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1. 发明授权

US08871711B2 Fibroblast growth factor-9 promotes hair follicle regeneration after wounding 有权
标题翻译：成纤维细胞生长因子-9促进创伤后的毛囊再生
公开(公告)号：US08871711B2
公开(公告)日：2014-10-28
申请号：US13129100
申请日：2009-11-11
申请人： George Cotsarelis , Oh Sang Kwon
发明人： George Cotsarelis , Oh Sang Kwon
IPC分类号： A61K38/17 , A61M37/00 , A61P17/14 , A61Q7/00 , A61K8/64 , A61K38/18
CPC分类号： A61K38/1825 , A61K8/64 , A61K38/1712 , A61K45/06 , A61M37/00 , A61M2037/0007 , A61N5/10 , A61N2005/1098 , A61Q7/00 , Y10S514/88
摘要： The present invention provides methods for treating hair loss, treating, inhibiting, or suppressing a degenerative skin disorder, treating androgenetic alopecia (AGA), generating new hair follicles (HF), and increasing the size of existing HF. The methods comprise epidermal disruption or administration of wnt, and administration of a fibroblast growth factor-9 polypeptide or another compound that upregulates sonic hedgehog gene signaling.
摘要翻译：本发明提供了治疗脱发，治疗，抑制或抑制退行性皮肤病，治疗雄激素性脱发（AGA），产生新毛囊（HF）以及增加现有HF的大小的方法。所述方法包括表皮破坏或施用wnt，以及施用成纤维细胞生长因子-9多肽或上调声刺猬蛋白基因信号传导的另一种化合物。

2. 发明申请

US20110282267A1 FIBROBLAST GROWTH FACTOR-9 PROMOTES HAIR FOLLICLE REGENERATION AFTER WOUNDING 有权
标题翻译： FIBROBLAST GROWTH FACTOR-9 PROMOTES发光发光后再生
公开(公告)号：US20110282267A1
公开(公告)日：2011-11-17
申请号：US13129100
申请日：2009-11-11
申请人： George Cotsarelis , Oh Sang Kwon
发明人： George Cotsarelis , Oh Sang Kwon
IPC分类号： A61M37/00 , A61P17/00 , A61P35/00 , A61K38/18 , A61P17/14
CPC分类号： A61K38/1825 , A61K8/64 , A61K38/1712 , A61K45/06 , A61M37/00 , A61M2037/0007 , A61N5/10 , A61N2005/1098 , A61Q7/00 , Y10S514/88
摘要： The present invention provides methods for treating hair loss, treating, inhibiting, or suppressing a degenerative skin disorder, treating androgenetic alopecia (AGA), generating new hair follicles (HF), and increasing the size of existing HF. The methods comprise epidermal disruption or administration of wnt, and administration of a fibroblast growth factor-9 polypeptide or another compound that upregulates sonic hedgehog gene signaling.
摘要翻译：本发明提供了治疗脱发，治疗，抑制或抑制退行性皮肤病，治疗雄激素性脱发（AGA），产生新毛囊（HF）以及增加现有HF的大小的方法。所述方法包括表皮破坏或施用wnt，以及施用成纤维细胞生长因子-9多肽或上调声刺猬蛋白基因信号传导的另一种化合物。

3. 发明授权

US5279969A Method of identifying and modulating the activity of label retaining cells in hair follicles for diagnostic and therapeutic purposes 失效
公开(公告)号：US5279969A
公开(公告)日：1994-01-18
申请号：US971687
申请日：1992-11-04
申请人： Robert M. Lavker , Tung-Tien Sun , George Cotsarelis
发明人： Robert M. Lavker , Tung-Tien Sun , George Cotsarelis
IPC分类号： C12Q1/02 , C12N5/071 , C12N5/074 , G01N33/50 , G01N33/48
CPC分类号： C12N5/0628 , G01N33/5005 , G01N33/5008 , C12N2500/40 , C12N2501/01 , C12N2501/11 , C12N2501/33 , C12N2501/39 , C12N2501/70 , C12N2501/998 , C12N2503/02
摘要： Methods of detecting label retaining cells in self-renewing tissues, such as hair follicle, are provided. Methods of modulating the activity of slow-cycling cells and methods of evaluating the efficacy of agents for modulating the activity of stem cell populations are also provided. Generally, cells are continuously labeled, induced into a proliferative phase by exposure to an agent such as TPA or a cytokine, and then observed in relation to established criteria.

