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1. 发明授权

US5019593A Antifungal fermentation products and compositions thereof 失效
标题翻译：抗真菌发酵产物及其组合物
公开(公告)号：US5019593A
公开(公告)日：1991-05-28
申请号：US079192
申请日：1987-07-29
申请人： George M. Garrity , Maria B. Lopez , Otto D. Hensens , Richard L. Monaghan , Deborah L. Zink
发明人： George M. Garrity , Maria B. Lopez , Otto D. Hensens , Richard L. Monaghan , Deborah L. Zink
IPC分类号： A01N37/44 , A01N37/46 , A01N47/44 , A61K31/195 , C07C67/00 , C07C229/30 , C07C231/00 , C07C231/12 , C07C233/47 , C07C239/00 , C07C279/14 , C12P13/00 , C12P13/02 , C12P13/04 , C12R1/66
CPC分类号： A01N37/44 , A01N47/44 , C07C279/14 , C12P13/04
摘要： A mixture of derivatives of 2-amino-3,4,5,14-tetrahydroxy-6-eicosenoic acid has been isolated from a culture medium after cultivation of microorganisms belonging to the genus Aspergillus. The compounds are useful as antifungal agents.

2. 发明授权

US5064856A Novel HMG-CoA synthase inhibitors 失效
标题翻译：新型HMG-COA合成酶抑制剂
公开(公告)号：US5064856A
公开(公告)日：1991-11-12
申请号：US387668
申请日：1989-07-31
申请人： George M. Garrity , Robert Giacobbe , Michael D. Greenspan , Otto D. Hensens , Henry Joshua , Maria T. D. Matas , Isabel Martin , James A. Milligan , Sagrario M. del Val , Walter Rozdilsky , Janet C. Onishi , Jerrold M. Liesch
发明人： George M. Garrity , Robert Giacobbe , Michael D. Greenspan , Otto D. Hensens , Henry Joshua , Maria T. D. Matas , Isabel Martin , James A. Milligan , Sagrario M. del Val , Walter Rozdilsky , Janet C. Onishi , Jerrold M. Liesch
IPC分类号： C12P17/02 , A61K31/34 , A61K31/365 , A61P3/06 , C07D303/40 , C07D493/10 , C07D493/20 , C12N1/14 , C12N9/99 , C12P17/18 , C12R1/00 , C12R1/645
CPC分类号： C07D493/10 , C07D303/40
摘要： Compound of formulae (I) and (II) are HMG-CoA synthase inhibitors and exhibit antifungal activity. ##STR1##

3. 发明授权

US5627057A Inhibitor compounds of farnesyl-protein transferase and chemotherapeutic compositions containing the same, produced by strain ATCC 55532 失效
标题翻译：法呢基蛋白转移酶的抑制剂化合物和含有该化合物的化学治疗组合物，由ATCC 55532
公开(公告)号：US5627057A
公开(公告)日：1997-05-06
申请号：US611700
申请日：1996-03-06
申请人： Sheo B. Singh , George M. Garrity , Olga Genillourd , Russell B. Lingham , Isabel Martin , Mary Nallin-Omstead , Keith C. Silverman , Deborah L. Zink
发明人： Sheo B. Singh , George M. Garrity , Olga Genillourd , Russell B. Lingham , Isabel Martin , Mary Nallin-Omstead , Keith C. Silverman , Deborah L. Zink
IPC分类号： A61K31/225 , A61K31/231 , A61K31/232 , A61K31/365 , C07C69/738 , C07D321/00 , C12P17/08 , C12N1/20 , C12P1/06 , C12P33/00
CPC分类号： C12R1/045 , A61K31/225 , A61K31/231 , A61K31/232 , A61K31/365 , C07C69/738 , C07D321/00 , C12P17/08 , Y10S435/822
摘要： The present invention is directed to compounds which inhibit farnesyl-protein transferase (FPTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras. Furthermore, Actinoplanes sp. ATCC 55532 and Streptomces sp. ATCC 55550 are microorganisms which are capable of producing the disclosed compounds which are classified as carboxylic acid esters. In addition a method for preparing the compounds is disclosed which includes cultivating strain ATCC 55532 or strain ATCC 55550. The strains are independently capable of producing the carboxylic acid ester compounds.
摘要翻译：本发明涉及抑制法呢基蛋白转移酶（FPTase）和致癌基因蛋白Ras的法呢基化的化合物。本发明进一步涉及含有本发明化合物的化疗组合物和抑制法呢基蛋白转移酶的方法和癌基因蛋白Ras的法呢基化。此外，Actinoplanes sp。 ATCC 55532和Streptomces sp。 ATCC 55550是能够产生被分类为羧酸酯的公开化合物的微生物。此外，公开了制备化合物的方法，其包括培养菌株ATCC 55532或菌株ATCC 55550.菌株独立地能够产生羧酸酯化合物。

