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1. 发明申请

US20120141337A1 FLUORESCENCE DETECTOR, FILTER DEVICE AND RELATED METHODS 有权
标题翻译：荧光检测器，过滤器和相关方法
公开(公告)号：US20120141337A1
公开(公告)日：2012-06-07
申请号：US13348495
申请日：2012-01-11
申请人： George Maltezos , John Kim Lee , Axel Scherer , Emil Kartalov
发明人： George Maltezos , John Kim Lee , Axel Scherer , Emil Kartalov
IPC分类号： B01L3/00
CPC分类号： G01N21/6456 , G01N21/6452 , Y10T137/2224
摘要： A microfluidic filter is disclosed. The filter can be used with onchip fluid filtration such as whole blood filtration for microfluidic blood analysis. The filter is able to filter the necessary volume of fluid and in particular blood in an acceptable time frame.
摘要翻译：公开了一种微流体过滤器。过滤器可用于片上流体过滤，如全血过滤用于微流体血液分析。过滤器能够在可接受的时间范围内过滤所需体积的流体，特别是血液。

2. 发明申请

US20080142157A1 CONTROL ARRANGEMENT FOR MICROFLUIDIC DEVICES AND RELATED METHODS AND SYSTEMS 有权
标题翻译：微流体装置的控制装置及相关方法和系统
公开(公告)号：US20080142157A1
公开(公告)日：2008-06-19
申请号：US11874211
申请日：2007-10-18
申请人： George Maltezos , Axel Scherer
发明人： George Maltezos , Axel Scherer
IPC分类号： B32B37/16
CPC分类号： F16K99/0026 , B01L3/502707 , B01L3/502738 , B01L2300/0681 , B01L2300/0816 , B01L2400/0487 , B01L2400/0655 , F16K99/0001 , F16K99/0034 , F16K99/0046 , F16K2099/0084 , Y10T156/1093
摘要： Communication between microchannels of a microfluidic circuit is controlled through a combination between a membrane and a pin-actuated valve arrangement. The deformable membrane contributes to the formation of the surface of the microchannels. Alternatively, or in addition, the valve arrangement is operated through combination of the membrane with a control fluid. Systems, devices and methods based on such communication are shown. Also shown are methods to manufacture a system having a fluidic circuit and a control arrangement.
摘要翻译：微流体电路的微通道之间的通信通过膜和引脚致动阀装置之间的组合来控制。可变形膜有助于微通道表面的形成。或者或另外，通过膜与控制流体的组合来操作阀装置。显示了基于这种通信的系统，设备和方法。还示出了制造具有流体回路和控制装置的系统的方法。

3. 发明授权

US09316586B2 Apparatus for thermal cycling 有权
标题翻译：热循环装置
公开(公告)号：US09316586B2
公开(公告)日：2016-04-19
申请号：US13417121
申请日：2012-03-09
申请人： George Maltezos , Matthew Johnston , David Goodwin , Axel Scherer , Christopher I. Walker
发明人： George Maltezos , Matthew Johnston , David Goodwin , Axel Scherer , Christopher I. Walker
IPC分类号： G01N21/64 , B01L7/00 , B01L3/00
CPC分类号： G01N21/645 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2200/147 , B01L2300/0829 , B01L2300/0838 , B01L2300/12 , B01L2300/168 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , B01L2300/1861
摘要： This invention provides a system for performing PCR, and real time PCR in particular, with great speed and specificity. The system employs a heat block containing a liquid composition to rapidly transfer heat to and from reaction vessels. The system makes use of the reflective properties of the liquid metal to reflect signal from the PCR into the vessel and out the top. In this way, the signal can be measured by an optical assembly in real time without removing the vessels from the heat block.
摘要翻译：本发明提供了一种用于特别快速和特异性地进行PCR和实时PCR的系统。该系统采用含有液体组合物的热块来快速地将热量传递到反应容器和从其返回。该系统利用液态金属的反射特性，将来自PCR的信号反射入容器并排出顶部。以这种方式，可以通过光学组件实时地测量信号，而不从容器中取出容器。

4. 发明授权

US08069688B2 Gemstones and methods for controlling the appearance thereof 有权
标题翻译：宝石及其外观的控制方法
公开(公告)号：US08069688B2
公开(公告)日：2011-12-06
申请号：US12325120
申请日：2008-11-28
申请人： George Maltezos , Axel Scherer
发明人： George Maltezos , Axel Scherer
IPC分类号： A44C17/00
CPC分类号： A44C17/001
摘要： Methods of fabricating improved gemstones and gemstones thus obtained are described. Roughness is introduced on facets of a gemstone through application of nanometer and/or micrometer sized features, to provide the facets with a hazy white-colored appearance. Alternatively, millimeter-sized reflective features can be applied on the facets, to form a gemstone with improved scintillation or play of light.
摘要翻译：描述了如此获得的改进的宝石和宝石的制造方法。通过应用纳米和/或微米尺寸的特征，在宝石的小面上引入粗糙度，以使面具有朦胧的白色外观。或者，可以在刻面上应用毫米尺寸的反射特征，以形成具有改善的闪烁或光照的宝石。

