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1. 发明申请

US20070106108A1 Brachytherapy Apparatus and Methods for Using Them 有权
标题翻译：近距离放射治疗仪及其使用方法
公开(公告)号：US20070106108A1
公开(公告)日：2007-05-10
申请号：US11276851
申请日：2006-03-16
申请人： George Hermann , Eduardo Chi Sing , Gail Lebovic , Mark Cole , Mark Ritchart , Than Nguyen
发明人： George Hermann , Eduardo Chi Sing , Gail Lebovic , Mark Cole , Mark Ritchart , Than Nguyen
IPC分类号： A61N5/00 , A61M36/00
CPC分类号： A61N5/1015 , A61N2005/1018
摘要： Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.
摘要翻译：用于将近距离放射治疗递送到目标组织区域的装置包括细长主体，其包括近端，远端，其尺寸适于引入到组织道中并且承载多个细长构件，包括用于接收辐射源的路径。细长构件可在折叠和膨胀构型之间移动。在使用期间，通过组织产生管道，并且携带细长构件的细长体通过管道前进到目标位置，细长构件处于收缩构型。细长构件在目标位置处被引导到扩展构型，并且例如通过沿着路径引入一个或多个辐射源，传送辐射以在目标位置处理组织。

2. 发明申请

US20080033449A1 INTRAOCULAR LENS INSERTION APPARATUS AND LENS CASE 有权
标题翻译：内镜镜片插入装置和镜头盒
公开(公告)号：US20080033449A1
公开(公告)日：2008-02-07
申请号：US11627931
申请日：2007-01-26
申请人： Mark Cole , Nicholas Martin , Steven Anderson , Rod Peterson
发明人： Mark Cole , Nicholas Martin , Steven Anderson , Rod Peterson
IPC分类号： A61F9/007 , A61F2/16
CPC分类号： A61F2/1678 , A61F2/1662 , A61F2/1664 , A61F2/1691
摘要： A lens case for storing an intraocular lens contains a housing for storing an intraocular lens and a support member configured to support the intraocular lens. The support member includes a plurality of jaws, the jaws having a closed configuration for holding the intraocular lens and an open configuration for releasing the intraocular lens. The lens case further comprises a passage formed when the jaws are in the open configuration, the passage including an opening in the lens case for transfer of the intraocular lens into an intraocular lens inserter. The lens case may further comprise an intraocular lens that is disposed between the jaws, the intraocular lens comprising an optic and a haptic coupled to the optic. The lens case may be configured to maintain the haptic in either a first position in which a distal portion of the haptic is disposed farther from the optic or a second position in which the distal portion of the haptic is disposed closer to optic. Preferably, the lens case is configured to provide the second position during transfer of the intraocular lens into an inserter and/or inserter cartridge.
摘要翻译：用于存储眼内透镜的透镜盒包括用于存储眼内透镜的壳体和被配置为支撑眼内透镜的支撑构件。支撑构件包括多个钳口，钳口具有用于保持眼内透镜的闭合构型和用于释放眼内透镜的打开构造。透镜壳还包括当夹爪处于打开构造时形成的通道，该通道包括透镜壳体中的用于将眼内透镜转移到眼内透镜插入器中的开口。透镜壳还可以包括设置在夹爪之间的眼内透镜，眼内透镜包括光学元件和耦合到光学元件的触觉件。透镜壳可以被配置为将触觉件保持在第一位置，其中触觉件的远端部分被放置得远离光学元件或第二位置，其中触觉件的远端部分设置成更靠近光学元件。优选地，透镜壳被配置为在将眼内透镜转移到插入器和/或插入器盒中期间提供第二位置。

3. 发明申请

US20070095700A1 INTRAOCULAR LENS AND CARTRIDGE PACKAGING WITH LENS-LOADING FUNCTION 有权
公开(公告)号：US20070095700A1
公开(公告)日：2007-05-03
申请号：US11563621
申请日：2006-11-27
申请人： Rod Peterson , Mark Cole , Robert Ott
发明人： Rod Peterson , Mark Cole , Robert Ott
IPC分类号： A61B19/02
CPC分类号： A61F2/1691 , A61F2/1678
摘要： A lens and cartridge packaging system and method of use which simplify the removal and transfer of an IOL to an IOL insertion device is disclosed. The packaging system enables a user to easily load an IOL into a cartridge without the use of forceps. In addition, the packaging system also allows a user to fold and insert the IOL into a cartridge without damaging the IOL and/or compromising IOL sterility. In addition, the related methods of use minimize and/or eliminate damage to the IOL during unpackaging, folding, transfer and loading procedures.

