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1. 发明申请

US20070123542A1 Substituted [4-(4-phenyl-piperazin-1-yl)-cyclohexyl]-urea compounds 有权
标题翻译：取代的[4-（4-苯基 - 哌嗪-1-基） - 环己基] - 脲化合物
公开(公告)号：US20070123542A1
公开(公告)日：2007-05-31
申请号：US11453128
申请日：2006-06-14
申请人： George Chiu , Peter Connolly , Jessica Liu , Steven Middleton , Virginia Pulito , Shengjian Li
发明人： George Chiu , Peter Connolly , Jessica Liu , Steven Middleton , Virginia Pulito , Shengjian Li
IPC分类号： A61K31/495 , C07D241/04
CPC分类号： C07D295/155 , C07D295/135
摘要： The present invention relates to substituted [4-(4-phenyl-piperazin-1-yl)-cyclohexyl]-urea compounds of Formula (I) and pharmaceutically acceptable forms thereof, as α1a/α1d adrenoreceptor modulators for the treatment of benign prostatic hypertrophy and lower urinary tract symptoms. The present invention also relates to pharmaceutical compositions comprising said new compounds, new processes to prepare these new compounds and new uses as a medicine as well as methods of treatment.
摘要翻译：本发明涉及式（I）的取代的[4-（4-苯基 - 哌嗪-1-基） - 环己基] - 脲化合物及其药学上可接受的形式，作为α1a / 用于治疗良性前列腺肥大和下尿路症状的肾上腺素受体调节剂。本发明还涉及包含所述新化合物的药物组合物，制备这些新化合物的新方法和作为药物的新用途以及治疗方法。

2. 发明申请

US20070093500A1 Substituted isoindole-1,3-diones 有权
标题翻译：取代的异吲哚-1,3-二酮
公开(公告)号：US20070093500A1
公开(公告)日：2007-04-26
申请号：US11451196
申请日：2006-06-12
申请人： George Chiu , Peter Connolly , Jessica Liu , Steven Middleton , Virginia Pulito , Shengjian Li
发明人： George Chiu , Peter Connolly , Jessica Liu , Steven Middleton , Virginia Pulito , Shengjian Li
IPC分类号： A61K31/496 , C07D403/02 , C07D471/02
CPC分类号： C07D209/48 , C07D209/66 , C07D471/04
摘要： The present invention relates to substituted isoindole-1,3-dione compounds of Formula (I) and pharmaceutically acceptable forms thereof, as α1a/α1d adrenoreceptor modulators for the treatment of benign prostatic hypertrophy and lower urinary tract symptoms. The present invention also relates to pharmaceutical compositions comprising said new compounds, new processes to prepare these new compounds and new uses as a medicine as well as methods of treatment.
摘要翻译：本发明涉及式（I）的取代的异吲哚-1,3-二酮化合物及其药学上可接受的形式，作为用于治疗的α1a1/α1D1肾上腺素受体调节剂良性前列腺肥大和下尿路症状。本发明还涉及包含所述新化合物的药物组合物，制备这些新化合物的新方法和作为药物的新用途以及治疗方法。