4. 发明授权

US09642789B2 Methods for generating new hair follicles, treating baldness, and hair removal 有权
公开(公告)号：US09642789B2
公开(公告)日：2017-05-09
申请号：US12904981
申请日：2010-10-14
申请人： George Cotsarelis , Mayumi Ito
发明人： George Cotsarelis , Mayumi Ito
IPC分类号： A61Q7/00 , A61K8/49 , A61K9/00 , A61B8/00 , A61K8/65 , A61Q5/00 , A61Q5/10 , A61K31/506 , A61K31/517 , A61K31/65 , A61K35/36 , A61K38/18 , A61M37/00 , A61B17/00 , A61B18/00
CPC分类号： A61K8/4953 , A61B2017/00765 , A61B2018/00452 , A61K8/65 , A61K9/0014 , A61K31/506 , A61K31/517 , A61K31/65 , A61K35/36 , A61K38/1825 , A61K2800/74 , A61K2800/805 , A61M37/00 , A61M2037/0007 , A61Q5/00 , A61Q5/10 , A61Q7/00
摘要： The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.

5. 发明申请

US20100120768A1 METHODS, KITS, AND COMPOSITIONS FOR GENERATING NEW HAIR FOLLICLES AND GROWING HAIR 有权
标题翻译：用于产生新的头发毛发和生长头发的方法，用具和组合物
公开(公告)号：US20100120768A1
公开(公告)日：2010-05-13
申请号：US12443122
申请日：2007-09-27
申请人： David Steinberg , Kevin Pojasek , Stephen Prouty , George Cotsarelis , Mayumi Ito
发明人： David Steinberg , Kevin Pojasek , Stephen Prouty , George Cotsarelis , Mayumi Ito
IPC分类号： A61K31/5377 , A61K31/135 , A61K31/203 , A61K31/496 , A61K31/436 , A61K31/506 , A61K31/155 , A61K31/435 , A61P17/14
CPC分类号： A61K9/0014 , A61K8/02 , A61K8/70 , A61K2800/782 , A61K2800/91 , A61Q7/00
摘要： The invention features methods, kits, and compositions for generating new hair follicles and growing hair on a subject.
摘要翻译：本发明的特征在于产生新毛囊和在受试者上生长头发的方法，试剂盒和组合物。

6. 发明授权

US09700502B2 Methods for generating new hair follicles, treating baldness, and hair removal 有权
公开(公告)号：US09700502B2
公开(公告)日：2017-07-11
申请号：US12904822
申请日：2010-10-14
申请人： George Cotsarelis , Mayumi Ito
发明人： George Cotsarelis , Mayumi Ito
IPC分类号： A61Q7/00 , A61K8/49 , A61K9/00 , A61B8/00 , A61K8/65 , A61Q5/00 , A61Q5/10 , A61K31/506 , A61K31/517 , A61K31/65 , A61K35/36 , A61K38/18 , A61M37/00 , A61B17/00 , A61B18/00
CPC分类号： A61K8/4953 , A61B2017/00765 , A61B2018/00452 , A61K8/65 , A61K9/0014 , A61K31/506 , A61K31/517 , A61K31/65 , A61K35/36 , A61K38/1825 , A61K2800/74 , A61K2800/805 , A61M37/00 , A61M2037/0007 , A61Q5/00 , A61Q5/10 , A61Q7/00
摘要： The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.

7. 发明授权

US09220926B2 Methods for generating new hair follicles, treating baldness, and hair removal 有权
标题翻译：产生新毛囊，治疗秃发和脱毛的方法
公开(公告)号：US09220926B2
公开(公告)日：2015-12-29
申请号：US13327611
申请日：2011-12-15
申请人： George Cotsarelis , Mayumi Ito
发明人： George Cotsarelis , Mayumi Ito
IPC分类号： A61Q7/00 , A61Q5/10 , A61K8/65 , A61Q5/00 , A61B17/00 , A61B18/00
CPC分类号： A61K8/4953 , A61B2017/00765 , A61B2018/00452 , A61K8/65 , A61K9/0014 , A61K31/506 , A61K31/517 , A61K31/65 , A61K35/36 , A61K38/1825 , A61K2800/74 , A61K2800/805 , A61M37/00 , A61M2037/0007 , A61Q5/00 , A61Q5/10 , A61Q7/00
摘要： The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.
摘要翻译：本发明提供了治疗受试者的秃发并产生新的毛囊的方法，包括表皮破坏和施用促进将未表达的表皮细胞分化为毛囊细胞的化合物。本发明还提供了脱毛和诱导毛发色素沉着的方法。