4. 发明申请

US20060029739A1 Method for treating non-woven webs 有权
标题翻译：非织造纤维网处理方法
公开(公告)号：US20060029739A1
公开(公告)日：2006-02-09
申请号：US11222102
申请日：2005-09-08
申请人： James Eden , Mark Cole , Remo Santacecilia
发明人： James Eden , Mark Cole , Remo Santacecilia
IPC分类号： B05D5/00 , B05D3/02
CPC分类号： D04H1/413 , D04H1/407 , Y10T428/24 , Y10T442/20 , Y10T442/2311 , Y10T442/2336 , Y10T442/2352 , Y10T442/2484 , Y10T442/2508 , Y10T442/2525
摘要： The present invention describes a means for fixing skin care ingredients on the surface of non-woven webs and cellulosic mats. The active ingredients can be released (deposited) onto the skin by normal triggering mechanisms, which include the action of water or urine or by friction or rubbing. The fixative systems described herein provide the ability to control high load levels while not interfering with the wettabliity of the fabric or paper. Additionally, incompatible/reactive ingredients can be treated onto the same web and are kept as separate particles fixed to the surface until released.
摘要翻译：本发明描述了一种用于将护肤成分固定在无纺织物和纤维素垫的表面上的方法。活性成分可以通过正常的触发机制（包括水或尿的作用或摩擦或摩擦）释放（沉积）到皮肤上。本文所述的固定系统提供了控制高负载水平的能力，同时不干扰织物或纸的湿润性。另外，不相容/反应性成分可以处理在相同的纤维网上，并作为单独的颗粒保持固定到表面直到释放。

5. 发明申请

US20140296863A1 INSERTER CAP AND RELATED FEATURES 有权
标题翻译：插入卡和相关功能
公开(公告)号：US20140296863A1
公开(公告)日：2014-10-02
申请号：US13818550
申请日：2011-08-24
申请人： Steven R. Anderson , Mark Cole
发明人： Steven R. Anderson , Mark Cole
IPC分类号： A61F2/16
CPC分类号： A61F2/1672 , A61F2/1662 , A61F2/1667 , A61F2/167 , A61F2/1675 , A61F2/1678 , A61F2002/1681
摘要： A cap configured and dimensioned to sweep or fold one or more haptics when removed from an insertion device. The cap may further have a pin, one or more snaps and/or one or more locks. The cap may also have one or more ports and/or one or more windows. An insertion system having a handpiece, a cartridge, and a cap configured and dimensioned to sweep or fold one or more haptics when the cap is removed from the insertion system. The cap is configured and dimensioned to couple with the distal end of the cartridge.
摘要翻译：帽被配置和尺寸设计成当从插入装置移除时扫掠或折叠一个或多个襻。盖可以进一步具有销，一个或多个卡扣和/或一个或多个锁。盖子还可以具有一个或多个端口和/或一个或多个窗口。一种插入系统，具有手柄，盒和帽，其构造和尺寸设计成当帽从插入系统移除时扫掠或折叠一个或多个襻。盖被配置和尺寸设计成与盒的远端连接。

6. 发明申请

US20070123980A1 INTRAOCULAR LENS AND CARTRIDGE PACKAGING WITH LENS-LOADING FUNCTION 有权
标题翻译：镜头镜头和镜头包装与镜头加载功能
公开(公告)号：US20070123980A1
公开(公告)日：2007-05-31
申请号：US11563603
申请日：2006-11-27
申请人： Rod Peterson , Mark Cole , Robert Ott
发明人： Rod Peterson , Mark Cole , Robert Ott
IPC分类号： A61F2/16
CPC分类号： A61F2/1691 , A61F2/1678
摘要： A lens and cartridge packaging system and method of use which simplify the removal and transfer of an IOL to an IOL insertion device is disclosed. The packaging system enables a user to easily load an IOL into a cartridge without the use of forceps. In addition, the packaging system also allows a user to fold and insert the IOL into a cartridge without damaging the IOL and/or compromising IOL sterility. In addition, the related methods of use minimize and/or eliminate damage to the IOL during unpackaging, folding, transfer and loading procedures.
摘要翻译：公开了将IOL移除和转移到IOL插入装置的透镜和盒式封装系统及其使用方法。包装系统使用户能够轻松地将IOL加载到墨盒中，而无需使用镊子。此外，包装系统还允许用户将IOL折叠并插入盒中而不损坏IOL和/或损害IOL无菌性。此外，相关的使用方法在拆包，折叠，转移和装载过程中最小化和/或消除了IOL的损坏。

