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1. 发明授权

US10343350B2 Systems and methods for forming a nanopore in a lipid bilayer 有权
公开(公告)号：US10343350B2
公开(公告)日：2019-07-09
申请号：US15411780
申请日：2017-01-20
申请人： Genia Technologies, Inc.
发明人： Roger J. A. Chen , Randy Davis
IPC分类号： G01N33/487 , C12Q1/68 , B29C67/20 , B82Y5/00 , C12Q1/6869 , B82Y10/00 , B82Y40/00
摘要： Techniques for forming a nanopore in a lipid bilayer are described herein. In one example, an agitation stimulus level such as an electrical agitation stimulus is applied to a lipid bilayer wherein the agitation stimulus level tends to facilitate the formation of nanopores in the lipid bilayer. In some embodiments, a change in an electrical property of the lipid bilayer resulting from the formation of the nanopore in the lipid bilayer is detected, and a nanopore has formed in the lipid bilayer is determined based on the detected change in the lipid bilayer electrical property.

2. 发明授权

US10330633B2 System for communicating information from an array of sensors 有权
公开(公告)号：US10330633B2
公开(公告)日：2019-06-25
申请号：US15380721
申请日：2016-12-15
申请人： Genia Technologies, Inc.
发明人： Roger J. A. Chen
IPC分类号： G01N27/327 , G01N33/487 , C12Q1/6874 , G01N27/447
摘要： A system for communicating information from an array of sensors is disclosed. The system comprises a sensor array that includes a plurality of sensors, wherein each sensor senses a physical property of a material that is in communication with the sensor. The system further comprises signal processing circuitry associated with each sensor that integrates the output of the sensor over time and compares the integrated output to a threshold. The system further comprises a communication network coupled to the signal processing circuitry that outputs information indicating that the integrated output corresponding to a given sensor has reached the threshold.

3. 发明授权

US10156541B2 System for detecting electrical properties of a molecular complex 有权
公开(公告)号：US10156541B2
公开(公告)日：2018-12-18
申请号：US15819994
申请日：2017-11-21
申请人： Genia Technologies, Inc.
发明人： Roger J. A. Chen
IPC分类号： G01N27/327 , G01N33/487 , C12Q1/6874 , G01N27/447
摘要： A system for detecting electrical properties of a molecular complex is disclosed. The system includes an electrode electrically coupled to a molecular complex that outputs an electrical signal affected by an electrical property of the molecular complex, wherein the effect of the electrical property of the molecular complex on the electrical signal is characterized by an expected bandwidth. The system further includes an integrating amplifier circuit configured to receive the electrical signal from the electrode. The integrating amplifier circuit is further configured to selectively amplify and integrate a portion of the electrical signal over time within a predetermined bandwidth, wherein the predetermined bandwidth is selected at least in part based on the expected bandwidth.

4. 发明授权

US10036739B2 Adjustable bilayer capacitance structure for biomedical devices 有权
公开(公告)号：US10036739B2
公开(公告)日：2018-07-31
申请号：US14606632
申请日：2015-01-27
申请人： Genia Technologies, Inc.
发明人： Jennifer Hovis , Hui Tian , Roger J. A. Chen
IPC分类号： G01N27/447 , G01N33/487
摘要： A nanopore sequencing device is disclosed. The nanopore sequencing device includes a working electrode. It further includes a dielectric layer, wherein a portion of the dielectric layer is disposed horizontally adjacent to the working electrode and a portion of the dielectric layer is disposed above and covering a portion of the working electrode, and wherein the dielectric layer forms a well having an opening above an uncovered portion of the working electrode. A base surface area of the working electrode is greater than a base surface area of the opening above the uncovered portion of the working electrode.

5. 发明授权

US09863904B2 Nanopore-based sequencing with varying voltage stimulus 有权
公开(公告)号：US09863904B2
公开(公告)日：2018-01-09
申请号：US14971667
申请日：2015-12-16
申请人： Genia Technologies, Inc.
发明人： Roger J. A. Chen , Hui Tian , Bill Maney
IPC分类号： G01N27/447 , G01N27/22 , C12Q1/68 , G01N33/487
CPC分类号： G01N27/228 , C12Q1/6869 , G01N27/3273 , G01N27/44791 , G01N33/48721 , C12Q2527/125 , C12Q2565/607 , C12Q2565/629 , C12Q2565/631
摘要： A method of analyzing a molecule is disclosed. A voltage source is selectively connected to or disconnected from a capacitor using a switch controlled by a reset signal. A charge is stored in a capacitor when the voltage source is connected to the capacitor. The capacitor is discharged through a nanopore in a membrane when the voltage source is disconnected from the capacitor. A duty cycle of the reset signal is determined such that the voltage source and the capacitor is connected for at least a one tenth portion of a reset signal period and disconnected for a remaining portion of the reset signal period, such that a voltage across the nanopore is maintained at a higher level during the portion of the reset signal period in which the connection is maintained than during the remaining portion of the reset signal period in which the connection is not maintained.

