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    • 1. 发明授权
    • Naphthalene isoxazoline invertebrate pest control agents
    • 萘异恶唑啉无脊椎动物害虫防治剂
    • US08410153B2
    • 2013-04-02
    • US12663751
    • 2008-06-20
    • George Philip LahmJeffrey Keith LongMing Xu
    • George Philip LahmJeffrey Keith LongMing Xu
    • A61K31/42C07D261/04
    • A01N43/80C07D261/04
    • Disclosed are compounds of Formula 1, wherein R1 is halogen, C1-C2 haloalkyl or C1-C2 haloalkoxy; R2 is H, halogen or cyano; R3 is H, halogen or CF3; R4 is H, C2-C7 alkylcarbonyl or C2-C7 alkoxycarbonyl; and R5 is C1-C6 alkyl or C1-C6 haloalkyl, each substituted with one substituent independently selected from hydroxy, C1-C6 alkoxy, C1-C6 alkylthio, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, C2-C7 alkylaminocarbonyl, C3-C9 dialkylaminocarbonyl, C2-C7 haloalkylaminocarbonyl and C3-C9 halodialkylaminocarbonyl. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.
    • 公开了式1的化合物,其中R 1是卤素,C 1 -C 2卤代烷基或C 1 -C 2卤代烷氧基; R2是H,卤素或氰基; R3是H,卤素或CF3; R4是H,C2-C7烷基羰基或C2-C7烷氧基羰基; 并且R 5是被一个独立地选自羟基,C 1 -C 6烷氧基,C 1 -C 6烷硫基,C 1 -C 6烷基亚磺酰基,C 1 -C 6烷基磺酰基,C 2 -C 7烷基氨基羰基,C 3 -C 6烷基氨基羰基, C 9二烷基氨基羰基,C 2 -C 7卤代烷基氨基羰基和C 3 -C 9卤代二烷基氨基羰基。 还公开了含有式1化合物和控制无脊椎动物害虫的方法的组合物,包括使无脊椎害虫或其环境与生物有效量的本发明化合物或组合物接触。
    • 3. 发明申请
    • ANIMAL PEST CONTROL METHOD
    • 动物虫控制方法
    • US20100173948A1
    • 2010-07-08
    • US12663848
    • 2008-06-26
    • George Philip LahmJeffrey Keith LongMing Xu
    • George Philip LahmJeffrey Keith LongMing Xu
    • A01N43/40A01N43/80A01P7/00A01P17/00
    • A61K31/4439A01N43/80A61K9/0019A61K9/0053A61K31/42
    • Disclosed is a method for protecting an animal from a parasitic invertebrate pest comprising treating an animal orally or by injection with a pesticidally effective amount of a compound of Formula 1, wherein R1 is halogen, C1-C3 haloalkyl or C1-C3 haloalkoxy; R2 is H, halogen, C1-C3 alkyl, C1-C3 haloalkyl or cyano; R3 is H, halogen, C1-C3 haloalkyl or C1-C3 haloalkoxy; R4 is halogen, C1-C3 alkyl, C1-C3 haloalkyl or C1-C3 haloalkoxy; R5 is H, CH3, C2-C4 alkylcarbonyl, C2-C4 haloalkylcarbonyl, C2-C5 alkoxycarbonyl or CH2O(C1-C3 alkyl); R6 is C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl or C3-C6 halocycloalkyl, each group substituted with one R7; or R6 is (CH2)mQ; and Q, R7, R8a and R8b are as defined in the disclosure.
    • 公开了一种保护动物免受寄生无脊椎害虫的方法,包括用杀虫有效量的式1化合物口服或注射处理动物,其中R1是卤素,C1-C3卤代烷基或C1-C3卤代烷氧基; R2是H,卤素,C1-C3烷基,C1-C3卤代烷基或氰基; R3是H,卤素,C1-C3卤代烷基或C1-C3卤代烷氧基; R4是卤素,C1-C3烷基,C1-C3卤代烷基或C1-C3卤代烷氧基; R5是H,CH3,C2-C4烷基羰基,C2-C4卤代烷基羰基,C2-C5烷氧基羰基或CH2O(C1-C3烷基); R6是C1-C6烷基,C1-C6卤代烷基,C3-C6环烷基或C3-C6卤代环烷基,每个基团被一个R7取代; 或R6是(CH2)mQ; 并且Q,R7,R8a和R8b如本公开所定义。
    • 10. 发明授权
    • Isoxazoline insecticides
    • 异恶唑啉杀虫剂
    • US08623875B2
    • 2014-01-07
    • US12602821
    • 2008-06-10
    • George Philip LahmTy WagerleMing Xu
    • George Philip LahmTy WagerleMing Xu
    • A61K31/496A61K31/454A61K31/4439A61K31/422A61K31/42C07D413/12C07D261/04
    • A01N43/80A01N43/54A01N43/78A01N43/90A01N53/00A01N57/16A01N57/28A01N63/02A01N63/04C07D261/04C07D413/04C07D413/10C07D413/12C07D413/14
    • Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein A is a 6-membered aromatic ring containing carbon atoms and 0-3 nitrogen atoms as ring members, said ring optionally substituted with 1-5 substituents independently selected from R2; R1 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C4-C7 alkylcycloalkyl or C4-C7 cycloalkylalkyl, each optionally substituted with one or more substituents independently selected from R21; R21 is independently H, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 haloalkylthio, C1-C6 alkylsulfinyl, C1-C6 haloalkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkylsulfonyl, CN or NO2; and Q is as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.
    • 公开了式1的化合物,包括所有几何和立体异构体的N-氧化物及其盐,其中A是含有碳原子和0-3个氮原子作为环成员的6元芳族环,所述环任选被1- 5个独立地选自R 2的取代基; R1是C1-C6烷基,C2-C6烯基,C2-C6炔基,C3-C6环烷基,C4-C7烷基环烷基或C4-C7环烷基烷基,各自任选地被一个或多个独立地选自R 21的取代基取代; R21独立地是H,卤素,C1-C6烷基,C1-C6烷氧基,C1-C6卤代烷氧基,C1-C6烷硫基,C1-C6卤代烷硫基,C1-C6烷基亚磺酰基,C1-C6卤代烷基亚磺酰基,C1-C6烷基磺酰基,C1-C6 卤代烷基磺酰基,CN或NO 2; 并且Q如本公开中所定义。 还公开了含有式1化合物和控制无脊椎动物害虫的方法的组合物,包括使无脊椎害虫或其环境与生物有效量的本发明化合物或组合物接触。