下。这些高度定向的3D支架能够诱导接触引导和引导哺乳动物细胞生长。胶原纤维模拟具有特征性D周期的体内纤维的构建，并且成纤维细胞上的整联蛋白受体对该组织作出反应。三维胶原凝胶作为生物材料的工业应用从药物输送到烧伤修复或组织工程系统是广泛的。

5. 发明申请

US20100221521A1 Shear thickening fluid containment in polymer composites 审中-公开
标题翻译：聚合物复合材料中剪切增稠流体的遏制
公开(公告)号：US20100221521A1
公开(公告)日：2010-09-02
申请号：US11516956
申请日：2006-09-07
申请人： Norman Wagner , John E. Kirkwood , Ronald G. Egres, JR.
发明人： Norman Wagner , John E. Kirkwood , Ronald G. Egres, JR.
IPC分类号： B32B3/26 , B32B5/16 , C08L75/04 , C08L63/00 , C08L23/00 , C08L23/06 , C08L23/12 , C08L33/12 , C08L27/06 , C08L31/00 , C08L77/00 , C08J9/00
CPC分类号： B01F17/0028 , Y10T428/249953 , Y10T428/249978 , Y10T428/25
摘要： Shear thickening fluid suspoemulsions are shown to exhibit unique material properties that have potential application in a broad range of fields of use. Suspoemulsions containing shear thickening fluids as immiscible blends exhibit a nontrivial shear thickening response for volume fractions as low as 10% of STF in the silicone emulsion. Measurements indicate that the system shows phase inversion and it is even possible to form materials with a cocontinuous microstructure with interesting, hysteretic, shear sensitive behavior. Novel STF containing composites with rubbers are formed by blending the shear thickening fluid within the rubber precursors and then adding the catalyzing agent. It was possible to contain STF in each of the silicones tested and the rubbers exhibited different behavior with incased STF. Shear thickening fluid was added to open cell polyurethane to create a Foam-STF composite which was found to exhibit an significant shear thickening response. Finally, STF composites were also formed by polymer blending, leading to materials with unique and superior performance as a consequence of the STF content and multiphase microstructure.
摘要翻译：剪切增稠液悬浮乳液显示具有独特的材料性质，其具有潜在的应用范围广泛的使用领域。含有剪切增稠流体作为不混溶混合物的混合乳液对于硅氧烷乳液中低至10％的STF的体积分数显示出不均匀的剪切增稠响应。测量表明该系统显示出相位反转，甚至可能形成具有有趣，滞后，剪切敏感行为的连续微观结构的材料。通过将橡胶前体中的剪切增稠流体混合，然后加入催化剂，形成含有橡胶的新型含STF复合材料。在测试的每个有机硅中都可以含有STF，橡胶在STF中表现出不同的行为。将剪切增稠液加入到开孔聚氨酯中以产生泡沫-STF复合材料，其被发现显示出显着的剪切增稠反应。最后，通过聚合物共混形成STF复合材料，由于STF含量和多相显微组织，导致具有独特优异性能的材料。

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