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1. 发明申请

US20070184507A1 Methods for predicting outcome in traumatic brain injury 审中-公开
标题翻译：预防创伤性脑损伤结局的方法
公开(公告)号：US20070184507A1
公开(公告)日：2007-08-09
申请号：US11737561
申请日：2007-04-19
申请人： George Jackowski , Eric Stanton , Petro Kupchak , Miyoko Takahashi , Michelle Davey
发明人： George Jackowski , Eric Stanton , Petro Kupchak , Miyoko Takahashi , Michelle Davey
IPC分类号： G01N33/53 , A61B6/00
CPC分类号： G01N33/6896 , A61B6/501 , G01N2333/988
摘要： The invention describes methods for predicting outcome for patients suffering from traumatic brain injury (TBI) by evaluating levels of markers commonly associated with cellular damage in bodily fluids. Utilization of such methods improves diagnosis and treatment of patients suffering from traumatic brain injury, thus potentially minimizing and/or eliminating long-term adverse effects in these patients.
摘要翻译：本发明描述了通过评估通常与体液细胞损伤相关的标记物的水平来预测患有创伤性脑损伤（TBI）的患者的结果的方法。这种方法的使用改善了患有创伤性脑损伤的患者的诊断和治疗，从而可能最小化和/或消除这些患者的长期不良反应。

2. 发明申请

US20060051814A1 Methods for predicting outcome in traumatic brain injury 审中-公开
标题翻译：预防创伤性脑损伤结局的方法
公开(公告)号：US20060051814A1
公开(公告)日：2006-03-09
申请号：US11201349
申请日：2005-08-10
申请人： George Jackowski , Eric Stanton , Petro Kupchak , Miyoko Takahashi , Michelle Davey
发明人： George Jackowski , Eric Stanton , Petro Kupchak , Miyoko Takahashi , Michelle Davey
IPC分类号： G01N33/53
CPC分类号： G01N33/6896 , A61B6/501 , G01N2333/988
摘要： The invention describes methods for predicting outcome for patients suffering from traumatic brain injury (TBI) by evaluating levels of markers commonly associated with cellular damage in bodily fluids. Utilization of such methods improves diagnosis and treatment of patients suffering from traumatic brain injury, thus potentially minimizing and/or eliminating long-term adverse effects in these patients.
摘要翻译：本发明描述了通过评估通常与体液细胞损伤相关的标记物的水平来预测患有创伤性脑损伤（TBI）的患者的结果的方法。这种方法的使用改善了患有创伤性脑损伤的患者的诊断和治疗，从而可能最小化和/或消除这些患者的长期不良反应。