4. 发明授权

US5510371A Inhibitors of farnesyl-protein transferase 失效
公开(公告)号：US5510371A
公开(公告)日：1996-04-23
申请号：US254228
申请日：1994-06-06
申请人： Sheo B. Singh , George M. Garrity , Olga Genillourd , Russell B. Lingham , Isabel Martin , Mary N. Omstead , Keith C. Silverman , Deborah L. Zink
发明人： Sheo B. Singh , George M. Garrity , Olga Genillourd , Russell B. Lingham , Isabel Martin , Mary N. Omstead , Keith C. Silverman , Deborah L. Zink
IPC分类号： A61K31/225 , A61K31/231 , A61K31/232 , A61K31/365 , C07C69/738 , C07D321/00 , C12P17/08 , A61K31/335
CPC分类号： C12R1/045 , A61K31/225 , A61K31/231 , A61K31/232 , A61K31/365 , C07C69/738 , C07D321/00 , C12P17/08 , Y10S435/822
摘要： The present invention is directed to compounds which inhibit farnesyl-protein transferase (FPTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

5. 发明授权

US5008187A Antifungal fermentation product 失效
标题翻译：抗真菌发酵产品
公开(公告)号：US5008187A
公开(公告)日：1991-04-16
申请号：US278385
申请日：1988-12-01
申请人： Louis Chaiet , Sheldon B. Zimmerman , Richard L. Monaghan , George M. Garrity
发明人： Louis Chaiet , Sheldon B. Zimmerman , Richard L. Monaghan , George M. Garrity
IPC分类号： C07D309/38 , C12P19/02
CPC分类号： C12R1/77 , C07D309/38 , C12P19/02 , Y10S435/911 , Y10S435/929
摘要： A new antifungal agent which exhibits a moderately broad spectrum of activity towards filamentous fungi and also against Cryptococcus species of the yeast fungi, and which has been isolated from a solid stationary fermentation of an unidentified species of Fusarium is described.
摘要翻译：描述了一种新的抗真菌剂，其对丝状真菌和对酵母真菌的隐球菌属物种具有中等广谱的活性，并且已经从未鉴定的镰刀菌属的固体发酵中分离出来。

6. 发明申请

US20130013603A1 SEMIOTIC INDEXING OF DIGITAL RESOURCES 有权
标题翻译：数字资源的半导体指数
公开(公告)号：US20130013603A1
公开(公告)日：2013-01-10
申请号：US13478973
申请日：2012-05-23
申请人： Charles T. Parker , George M. Garrity
发明人： Charles T. Parker , George M. Garrity
IPC分类号： G06F17/30
CPC分类号： G06F17/30707 , G06F17/3071
摘要： A method of classifying a plurality of documents. The method includes steps of providing a first set of classification terms and a second set of classification terms, the second set of classification terms being different from the first set of classification terms; generating a first frequency array of a number of occurrences of each term from the first set of classification terms in each document; generating a second frequency array of a number of occurrences of each term from the second set of classification terms in each document; generating a first similarity matrix from the first frequency array; generating a second similarity matrix from the second frequency array; determining an entrywise combination of the first similarity matrix and the second similarity matrix; and clustering the plurality of documents based on the result of the entrywise combination.
摘要翻译：一种分类多个文件的方法。该方法包括提供第一组分类项和第二组分类项的步骤，第二组分类项与第一组分类项不同; 从每个文档中的第一组分类项中产生出每个项的多次出现的第一频率阵列; 从每个文档中的第二组分类项生成每个项的多次出现的第二频率阵列; 从所述第一频率阵列生成第一相似矩阵; 从所述第二频率阵列生成第二相似矩阵; 确定所述第一相似度矩阵和所述第二相似矩阵的入口组合; 并且基于条目组合的结果对多个文档进行聚类。

7. 发明授权

US5290689A New cyclic FR-900520 microbial biotransformation agent 失效
标题翻译：新型循环FR-900520微生物生物转化剂
公开(公告)号：US5290689A
公开(公告)日：1994-03-01
申请号：US951973
申请日：1992-09-28
申请人： George M. Garrity , Magda M. Gagliardi , Shieh-Shung T. Chen
发明人： George M. Garrity , Magda M. Gagliardi , Shieh-Shung T. Chen
IPC分类号： C07H19/01 , C12P17/18 , C12P19/44 , C12P1/04
CPC分类号： C07H19/01 , C12P17/188 , C12P19/445
摘要： Described is a process for producing a new immunosuppressant, a C-19/C-22 cyclic hemiketal (Compound I) biotransformation analog of FR-900520, under novel fermentation conditions utilizing the novel microorganism, Streptomyces sp. (Merck Culture Collection MA6969) ATCC No. 55280. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow, liver, lung, kidney and heart transplants.
摘要翻译：描述了在新型发酵条件下利用新型微生物Streptomyces sp。生产新的免疫抑制剂，FR-900520的C-19 / C-22环状半缩酮（化合物I）生物转化类似物的方法。（Merck Culture Collection MA6969）ATCC No.55580。大环内酯类免疫抑制剂可用于防止外来器官移植物的人宿主排斥。骨髓，肝，肺，肾和心脏移植。