3. 发明申请

US20060173015A1 Cyclohexyldiamines as selective alpha 1a/1d adrenoreceptor antagonists for the treatment of benign prostatic hypertrophy and lower urinary tract symptoms 审中-公开
标题翻译：环己基二胺作为选择性α1a / 1d肾上腺素受体拮抗剂治疗良性前列腺肥大和下尿路症状
公开(公告)号：US20060173015A1
公开(公告)日：2006-08-03
申请号：US11262551
申请日：2005-10-28
申请人： George Chiu , Shengjian Li , Peter Connolly , Virginia Pulito , Jessica Liu , Steven Middleton
发明人： George Chiu , Shengjian Li , Peter Connolly , Virginia Pulito , Jessica Liu , Steven Middleton
IPC分类号： A61K31/495 , A61K31/496 , C07D403/02 , C07D241/04
CPC分类号： C07D213/71 , C07D295/116
摘要： The present invention relates to compounds of Formula (I) or a pharmaceutically acceptable form thereof, as dual selective α1a/α1d adrenoreceptor antagonists for the treatment of benign prostatic hypertrophy and lower urinary tract symptoms. The present invention also relates to pharmaceutical compositions comprising said new compounds, new processes to prepare these new compounds and new uses as a medicine as well as method of treatments.
摘要翻译：本发明涉及用于治疗良性前列腺肥大的双重选择性α1A/α1D1肾上腺素受体拮抗剂的式（I）化合物或其药学上可接受的形式，下尿路症状。本发明还涉及包含所述新化合物的药物组合物，制备这些新化合物的新方法和作为药物的新用途以及治疗方法。

4. 发明申请

US20070112016A1 Novel 3-spirocyclic indolyl derivatives useful as ORL-1 receptor modulators 有权
标题翻译：用作ORL-1受体调节剂的新型3-螺环吲哚衍生物
公开(公告)号：US20070112016A1
公开(公告)日：2007-05-17
申请号：US11440731
申请日：2006-05-25
申请人： Kathleen Battista , Gilles Bignan , Peter Connolly , Jessica Liu , Steven Middleton , Michael Orsini
发明人： Kathleen Battista , Gilles Bignan , Peter Connolly , Jessica Liu , Steven Middleton , Michael Orsini
IPC分类号： A61K31/4747 , C07D471/10
CPC分类号： C07D471/10
摘要： The present invention is directed to novel 3-spirocyclic indolyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the ORL-1 receptor.
摘要翻译：本发明涉及新颖的3-螺环吲哚衍生物，含有它们的药物组合物及其用于治疗由ORL-1受体调节的病症和状况的用途。

5. 发明申请

US20080015214A1 3-PIPERIDIN-4-YL-INDOLE ORL-1 RECEPTOR MODULATORS 审中-公开
标题翻译： 3-PIPERIDIN-4-YL-INDOLE ORL-1受体调节剂
公开(公告)号：US20080015214A1
公开(公告)日：2008-01-17
申请号：US11550421
申请日：2006-10-18
申请人： Gilles Bignan , Kathleen Battista , Peter Connolly , Jessica Liu , Steven Middleton , Michael Orsini , Allen Reitz
发明人： Gilles Bignan , Kathleen Battista , Peter Connolly , Jessica Liu , Steven Middleton , Michael Orsini , Allen Reitz
IPC分类号： A61K31/454 , A61K31/437 , A61K31/4545 , A61P1/00 , A61P25/00 , A61P9/00 , C07D401/02 , C07D401/14 , C07D471/02
CPC分类号： C07D401/04 , C07D405/14 , C07D471/04
摘要： The present invention is directed to novel 3-piperidin-4-yl-indole derivatives of formula (I) and forms thereof, wherein X, R1, R2, R3, R4 and R5 are as herein defined, pharmaceutical compositions thereof and use as ORL-1 receptor modulators for treating, preventing or ameliorating ORL-1 receptor mediated disorders and conditions.
摘要翻译：本发明涉及新的式（I）的3-哌啶-4-基 - 吲哚衍生物及其形式，其中X，R 1，R 2，R R 4，R 4和R 5如本文所定义，其药物组合物用作ORL-1受体调节剂，用于治疗，预防或改善 ORL-1受体介导的病症和病症。

6. 发明申请

US20170208901A1 APPARATUS AND RELATED METHODS FOR SECURING THE HEEL OF A FOOT WITHIN FOOTWEAR 审中-公开
公开(公告)号：US20170208901A1
公开(公告)日：2017-07-27
申请号：US15004734
申请日：2016-01-22
申请人： Jessica Liu
发明人： Jessica Liu
IPC分类号： A43B23/28
CPC分类号： A43B23/28 , A43B1/0081
摘要： A device for directly securing the heel of the foot of a wearer to the interior of a rear heel cap of a shoe. The device can include a first portion for adhering directly to the skin of the heel of the wearer's foot. The device can include a second portion for adhering directly to the material of the interior heel of the shoe. The device can be particularly useful in connection with shoes leaving the upper portion of the foot exposed without securing straps and having high heels. The device is subject to a shear force between the first and second portions when worn as opposed to a tensile force more commonly exhibited when a base of an implement is attached to the sole of a shoe.