5. 发明授权

US08033136B2 Enhancing the optical characteristics of a gemstone 有权
标题翻译：增强宝石的光学特性
公开(公告)号：US08033136B2
公开(公告)日：2011-10-11
申请号：US11635386
申请日：2006-12-06
申请人： George Maltezos , Axel Scherer , Jeremy Witzens
发明人： George Maltezos , Axel Scherer , Jeremy Witzens
IPC分类号： A44C17/00
CPC分类号： A44C17/00 , A44C17/001 , A44C17/005 , G01N21/87 , G02B5/18 , G02B5/1857
摘要： Various embodiments described herein comprise a gemstone or other piece of jewelry, which incorporates one or more diffractive optical elements to enhance the fire displayed by the gemstone. In certain embodiments, the diffractive optical element comprises a diffraction grating etched on one or more facets of the gemstone.
摘要翻译：本文描述的各种实施例包括宝石或其他珠宝首饰，其包含一个或多个衍射光学元件以增强由宝石显示的火。在某些实施例中，衍射光学元件包括在宝石的一个或多个刻面上刻蚀的衍射光栅。

6. 发明授权

US07790118B2 Microfluidic devices and related methods and systems 有权
标题翻译：微流体装置及相关方法和系统
公开(公告)号：US07790118B2
公开(公告)日：2010-09-07
申请号：US11874213
申请日：2007-10-18
申请人： George Maltezos , Axel Scherer
发明人： George Maltezos , Axel Scherer
IPC分类号： B01J10/00 , C12M3/00 , B01D15/04 , F16K7/00
CPC分类号： B01L3/502738 , B01L3/502707 , B01L3/52 , B01L2200/0689 , B01L2200/16 , B01L2300/044 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487 , B01L2400/0633 , B01L2400/0655 , Y10T137/2224 , Y10T137/87716
摘要： In a fluidic device with a storage compartment communication is allowed between the storage compartment and other portions of the device. The communication is controlled through a valve arrangement and a membrane covering the compartment. The valve arrangement can be provided through a sealing clamp with clamp fingers. The clamp fingers control communication between the storage compartment and remaining portions of the fluidic device.
摘要翻译：在具有储藏室的流体装置中，允许储存室和装置的其它部分之间进行连通。通信通过阀装置和覆盖隔室的膜进行控制。阀门装置可以通过带夹钳的密封夹具提供。夹钳手指控制储存室与流体装置的剩余部分之间的连通。

7. 发明申请

US20090011417A1 Testing Device 审中-公开
标题翻译：测试设备
公开(公告)号：US20090011417A1
公开(公告)日：2009-01-08
申请号：US12044922
申请日：2008-03-07
申请人： George Maltezos , Axel Scherer , Jingqing Huang , Alex Dickinson , Matthew Johnston
发明人： George Maltezos , Axel Scherer , Jingqing Huang , Alex Dickinson , Matthew Johnston
IPC分类号： C12Q1/68 , C12M1/00 , C12M1/24 , G06Q90/00 , C12M1/33 , C07H21/00
CPC分类号： B01L3/502 , B01L7/52 , B01L2200/143 , B01L2200/16 , B01L2300/021 , B01L2300/024 , B01L2300/0809 , B01L2300/0838 , B01L2300/0867 , B01L2400/0478 , B01L2400/0487 , B01L2400/0644 , G06Q99/00
摘要： The invention provides, in different aspects, a system, sample preparation device, sample processing cartridge, kit, methods of use, business methods, and computer program product.
摘要翻译：本发明在不同方面提供了系统，样品制备装置，样品处理盒，试剂盒，使用方法，商业方法和计算机程序产品。

