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1. 发明授权

US08406837B2 Means and methods for cytometric therapies 有权
标题翻译：细胞疗法的方法和方法
公开(公告)号：US08406837B2
公开(公告)日：2013-03-26
申请号：US12513258
申请日：2007-11-01
申请人： George T. Gillies , Helen Fillmore , William C. Broaddus , Boyd M. Evans, III , Stephen W. Allison
发明人： George T. Gillies , Helen Fillmore , William C. Broaddus , Boyd M. Evans, III , Stephen W. Allison
IPC分类号： A61B5/00
CPC分类号： A61B5/0084 , A61B5/0071 , A61B5/0075
摘要： A functionalized tip is incorporated into catheters for the cytometric delivery of cells into the brain and other body parts. For use in the brain, the tip forms part of a neurosurgical probe having a proximal end and a distal end. In addition to the functionalized tip, the probe has at least one cell slurry delivery lumen and a plurality of optical fibers configured along the probe, terminating in the tip to provide the photo-optical capability needed to monitor the viability and physiological behavior of the grafted cells as well as certain characteristics of the cellular environment. Details are also presented of the use of a neurocatheter having a cytometric tip of the type disclosed in the invention, as employed within the context of a feedback and control system for regulating the number of cells delivered to the brain of a patient.
摘要翻译：一个功能化的尖端被并入到导管中，用于将细胞细胞传递到脑和其他身体部位。为了在脑中使用，尖端形成具有近端和远端的神经外科探针的一部分。除了功能化的尖端之外，探针具有至少一个细胞浆液递送腔和沿着探针配置的多个光纤，终止于尖端，以提供监测嫁接的生存力和生理行为所需的光学光学能力细胞以及细胞环境的某些特征。还提供了在用于调节递送到患者脑部的细胞数量的反馈和控制系统的上下文中使用的具有本发明公开的类型的细胞计数尖端的神经导管的用途的细节。

2. 发明授权

US06805839B2 Response microcantilever thermal detector 失效
标题翻译：响应微悬臂梁热探测器
公开(公告)号：US06805839B2
公开(公告)日：2004-10-19
申请号：US09811234
申请日：2001-03-16
申请人： Joseph P. Cunningham , Slobodan Rajic , Panagiotis G. Datskos , Boyd M. Evans, III
发明人： Joseph P. Cunningham , Slobodan Rajic , Panagiotis G. Datskos , Boyd M. Evans, III
IPC分类号： G01N1506
CPC分类号： G01J3/36 , G01J3/0259 , G01J5/40 , G01J5/601 , G01N21/171
摘要： A “folded leg” thermal detector microcantilever constructed of a substrate with at least one leg interposed between a fixed end and a deflective end, each leg having at least three essentially parallel leg segments interconnected on alternate opposing ends and aligned in a serpentine pattern with only the first leg segment attached to the fixed end and only the last leg segment attached to the deflective end. Alternate leg segment are coated on the pentalever with coating applied to the top of the first, third, and fifth leg segments of each leg and to the bottom of the second and fourth leg segments of each leg.
摘要翻译：由基板构成的“折叠腿”热探测器微悬臂梁，其中至少一个腿插入在固定端和偏转端之间，每个腿部具有至少三个基本上平行的腿部段，其互相连接在交替的相对端部上并仅以蛇形图案对准第一腿段连接到固定端，仅连接到偏转端的最后腿段。替代腿部被涂覆在五叶木上，其中涂层施加到每个腿的第一，第三和第五腿部的顶部以及每个腿的第二和第四腿部的底部。

3. 发明授权

US06525307B1 Integrated optical interrogation of micro-structures 失效
标题翻译：微结构的集成光学询问
公开(公告)号：US06525307B1
公开(公告)日：2003-02-25
申请号：US09397552
申请日：1999-09-16
申请人： Boyd M. Evans, III , Panagiotis G. Datskos , Slobodan Rajic
发明人： Boyd M. Evans, III , Panagiotis G. Datskos , Slobodan Rajic
IPC分类号： G01J104
CPC分类号： G01B7/34
摘要： The invention is an integrated optical sensing element for detecting and measuring changes in position or deflection. A deflectable member, such as a microcantilever, is configured to receive a light beam. A waveguide, such as an optical waveguide or an optical fiber, is positioned to redirect light towards the deflectable member. The waveguide can be incorporated into the deflectable member or disposed adjacent to the deflectable member. Means for measuring the extent of position change or deflection of the deflectable member by receiving the light beam from the deflectable member, such as a photodetector or interferometer, receives the reflected light beam from the deflectable member. Changes in the light beam are correlated to the changes in position or deflection of the deflectable member. A plurality of deflectable members can be arranged in a matrix or an array to provide one or two-dimensional imaging or sensing capabilities.
摘要翻译：本发明是用于检测和测量位置或偏转变化的集成光学传感元件。诸如微悬臂梁的可偏转构件被构造成接收光束。诸如光波导或光纤的波导被定位成将光重定向到可偏转构件。波导可以结合到可偏转构件中或邻近可偏转构件设置。用于通过接收来自可偏转构件（例如光电检测器或干涉仪）的光束来测量可偏转构件的位置变化或偏转程度的装置接收来自可偏转构件的反射光束。光束的变化与可偏转构件的位置或偏转的变化相关。多个可偏转构件可以以矩阵或阵列布置以提供一维或二维成像或感测能力。

4. 发明授权

US5754290A Monolithic spectrometer 失效
标题翻译：单片光谱仪
公开(公告)号：US5754290A
公开(公告)日：1998-05-19
申请号：US749878
申请日：1996-11-15
申请人： Slobodan Rajic , Charles M. Egert , William K. Kahl , William B. Snyder, Jr. , Boyd M. Evans, III , Troy A. Marlar , Joseph P. Cunningham
发明人： Slobodan Rajic , Charles M. Egert , William K. Kahl , William B. Snyder, Jr. , Boyd M. Evans, III , Troy A. Marlar , Joseph P. Cunningham
IPC分类号： G01J3/28
CPC分类号： G01J3/28 , G01J3/0259
摘要： A monolithic spectrometer is disclosed for use in spectroscopy. The spectrometer is a single body of translucent material with positioned surfaces for the transmission, reflection and spectral analysis of light rays.
摘要翻译：公开了用于光谱学的单片光谱仪。光谱仪是单体半透明材料，具有定位的表面，用于光线的透射，反射和光谱分析。

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