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1. 发明申请

WO2013003530A1 DEVICES AND METHODS FOR REDUCING RADIOLYSIS OF RADIOLABELED COMPOUNDS 审中-公开
标题翻译：用于减少放射性化合物的放射性的装置和方法
公开(公告)号：WO2013003530A1
公开(公告)日：2013-01-03
申请号：PCT/US2012/044527
申请日：2012-06-28
申请人： GENERAL ELECTRIC COMPANY , RENSCH, Christian , BALLER, Marko , BOELD, Christoph , HORVATH-KLEIN, Ruben Julian , SAMPER, Victor , ULIN, Johan
发明人： RENSCH, Christian , BALLER, Marko , BOELD, Christoph , HORVATH-KLEIN, Ruben Julian , SAMPER, Victor , ULIN, Johan
IPC分类号： C07B59/00 , B01J19/00
CPC分类号： C07B59/00 , G21F9/06 , G21F9/12
摘要： Disclosed are devices and methods for reducing radiolysis of radiopharmaceuticals during filtration, concentration and purification. The devices comprises two or more confining geometry having a cross-section dimension below the beta(+) or beta(-) range of the radioisotope in use, when containing the radioisotope, and configured in such a way that neighboring geometries are isolated from its nearest neighbor such that no measurable kinetic positron energy transfer occurs between the confining geometries when containing the radioisotope. Methods of filtration of radioisotope containing mixtures are also disclosed.
摘要翻译：公开了用于在过滤，浓缩和纯化期间减少放射性药物的放射分解的装置和方法。这些装置包括两个或更多个约束几何形状，其在使用时具有低于放射性同位素的β（+）或β（ - ）范围的横截面尺寸，当包含放射性同位素时，并且以这样一种方式构造相邻几何形状最近邻居，使得当包含放射性同位素时，在约束几何之间不发生可测量的动能正电子能量转移。还公开了含有放射性同位素的混合物的过滤方法。

2. 发明申请

WO2013101568A1 MICROFLUIDIC CASSETTE HANDLING SYSTEM 审中-公开
标题翻译：微流控CASSETTE处理系统
公开(公告)号：WO2013101568A1
公开(公告)日：2013-07-04
申请号：PCT/US2012/070433
申请日：2012-12-19
申请人： GENERAL ELECTRIC COMPANY
发明人： SAMPER, Victor , BOELD, Christoph , RENSCH, Christian , HORVATH-KLEIN, Ruben Julian
IPC分类号： B01J19/00 , B01L9/00 , G01N35/04
CPC分类号： B01J19/0093 , B01J2219/0081 , B01J2219/00986 , G01N35/00029 , G01N35/04 , G01N2035/0425
摘要： Techniques and devices are provided related to a handling system for cassettes for radiolabeled compound synthesis that include a magazine that is unshielded and that is configured to receive a plurality of microfluidic synthesis cassettes. In one embodiment, the plurality of microfluidic synthesis cassettes include nonradioactive reagents to generate a radiolabeled compound when reacted with a radioactive isotope. In this manner, a cassette handling device may be stored unshielded and may be coupled to a cassette handling platform to allow advancement of the plurality of microfluidic synthesis cassettes into the cassette handling platform and, in turn, a shielded radiosynthesis machine.
摘要翻译：提供了与用于放射性标记化合物合成的盒的处理系统相关的技术和装置，其包括非屏蔽的盒，并且被配置为容纳多个微流体合成盒。在一个实施方案中，多个微流体合成盒包括当与放射性同位素反应时产生放射性标记的化合物的非放射性试剂。以这种方式，盒式磁带处理装置可以非屏蔽地存储并且可以耦合到盒式处理平台，以允许将多个微流体合成盒推进到盒式处理平台中，并进而进行屏蔽放射合成机。

3. 发明申请

WO2011006166A1 ELECTROCHEMICAL PHASE TRANSFER DEVICES AND METHODS 审中-公开
标题翻译：电化学相转移装置及方法
公开(公告)号：WO2011006166A1
公开(公告)日：2011-01-13
申请号：PCT/US2010/041735
申请日：2010-07-12
申请人： GENERAL ELECTRIC COMPANY , BALLER, Marko , SAMPER, Victor , RENSCH, Christian , BOELD, Christoph
发明人： BALLER, Marko , SAMPER, Victor , RENSCH, Christian , BOELD, Christoph
IPC分类号： G21G1/00 , B01D59/38
CPC分类号： G21G1/001 , G21G2001/0015
摘要： Devices and methods for electrochemical phase transfer utilize at least one electrode formed from either glassy carbon or a carbon and polymer composite. The device includes a device housing defining an inlet port (42), an outlet port (44) and an elongate fluid passageway (36) extending therebetween. A capture electrode (12) and a counter electrode are positioned within said housing such that the fluid passageway extends between the capture and counter electrodes.
摘要翻译：用于电化学相转移的装置和方法利用由玻璃碳或碳和聚合物复合材料形成的至少一个电极。该装置包括限定入口端口（42），出口端口（44）和在其间延伸的细长流体通道（36）的装置壳体。捕获电极（12）和对电极位于所述壳体内，使得流体通道在捕获电极和对电极之间延伸。