7. 发明申请

US20060200167A1 Devices and methods for storing, loading, and delivering an intraocular lens 有权
公开(公告)号：US20060200167A1
公开(公告)日：2006-09-07
申请号：US11071549
申请日：2005-03-02
申请人： Rod Peterson , Robert Ott , Mark Cole
发明人： Rod Peterson , Robert Ott , Mark Cole
IPC分类号： A61F9/00
CPC分类号： A61F2/1678 , A61F2/1691
摘要： A cartridge for delivering an intraocular lens into the eye of a subject that comprises a body disposed along a longitudinal axis having a distal end and a proximal end, and a tapered lumen disposed along the longitudinal axis having an aperture at the distal end of the body. The aperture and at least a portion of the tapered lumen each consist of an upper portion and a lower portion. The upper portions of the aperture and lumen each have a first width and a cross-section that is generally arcuate. The lower portions of the aperture and lumen each have a cross-section that is generally horizontally disposed and have a second width that is greater than the first width of the aperture and lumen. The cartridge may be loaded with an intraocular lens using a packaging system. The intraocular lens may be placed into the eye of a subject using a corresponding inserter having a pushrod with a saddle disposed at the tip thereof. The intraocular lens is preferably draped over the saddle during insertion.

8. 发明申请

US20060184181A1 Front loading IOL insertion apparatus and method of using 有权
标题翻译：前置IOL插入装置及其使用方法
公开(公告)号：US20060184181A1
公开(公告)日：2006-08-17
申请号：US11056501
申请日：2005-02-11
申请人： Mark Cole , Rod Peterson
发明人： Mark Cole , Rod Peterson
IPC分类号： A61F9/00
CPC分类号： A61F2/1662 , A61F2/1691
摘要： An insertion system is provided for delivering an intraocular lens into the eye of a subject. The insertion system comprises an inserter for delivering the intraocular lens and a lens case for holding the intraocular lens prior to delivery. The inserter comprises handpiece having a longitudinal axis, a proximal end, and a distal end. The inserter further comprises a nosepiece disposed at the distal end of the inserter, the nosepiece having a rotational axis that is substantially perpendicular to the longitudinal axis and a load chamber with a transfer interface for receiving the intraocular lens. The lens case has a transfer port for transferring the intraocular lens from the lens case into the load chamber. Once the intraocular lens is transferred into the load chamber, the nosepiece is adapted to rotate approximately 180 degrees about the rotational axis between a first position for loading the intraocular lens and a second position for delivering the intraocular lens into the eye.
摘要翻译：提供插入系统用于将眼内透镜输送到受试者的眼睛中。插入系统包括用于输送眼内透镜的插入器和用于在输送之前保持眼内透镜的透镜壳体。插入器包括具有纵向轴线，近端和远端的手持件。插入器还包括设置在插入器的远端处的鼻梁，鼻梁具有基本上垂直于纵向轴线的旋转轴线和具有用于接收眼内透镜的转移界面的负载室。透镜壳具有用于将眼内透镜从透镜壳转移到装载室中的传送口。一旦眼内透镜被转移到装载室中，鼻梁适于在用于装载眼内透镜的第一位置和用于将眼内透镜输送到眼睛中的第二位置之间围绕旋转轴旋转大约180度。

