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1. 发明申请

US20080068920A1 Gas delivery configurations, foam control systems, and bag molding methods and articles for collapsible bag vessels and bioreactors 审中-公开
标题翻译：气体输送配置，泡沫控制系统和用于可折叠袋容器和生物反应器的袋成型方法和制品
公开(公告)号：US20080068920A1
公开(公告)日：2008-03-20
申请号：US11818901
申请日：2007-06-15
申请人： Parrish Galliher , Geoffrey Hodge , Michael Fisher
发明人： Parrish Galliher , Geoffrey Hodge , Michael Fisher
IPC分类号： B65D25/00 , B01F13/02 , B05B12/00 , B65D30/00 , B31B1/00
CPC分类号： B65D33/02 , B01F3/04106 , B01F13/0827 , B01F15/00831 , B01F15/0085 , B01F2215/0073 , B29C45/16 , B29K2023/0633 , B29L2031/7128 , C12M23/14 , C12M29/06 , C12M41/02
摘要： Systems for containing and manipulating fluids including systems and methods involving supported collapsible bags that may be used as reactors for performing chemical, biochemical and/or biological reactions contained therein are provided. Generally, a series of improvements and features for fluid containment systems such as gas delivery configurations, foam control systems and bag molding methods and articles for supported collapsible bag vessels and bioreactors are provided. For instance, in one aspect, fluids contained in a vessel can be sparged, e.g., such that a fluid is directed into a container of the vessel, and in some cases, the sparging can be controlled by rapidly activating or altering the degree of sparging as needed. Multiple spargers may be used in some cases. In another aspect, the vessel includes a seamless collapsible bag. In some cases, the collapsible bag may be injected, blown, or spin cast molded. In yet another aspect, the vessel includes a device which can reduce the foam produced or contained within the vessel. Sensors and/or controllers may optionally be used to monitor and/or control foaming.
摘要翻译：提供了用于容纳和操纵流体的系统，包括可用作用于执行其中包含的化学，生物化学和/或生物反应的反应器的负载可折叠袋的系统和方法。通常，提供了用于流体容纳系统的一系列改进和特征，例如气体输送配置，泡沫控制系统和袋成型方法以及用于支撑的可折叠袋容器和生物反应器的制品。例如，在一个方面，容器中包含的流体可以被喷射，例如使得流体被引导到容器的容器中，并且在一些情况下，可以通过快速激活或改变喷射程度来控制喷射如所须。在某些情况下可能会使用多种喷射器。在另一方面，容器包括无缝的可折叠袋。在一些情况下，可折叠袋可以被注入，吹塑或旋转铸塑。在另一方面，容器包括可以减少容器内产生或容纳的泡沫的装置。传感器和/或控制器可以可选地用于监测和/或控制发泡。

2. 发明授权

US08298054B2 System and method for manufacturing 有权
标题翻译：系统和制造方法
公开(公告)号：US08298054B2
公开(公告)日：2012-10-30
申请号：US11050133
申请日：2005-02-03
申请人： Geoffrey Hodge , Parrish Galliher , Michael Fisher
发明人： Geoffrey Hodge , Parrish Galliher , Michael Fisher
IPC分类号： F24F7/00 , B01L1/04
CPC分类号： G05D27/02 , G05B15/02 , G05B19/41865 , G05B2219/31075 , G05B2219/32287 , Y02P90/04 , Y02P90/14 , Y02P90/16 , Y02P90/185 , Y02P90/20
摘要： Embodiments of the present invention are directed to a customizable bio-manufacturing system which includes a manufacturing space having a first air handling system for providing supply air and a second air handling system for handling exhaust air, the supply air system being optionally provided with at least one of filtration, heating, cooling and or humidity control and a plurality of portable modules provided within the manufacturing space. At least one module having an interior capable of being interconnected with another module interior and each module's interior includes one or more components to perform at least one specific task of a biological, chemical, and/or pharmaceutical manufacturing process. At least one module includes an on-board environmental control system for controlling an environment within the module and a connection means for interconnecting the module interior with another module interior. The system also includes a central controller operating to at least perform one or more of operation and information collection for the operation of at least one of the system and one or more modules.
摘要翻译：本发明的实施例涉及一种可定制的生物制造系统，其包括具有用于提供供应空气的第一空气处理系统和用于处理排气的第二空气处理系统的制造空间，供应空气系统可选地至少设置过滤，加热，冷却和/或湿度控制之一以及设置在制造空间内的多个便携式模块。至少一个模块具有能够与另一个模块内部互连的内部，并且每个模块的内部包括执行生物，化学和/或药物制造过程的至少一个特定任务的一个或多个组件。至少一个模块包括用于控制模块内的环境的车载环境控制系统和用于将模块内部与另一个模块内部互连的连接装置。该系统还包括中央控制器，其操作以至少执行用于系统和一个或多个模块中的至少一个的操作的操作和信息收集中的一个或多个。

