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1. 发明申请

US20100041645A1 RHO KINASE INHIBITORS 有权
标题翻译： RHO激酶抑制剂
公开(公告)号：US20100041645A1
公开(公告)日：2010-02-18
申请号：US12521817
申请日：2008-01-02
申请人： Georg Dahmann , Eugene Richard Hickey , Xiang Li , Wang Mao , Daniel R. Marshall , Tina M. Morwick , Robert Sibley , Roger John Snow , Ronald J. Sorcek , Frank Wu , Erick Richard Roush Young
发明人： Georg Dahmann , Eugene Richard Hickey , Xiang Li , Wang Mao , Daniel R. Marshall , Tina M. Morwick , Robert Sibley , Roger John Snow , Ronald J. Sorcek , Frank Wu , Erick Richard Roush Young
IPC分类号： A61K31/472 , C07D217/22 , C07D413/08 , C07D417/08 , A61K31/5377 , A61K31/541 , A61P11/00 , A61P35/00 , A61P25/00
CPC分类号： C07C275/28 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/42 , C07C323/62 , C07C2602/08 , C07D209/44 , C07D211/26 , C07D211/34 , C07D217/02 , C07D217/04 , C07D223/16 , C07D231/12 , C07D249/08 , C07D277/46 , C07D277/60 , C07D285/135 , C07D295/088 , C07D295/135 , C07D307/68 , C07D417/04 , C07D471/04 , C07D498/04 , C07D513/04
摘要： Substituted amide and urea derivatives useful as inhibitors of Rho kinase are described, which inhibitors can be useful in the treatment of various disorders such as cardiovascular diseases, cancer, neurological diseases, renal diseases, bronchial asthma, erectile dysfunction and glaucoma.
摘要翻译：描述了可用作Rho激酶抑制剂的取代的酰胺和脲衍生物，该抑制剂可用于治疗各种疾病如心血管疾病，癌症，神经疾病，肾脏疾病，支气管哮喘，勃起功能障碍和青光眼。

2. 发明授权

US08093266B2 Rho kinase inhibitors 有权
标题翻译： Rho激酶抑制剂
公开(公告)号：US08093266B2
公开(公告)日：2012-01-10
申请号：US12521817
申请日：2008-01-02
申请人： Georg Dahmann , Eugene Richard Hickey , Xiang Li , Wang Mao , Daniel R. Marshall , Tina M. Morwick , Robert Sibley , Roger John Snow , Ronald J. Sorcek , Frank Wu , Erick Richard Roush Young
发明人： Georg Dahmann , Eugene Richard Hickey , Xiang Li , Wang Mao , Daniel R. Marshall , Tina M. Morwick , Robert Sibley , Roger John Snow , Ronald J. Sorcek , Frank Wu , Erick Richard Roush Young
IPC分类号： A61K31/472 , A61K31/4365 , A61K31/17 , C07D217/22 , C07D211/34 , C07C233/64 , C07C275/28
CPC分类号： C07C275/28 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/42 , C07C323/62 , C07C2602/08 , C07D209/44 , C07D211/26 , C07D211/34 , C07D217/02 , C07D217/04 , C07D223/16 , C07D231/12 , C07D249/08 , C07D277/46 , C07D277/60 , C07D285/135 , C07D295/088 , C07D295/135 , C07D307/68 , C07D417/04 , C07D471/04 , C07D498/04 , C07D513/04
摘要： Substituted amide and urea derivatives useful as inhibitors of Rho kinase are described, which inhibitors can be useful in the treatment of various disorders such as cardiovascular diseases, cancer, neurological diseases, renal diseases, bronchial asthma, erectile dysfunction and glaucoma.
摘要翻译：描述了可用作Rho激酶抑制剂的取代的酰胺和脲衍生物，该抑制剂可用于治疗各种疾病如心血管疾病，癌症，神经疾病，肾脏疾病，支气管哮喘，勃起功能障碍和青光眼。