9. 发明授权

US5902310A Apparatus and method for marking tissue 失效
标题翻译：用于标记组织的装置和方法
公开(公告)号：US5902310A
公开(公告)日：1999-05-11
申请号：US802958
申请日：1997-02-21
申请人： Seth A. Foerster , Mark Cole , Eugene B. Reu , Mark A. Ritchart , John L. Wardle
发明人： Seth A. Foerster , Mark Cole , Eugene B. Reu , Mark A. Ritchart , John L. Wardle
IPC分类号： A61B10/02 , A61B10/00 , A61B17/00 , A61B17/064 , A61B17/068 , A61B17/10 , A61B17/28 , A61B19/00 , A61K49/00
CPC分类号： A61K49/006 , A61B17/0644 , A61B17/0682 , A61B90/39 , A61B10/0275 , A61B10/0283 , A61B17/064 , A61B17/10 , A61B2017/2905 , A61B2090/037 , A61B2090/3908 , A61B2090/3987
摘要： An implantable marking device is provided which is designed to percutaneously deliver permanent markers to desired tissue locations within a patient's body, even if the desired locations are laterally disposed relative to the distal end of the delivery device, as is the case for conduit or cavity walls. This provides several advantages to the physician in diagnosis and management of tissue abnormalities, such as a means of localization of a tissue abnormality for follow-up surgical treatment, and a means of tissue abnormality site identification for purposes of ongoing diagnostic follow-up. In one preferred construction, a radiographic clip is configured in the form of a surgical staple. A disposable tissue marker applier, which comprises a flexible tube, pull wire, and squeeze handle, is employed to advance and deploy the clip to a desired tissue location. Either a flexible or a rigid introducer is also provided for providing access to the site to be marked.
摘要翻译：设置可植入的标记装置，其被设计成将永久性标记经皮递送到患者体内所需的组织位置，即使所需位置相对于输送装置的远端横向设置，如导管或腔壁的情况。这为医师诊断和管理组织异常提供了几个优点，例如用于随访手术治疗的组织异常的定位手段，以及用于正在进行的诊断随访的组织异常部位识别的手段。在一个优选的结构中，放射照相夹被配置成外科缝合钉的形式。使用包括柔性管，拉丝和挤压手柄的一次性组织标记器施加器来将夹子推进并展开到期望的组织位置。还提供了柔性或刚性引导器来提供对要标记的位置的访问。

10. 发明授权

US5810806A Methods and devices for collection of soft tissue 失效
标题翻译：用于收集软组织的方法和装置
公开(公告)号：US5810806A
公开(公告)日：1998-09-22
申请号：US705622
申请日：1996-08-29
申请人： Mark A. Ritchart , Minh Tran , Mark Cole , Fred H. Burbank
发明人： Mark A. Ritchart , Minh Tran , Mark Cole , Fred H. Burbank
IPC分类号： A61B10/02 , A61B10/00 , A61B17/00 , A61B17/32 , A61B18/14 , A61B19/00 , A61B17/39
CPC分类号： A61B10/0266 , A61B18/1482 , A61B10/02 , A61B2017/0046 , A61B2017/00796 , A61B2017/32004 , A61B2018/00208 , A61B2018/1407 , A61B2018/1861 , A61B2090/062 , A61B2090/378 , A61B2090/3908
摘要： This invention provides an inventive tissue sampling probe which offers many advantages over probes available in the prior art. Unexpectedly superior results are obtained in connection with the retrieval of intact tissue specimens, because of a unique combination of cutting features, including, for example, the employment of an electrosurgical cutting element and a vacuum assist in one preferred embodiment. A particularly important feature of the invention is the ability to manipulate the electrosurgical cutting element to cleanly sever the distal end of the tissue specimen. In certain embodiments, this is accomplished without any cutting impact on surrounding tissue. The versatility of the invention permits its use in many applications, including, for example, breast biopsies, laparoscopic surgery, and lymphadenectomy procedures.
摘要翻译：本发明提供了一种创新的组织取样探针，其提供了优于现有技术中可用的探针的许多优点。由于在一个优选实施例中包括例如使用电外科切割元件和真空辅助的切割特征的独特组合，可以获得与完整组织标本的检索有关的意想不到的优异结果。本发明的一个特别重要的特征是能够操纵电外科切割元件来清洁地切断组织标本的远端。在某些实施方案中，这是在对周围组织没有任何切割冲击的情况下实现的。本发明的多功能性允许其在许多应用中使用，包括例如乳房活组织检查，腹腔镜手术和淋巴结清扫手术。

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