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1. 发明授权

US4976117A Device and process for producing cold and/or heat by solid-gas reaction 失效
标题翻译：通过固体气体反应生产冷和/或热的装置和方法
公开(公告)号：US4976117A
公开(公告)日：1990-12-11
申请号：US314827
申请日：1989-02-27
申请人： Georges Crozat , Michel Lebrun
发明人： Georges Crozat , Michel Lebrun
IPC分类号： C09K5/00 , C09K5/02 , C09K5/16 , F25B17/08 , F25B29/00 , F25B47/02
CPC分类号： F25B29/006 , C09K5/16 , F25B17/08
摘要： The device comprises at least two reactors (R1, R2) containing the same solid compound, communication circuits between these reactors, the evaporator (E), the condenser (C) and the gas collector (Co) and means are provided for successively starting the solid-gas reactions in the two reactors and for producing the openings and closings of the various communication circuits in a predetermined order to obtain a continuous production of cold.
摘要翻译： PCT No.PCT / FR88 / 00256 Sec。 371日期1989年2月27日 102（e）日期1989年2月27日PCT提交1988年5月20日PCT公布。出版物WO88 / 09466 该装置包括至少两个含有相同固体化合物的反应器（R1，R2），这些反应器之间的连通回路，蒸发器（E），冷凝器（C）和气体收集器（Co），以及提供了用于在两个反应器中连续启动固体气体反应并且以预定顺序产生各种通信电路的开口和关闭以获得连续冷产生的装置。

2. 发明授权

US5773698A Chimeric nitrilase-encoding gene for herbicidal resistance 失效
标题翻译：用于除草抗性的嵌合腈水解酶编码基因
公开(公告)号：US5773698A
公开(公告)日：1998-06-30
申请号：US657175
申请日：1996-06-03
申请人： Bernard Leroux , Bernard Pelissier , Michel Lebrun
发明人： Bernard Leroux , Bernard Pelissier , Michel Lebrun
IPC分类号： A01H5/00 , A01N37/34 , C07H21/04 , C12N9/78 , C12N15/82 , C12N15/83 , C12N5/04 , C12N15/31
CPC分类号： C12N9/78 , C12N15/8274
摘要： Chimeric gene which is usable for endowing plants with resistance to a herbicide based on 3,5-dihalo-4-hydroxybenzonitrile, comprising at least one gene coding for resistance to this herbicide, a foreign promoter and, optionally, a polyadenylation signal region, wherein the promoter originates from a gene which is naturally expressed in plant cells and is chosen from the group comprising the promoter of the 35 S RNA for cauliflower mosaic virus (CaMV 35S) and the promoter of the small subunit (SSU) of sunflower (Helianthus annuus) ribulose-1,5-bisphosphate carboxylase/oxygenase (RubisCO).
摘要翻译：可用于赋予植物对基于3,5-二卤代-4-羟基苄腈的除草剂具有抗性的嵌合基因，其包含至少一种编码对该除草剂的抗性的基因，外源启动子和任选的多腺苷酸化信号区，其中启动子起源于在植物细胞中天然表达的基因，并且选自包含花椰菜花叶病毒（CaMV 35S）的35S RNA的启动子和向日葵的小亚基（SSU）的启动子（向日葵）核酮糖-1,5-二磷酸羧化酶/加氧酶（RubisCO）。

3. 发明授权

US5725338A Drill bit having a hemispherical head with an evolutive cut 失效
标题翻译：钻头具有具有演化切割的半球形头部
公开(公告)号：US5725338A
公开(公告)日：1998-03-10
申请号：US780233
申请日：1997-01-08
申请人： Maurice Jean Cabaret , Christian Thierry Daude , Daniel Marcel Eugene Lavocat , Jean Pierre Leboulanger , Michel Lebrun , Fran.cedilla.ois Masson , Gilles Rouge , Bernard Gilbert Roy
发明人： Maurice Jean Cabaret , Christian Thierry Daude , Daniel Marcel Eugene Lavocat , Jean Pierre Leboulanger , Michel Lebrun , Fran.cedilla.ois Masson , Gilles Rouge , Bernard Gilbert Roy
IPC分类号： B23B51/00 , B23B31/00 , B23C5/10
CPC分类号： B23C5/1009 , B23B31/005 , B23B2231/0256 , Y10T407/1948 , Y10T408/9097
摘要： The cutting end or head of a helically grooved drill bit is of generally hemispherical shape and has four cutting lips, two of which are disposed in end-to-end relationship at the point S of the bit. The cutting angle of the edge of each lip is evolutive, varying from 0.degree. at the point S to a value, determined experimentally in accordance with the material to be machined, at a position P at the intersection of the cutting edge with the end of the outer diameter d of the bit.
摘要翻译：螺旋槽钻头的切割端或头部通常为半球形，并具有四个切削刃，其中两个在钻头的点S处以端对端关系设置。每个唇缘的边缘的切割角度是演化的，从点S处的0°变化到根据被加工材料实验确定的值，在切削刃与端部的交点处的位置P处钻头的外径d。