8. 发明申请

US20080133267A1 SYSTEM AND METHOD FOR INDIVIDUALIZED PATIENT CARE 审中-公开
标题翻译：用于个体化患者护理的系统和方法
公开(公告)号：US20080133267A1
公开(公告)日：2008-06-05
申请号：US11947758
申请日：2007-11-29
申请人： George Maltezos , Axel Scherer
发明人： George Maltezos , Axel Scherer
IPC分类号： G06Q50/00
CPC分类号： G06Q50/22 , G06Q10/10
摘要： A system for individualized patient care, including: a microfluidic bodily fluid reader, programmable to search for different species or components in a bodily fluid inserted in the microfluidic bodily fluid reader; a local computer analysis unit configured to receive data from the microfluidic reader; and a centralized server connectable to the local computer analysis unit. Additionally, a method for monitoring a patient's health is shown, including: reviewing medical history and current medical status of a patient; determining which species of a patient's bodily fluid should be monitored; preparing a microfluidic bodily fluid reader containing reagents for analysis of the species to be monitored; saving patient history and patient's current state; testing the patient with the microfluidic bodily fluid reader; analyzing patient data based on the testing and issuing an alert in case an abnormality is found; further analyzing the patient data for trends indicating that other tests should be added or removed; and adding or removing the other tests through personalization of the microfluidic bodily fluid reader.
摘要翻译：一种用于个体化患者护理的系统，包括：微流体体液读取器，可编程以搜索插入在微流体体液读取器中的体液中的不同种类或组分; 配置为从微流体读取器接收数据的本地计算机分析单元; 以及可连接到本地计算机分析单元的集中式服务器。另外，显示了一种用于监测患者健康的方法，包括：检查患者的病史和当前的医疗状况; 确定应监测患者体液的哪一种; 制备含有用于分析要监测的物种的试剂的微流体体液读数器; 节省患者病史和病人现状; 用微流体体液阅读器测试患者; 根据测试分析患者数据，发现异常时发出警报; 进一步分析患者数据，了解应该添加或删除其他检测的趋势; 以及通过微流体体液读取器的个性化来添加或除去其它测试。

9. 发明申请

US20070157667A1 Enhancing the optical characteristics of a gemstone 有权
标题翻译：增强宝石的光学特性
公开(公告)号：US20070157667A1
公开(公告)日：2007-07-12
申请号：US11635386
申请日：2006-12-06
申请人： George Maltezos , Axel Scherer , Jeremy Witzens
发明人： George Maltezos , Axel Scherer , Jeremy Witzens
IPC分类号： A44C17/00
CPC分类号： A44C17/00 , A44C17/001 , A44C17/005 , G01N21/87 , G02B5/18 , G02B5/1857
摘要： Various embodiments described herein comprise a gemstone or other piece of jewelry, which incorporates one or more diffractive optical elements to enhance the fire displayed by the gemstone. In certain embodiments, the diffractive optical element comprises a diffraction grating etched on one or more facets of the gemstone.
摘要翻译：本文描述的各种实施例包括宝石或其他珠宝首饰，其包含一个或多个衍射光学元件以增强由宝石显示的火。在某些实施例中，衍射光学元件包括在宝石的一个或多个刻面上刻蚀的衍射光栅。

10. 发明申请

US20060288708A1 Thermal management techniques, apparatus and methods for use in microfluidic devices 有权
标题翻译：用于微流体装置的热管理技术，装置和方法
公开(公告)号：US20060288708A1
公开(公告)日：2006-12-28
申请号：US11297106
申请日：2005-12-07
申请人： George Maltezos , Matthew Johnston , Axel Scherer
发明人： George Maltezos , Matthew Johnston , Axel Scherer
IPC分类号： F25B21/02
CPC分类号： B01L3/5027 , F25B21/02 , F25B21/04 , H01L35/30
摘要： A heating/cooling device for a microfluidic apparatus having a thermal insulating substrate. The device includes heating/cooling chamber for heating and/or cooling a sample disposed in the chamber; a waste heat channel for carrying away waste heat and/or waste cooling; and at least one Peltier junction having first and second opposing faces, the first face thereof facing towards said heating/cooling chamber and being in thermal communication therewith for providing either heat or cooling to the chamber in response to a flow of electrical current through the at least one Peltier junction, the second face thereof facing towards said waste heat channel and being in thermal communication therewith for either receiving heat from or dumping heat to the channel in response to a flow of electrical current through the Peltier junction.
摘要翻译：一种用于具有绝热基底的微流体装置的加热/冷却装置。该装置包括用于加热和/或冷却设置在腔室中的样品的加热/冷却室; 用于浪费废热和/或废物冷却的废热通道; 以及至少一个珀尔帖接头，其具有第一和第二相对面，其第一面朝向所述加热/冷却室并与其热连通，用于响应于电流通过所述的电流而向所述室提供加热或冷却至少一个珀耳帖接头，其第二面朝向所述废热通道并与其热连通，以响应于通过珀尔帖接头的电流流动来接收热量或将热量倾倒至通道。

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