3. 发明授权

US07527939B2 Polyclonal-monoclonal ELISA assay for detecting N-terminus proBNP 失效
标题翻译：用于检测N末端proBNP的多克隆单克隆ELISA检测
公开(公告)号：US07527939B2
公开(公告)日：2009-05-05
申请号：US11375432
申请日：2006-03-13
申请人： Michelle Davey , George Jackowski , Peter Kupchak , Eric Stanton
发明人： Michelle Davey , George Jackowski , Peter Kupchak , Eric Stanton
IPC分类号： C07K16/26 , C12P21/08 , C12Q1/28 , G01N33/53 , G01N33/535 , G01N33/543 , G01N33/577 , G01N33/74 , C12N5/20 , G01N33/544 , G01N33/545
CPC分类号： G01N33/74 , C07K16/26 , C07K2317/31 , C07K2317/34 , C12N5/163 , G01N33/535 , G01N33/543 , G01N33/545 , G01N33/6893 , G01N2333/58 , G01N2800/325 , G01N2800/56 , G01N2800/7019 , Y10S436/811 , Y10S530/80
摘要： A specific and sensitive in vitro ELISA assay and diagnostic test kit is disclosed for determining levels of NT-proBNP protein in a variety of bodily fluids, non-limiting examples of which are blood, serum, plasma, urine and the like. The NT-proBNP ELISA assay test employs the sandwich ELISA technique to measure circulating NT-proBNP in human plasma. In order to obtain antibodies with specific binding properties for targeted amino acid sequences within human proBNP, recombinant human proBNP (or rhproBNP) was expressed and purified for use as an immunogen. Polyclonal antibodies (PAb) to specific amino acid sequences were subsequently purified from goat serum by sequential affinity purification. Monoclonal antibodies were raised against specific polypeptides. Recombinant human NT-proBNP (or rhNT-proBNP) was expressed and purified in order to obtain material for use in calibration of a quantitative method for measurement of human NT-proBNP.
摘要翻译：公开了一种特异性和灵敏的体外ELISA测定和诊断测试试剂盒，用于测定各种体液中NT-proBNP蛋白的水平，其非限制性实例是血液，血清，血浆，尿液等。 NT-proBNP ELISA测定采用夹心ELISA技术测定人血浆中的NT-proBNP循环。为获得具有针对人proBNP靶向氨基酸序列的特异性结合特性的抗体，重组人proBNP（或rhproBNP）被表达和纯化，用作免疫原。随后通过连续亲和纯化从山羊血清中纯化特异性氨基酸序列的多克隆抗体（PAb）。针对特定多肽产生单克隆抗体。表达和纯化重组人NT-proBNP（或rhNT-proBNP），以获得用于校准人NT-proBNP的定量方法的材料。

4. 发明申请

US20050287613A1 Polyclonal-polyclonal ELISA assay for detecting N-terminus-proBNP 审中-公开
标题翻译：用于检测N末端-BNP的多克隆多克隆ELISA检测
公开(公告)号：US20050287613A1
公开(公告)日：2005-12-29
申请号：US10299977
申请日：2002-11-18
申请人： George Jackowski , Michelle Davey , Eric Stanton , Peter Kupchak
发明人： George Jackowski , Michelle Davey , Eric Stanton , Peter Kupchak
IPC分类号： G01N33/68 , G01N33/74 , G01N33/53
CPC分类号： G01N33/74 , G01N33/6887
摘要： A specific and sensitive in vitro ELISA assay and diagnostic test kit is disclosed for determining levels of NT-proBNP protein in a variety of bodily fluids, non-limiting examples of which are blood, serum, plasma, urine and the like. The NT-proBNP ELISA assay test employs the sandwich ELISA technique to measure circulating NT-proBNP in human plasma. In order to obtain antibodies with specific binding properties for targeted amino acid sequences within human proBNP, recombinant human proBNP (or rhproBNP) was expressed and purified for use as an immunogen. Polyclonal antibodies (PAb) to specific amino acid sequences were subsequently purified from goat serum by sequential affinity purification. Recombinant human NT-proBNP (or rhNT-proBNP) was expressed and purified in order to obtain material for use in calibration of a quantitative method for measurement of human NT-proBNP.
摘要翻译：公开了一种特异性和灵敏的体外ELISA测定和诊断测试试剂盒，用于测定各种体液中NT-proBNP蛋白的水平，其非限制性实例是血液，血清，血浆，尿等。 NT-proBNP ELISA测定采用夹心ELISA技术测定人血浆中的NT-proBNP循环。为获得具有针对人proBNP靶向氨基酸序列的特异性结合特性的抗体，重组人proBNP（或rhproBNP）被表达和纯化，用作免疫原。随后通过连续亲和纯化从山羊血清中纯化特异性氨基酸序列的多克隆抗体（PAb）。表达和纯化重组人NT-proBNP（或rhNT-proBNP），以获得用于校准人NT-proBNP的定量方法的材料。