4. 发明申请

WO2012015856A1 FLUID CONNECTOR DEVICES AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：流体连接器装置及其制造和使用方法
公开(公告)号：WO2012015856A1
公开(公告)日：2012-02-02
申请号：PCT/US2011/045443
申请日：2011-07-27
申请人： GENERAL ELECTRIC COMPANY , BALLER, Marko , RENSCH, Christian , SAMPER, Victor
发明人： BALLER, Marko , RENSCH, Christian , SAMPER, Victor
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01J19/0093 , B01J2219/00806 , B01J2219/00813 , B01L9/527 , B01L2200/027 , B01L2200/0689 , B01L2300/0861 , B01L2300/123 , B01L2300/161
摘要： A fluid connector device (10) is provided. The fluid connector device includes a coupling substrate (12) having a conformal recess (20), a reconnectable fitting (18) disposed in the recess to provide a first passageway, and a force applying element (16) operatively coupled to the reconnectable fitting (18), or the coupling substrate (12), or both the reconnectable fitting (18) and the coupling substrate (12) to at least partially provide a sealing force between the reconnectable fitting (18) and the coupling substrate (12), wherein at least one of the force applying element (16), the reconnectable fitting (18), and the coupling substrate (12) comprises one or more degrees of freedom for self alignment of the reconnectable fitting (18) and the conformal recess (12).
摘要翻译：提供了一种流体连接器装置（10）。流体连接器装置包括具有共形凹槽（20）的联接基板（12），设置在凹槽中以提供第一通道的可重新连接的配件（18），以及可操作地连接到可重新连接的配件 18）或耦合衬底（12），或者可重新连接的配件（18）和耦合衬底（12）两者至少部分地提供可重新连接的配件（18）和耦合衬底（12）之间的密封力，其中施力元件（16），可重新连接的配件（18）和联接基板（12）中的至少一个包括用于可重新连接的配件（18）和保形凹部（12）的自对准的一个或多个自由度，。

5. 发明申请

WO2011082276A1 MICROVALVE 审中-公开
标题翻译：微型阀
公开(公告)号：WO2011082276A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/062453
申请日：2010-12-30
申请人： GENERAL ELECTRIC COMPANY , SAMPER, Victor , RENSCH, Christian , BOELD, Christoph , BALLER, Marko
发明人： SAMPER, Victor , RENSCH, Christian , BOELD, Christoph , BALLER, Marko
IPC分类号： F16K99/00
CPC分类号： F16K99/0001 , F16K99/0015 , F16K2099/008
摘要： A microvalve assembly (10) includes an elongate valve body (14) having opposed first and second major surfaces, the first major surface defining a valve recess (34) and the second major surface defining first and second fluid ports (20,22). Both the fluid input port and the fluid output port extend in fluid communication with the valve recess. A gasket (12) is freely positioned within the valve recess so as to extend in overlying registry with either or both of fluid ports. A valve cover (16) is bonded to the valve body and includes a first planar surface positioned in overlying registry with the valve recess so as to enclose the gasket therein. The valve cover is deflectable into the valve recess so as to cause the gasket to seal at least one of the fluid ports.
摘要翻译：微阀组件（10）包括具有相对的第一和第二主表面的细长阀体（14），所述第一主表面限定阀凹部（34），所述第二主表面限定第一和第二流体端口（20,22）。流体输入端口和流体输出端口都与阀门凹口流体连通地延伸。垫片（12）自由地定位在阀凹部内，以便在任一个或两个流体端口的上面对准中延伸。阀盖（16）与阀体结合并且包括位于与阀凹部对齐的第一平坦表面，以便将垫圈包围在其中。阀盖可偏转到阀门凹口中，以便使垫圈密封至少一个流体端口。

6. 发明公开

EP2598243A1 FLUID CONNECTOR DEVICES AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：流体连接器装置和方法的生产和使用
公开(公告)号：EP2598243A1
公开(公告)日：2013-06-05
申请号：EP11741058.9
申请日：2011-07-27
申请人： General Electric Company
发明人： BALLER, Marko , RENSCH, Christian , SAMPER, Victor
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01J19/0093 , B01J2219/00806 , B01J2219/00813 , B01L9/527 , B01L2200/027 , B01L2200/0689 , B01L2300/0861 , B01L2300/123 , B01L2300/161
摘要： A fluid connector device (10) is provided. The fluid connector device includes a coupling substrate (12) having a conformal recess (20), a reconnectable fitting (18) disposed in the recess to provide a first passageway, and a force applying element (16) operatively coupled to the reconnectable fitting (18), or the coupling substrate (12), or both the reconnectable fitting (18) and the coupling substrate (12) to at least partially provide a sealing force between the reconnectable fitting (18) and the coupling substrate (12), wherein at least one of the force applying element (16), the reconnectable fitting (18), and the coupling substrate (12) comprises one or more degrees of freedom for self alignment of the reconnectable fitting (18) and the conformal recess (12).

