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1. 发明专利

JP2013223503A Gene expression marker for colorectal cancer prognosis 有权
标题翻译：基因表达标记为色素癌预后
公开(公告)号：JP2013223503A
公开(公告)日：2013-10-31
申请号：JP2013124948
申请日：2013-06-13
申请人： Genomic Health Inc , ジェノミックヘルス, インコーポレイテッド , Nsabp Foundation Inc , エヌエスエービーピーファウンデーション, インコーポレイテッド
发明人： COWENS WAYNE , BAKER JOFFRE B , CLARK KIM , HACKETT JAMES , WATSON DREW , PAIK SOONMYUNG
IPC分类号： C12Q1/68 , C12N15/09
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , G01N33/57419 , G01N33/57446
摘要： PROBLEM TO BE SOLVED: To provide genes and gene sets, the expression levels of which are useful for predicting outcome of colorectal cancer.SOLUTION: A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprises determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the subject. In one aspect, a method for predicting the clinical outcome in a subject diagnosed with colorectal cancer following surgical resection of the cancer, comprises determining the expression level of one or more predictive RNA transcripts or their expression products, in a biological sample comprising cancer cells obtained from the subject.
摘要翻译：要解决的问题：提供基因和基因组，其表达水平可用于预测结肠直肠癌的结局。解决方案：预测诊断为结肠直肠癌的受试者的临床结果的方法包括确定一种或多种结直肠癌的表达的证据在从受试者获得的癌细胞的生物样品中的更多预测性RNA转录物或其表达产物。在一个方面，一种用于预测在手术切除癌症后诊断为结肠直肠癌的受试者中的临床结果的方法包括在包含获得的癌细胞的生物样品中测定一种或多种预测性RNA转录物或其表达产物的表达水平从主题。

2. 发明专利

JP2013226150A Gene expression marker for colorectal cancer prognosis 有权
标题翻译：基因表达标记为色素癌预后
公开(公告)号：JP2013226150A
公开(公告)日：2013-11-07
申请号：JP2013124949
申请日：2013-06-13
申请人： Genomic Health Inc , ジェノミックヘルス, インコーポレイテッド , Nsabp Foundation Inc , エヌエスエービーピーファウンデーション, インコーポレイテッド
发明人： COWENS WAYNE , BAKER JOFFRE B , CLARK KIM , HACKETT JAMES , WATSON DREW , PAIK SOONMYUNG
IPC分类号： C12Q1/68 , C12N15/09 , G01N33/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , G01N33/57419 , G01N33/57446
摘要： PROBLEM TO BE SOLVED: To provide a gene having its expression level useful for predicting colorectal cancer outcome and a gene set.SOLUTION: A method for predicting clinical outcome in a subject diagnosed as colorectal cancer comprises determining evidence of the expression of one or more predictive RNA transcripts, especially evidence of the expression of an RNA transcript of MYBL2 or their expression products in a biological sample of cancer cells obtained from the subject. In one embodiment, a method for predicting the clinical outcome in a subject diagnosed as colorectal cancer following surgical resection of the cancer comprises measuring the expression level of one or more RNA transcripts or their expression products predictive of relevance, in a biological sample comprising cancer cells obtained from the subject.
摘要翻译：要解决的问题：提供其表达水平可用于预测结肠直肠癌结果和基因组的基因。解决方案：用于预测诊断为结肠直肠癌的受试者的临床结果的方法包括确定一种或多种预测的表达的证据 RNA转录物，特别是在从受试者获得的癌细胞的生物样品中表达MYBL2或其表达产物的RNA转录物的证据。在一个实施方案中，用于预测在手术切除癌症后诊断为结肠直肠癌的受试对象中的临床结果的方法包括在包含癌细胞的生物样品中测量一种或多种RNA转录物或其表达产物的表达产物的表达水平，从主题获得。