3. 发明授权

US08450317B2 CXCR3 receptor antagonists 有权
标题翻译： CXCR3受体拮抗剂
公开(公告)号：US08450317B2
公开(公告)日：2013-05-28
申请号：US12768268
申请日：2010-04-27
申请人： Jennifer A. Kowalski , Daniel Richard Marshall , Anthony S. Prokopowicz, III , Sabine Schlyer , Robert Sibley , Ronald John Sorcek , Di Wu , Frank Wu , Erick Richard Roush Young
发明人： Jennifer A. Kowalski , Daniel Richard Marshall , Anthony S. Prokopowicz, III , Sabine Schlyer , Robert Sibley , Ronald John Sorcek , Di Wu , Frank Wu , Erick Richard Roush Young
IPC分类号： C07D239/34 , C07D239/42 , A61K31/506
CPC分类号： C07D471/04 , C07D209/48 , C07D213/26 , C07D213/56 , C07D213/65 , C07D213/74 , C07D217/00 , C07D231/10 , C07D233/90 , C07D235/04 , C07D239/34 , C07D239/42 , C07D277/30 , C07D295/185 , C07D307/68 , C07D317/68 , C07D319/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D417/12 , C07D491/08
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 to R5, A, B, D and X are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1至R 5，A，B，D和X如本文所定义。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

4. 发明申请

US20080161297A1 RHO KINASE INHIBITORS 有权
标题翻译： RHO激酶抑制剂
公开(公告)号：US20080161297A1
公开(公告)日：2008-07-03
申请号：US11856740
申请日：2007-09-18
申请人： Todd Bosanac , John David Ginn , Eugene Richard Hickey , Thomas Martin Kirrane , Weimin Liu , Anthony S. Prokopowicz , Sabine K. Schlyer , Cheng-Kon Shih , Roger John Snow , Michael Robert Turner , Frank Wu , Erick Richard Young
发明人： Todd Bosanac , John David Ginn , Eugene Richard Hickey , Thomas Martin Kirrane , Weimin Liu , Anthony S. Prokopowicz , Sabine K. Schlyer , Cheng-Kon Shih , Roger John Snow , Michael Robert Turner , Frank Wu , Erick Richard Young
IPC分类号： A61K31/4725 , A61P9/00 , A61P13/00 , A61P15/10 , A61P27/06 , A61P11/06 , A61K31/517 , A61K31/5377 , A61K31/496 , C07D239/88 , C07D217/24 , C07D401/02 , C07D417/02 , A61K31/541 , A61K31/472
CPC分类号： A61K31/472 , A61K31/4725 , A61K31/496 , A61K31/517 , A61K31/5377 , A61K31/541 , C07D217/24 , C07D239/88 , C07D239/90 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D487/08
摘要： Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-quinazolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compositions comprising such compounds, methods for using such compounds and processes for making such compounds.
摘要翻译：公开了用作Rho激酶抑制剂的新型取代的2H-异喹啉-1-酮和3H-喹唑啉-4-酮衍生物，并用于治疗通过Rho激酶（包括心血管疾病）的活性介导或维持的多种疾病和病症包含这些化合物的药物组合物，使用这些化合物的方法和制备这些化合物的方法。

5. 发明授权

US08809326B2 Isoquinolinone Rho kinase inhibitors 有权
标题翻译：异喹啉酮Rho激酶抑制剂
公开(公告)号：US08809326B2
公开(公告)日：2014-08-19
申请号：US11856740
申请日：2007-09-18
申请人： Todd Bosanac , John David Ginn , Eugene Richard Hickey , Thomas Martin Kirrane, Jr. , Weimin Liu , Anthony S. Prokopowicz , Sabine K. Schlyer , Cheng-Kon Shih , Roger John Snow , Michael Robert Turner , Frank Wu , Erick Richard Young
发明人： Todd Bosanac , John David Ginn , Eugene Richard Hickey , Thomas Martin Kirrane, Jr. , Weimin Liu , Anthony S. Prokopowicz , Sabine K. Schlyer , Cheng-Kon Shih , Roger John Snow , Michael Robert Turner , Frank Wu , Erick Richard Young
IPC分类号： A61P9/00 , A61P13/00 , A61P15/10 , A61P27/06 , A61P11/06 , C07D217/24 , C07D401/02 , C07D417/02 , C07D239/88 , A61K31/541 , A61K31/4725 , A61K31/472 , C07D239/90 , C07D487/08 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , A61K31/517 , A61K31/5377 , A61K31/496
CPC分类号： A61K31/472 , A61K31/4725 , A61K31/496 , A61K31/517 , A61K31/5377 , A61K31/541 , C07D217/24 , C07D239/88 , C07D239/90 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D487/08
摘要： Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-quinazolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compositions comprising such compounds, methods for using such compounds and processes for making such compounds.
摘要翻译：公开了用作Rho激酶抑制剂的新型取代的2H-异喹啉-1-酮和3H-喹唑啉-4-酮衍生物，并用于治疗通过Rho激酶（包括心血管疾病）的活性介导或维持的多种疾病和病症包含这些化合物的药物组合物，使用这些化合物的方法和制备这些化合物的方法。