5. 发明授权

US09371382B2 Polyclonal-monoclonal ELISA assay for detecting N-terminus pro-BNP 有权
标题翻译：用于检测N末端前BNP的多克隆单克隆ELISA检测
公开(公告)号：US09371382B2
公开(公告)日：2016-06-21
申请号：US13236447
申请日：2011-09-19
申请人： Michelle Davey , George Jackowski , Peter Kupchak , Eric Stanton
发明人： Michelle Davey , George Jackowski , Peter Kupchak , Eric Stanton
IPC分类号： C07K16/26 , C12N5/20 , G01N33/543 , G01N33/74 , G01N33/535 , C12N5/16 , G01N33/545
CPC分类号： G01N33/74 , C07K16/26 , C07K2317/31 , C07K2317/34 , C12N5/163 , G01N33/535 , G01N33/543 , G01N33/545 , G01N33/6893 , G01N2333/58 , G01N2800/325 , G01N2800/56 , G01N2800/7019 , Y10S436/811 , Y10S530/80
摘要： A specific and sensitive in vitro ELISA assay and diagnostic test kit is disclosed for determining levels of NT-proBNP protein in a variety of bodily fluids, non-limiting examples of which are blood, serum, plasma, urine and the like.
摘要翻译：公开了一种特异性和灵敏的体外ELISA测定和诊断测试试剂盒，用于测定各种体液中NT-proBNP蛋白的水平，其非限制性实例是血液，血清，血浆，尿液等。

6. 发明申请

US20090325195A1 POLYCLONAL-MONOCLONAL ELISA ASSAY FOR DETECTING N-TERMINUS PRO-BNP 审中-公开
标题翻译：用于检测N-末端PRO-BNP的多环 - 单克隆ELISA测定
公开(公告)号：US20090325195A1
公开(公告)日：2009-12-31
申请号：US12421409
申请日：2009-04-09
申请人： Michelle Davey , George Jackowski , Peter Kupchak , Eric Stanton
发明人： Michelle Davey , George Jackowski , Peter Kupchak , Eric Stanton
IPC分类号： G01N33/53
CPC分类号： G01N33/74 , C07K16/26 , C07K2317/31 , C07K2317/34 , C12N5/163 , G01N33/535 , G01N33/543 , G01N33/545 , G01N33/6893 , G01N2333/58 , G01N2800/325 , G01N2800/56 , G01N2800/7019 , Y10S436/811 , Y10S530/80
摘要： A specific and sensitive in vitro ELISA assay and diagnostic test kit is disclosed for determining levels of NT-proBNP protein in a variety of bodily fluids, non-limiting examples of which are blood, serum, plasma, urine and the like. The NT-proBNP ELISA assay test employs the sandwich ELISA technique to measure circulating NT-proBNP in human plasma. In order to obtain antibodies with specific binding properties for targeted amino acid sequences within human proBNP, recombinant human proBNP (or rhproBNP) was expressed and purified for use as an immunogen. Polyclonal antibodies (PAb) to specific amino acid sequences were subsequently purified from goat serum by sequential affinity purification. Monoclonal antibodies were raised against specific polypeptides. Recombinant human NT-proBNP (or rhNT-proBNP) was expressed and purified in order to obtain material for use in calibration of a quantitative method for measurement of human NT-proBNP.
摘要翻译：公开了一种特异性和灵敏的体外ELISA测定和诊断测试试剂盒，用于测定各种体液中NT-proBNP蛋白的水平，其非限制性实例是血液，血清，血浆，尿液等。 NT-proBNP ELISA测定采用夹心ELISA技术测定人血浆中的NT-proBNP循环。为获得具有针对人proBNP靶向氨基酸序列的特异性结合特性的抗体，重组人proBNP（或rhproBNP）被表达和纯化，用作免疫原。随后通过连续亲和纯化从山羊血清中纯化特异性氨基酸序列的多克隆抗体（PAb）。针对特定多肽产生单克隆抗体。表达和纯化重组人NT-proBNP（或rhNT-proBNP），以获得用于校准人NT-proBNP的定量方法的材料。