3. 发明专利

JP2013176398A Gene expression marker for colorectal cancer prognosis 有权
标题翻译：基因表达标记为色素癌预后
公开(公告)号：JP2013176398A
公开(公告)日：2013-09-09
申请号：JP2013124950
申请日：2013-06-13
申请人： Genomic Health Inc , ジェノミックヘルス, インコーポレイテッド , Nsabp Foundation Inc , エヌエスエービーピーファウンデーション, インコーポレイテッド
发明人： COWENS WAYNE , BAKER JOFFRE B , CLARK KIM , HACKETT JAMES , WATSON DREW , PAIK SOONMYUNG
IPC分类号： C12Q1/68 , C12N15/09 , G01N33/50
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , G01N33/57419 , G01N33/57446
摘要： PROBLEM TO BE SOLVED: To provide genes whose expression levels are useful for predicting the outcome of colorectal cancer, and a gene set.SOLUTION: A method of predicting a clinical outcome in a subject includes determining the evidence of expression of one or more predictive RNA transcripts in a biological sample of cancer cells obtained from the subject diagnosed with colorectal cancer, or the evidence of presence of these expression products. The method is provided for predicting a clinical outcome after the surgical resection of the cancer of the subject diagnosed with colorectal cancer, and includes measuring the expression levels of one or more of predictive RNA transcripts listed in Tables 1A-B, 2A-B, 3A-B, 4A-B, 5A-B, 6, and/or 7, or their expression products, in a biological sample comprising cancer cells obtained from the subject.
摘要翻译：要解决的问题：提供其表达水平可用于预测结肠直肠癌的结果的基因和基因组。解决方案：预测受试者的临床结果的方法包括确定一种或多种预测RNA的表达证据从被诊断为结肠直肠癌的受试者获得的癌细胞的生物样品中的转录物或这些表达产物的存在的证据。该方法用于预测在诊断为结肠直肠癌的受试者的手术切除癌症后的临床结果，并且包括测量表1A-B，2A-B，3A中列出的一种或多种预测性RNA转录物的表达水平 -B，4A-B，5A-B，6和/或7，或其表达产物，包含从受试者获得的癌细胞的生物样品中。

4. 发明专利

JP2013226151A Gene expression marker for colorectal cancer prognosis 有权
标题翻译：基因表达标记为色素癌预后
公开(公告)号：JP2013226151A
公开(公告)日：2013-11-07
申请号：JP2013124951
申请日：2013-06-13
申请人： Genomic Health Inc , ジェノミックヘルス, インコーポレイテッド , Nsabp Foundation Inc , エヌエスエービーピーファウンデーション, インコーポレイテッド
发明人： COWENS WAYNE , BAKER JOFFRE B , CLARK KIM , HACKETT JAMES , WATSON DREW , PAIK SOONMYUNG
IPC分类号： C12Q1/68 , C12N15/09
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , G01N33/57419 , G01N33/57446
摘要： PROBLEM TO BE SOLVED: To provide a gene having its expression level useful for predicting colorectal cancer outcome and a gene set.SOLUTION: Measurement of an expression level of one or more predictive RNA transcripts, especially an RNA transcript of INHBA or an expression product thereof shows the relation between clinical outcome and gene expression. In a gene showing a risk rate >1.0 and p
摘要翻译：要解决的问题：提供其表达水平可用于预测结肠直肠癌预后和基因组的基因。解决方案：测量一种或多种预测性RNA转录物，特别是INHBA的RNA转录物或其表达产物的表达水平显示临床结果与基因表达的关系。在风险率> 1.0且p <0.1的基因中，使用RFI作为临床结果的测量标准，并将单因素Cox比例风险回归分析应用于混合的第二疾病阶段（Dukes B）和第三疾病患者疾病阶段（公爵C）。

5. 发明专利

JP2013215201A Gene expression marker for colorectal cancer prognosis 审中-公开
标题翻译：基因表达标记为色素癌预后
公开(公告)号：JP2013215201A
公开(公告)日：2013-10-24
申请号：JP2013124952
申请日：2013-06-13
申请人： Genomic Health Inc , ジェノミックヘルス, インコーポレイテッド , Nsabp Foundation Inc , エヌエスエービーピーファウンデーション, インコーポレイテッド
发明人： COWENS WAYNE , BAKER JOFFRE B , CLARK KIM , HACKETT JAMES , WATSON DREW , PAIK SOONMYUNG
IPC分类号： C12Q1/68 , C12N15/09
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , G01N33/57419 , G01N33/57446
摘要： PROBLEM TO BE SOLVED: To provide genes and gene sets, the expression levels of which are useful for predicting outcome of colorectal cancer.SOLUTION: A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprises determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the subject. In one embodiment, the method for predicting the clinical outcome in a subject diagnosed with colorectal cancer following surgical resection of the cancer, comprises determining the expression level of one or more predictive RNA transcripts in a biological sample comprising cancer cells obtained from the subject.
摘要翻译：要解决的问题：提供基因和基因组，其表达水平可用于预测结肠直肠癌的结局。解决方案：预测诊断为结肠直肠癌的受试者的临床结果的方法包括确定一种或多种结直肠癌的表达的证据在从受试者获得的癌细胞的生物样品中的更多预测性RNA转录物或其表达产物。在一个实施方案中，用于预测在手术切除癌症之后诊断为结肠直肠癌的受试者中的临床结果的方法包括确定包含从受试者获得的癌细胞的生物样品中的一种或多种预测性RNA转录物的表达水平。