4. 发明授权

US5057132A Device for producing cold and/or heat by a solid-gas reaction 失效
标题翻译：用于通过固体气体反应生产冷和/或热的装置
公开(公告)号：US5057132A
公开(公告)日：1991-10-15
申请号：US461940
申请日：1990-01-08
申请人： Michel Lebrun , Michel Mayslich , Bernard Spinner
发明人： Michel Lebrun , Michel Mayslich , Bernard Spinner
IPC分类号： F25B17/08 , F28D20/00
CPC分类号： F25B17/08 , F28D20/003 , Y02B30/62 , Y02E60/142
摘要： Device for producing cold and/or heat by a solid gas reaction comprising a first and a second reactor each of which contains a salt capable of reacting by absorption with a gas by an exothermic reaction, the first reactor being in communication in a first operating stage with an enclosure intended to retain the gas, the second reactor being in communication, in the first operating stage, with an enclosure intended to release the gas, according to the invention, each reactor comprises a different salt. A device comprising four reactors provided with three different salts is also described.
摘要翻译：用于通过固体气体反应产生冷和/或加热的装置，包括第一和第二反应器，每个反应器含有能够通过吸收与气体通过放热反应而反应的盐，第一反应器在第一操作阶段中连通具有旨在保持气体的外壳，第二反应器在第一操作阶段中与用于释放气体的外壳连通，根据本发明，每个反应器包括不同的盐。还描述了包括具有三种不同盐的四个反应器的装置。

5. 发明授权

US06313282B1 Isolated DNA sequence which can serve as terminator region in a chimeric gene capable of being used for the transformation of plants 失效
标题翻译：分离的DNA序列，其可以用作能够用于植物转化的嵌合基因中的终止子区域
公开(公告)号：US06313282B1
公开(公告)日：2001-11-06
申请号：US08896771
申请日：1997-07-18
申请人： Rossitza Atanassova , Richard De Rose , Georges Freyssinet , Claude Gigot , Michel Lebrun
发明人： Rossitza Atanassova , Richard De Rose , Georges Freyssinet , Claude Gigot , Michel Lebrun
IPC分类号： C07H2104
CPC分类号： C12N15/8223 , C12N15/8222 , C12N15/8229
摘要： Isolated DNA sequence which can serve as terminator region in a chimeric gene capable of being used for the transformation of plants 1) Chimeric gene for the transformation of plants. 2) It comprises at least, in the direction of transcription, a promoter region, a transgene and a terminator region, characterized in that the terminator region consists of at least one terminator region from a plant histone gene permitting the expression of the protein in the regions of rapid growth. 3) Production of transgenic plants.
摘要翻译：可用作能够用于植物转化的嵌合基因中的终止子区域的分离的DNA序列1）用于转化植物的嵌合基因.2）至少在转录方向上有启动子区域，转基因和终止区，其特征在于终止区由至少一个来自植物组蛋白基因的终止子区组成，允许蛋白质在快速生长区域中表达。3）转基因植物的生产。