6. 发明授权

US08986629B2 Sensor circuit for controlling, detecting, and measuring a molecular complex 有权
标题翻译：用于控制，检测和测量分子复合物的传感器电路
公开(公告)号：US08986629B2
公开(公告)日：2015-03-24
申请号：US13777879
申请日：2013-02-26
申请人： Genia Technologies, Inc.
发明人： Kevin Deierling , Roger J. A. Chen , David J. Fullagar
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48 , C12Q1/68 , G01N33/487
CPC分类号： G01N27/4473 , C12Q1/6869 , C12Q1/6874 , G01N27/44782 , G01N27/44791 , G01N33/48721 , Y10T436/11 , C12Q2565/631 , C12Q2565/607
摘要： A device for controlling, detecting, and measuring a molecular complex is disclosed. The device comprises a common electrode. The device further comprises a plurality of measurement cells. Each measurement cell includes a cell electrode and an integrator electronically coupled to the cell electrode. The integrator measures the current flowing between the common electrode and the cell electrode. The device further comprises a plurality of analog-to-digital converters, wherein an integrator from the plurality of measurement cells is electrically coupled to one analog-to-digital converter of the plurality of analog-to-digital converters.
摘要翻译：公开了一种用于控制，检测和测量分子复合物的装置。该装置包括公共电极。该装置还包括多个测量单元。每个测量单元包括电池耦合到电池电极的单元电极和积分器。积分器测量在公共电极和电池电极之间流动的电流。该装置还包括多个模数转换器，其中来自多个测量单元的积分器电耦合到多个模数转换器的一个模 - 数转换器。

7. 发明授权

US10215731B2 Nanopore-based sequencing with varying voltage stimulus 有权
公开(公告)号：US10215731B2
公开(公告)日：2019-02-26
申请号：US15371106
申请日：2016-12-06
申请人： Genia Technologies, Inc.
发明人： Roger J. A. Chen , Hui Tian , J. William Maney, Jr.
IPC分类号： G01N27/447 , B01L3/00 , C12Q1/6869 , G01N33/487
摘要： A method of analyzing a molecule in a nanopore is disclosed. A voltage is applied across a nanopore that is inserted in a membrane by coupling the nanopore to a voltage source. The nanopore is decoupled from the voltage source. After the decoupling, a rate of decay of the voltage across the nanopore is determined. A molecule in the nanopore is distinguished from other possible molecules based on the determined rate of decay of the voltage across the nanopore.

8. 发明授权

US09869655B2 System for detecting electrical properties of a molecular complex 有权
公开(公告)号：US09869655B2
公开(公告)日：2018-01-16
申请号：US14558268
申请日：2014-12-02
申请人： Genia Technologies, Inc.
发明人： Roger J. A. Chen
IPC分类号： G01N27/327 , G01N33/487
CPC分类号： G01N27/3278 , C12Q1/6874 , G01N27/44791 , G01N33/48721
摘要： A system for detecting electrical properties of a molecular complex is disclosed. The system includes an electrode electrically coupled to a molecular complex that outputs an electrical signal affected by an electrical property of the molecular complex, wherein the effect of the electrical property of the molecular complex on the electrical signal is characterized by an expected bandwidth. The system further includes an integrating amplifier circuit configured to: receive the electrical signal from the electrode. The integrating amplifier circuit is further configured to selectively amplify and integrate a portion of the electrical signal over time within a predetermined bandwidth, wherein the predetermined bandwidth is selected at least in part based on the expected bandwidth.

9. 发明授权

US09551697B2 Non-faradaic, capacitively coupled measurement in a nanopore cell array 有权
标题翻译：纳米孔单元阵列中的非法拉第电容耦合测量
公开(公告)号：US09551697B2
公开(公告)日：2017-01-24
申请号：US14056795
申请日：2013-10-17
申请人： Genia Technologies, Inc.
发明人： Roger J. A. Chen
IPC分类号： G01N27/447 , G01N33/487 , G01N27/327
CPC分类号： G01N27/44791 , G01N27/3278 , G01N27/4473 , G01N27/44743 , G01N33/48721
摘要： A method of identifying a molecule is disclosed. A molecule is drawn to a nanopore by applying a first voltage signal to a pair of electrodes during a first period, wherein the first voltage signal causes a first ionic current through the nanopore that is indicative of a property of a portion of the molecule proximate to the nanopore. The molecule is released from the nanopore by applying a second voltage signal to the pair of electrodes during a second period, wherein the second voltage signal causes a second ionic current through the nanopore. The first period and the second period are determined based at least in part on a net ionic current through the nanopore comprising the first ionic current and the second ionic current.
摘要翻译：公开了鉴定分子的方法。通过在第一周期期间将一个第一电压信号施加到一对电极上，将一个分子吸引到纳米孔，其中第一电压信号引起通过纳米孔的第一离子电流，其指示分子的一部分的性质接近于纳米孔。在第二时段期间，通过在所述一对电极施加第二电压信号，从所述纳米孔释放所述分子，其中所述第二电压信号引起通过所述纳米孔的第二离子电流。至少部分地基于通过包含第一离子电流和第二离子电流的纳米孔的净离子电流确定第一周期和第二周期。

10. 发明授权

US09393541B2 Temperature regulation of measurement arrays 有权
公开(公告)号：US09393541B2
公开(公告)日：2016-07-19
申请号：US14794524
申请日：2015-07-08
申请人： Genia Technologies, Inc.
发明人： Roger J. A. Chen
IPC分类号： G05D23/00 , B01J19/00 , G05D23/20
CPC分类号： B01J19/0046 , B01J2219/00495 , B01J2219/00698 , G05D23/1919 , G05D23/2034 , G05D23/2037
摘要： A system for regulating a temperature of a measurement array is disclosed. The system includes a measurement array including a plurality of sensors, wherein the plurality of sensors are integrated onto an integrated circuit die. The system includes a thermal sensor integrated onto the integrated circuit die, wherein the thermal sensor senses a temperature associated with the plurality of sensors. The system further includes a heat pump coupled to the integrated circuit die, wherein the heat pump is controlled by a feedback control circuit including the thermal sensor.

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