6. 发明专利

JP2013074894A Gene expression marker for colorectal cancer prognosis 有权
标题翻译：基因表达标记为色素癌预后
公开(公告)号：JP2013074894A
公开(公告)日：2013-04-25
申请号：JP2012272400
申请日：2012-12-13
申请人： Genomic Health Inc , ジェノミックヘルス, インコーポレイテッド , Nsabp Foundation Inc , エヌエスエービーピーファウンデーション, インコーポレイテッド
发明人： COWENS WAYNE , BAKER JOFFRE B , CLARK KIM , HACKETT JAMES , WATSON DREW , PAIK SOONMYUNG
IPC分类号： C12Q1/68 , C12N15/09
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , G01N33/57419 , G01N33/57446
摘要： PROBLEM TO BE SOLVED: To provide genes and gene sets having the expression levels which are useful for predicting outcome of colorectal cancer.SOLUTION: A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprises determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the subject. In one embodiment, the method for predicting the clinical outcome in a subject diagnosed with colorectal cancer following surgical resection of the cancer comprises determining the expression level of one or more predictive RNA transcripts listed in Tables 1A-B, 2A-B, 3A-B, 4A-B, 5A-B, 6 and/or 7, or their expression products, in a biological sample comprising cancer cells obtained from the subject.
摘要翻译：要解决的问题：提供具有可用于预测结肠直肠癌结果的表达水平的基因和基因组。解决方案：在诊断为结肠直肠癌的受试者中预测临床结果的方法包括确定从受试者获得的癌细胞的生物样品中一种或多种预测性RNA转录物或其表达产物的表达的证据。在一个实施方案中，用于预测在癌症手术切除后诊断为结肠直肠癌的受试者中的临床结果的方法包括确定表1A-B，2A-B，3A-B中列出的一种或多种预测性RNA转录物的表达水平，4A-B，5A-B，6和/或7，或其表达产物，包含从受试者获得的癌细胞的生物样品中。版权所有（C）2013，JPO＆INPIT

7. 发明专利

JP2013146279A Gene expression profiling in biopsied tumor tissue 有权
公开(公告)号：JP2013146279A
公开(公告)日：2013-08-01
申请号：JP2013097282
申请日：2013-05-07
申请人： Genomic Health Inc , ジェノミックヘルス, インコーポレイテッド
发明人： BAKER JOFFRE B , CRONIN MAUREEN T , KIEFER MICHAEL C , SHAK STEVE , WALKER MICHAEL G
IPC分类号： C12N15/09 , C12Q1/68 , C12M1/00 , C12N15/10 , G01N33/574
CPC分类号： G01N33/57484 , C12N15/1003 , C12Q1/686 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57415
摘要： PROBLEM TO BE SOLVED: To provide a method of predicting the likelihood of long-term survival of a breast cancer patient without the recurrence of breast cancer, following surgical removal of the primary tumor.SOLUTION: A method of predicting the likelihood of long-term survival of a breast cancer patient without the recurrence of breast cancer, following surgical removal of the primary tumor, includes determining the expression level of RNA transcripts of CCNB1 in a breast cancer tissue sample obtained from the patient, normalized against a reference set of the RNA transcripts, wherein overexpression of the CCNB1 indicates a decreased likelihood of long-term survival without breast cancer recurrence.

8. 发明专利

JP2013146278A Gene expression profiling in biopsied tumor tissue 有权
标题翻译：生物型肿瘤组织中的基因表达谱
公开(公告)号：JP2013146278A
公开(公告)日：2013-08-01
申请号：JP2013097281
申请日：2013-05-07
申请人： Genomic Health Inc , ジェノミックヘルス, インコーポレイテッド
发明人： BAKER JOFFRE B , CRONIN MAUREEN T , KIEFER MICHAEL C , SHAK STEVE , WALKER MICHAEL G
IPC分类号： C12N15/09 , C12Q1/68 , C12M1/00 , C12N15/10 , G01N33/574
CPC分类号： G01N33/57484 , C12N15/1003 , C12Q1/686 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57415
摘要： PROBLEM TO BE SOLVED: To provide a method of predicting the likelihood of long-term survival of a breast cancer patient without the recurrence of breast cancer, following surgical removal of the primary tumor.SOLUTION: A method of predicting the likelihood of long-term survival of a breast cancer patient without the recurrence of breast cancer, following surgical removal of the primary tumor, includes determining the expression level of RNA transcripts of CCNB1 in a breast cancer tissue sample obtained from the patient, normalized against a reference set of the RNA transcripts, wherein overexpression of the CCNB1 indicates a decreased likelihood of long-term survival without breast cancer recurrence.
摘要翻译：要解决的问题：提供一种在手术切除原发性肿瘤后，预测乳腺癌患者长期存活可能性而无乳腺癌复发的方法。解决方案：预测长期可能性的方法在手术切除原发性肿瘤之后，乳腺癌患者的存活不包括乳腺癌的复发，包括确定从患者获得的乳腺癌组织样品中CCNB1的RNA转录物的表达水平，使其与参照组的RNA标准化转录物，其中CCNB1的过度表达表明在不存在乳腺癌复发的情况下长期存活的可能性降低。

