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    • 2. 发明授权
    • Method for enhancing dissolution properties of relatively insoluble
dietary supplements and product incorporating same
    • 增加相对不溶性膳食补充剂和加入其的产品的溶出性质的方法
    • US6056971A
    • 2000-05-02
    • US899454
    • 1997-07-23
    • Robert Goldman
    • Robert Goldman
    • A23L1/30A23L1/308A61K9/48A61K31/122
    • A61K9/4858A23L33/21A61K31/122A61K9/4866A23V2002/00
    • A method for enhancing the dissolution properties of relatively insoluble dietary supplements is provided in accordance with the invention. The method includes the steps of providing at least one relatively water insoluble dietary supplement, solubilizing the dietary supplement with a solubilizer, and incorporating an edible polyhydric alcohol into the solubilized dietary supplement to provide a liquid dietary supplement composition that will dissolve spontaneously in the gastrointestinal tract with the minimum agitation which normally occurs there due to peristaltic action. The liquid dietary supplement composition can be readily supplied by incorporation in a gelatin capsule and a gelatin capsule having a liquid dietary supplement incorporated therein is also provided in accordance with the invention. The gelatin capsule dissolves readily in the digestive tract and the dietary supplement has enhanced bioavailability in comparison to prior art gelatin capsules.
    • 根据本发明提供了增强相对不溶性膳食补充剂的溶解性质的方法。 该方法包括以下步骤:提供至少一种相对不溶于水的膳食补充剂,使膳食补充剂溶解增溶剂,并将可食用的多元醇加入到溶解的膳食补充剂中,以提供在胃肠道中自发溶解的液体膳食补充剂组合物 由于蠕动作用,通常在那里发生最小的搅动。 液体膳食补充剂组合物可以容易地通过掺入明胶胶囊中提供,并且根据本发明也提供了其中结合有液体膳食补充剂的明胶胶囊。 明胶胶囊易于溶解在消化道中,与现有技术的明胶胶囊相比,膳食补充剂具有增强的生物利用度。
    • 3. 发明申请
    • Foldable cutting board
    • 折叠砧板
    • US20070170629A1
    • 2007-07-26
    • US11336262
    • 2006-01-20
    • Robert Goldman
    • Robert Goldman
    • B23Q3/00
    • A47J47/005Y10S269/90
    • A versatile, foldable and disposable cutting board for preparing food is made of a thin, resiliently flexible sheet of propylene, stainless steel or other cut-resistant material. The board has a triangular section projecting away from the user to form a distal pouring funnel and spout when the board is folded along its middle by grabbing both sides and moving them toward each other. A narrow fence extending upwardly from the periphery of the board dips gradually along the distal edge toward a near horizontal position at the apex of the triangular section. The fence is interrupted along an offset portion of the proximal edge in order to provide clearance for the blade and handle of a chopping or mincing instrument.
    • 用于制备食物的多功能,可折叠和一次性切割板由丙烯,不锈钢或其他切割材料的薄弹性柔性片材制成。 该板具有一个三角形部分,远离用户伸出,以形成一个远端倾倒漏斗,并且当板沿着其中间折叠时抓住两侧并将它们朝向彼此移动。 从板的周边向上延伸的窄栅栏沿着远端边缘逐渐朝向在三角形部分的顶点处的接近水平位置。 栅栏沿着近边缘的偏移部分中断,以便为切割或切碎仪器的刀片和手柄提供间隙。
    • 4. 发明申请
    • Multi-function catheter and use thereof
    • 多功能导管及其使用
    • US20050267407A1
    • 2005-12-01
    • US11097582
    • 2005-04-01
    • Robert Goldman
    • Robert Goldman
    • A61M29/00
    • A61M25/1011A61B17/12113A61B2017/00557A61B2017/1205A61F2/945A61F2/958A61L29/16A61L29/18A61M2025/105A61M2025/1052
    • A catheter for delivering an agent to an area of treatment is presented. The catheter includes a catheter body, a balloon assembly coupled to the catheter body, a first lumen, and a second lumen. The balloon assembly has spaced-apart balloons that define an area between the balloons. The first lumen extends along the catheter body to pass an inflation material to the balloons to control an inflation level of the balloons. The second lumen extends along the catheter body and having an outlet in the area between the balloons. There may be a third lumen for bypassing a biological fluid such as blood while the catheter is being used. The method of using this catheter is also presented. The method entails simultaneously inflating the balloons to isolate a treatment area and adding an agent to the treatment area through one of the lumens.
    • 提出了一种用于将药剂递送到治疗区域的导管。 导管包括导管主体,耦合到导管主体的球囊组件,第一腔和第二腔。 球囊组件具有间隔开的气囊,其限定气囊之间的区域。 第一腔沿着导管体延伸以将充气材料传递到气囊以控制气囊的充气水平。 第二腔沿着导管主体延伸并且在气球之间的区域中具有出口。 当使用导管时,可能存在用于旁路生物流体例如血液的第三腔。 还介绍了使用该导管的方法。 该方法同时使气囊充气以分离治疗区域,并通过其中一个内腔将药剂添加到治疗区域。
    • 10. 发明授权
    • Dual mechanism controlled release system for drug dosage forms
    • 药物剂型双机制控制释放系统
    • US5175003A
    • 1992-12-29
    • US505723
    • 1990-04-06
    • Robert Goldman
    • Robert Goldman
    • A61K9/50
    • A61K9/5078
    • A dual mechanism polymer mixture composed of pH-sensitive enteric materials and film-forming plasticizers capable of conferring permeability to the enteric material, for use in drug-delivery systems; a matrix pellet composed of a dual mechanism polymer mixture permeated with drug and sometimes covering a pharmaceutically neutral nucleus; a membrane-coated pellet comprising a matrix pellet coated with a dual mechanism polymer mixture envelope of the same or different composition; and a pharmaceutical dosage form containing matrix pellets. The matrix pellet releases acid-soluble drugs by diffusion in acid pH and by disintegration at pH levels of nominally about 5.0 or higher.
    • 由pH敏感性肠溶性物质和能够赋予肠道材料渗透性的成膜增塑剂组成的双机制聚合物混合物,用于药物输送系统; 由双重机理聚合物混合物组成的基质颗粒,其渗透药物并有时覆盖药物中性细胞核; 一种膜包衣的丸粒,其包含涂覆有相同或不同组成的双重机械聚合物混合物包层的基质颗粒; 和含有基质颗粒的药物剂型。 基质沉淀物通过在酸性pH下扩散并通过在标称约5.0或更高的pH水平下分解来释放酸溶性药物。