6. 发明授权

US5905186A Chimeric plant genes based on upstream regulatory elements of helianthinin 失效
标题翻译：基于上呼吸素调节元件的嵌合植物基因
公开(公告)号：US5905186A
公开(公告)日：1999-05-18
申请号：US480344
申请日：1995-06-07
申请人： Terry Thomas , Georges Freyssinet , Michel Lebrun , Molly Bogue
发明人： Terry Thomas , Georges Freyssinet , Michel Lebrun , Molly Bogue
IPC分类号： A01H1/00 , C07K14/415 , C12N9/10 , C12N15/09 , C12N15/29 , C12N15/82 , A01H5/00 , C12N5/04
CPC分类号： C12N15/8222 , C07K14/415 , C12N15/8227 , C12N15/8234 , C12N15/8238 , C12N9/10
摘要： Helianthinin is an 11S seed storage protein of sunflower embryos. The present invention is directed to the 5' regulatory regions of helianthinin genes. More particularly, the present invention is directed to specific cis-regulatory elements of this regulatory region which direct tissue-specific gene expression. The present invention provides chimeric genes comprising the cis-regulatory elements linked to a coding sequence from a heterologous gene to control expression of these genes. The chimeric genes provided by the instant invention are useful in conferring herbicide resistance and improved seed lipid quality to transgenic plants
摘要翻译：向日葵是一种向日葵胚胎的11S种子储存蛋白。本发明涉及向日葵基因的5'调节区。更具体地，本发明涉及这种调节区域的特异性顺式调节元件，其指导组织特异性基因表达。本发明提供嵌合基因，其包含与来自异源基因的编码序列连接以控制这些基因的表达的顺式调节元件。由本发明提供的嵌合基因可用于赋予转基因植物抗除草剂抗性和改善的种子脂质量

7. 发明授权

US5824865A Chimeric plant genes based on upstream regulatory elements of helianthinin 失效
标题翻译：基于上呼吸素调节元件的嵌合植物基因
公开(公告)号：US5824865A
公开(公告)日：1998-10-20
申请号：US480346
申请日：1995-06-07
申请人： Terry Thomas , Georges Freyssinet , Michel Lebrun , Molly Bogue
发明人： Terry Thomas , Georges Freyssinet , Michel Lebrun , Molly Bogue
IPC分类号： C07K14/415 , C12N9/10 , C12N15/29 , C12N15/82 , A01H5/00 , C12N5/04
CPC分类号： C12N15/8234 , C07K14/415 , C12N15/8222 , C12N15/8227 , C12N15/8238 , C12N9/10
摘要： Helianthinin is an 11S seed storage protein of sunflower embryos. The present invention is directed to the 5' regulatory regions of helianthinin genes. More particularly, the present invention is directed to specific cis-regulatory elements of this regulatory region which direct abscisic acid-responsive gene expression. The present invention provides chimeric genes comprising the cis-regulatory elements linked to a coding sequence from a heterologous gene to control expression of these genes. The chimeric genes provided by the instant invention are useful in conferring herbicide resistance and improved seed lipid quality to transgenic plants.
摘要翻译：向日葵是一种向日葵胚胎的11S种子储存蛋白。本发明涉及向日葵基因的5'调节区。更具体地，本发明涉及这种调节区域的特异性顺式调节元件，其直接导致脱落酸反应性基因表达。本发明提供嵌合基因，其包含与来自异源基因的编码序列连接以控制这些基因的表达的顺式调节元件。由本发明提供的嵌合基因可用于赋予转基因植物抗除草剂抗性和改善的种子脂质量。

8. 发明授权

US5510471A Chimeric gene for the transformation of plants 失效
标题翻译：用于植物转化的嵌合基因
公开(公告)号：US5510471A
公开(公告)日：1996-04-23
申请号：US251621
申请日：1994-05-31
申请人： Michel Lebrun , Bernard Leroux , Alain Sailland
发明人： Michel Lebrun , Bernard Leroux , Alain Sailland
IPC分类号： A01H1/00 , A01H5/00 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/30 , C12N15/54 , C12N15/62 , C12N15/82 , C12R1/01 , C12R1/91 , C07H17/00 , C12N15/00 , C12N15/29
CPC分类号： C12N15/62 , C12N15/8275 , C07K2319/08
摘要： Chimeric gene for conferring to plants an increased tolerance to a herbicide having as its target EPSPS comprises, in the direction of transcription, a promoter region, a transit peptide region, a coding sequence for glyphosate tolerance and a polyadenylation signal region, wherein the transit peptide region comprises, in the direction of translation, at least one transit peptide of a plant gene encoding a plastid-localised enzyme, a partial sequence of the N-terminal mature part of a plant gene encoding a plastid-localised enzyme and then a second transit peptide of a plant gene encoding a plastid- localised enzyme. Production of glyphosate-tolerant plants is disclosed.
摘要翻译：用于赋予植物对具有作为其目标EPSPS的除草剂的增加的耐受性的嵌合基因包括在转录方向上的启动子区，转运肽区，草甘膦耐受的编码序列和多聚腺苷酸化信号区，其中转运肽翻译方向包括编码质体定位酶的植物基因的至少一个转运肽，编码质体定位酶的植物基因的N末端成熟部分的部分序列，然后是第二转运编码质体定位酶的植物基因的肽。公开了耐草甘膦植物的生产。