6. 发明授权

US08362249B2 CXCR3 receptor antagonists 有权
标题翻译： CXCR3受体拮抗剂
公开(公告)号：US08362249B2
公开(公告)日：2013-01-29
申请号：US12764136
申请日：2010-04-21
申请人： John David Ginn , Daniel Richard Marshall , Anthony S. Prokopowicz , Sabine Schlyer , Robert Sibley , Michael Robert Turner , Di Wu , Frank Wu
发明人： John David Ginn , Daniel Richard Marshall , Anthony S. Prokopowicz , Sabine Schlyer , Robert Sibley , Michael Robert Turner , Di Wu , Frank Wu
IPC分类号： C07D231/12 , C07D401/12 , C07D401/14 , C07D413/12 , C07D471/04 , C07D513/04 , A61K31/496
CPC分类号： C07D403/06 , C07D401/12 , C07D403/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 to R6, A, B, X, Y and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1至R 6，A，B，X，Y和n如本文所定义。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

7. 发明授权

US08722709B2 Mineralocorticoid receptor antagonists 有权
标题翻译：盐皮质激素受体拮抗剂
公开(公告)号：US08722709B2
公开(公告)日：2014-05-13
申请号：US13290392
申请日：2011-11-07
申请人： Xin Guo , Stephen J. Boyer , Di Wu , Frank Wu
发明人： Xin Guo , Stephen J. Boyer , Di Wu , Frank Wu
IPC分类号： A61K31/4439 , C07D401/04
CPC分类号： C07D401/04 , C07D213/75 , C07D413/04 , C07D417/14
摘要： Mineralocorticoid receptor antagonists, of which the following is exemplary.
摘要翻译：盐皮质激素受体拮抗剂，其中以下是示例性的。

8. 发明申请

US20070040269A1 Thermally enhanced cavity down ball grid array package 审中-公开
标题翻译：热增强腔下球栅阵列封装
公开(公告)号：US20070040269A1
公开(公告)日：2007-02-22
申请号：US11207886
申请日：2005-08-22
申请人： Pei-Haw Tsao , Frank Wu , Chung-Yi Lin
发明人： Pei-Haw Tsao , Frank Wu , Chung-Yi Lin
IPC分类号： H01L23/34
CPC分类号： H01L23/3128 , H01L23/13 , H01L23/16 , H01L23/36 , H01L23/49816 , H01L24/48 , H01L24/83 , H01L2224/48091 , H01L2224/48227 , H01L2224/73265 , H01L2224/83 , H01L2924/00014 , H01L2924/01029 , H01L2924/14 , H01L2924/15311 , H01L2924/1532 , H01L2924/181 , H01L2924/351 , H01L2924/00 , H01L2224/45099 , H01L2224/45015 , H01L2924/207
摘要： A thermally-enhanced cavity down ball grid array (CDBGA) package is provided. In one embodiment, the CDBGA package comprises a heat dissipating substrate having a heat spreader and a chip carrier, the chip carrier having a cavity therethrough to allow a chip to be attached to the heat spreader. A chip having an active surface and a corresponding back surface, has the back surface of the chip mounted on the heat spreader. A dummy chip is attached to the active surface of the chip. The dummy chip has a coefficient of thermal expansion approximately equal to the coefficient of thermal expansion of the chip. An encapsulant encapsulates the chip and portions of the dummy chip. Dummy chip 90 has a coefficient of thermal expansion (CTE) approximately equal to the coefficient of thermal expansion of the chip 40. Because the CTE of the dummy chip 90 is approximately equal to the CTE of the chip 40 and the amount of the encapsulant 60 used will be substantially reduced due to present of the dummy chip, this minimizes the thermal stresses and warpage induced on the chip 40, thereby reducing the occurrence of delamination in chip 40.
摘要翻译：提供了一种热增强型腔下球栅阵列（CDBGA）封装。在一个实施例中，CDBGA封装包括具有散热器和芯片载体的散热基板，芯片载体具有穿过其中的空腔以允许芯片附接到散热器。具有活性表面和对应的背面的芯片具有安装在散热器上的芯片的背面。虚拟芯片附着到芯片的有源表面。虚拟芯片的热膨胀系数近似等于芯片的热膨胀系数。密封剂封装芯片和虚拟芯片的部分。虚拟芯片90的热膨胀系数（CTE）近似等于芯片40的热膨胀系数。由于虚拟芯片90的CTE大致等于芯片40的CTE，并且由于存在虚设芯片，所使用的密封剂60的量将显着降低，所以最小化芯片40上引起的热应力和翘曲从而减少芯片40中的分层的发生。