7. 发明公开

EP2519763A1 MICROVALVE 审中-公开
标题翻译：微型阀
公开(公告)号：EP2519763A1
公开(公告)日：2012-11-07
申请号：EP10799264.6
申请日：2010-12-30
申请人： General Electric Company
发明人： SAMPER, Victor , RENSCH, Christian , BOELD, Christoph , BALLER, Marko
IPC分类号： F16K99/00
CPC分类号： F16K99/0001 , F16K99/0015 , F16K2099/008
摘要： A microvalve assembly (10) includes an elongate valve body (14) having opposed first and second major surfaces, the first major surface defining a valve recess (34) and the second major surface defining first and second fluid ports (20,22). Both the fluid input port and the fluid output port extend in fluid communication with the valve recess. A gasket (12) is freely positioned within the valve recess so as to extend in overlying registry with either or both of fluid ports. A valve cover (16) is bonded to the valve body and includes a first planar surface positioned in overlying registry with the valve recess so as to enclose the gasket therein. The valve cover is deflectable into the valve recess so as to cause the gasket to seal at least one of the fluid ports.

8. 发明公开

EP2726443A1 DEVICES AND METHODS FOR REDUCING RADIOLYSIS OF RADIOLABELED COMPOUNDS 审中-公开
标题翻译：器件和方法以减少放射性辐标记化合物
公开(公告)号：EP2726443A1
公开(公告)日：2014-05-07
申请号：EP12738666.2
申请日：2012-06-28
申请人： General Electric Company
发明人： RENSCH, Christian , BALLER, Marko , BOELD, Christoph , HORVATH-KLEIN, Ruben Julian , SAMPER, Victor , ULIN, Johan
IPC分类号： C07B59/00 , B01J19/00
CPC分类号： C07B59/00 , G21F9/06 , G21F9/12
摘要： Disclosed are devices and methods for reducing radiolysis of radiopharmaceuticals during filtration, concentration and purification. The devices comprises two or more confining geometry having a cross-section dimension below the beta(+) or beta(-) range of the radioisotope in use, when containing the radioisotope, and configured in such a way that neighboring geometries are isolated from its nearest neighbor such that no measurable kinetic positron energy transfer occurs between the confining geometries when containing the radioisotope. Methods of filtration of radioisotope containing mixtures are also disclosed.

9. 发明公开

EP2797683A1 MICROFLUIDIC CASSETTE HANDLING SYSTEM 有权
标题翻译：微流控CASSETTE处理系统
公开(公告)号：EP2797683A1
公开(公告)日：2014-11-05
申请号：EP12818722.6
申请日：2012-12-19
申请人： General Electric Company
发明人： SAMPER, Victor , BOELD, Christoph , RENSCH, Christian , HORVATH-KLEIN, Ruben Julian
IPC分类号： B01J19/00 , B01L9/00 , G01N35/04
CPC分类号： B01J19/0093 , B01J2219/0081 , B01J2219/00986 , G01N35/00029 , G01N35/04 , G01N2035/0425
摘要： Techniques and devices are provided related to a handling system for cassettes for radiolabeled compound synthesis that include a magazine that is unshielded and that is configured to receive a plurality of microfluidic synthesis cassettes. In one embodiment, the plurality of microfluidic synthesis cassettes include nonradioactive reagents to generate a radiolabeled compound when reacted with a radioactive isotope. In this manner, a cassette handling device may be stored unshielded and may be coupled to a cassette handling platform to allow advancement of the plurality of microfluidic synthesis cassettes into the cassette handling platform and, in turn, a shielded radiosynthesis machine.

10. 发明公开

EP2452343A1 ELECTROCHEMICAL PHASE TRANSFER DEVICES AND METHODS 审中-公开
标题翻译：器件和方法电化学相转移
公开(公告)号：EP2452343A1
公开(公告)日：2012-05-16
申请号：EP10742049.9
申请日：2010-07-12
申请人： General Electric Company
发明人： BALLER, Marko , SAMPER, Victor , RENSCH, Christian , BOELD, Christoph
IPC分类号： G21G1/00 , B01D59/38
CPC分类号： G21G1/001 , G21G2001/0015
摘要： Devices and methods for electrochemical phase transfer utilize at least one electrode formed from either glassy carbon or a carbon and polymer composite. The device includes a device housing defining an inlet port (42), an outlet port (44) and an elongate fluid passageway (36) extending therebetween. A capture electrode (12) and a counter electrode are positioned within said housing such that the fluid passageway extends between the capture and counter electrodes.

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