8. 发明授权

US5221625A Cyclcic FR-900520 microbial biotransformation agent 失效
标题翻译： Cyclcic FR-900520微生物生物转化剂
公开(公告)号：US5221625A
公开(公告)日：1993-06-22
申请号：US818936
申请日：1992-01-10
申请人： Shieh-Shung T. Chen , Raymond F. White , Georgette Dezeny , Brian R. Petuch , George M. Garrity , Byron H. Arison , Amy M. Bernick
发明人： Shieh-Shung T. Chen , Raymond F. White , Georgette Dezeny , Brian R. Petuch , George M. Garrity , Byron H. Arison , Amy M. Bernick
IPC分类号： C12P17/16
CPC分类号： C12P17/16 , Y10S435/899
摘要： Described is a process for producing a new immunosuppressant, a C-19/C-22 cyclic hemiketal (Compound I) biotransformation analog of FR-900520, under novel fermentation conditions utilizing the novel microorganism, Streptomyces sp. (Merck Culture Collection MA6963) ATCC No. 55230. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow, liver, lung, kidney and heart transplants.
摘要翻译：描述了在新型发酵条件下利用新型微生物Streptomyces sp。生产新的免疫抑制剂，FR-900520的C-19 / C-22环状半缩酮（化合物I）生物转化类似物的方法。（Merck Culture Collection MA6963）ATCC No.55530。大环内酯类免疫抑制剂可用于预防异种器官移植的人宿主排斥反应。骨髓，肝，肺，肾和心脏移植。

9. 发明授权

US5194378A Process for producing FK-506 失效
标题翻译：生产FK-506的方法
公开(公告)号：US5194378A
公开(公告)日：1993-03-16
申请号：US772520
申请日：1991-10-07
申请人： Gino M. Salituro , Francis Dumont , George M. Garrity , Leeyuan Huang , E. Tracy T. Jones , Mary N. Omstead , Isabel M. Fernandez , Teresa D. Matas
发明人： Gino M. Salituro , Francis Dumont , George M. Garrity , Leeyuan Huang , E. Tracy T. Jones , Mary N. Omstead , Isabel M. Fernandez , Teresa D. Matas
IPC分类号： A61K31/435 , A61P37/06 , C07D498/18 , C12N1/20 , C12P17/18 , C12P19/44 , C12R1/325 , C12R1/465
CPC分类号： C12R1/465 , C12P17/188 , C12P19/445 , Y10S435/886
摘要： Described is a new process for producing the macrolide immunosuppressant, FK-506 under fermentation conditions utilizing the microorganism, Streptomyces sp., (Merck Culture Collection No. MA 6858) ATCC No. 55098. The immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.

10. 发明授权

US08903825B2 Semiotic indexing of digital resources 有权
标题翻译：数字资源的符号学索引
公开(公告)号：US08903825B2
公开(公告)日：2014-12-02
申请号：US13478973
申请日：2012-05-23
申请人： Charles T. Parker , George M. Garrity
发明人： Charles T. Parker , George M. Garrity
IPC分类号： G06F17/30
CPC分类号： G06F17/30707 , G06F17/3071
摘要： A method of classifying a plurality of documents. The method includes steps of providing a first set of classification terms and a second set of classification terms, the second set of classification terms being different from the first set of classification terms; generating a first frequency array of a number of occurrences of each term from the first set of classification terms in each document; generating a second frequency array of a number of occurrences of each term from the second set of classification terms in each document; generating a first similarity matrix from the first frequency array; generating a second similarity matrix from the second frequency array; determining an entrywise combination of the first similarity matrix and the second similarity matrix; and clustering the plurality of documents based on the result of the entrywise combination.
摘要翻译：一种分类多个文件的方法。该方法包括提供第一组分类项和第二组分类项的步骤，第二组分类项与第一组分类项不同; 从每个文档中的第一组分类项中产生出每个项的多次出现的第一频率阵列; 从每个文档中的第二组分类项生成每个项的多次出现的第二频率阵列; 从所述第一频率阵列生成第一相似矩阵; 从所述第二频率阵列生成第二相似矩阵; 确定所述第一相似度矩阵和所述第二相似矩阵的入口组合; 并且基于条目组合的结果对多个文档进行聚类。

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