7. 发明申请

US20060211070A1 Polyclonal-polyclonal ELISA assay for detecting N-terminus-proBNP 审中-公开
标题翻译：用于检测N末端-BNP的多克隆多克隆ELISA检测
公开(公告)号：US20060211070A1
公开(公告)日：2006-09-21
申请号：US11440809
申请日：2006-05-25
申请人： George Jackowski , Michelle Davey , Eric Stanton , Peter Kupchak
发明人： George Jackowski , Michelle Davey , Eric Stanton , Peter Kupchak
IPC分类号： G01N33/53
CPC分类号： G01N33/74 , G01N33/6887
摘要： A specific and sensitive in vitro ELISA assay and diagnostic test kit is disclosed for determining levels of NT-proBNP protein in a variety of bodily fluids, non-limiting examples of which are blood, serum, plasma, urine and the like. The NT-proBNP ELISA assay test employs the sandwich ELISA technique to measure circulating NT-proBNP in human plasma. In order to obtain antibodies with specific binding properties for targeted amino acid sequences within human proBNP, recombinant human proBNP (or rhproBNP) was expressed and purified for use as an immunogen. Polyclonal antibodies (PAb) to specific amino acid sequences were subsequently purified from goat serum by sequential affinity purification. Recombinant human NT-proBNP (or rhNT-proBNP) was expressed and purified in order to obtain material for use in calibration of a quantitative method for measurement of human NT-proBNP.
摘要翻译：公开了一种特异性和灵敏的体外ELISA测定和诊断测试试剂盒，用于测定各种体液中NT-proBNP蛋白的水平，其非限制性实例是血液，血清，血浆，尿液等。 NT-proBNP ELISA测定采用夹心ELISA技术测定人血浆中的NT-proBNP循环。为获得具有针对人proBNP靶向氨基酸序列的特异性结合特性的抗体，重组人proBNP（或rhproBNP）被表达和纯化，用作免疫原。随后通过连续亲和纯化从山羊血清中纯化特异性氨基酸序列的多克隆抗体（PAb）。表达和纯化重组人NT-proBNP（或rhNT-proBNP），以获得用于校准人NT-proBNP的定量方法的材料。

8. 发明申请

US20060154321A1 Polyclonal-monoclonal ELISA assay for detecting N-terminus proBNP 失效
公开(公告)号：US20060154321A1
公开(公告)日：2006-07-13
申请号：US11375432
申请日：2006-03-13
申请人： Michelle Davey , George Jackowski , Peter Kupchak , Eric Stanton
发明人： Michelle Davey , George Jackowski , Peter Kupchak , Eric Stanton
IPC分类号： G01N33/537 , G01N33/53 , G01N33/543
CPC分类号： G01N33/74 , C07K16/26 , C07K2317/31 , C07K2317/34 , C12N5/163 , G01N33/535 , G01N33/543 , G01N33/545 , G01N33/6893 , G01N2333/58 , G01N2800/325 , G01N2800/56 , G01N2800/7019 , Y10S436/811 , Y10S530/80
摘要： A specific and sensitive in vitro ELISA assay and diagnostic test kit is disclosed for determining levels of NT-proBNP protein in a variety of bodily fluids, non-limiting examples of which are blood, serum, plasma, urine and the like. The NT-proBNP ELISA assay test employs the sandwich ELISA technique to measure circulating NT-proBNP in human plasma. In order to obtain antibodies with specific binding properties for targeted amino acid sequences within human proBNP, recombinant human proBNP (or rhproBNP) was expressed and purified for use as an immunogen. Polyclonal antibodies (PAb) to specific amino acid sequences were subsequently purified from goat serum by sequential affinity purification. Monoclonal antibodies were raised against specific polypeptides. Recombinant human NT-proBNP (or rhNT-proBNP) was expressed and purified in order to obtain material for use in calibration of a quantitative method for measurement of human NT-proBNP.

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