9. 发明授权

US06566587B1 Mutated 5-enolpyruvylshikimate-3-phosphate synthase, gene coding for said protein and transformed plants containing said gene 失效
标题翻译：突变的5-烯醇丙酮酸莽草酸-3-磷酸合酶，编码所述蛋白质的基因和含有所述基因的转化植物
公开(公告)号：US06566587B1
公开(公告)日：2003-05-20
申请号：US08945144
申请日：1998-01-20
申请人： Michel Lebrun , Alain Sailland , Georges Freyssinet , Eric Degryse
发明人： Michel Lebrun , Alain Sailland , Georges Freyssinet , Eric Degryse
IPC分类号： C12N1582
CPC分类号： C12N9/1092 , C12N15/8275
摘要： The present invention relates to DNA molecules of plant origin encoding a modified 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) enzyme wherein the a first EPSPS coding sequence that normally encodes a threonine residue of a mature EPSPS sequence is modified to encode isoleucine of the mature EPSPS sequence, and a second EPSPS coding sequence that normally encodes a proline residue of a mature EPSPS sequence is modified to encode serine of the mature EPSPS sequence, wherein the first and second residues are respectively located at relatively positions 102 and 106 of a mature EPSPS sequence encoded by said DNA molecule; and the production of a transgenic plant resistant or tolerant to a herbicide of the phosphonomethylglycine family, e.g., glyphosate. The mutated enzyme, which substantially maintains the catalytic activity of the wild-type enzyme, allows for increased tolerance or tolerance of the plant to a herbicide of the phosphonomethylglycine family, and allows for the substantially normal growth or development of the plant, its organs, tissues or cells.
摘要翻译：本发明涉及编码经修饰的5-烯醇丙酮酸莽草酸-3-磷酸合成酶（EPSPS）酶的植物来源的DNA分子，其中通常将编码成熟EPSPS序列的苏氨酸残基的第一EPSPS编码序列修饰为编码修饰成熟的EPSPS序列，并且通常编码成熟EPSPS序列的脯氨酸残基的第二EPSPS编码序列被修饰以编码成熟EPSPS序列的丝氨酸，其中第一和第二残基分别位于成熟的EPSPS序列的相对位置102和106 由所述DNA分子编码的EPSPS序列; 以及产生对膦酰基甲基甘氨酸家族例如草甘膦的除草剂具有抗性或耐受性的转基因植物。基本上保持野生型酶的催化活性的突变酶允许植物对膦酰基甲基甘氨酸家族的除草剂的耐受性或耐受性增加，并允许植物，其器官的基本正常生长或发育，组织或细胞。

10. 发明授权

US06362396B1 Chimeric gene for the transformation of plants 失效
标题翻译：用于植物转化的嵌合基因
公开(公告)号：US06362396B1
公开(公告)日：2002-03-26
申请号：US09013520
申请日：1998-01-26
申请人： Nicole Chaubet , Claude Gigot , Georges Freyssinet , Bernard Leroux , Michel Lebrun , Alain Sailland
发明人： Nicole Chaubet , Claude Gigot , Georges Freyssinet , Bernard Leroux , Michel Lebrun , Alain Sailland
IPC分类号： A01H500
CPC分类号： C12N9/1092 , C12N15/8274
摘要： 1) Chimeric gone for conferring to plants an increased tolerance to a herbicide. 2) It comprises, in the direction of transcription, a promoter region, a transit peptide region, a sequence encoding glyphosate tolerance and a polyadenylation signal region, wherein the promoter region consists of at least one promoter of a plant histone gene enabling the expression of the herbicide tolerance protein in the regions of glyphosate accumulation. 3) Production of glyphosate-tolerant plants.
摘要翻译： 1）嵌合去除赋予植物增加对除草剂的耐受性。 2）其在转录方向包含启动子区，转运肽区，编码草甘膦耐受的序列和多聚腺苷酸化信号区，其中启动子区由植物组蛋白基因的至少一个启动子组成，使得能够表达草甘膦积累区域的除草剂耐受性蛋白。 3）耐草甘膦植物的生产。

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