3. 发明授权

US07629167B2 Disposable bioreactor systems and methods 有权
标题翻译：一次性生物反应器系统和方法
公开(公告)号：US07629167B2
公开(公告)日：2009-12-08
申请号：US11147124
申请日：2005-06-06
申请人： Geoffrey Hodge , Parrish Galliher , Michael Fisher
发明人： Geoffrey Hodge , Parrish Galliher , Michael Fisher
IPC分类号： C12M1/00 , C12M3/00 , C12M1/02 , B01F13/08
CPC分类号： C12M23/14 , B01F13/0827 , B01F15/0085 , B01F15/00896 , B01F2215/0073 , C12M27/02 , C12M27/20 , C12M41/12 , C12M41/26 , C12M41/34 , C12M41/48
摘要： Accordingly, in one embodiment of the invention, a bioreactor system is presented and includes a disposable container for housing biomaterials for processing, the disposable container including at least one input port, at least one exhaust port, at least one harvest port, and the integrity of the sterile environment is protected with sterile filters attached to all external open ports a structure for supporting the disposable container, one or more sensors for sensing one or more parameters of the biomaterials in the container, a heater for heating the contents of the container, the heater having a thermostat and mixing system arranged with the system such that biomaterials contained in the disposable container are mixed.
摘要翻译：因此，在本发明的一个实施例中，呈现生物反应器系统并且包括用于容纳用于处理的生物材料的一次性容器，该一次性容器包括至少一个输入端口，至少一个排气口，至少一个收集口和完整性无菌环境的无菌过滤器用连接到所有外部开放端口的无菌过滤器进行保护，用于支撑一次性容器的结构，用于感测容器中生物材料的一个或多个参数的一个或多个传感器，用于加热容器内容物的加热器，所述加热器具有与所述系统配置的恒温器和混合系统，使得包含在所述一次性容器中的生物材料混合。

4. 发明申请

US20050272146A1 Disposable bioreactor systems and methods 有权
标题翻译：一次性生物反应器系统和方法
公开(公告)号：US20050272146A1
公开(公告)日：2005-12-08
申请号：US11147124
申请日：2005-06-06
申请人： Geoffrey Hodge , Parrish Galliher , Michael Fisher
发明人： Geoffrey Hodge , Parrish Galliher , Michael Fisher
IPC分类号： B01F13/08 , C12M20060101 , C12M1/00 , C12M1/36
CPC分类号： C12M23/14 , B01F13/0827 , B01F15/0085 , B01F15/00896 , B01F2215/0073 , C12M27/02 , C12M27/20 , C12M41/12 , C12M41/26 , C12M41/34 , C12M41/48
摘要： Accordingly, in one embodiment of the invention, a bioreactor system is presented and includes a disposable container for housing biomaterials for processing, the disposable container including at least one input port, at least one exhaust port, at least one harvest port, and the integrity of the sterile environment is protected with sterile filters attached to all external open ports a structure for supporting the disposable container, one or more sensors for sensing one or more parameters of the biomaterials in the container, a heater for heating the contents of the container, the heater having a thermostat and mixing system arranged with the system such that biomaterials contained in the disposable container are mixed.
摘要翻译：因此，在本发明的一个实施例中，呈现生物反应器系统并且包括用于容纳用于处理的生物材料的一次性容器，该一次性容器包括至少一个输入端口，至少一个排气口，至少一个收集口和完整性无菌环境的无菌过滤器用连接到所有外部开放端口的无菌过滤器进行保护，用于支撑一次性容器的结构，用于感测容器中生物材料的一个或多个参数的一个或多个传感器，用于加热容器内容物的加热器，所述加热器具有与所述系统配置的恒温器和混合系统，使得包含在所述一次性容器中的生物材料混合。

5. 发明申请

US20050226794A1 System and method for manufacturing 有权
标题翻译：系统和制造方法
公开(公告)号：US20050226794A1
公开(公告)日：2005-10-13
申请号：US11050133
申请日：2005-02-03
申请人： Geoffrey Hodge , Parrish Galliher , Michael Fisher
发明人： Geoffrey Hodge , Parrish Galliher , Michael Fisher
IPC分类号： B01D1/00 , G05B15/02 , G05B19/042 , G05B19/418
CPC分类号： G05D27/02 , G05B15/02 , G05B19/41865 , G05B2219/31075 , G05B2219/32287 , Y02P90/04 , Y02P90/14 , Y02P90/16 , Y02P90/185 , Y02P90/20
摘要： Embodiments of the present invention are directed to a customizable bio-manufacturing system which includes a manufacturing space having a first air handling system for providing supply air and a second air handling system for handling exhaust air, the supply air system being optionally provided with at least one of filtration, heating, cooling and or humidity control and a plurality of portable modules provided within the manufacturing space. At least one module having an interior capable of being interconnected with another module interior and each module's interior includes one or more components to perform at least one specific task of a biological, chemical, and/or pharmaceutical manufacturing process. At least one module includes an on-board environmental control system for controlling an environment within the module and a connection means for interconnecting the module interior with another module interior. The system also includes a central controller operating to at least perform one or more of operation and information collection for the operation of at least one of the system and one or more modules.
摘要翻译：本发明的实施例涉及一种可定制的生物制造系统，其包括具有用于提供供应空气的第一空气处理系统和用于处理排气的第二空气处理系统的制造空间，供应空气系统可选地至少设置过滤，加热，冷却和/或湿度控制之一以及设置在制造空间内的多个便携式模块。至少一个模块具有能够与另一个模块内部互连的内部，并且每个模块的内部包括执行生物，化学和/或药物制造过程的至少一个特定任务的一个或多个组件。至少一个模块包括用于控制模块内的环境的车载环境控制系统和用于将模块内部与另一个模块内部互连的连接装置。该系统还包括中央控制器，其操作以至少执行用于系统和一个或多个模块中的至少一个的操作的操作和信息收集中的一个或多个。

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