7. 发明授权

US06635490B1 Procedure for the simultaneous quantitative and qualitative analysis of both flavonoid glycosides and steroidal glycosides 失效
标题翻译：同时量化和定性分析黄酮苷和类固醇糖苷的方法
公开(公告)号：US06635490B1
公开(公告)日：2003-10-21
申请号：US09578649
申请日：2000-05-25
申请人： Kejian Fu , Maciej A. Kaminski , Jessica Liu
发明人： Kejian Fu , Maciej A. Kaminski , Jessica Liu
IPC分类号： G01N3300
CPC分类号： A61K31/7048 , Y10T436/143333
摘要： A single rapid procedure for the quantitative and qualitative analysis of flavonoid glycosides and steroidal glycosides, in natural products, has been developed. The material is extracted with aqueous solutions of polar organic solvents in an ultrasonic bath. Interfering compounds are removed by pre-purification procedures prior to instrumental analysis by High Pressure Liquid Chromatography with Negative Ion Electrospray Mass Spectrometric Detection and on-line Diode Array Ultraviolet-Visible Spectroscopy. The analysis of flavonoid and steroidal glycosidic compounds in HOSTA leaves served as a model system.
摘要翻译：已经开发了一种用于定量和定性分析天然产物中类黄酮苷和甾体糖苷的快速方法。在超声波浴中用极性有机溶剂的水溶液萃取该物质。在通过负离子电喷雾质谱检测和在线二极管阵列紫外 - 可见光谱检测的高压液相色谱进行仪器分析之前，通过预纯化方法除去干扰化合物。 HOSTA叶中类黄酮和甾体糖苷化合物的分析作为模型系统。

8. 发明申请

US20160125537A1 PORTFOLIO MANAGEMENT 审中-公开
标题翻译：组合管理
公开(公告)号：US20160125537A1
公开(公告)日：2016-05-05
申请号：US14527360
申请日：2014-10-29
申请人： Theodore Tsung , Jessica Liu
发明人： Theodore Tsung , Jessica Liu
IPC分类号： G06Q40/06
CPC分类号： G06Q40/06
摘要： A method and system are provided. The method includes calculating respective moving average values for client holdings at a financial account level, an individual client level, and a household level based on end-of-day holding prices therefor. The method further includes calculating a financial account level risk metric, an individual level risk metric, and a household level risk metric responsive to the respective moving average values. The method also includes outputting a respective alarm signal for at least one financial firm employee responsive to any of the financial account level risk metric, the individual level risk metric, and the household level risk metric respectively exceeding a target financial account level risk metric, a target individual level risk metric, and a target household level risk metric. The target risk metrics are determined from respective client specified risk acceptance values at the financial account level, the individual client level, and the household level.
摘要翻译：提供了一种方法和系统。该方法包括基于日期持有价格计算在金融账户级别，个人客户端级别和家庭级别的客户持有量的相应移动平均值。该方法还包括响应于相应的移动平均值计算金融账户级别风险度量，个体级风险度量和家庭级风险度量。该方法还包括响应于分别超过目标金融帐户级别风险度量的任何金融账户级别风险度量，个人级别风险度量和家庭级别风险度量，为至少一个金融公司雇员输出相应的报警信号，目标个人水平风险度量和目标家庭层面风险度量。目标风险度量是根据客户在财务账户层面，个人客户层面和家庭层面的相应客户指定的风险接受值确定的。

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