8. 发明授权

US08252749B2 Methods, kits, and compositions for generating new hair follicles and growing hair 有权
标题翻译：用于产生新毛囊和生长头发的方法，试剂盒和组合物
公开(公告)号：US08252749B2
公开(公告)日：2012-08-28
申请号：US12443122
申请日：2007-09-27
申请人： David Steinberg , Kevin Pojasek , Stephen Prouty , George Cotsarelis , Mayumi Ito
发明人： David Steinberg , Kevin Pojasek , Stephen Prouty , George Cotsarelis , Mayumi Ito
IPC分类号： A61K38/00
CPC分类号： A61K9/0014 , A61K8/02 , A61K8/70 , A61K2800/782 , A61K2800/91 , A61Q7/00
摘要： The invention features methods, kits, and compositions for generating new hair follicles and growing hair on a subject.
摘要翻译：本发明的特征在于产生新毛囊和在受试者上生长头发的方法，试剂盒和组合物。

9. 发明申请

US20120156228A1 Methods, Kits, and Compositions for Generating New Hair Follicles and Growing Hair 审中-公开
标题翻译：用于产生新毛囊和生长发的方法，试剂盒和组合物
公开(公告)号：US20120156228A1
公开(公告)日：2012-06-21
申请号：US13229008
申请日：2011-09-09
申请人： David Steinberg , Kevin Pojasek , Stephen Prouty , George Cotsarelis , Mayumi Ito
发明人： David Steinberg , Kevin Pojasek , Stephen Prouty , George Cotsarelis , Mayumi Ito
IPC分类号： A61K39/00 , A61K31/33 , A61K31/5377 , A61K31/517 , A61P37/06 , A61K31/42 , A61P31/04 , A61P31/00 , A61P37/08 , A61P29/00 , A61K31/56 , A61K31/505
CPC分类号： A61K9/0014 , A61K8/02 , A61K8/70 , A61K2800/782 , A61K2800/91 , A61Q7/00
摘要： The invention features methods, kits, and compositions for generating new hair follicles and growing hair on a subject.
摘要翻译：本发明的特征在于产生新毛囊和在受试者上生长头发的方法，试剂盒和组合物。

10. 发明授权

US5753226A Methods of enhancing epithelial cell proliferation 失效
标题翻译：增强上皮细胞增殖的方法
公开(公告)号：US5753226A
公开(公告)日：1998-05-19
申请号：US419903
申请日：1995-04-11
申请人： Mark I. Greene , George Cotsarelis
发明人： Mark I. Greene , George Cotsarelis
IPC分类号： A61K38/00 , C07K7/08 , C07K14/14 , C07K16/28 , C12P21/08 , A61K39/395 , A61K38/02 , A61K38/03 , A61K39/15
CPC分类号： C07K7/08 , C07K14/005 , C07K16/28 , A61K38/00 , C12N2720/12022
摘要： Methods of enhancing epithelial cell proliferation are disclosed. The methods comprise the step of contacting epithelial cells with a compound that binds to reovirus type 3 receptor. Methods of treating an individual susceptible to or suffering from a condition, disease or disorder characterized by insufficient proliferation of epithelial cells are disclosed. The methods comprise the steps of identifying such individuals and administering to them a therapeutically effect amount of compound that binds to reovirus type 3 receptor and thereby enhances proliferation of epithelial cells. Methods of treating individuals suffering from wounds that involve epithelial cells are disclosed. The methods comprise the steps of identifying such individuals and administering to them a therapeutically effect amount of compound that binds to reovirus type 3 receptor and thereby enhances proliferation of epithelial cells.
摘要翻译：公开了增强上皮细胞增殖的方法。所述方法包括使上皮细胞与结合呼肠孤病毒3型受体的化合物接触的步骤。公开了治疗易感或患有以上皮细胞增殖不足为特征的疾病或病症的个体的方法。所述方法包括鉴定这些个体并向其施用治疗有效量的结合呼肠孤病毒3型受体并由此增强上皮细胞增殖的步骤。公开了治疗患有涉及上皮细胞的伤口的个体的方法。所述方法包括鉴定这些个体并向其施用治疗有效量的结合呼肠孤病毒3型受体并由此增强上皮细胞增殖的步骤。

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