9. 发明申请

US20060065958A1 Three dimensional package and packaging method for integrated circuits 审中-公开
标题翻译：集成电路的三维封装和封装方法
公开(公告)号：US20060065958A1
公开(公告)日：2006-03-30
申请号：US10953045
申请日：2004-09-29
申请人： Pei-Haw Tsao , Chao-Yuan Su , Allan Lin , Frank Wu , Chender Huang
发明人： Pei-Haw Tsao , Chao-Yuan Su , Allan Lin , Frank Wu , Chender Huang
IPC分类号： H01L23/495
CPC分类号： H01L25/03 , H01L23/3128 , H01L2224/45144 , H01L2224/48091 , H01L2224/48227 , H01L2924/01079 , H01L2924/01087 , H01L2924/15311 , H01L2924/19107 , H01L2924/00014 , H01L2924/00
摘要： A 3D package has: a three-dimensional (3D) package substrate, a land grid array (LGA) or quad flat no-lead (QFN) package mounted on the 3D package substrate, the LGA or QFN package having an LGA or QFN die on a first side of an LGA or QFN package substrate, and a second die mounted directly on a second side of the LGA or QFN package substrate opposite the first side.
摘要翻译： 3D封装具有：三维（3D）封装衬底，安装在3D封装衬底上的焊盘格子阵列（LGA）或四边形无引线（QFN）封装，具有LGA或QFN裸片的LGA或QFN封装在LGA或QFN封装衬底的第一侧上，以及直接安装在与第一侧相对的LGA或QFN封装衬底的第二侧上的第二管芯。

10. 发明授权

US5597209A Adjustable vehicle seat armrest with a ratchet 失效
标题翻译：带棘轮的可调式车座扶手
公开(公告)号：US5597209A
公开(公告)日：1997-01-28
申请号：US438770
申请日：1995-05-11
申请人： Kurt A. Bart , Wojciech Wdziekonski , Frank Wu
发明人： Kurt A. Bart , Wojciech Wdziekonski , Frank Wu
IPC分类号： A47C1/03 , B60N2/75 , A47C7/54
CPC分类号： B60N2/4633
摘要： An adjustable armrest for a vehicle seat in which a ratchet mechanism is provided to resist downward movement of the armrest and allow upward movement to adjust the armrest position relative to the seat back. The ratchet mechanism is released upon raising the armrest passed the upper end of its adjustment range enabling the armrest to be lowered to the lower end of its adjustment range wherein the ratchet mechanism again engages to hold the armrest in place. Attachment of the armrest to the seat back is provided by sliding the armrest over a mounting stud extending laterally from the seat back. A wire spring clip attached to the armrest seats in a groove in the stud to hold the armrest axially on the mounting stud. When assembled, the spring clip will be positioned at the interface between the armrest and the seat back enabling a flat tool such as a screw driver to be inserted between the armrest and the seat back to manipulate the clip to remove the armrest.
摘要翻译：一种用于车辆座椅的可调式扶手，其中提供棘轮机构以阻止扶手的向下运动，并允许向上运动以相对于座椅靠背调整扶手位置。棘轮机构在将扶手通过其调节范围的上端升高时释放，使得扶手能够降低到其调节范围的下端，其中棘轮机构再次接合以将扶手保持在适当位置。通过将扶手滑动到从座椅靠背横向延伸的安装螺柱上，将扶手安装到座椅靠背上。安装在扶手座上的电线弹簧夹座位于螺柱的凹槽中，以将扶手轴向保持在安装螺柱上。当组装时，弹簧夹将位于扶手和座椅靠背之间的接口处，使得能够在扶手和座椅靠背之间插入诸如螺丝刀的平面工具来操纵夹子以移除扶手。

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