9. 发明专利

JP2006129880A Gene expression profiling in biopsied tumor tissues 有权
标题翻译：生物型肿瘤组织中的基因表达谱
公开(公告)号：JP2006129880A
公开(公告)日：2006-05-25
申请号：JP2006040014
申请日：2006-02-16
申请人： Genomic Health Inc , ジェノミックヘルス, インコーポレイテッド
发明人： BAKER JOFFRE B , CRONIN MAUREEN T , KIEFER MICHAEL C , SHAK STEVE , WALKER MICHAEL G
IPC分类号： C12N15/09 , C12Q1/68 , C12M1/00 , C12N15/10 , G01N33/574
CPC分类号： G01N33/57484 , C12N15/1003 , C12Q1/686 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57415
摘要： PROBLEM TO BE SOLVED: To provide sensitive methods for measuring mRNA level in biopsied tumor tissues, about 190 breast cancer gene sets important in diagnosis and treatment of breast cancer, and genes included in gene sets used for treatment of breast cancer via the activation or breakage of biochemical controlling route or have influence on the reaction of the patient to the latently effective medicines, and provide the importance of abnormally low or high expressions of indentified genes. SOLUTION: This is a method for predicting the clinical test results of a patient diagnosed with a cancer and the steps for determining the expression level of one or more genes in the cancer tissues or their expression products from the patient wherein the genes are selected from the group consisting of p53BP2, cathepsin, cathepsin L, Ki67/MiB1 and thymidine kinase and the expression level is normalized to the control gene and include a step for comparing the results with the amount observed in the standard cancer tissue set. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为了提供敏感的方法来测量活检肿瘤组织中的mRNA水平，约190例乳腺癌诊断和治疗中重要的乳腺癌基因集，以及包含在用于治疗乳腺癌的基因组中的基因活化或破坏生化控制途径，或影响患者对潜在有效药物的反应，并提供异常低或高表达的识别基因的重要性。解决方案：这是一种用于预测诊断患有癌症的患者的临床测试结果的方法以及用于确定癌组织中的一种或多种基因或其患者的表达产物的表达水平的步骤，其中所述基因是选自由p53BP2，组织蛋白酶，组织蛋白酶L，Ki67 / MiB1和胸苷激酶组成的组，并且将表达水平归一化为对照基因，并且包括将结果与标准癌症组织中观察到的量进行比较的步骤。版权所有（C）2006，JPO＆NCIPI

10. 发明专利

JP2013176388A Gene expression marker for predicting response to chemotherapeutic agent 有权
标题翻译：用于预防化疗药物的基因表达标记
公开(公告)号：JP2013176388A
公开(公告)日：2013-09-09
申请号：JP2013103045
申请日：2013-05-15
申请人： Genomic Health Inc , ジェノミックヘルス, インコーポレイテッド , Fondazione Irccs Ist Nazional Dei Tumori , フォンダジョーネイアルキキエスイスティトゥトナジョネールデツモーリ
发明人： BAKER JOFFRE B , SHAK STEVEN , GIANNI LUCA
IPC分类号： C12Q1/68 , C12N15/09
CPC分类号： C12Q1/6886 , C12Q2600/106 , Y10S435/96
摘要： PROBLEM TO BE SOLVED: To provide sets of genes the expression of which is important in the prognosis of cancer, in particular, gene expression information useful for predicting whether cancer patients are likely to have a beneficial treatment response to chemotherapy.SOLUTION: A method for determining the likelihood of a beneficial response of a human patient with breast cancer to an anthracycline-based chemotherapy, comprises: determining a normalized expression level of an RNA transcript, or its expression product, of DICER1 in a breast cancer sample obtained from the patient; and predicting the likelihood of a beneficial response of the patient to the anthracycline-based chemotherapy, using the DICER1 normalized expression level, wherein the DICER1 normalized expression level is negatively correlated with the likelihood of a beneficial response of the patient to the anthracycline-based chemotherapy.
摘要翻译：要解决的问题：提供一组基因，其表达在癌症的预后中尤其重要，特别是可用于预测癌症患者是否可能对化学疗法有有益治疗反应的基因表达信息。解决方案：确定人类患有乳腺癌的患者对蒽环类化疗的有效反应的可能性包括：确定从患者获得的乳腺癌样品中DICER1的RNA转录物或其表达产物的归一化表达水平; 并使用DICER1标准化表达水平预测患者对蒽环类化疗的有益反应的可能性，其中DICER1标准化表达水平与患者对基于蒽环类化疗的有益反应的可能性负相关。

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