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1. 发明授权

US5891463A Nonocclusive drug delivery device and process for its manufacture 失效
标题翻译：非结合性药物输送装置及其制造方法
公开(公告)号：US5891463A
公开(公告)日：1999-04-06
申请号：US925356
申请日：1997-09-08
申请人： Gastone P. Bello , John W. Lyle , Donald A. Johnson
发明人： Gastone P. Bello , John W. Lyle , Donald A. Johnson
IPC分类号： A61K9/70 , A61K9/06
CPC分类号： A61K9/703 , A61K9/7084
摘要： A nonocclusive drug delivery device includes (a) an open cell, flexible, oleophilic thermoplastic resin foam layer, (b) a substantially moisture vapor permeable, liquid impermeable, flexible thermoplastic barrier layer bonded to the upper surface of the foam layer, (c) a pressure sensitive adhesive layer and (d) a drug composition comprising a drug and an oleophilic drug delivery vehicle.
摘要翻译：非缔合药物递送装置包括（a）开放细胞，柔性亲油性热塑性树脂泡沫层，（b）基本上水蒸汽可透过的液体不可渗透的柔性热塑性阻挡层，其结合到泡沫层的上表面，（c）压敏粘合剂层和（d）包含药物和亲油药物递送载体的药物组合物。

2. 发明授权

US5505958A Transdermal drug delivery device and method for its manufacture 失效
标题翻译：透皮给药装置及其制造方法
公开(公告)号：US5505958A
公开(公告)日：1996-04-09
申请号：US331724
申请日：1994-10-31
申请人： Gastone P. Bello , John W. Lyle , Donald A. Johnson
发明人： Gastone P. Bello , John W. Lyle , Donald A. Johnson
IPC分类号： A61F13/00 , A61F13/02 , A61K9/70
CPC分类号： A61K9/703 , A61F13/0226 , A61F13/0246 , A61K9/7084 , A61F2013/00906 , A61F2013/0296
摘要： A transdermal drug delivery device possessing a drug-storing matrix and at least one drug delivery device-securing component is manufactured from the same flexible cellular thermoplastic resin workpiece.
摘要翻译：具有药物储存基质和至少一种药物递送装置固定部件的透皮药物递送装置由相同的柔性细胞热塑性树脂工件制造。

3. 发明授权

US5716621A Nonocclusive drug delivery device and process for its manufacture 失效
公开(公告)号：US5716621A
公开(公告)日：1998-02-10
申请号：US675348
申请日：1996-07-03
申请人： Gastone P. Bello , John W. Lyle , Donald A. Johnson
发明人： Gastone P. Bello , John W. Lyle , Donald A. Johnson
IPC分类号： A61K9/70 , A61F13/20
CPC分类号： A61K9/703 , A61K9/7084
摘要： A nonocclusive drug delivery device includes (a) an open cell, flexible, oleophilic thermoplastic resin foam layer, (b) a substantially moisture vapor permeable, liquid impermeable, flexible thermoplastic barrier layer bonded to the upper surface of the foam layer, (c) a pressure sensitive adhesive layer and (d) a drug composition comprising a drug and an oleophilic drug delivery vehicle.

4. 发明授权

US5571079A Wound dressing 失效
标题翻译：伤口敷料
公开(公告)号：US5571079A
公开(公告)日：1996-11-05
申请号：US366670
申请日：1994-12-30
申请人： Gastone P. Bello , John W. Lyle , Donald A. Johnson
发明人： Gastone P. Bello , John W. Lyle , Donald A. Johnson
IPC分类号： A61F13/00 , A61F13/02 , A61F5/00
CPC分类号： A61F13/0203 , A61F2013/00161 , A61F2013/00217 , A61F2013/0074 , A61F2013/00889 , A61F2013/0091
摘要： A wound dressing possessing a wound exudate-absorbing component and at least one liquid-impermeable dressing-securing component is manufactured from the same flexible, cellular, thermoplastic resin workpiece.
摘要翻译：具有伤口渗出物吸收成分的伤口敷料和至少一种液体不可渗透的敷料固定部件由相同的柔性，细胞的热塑性树脂工件制造。

5. 发明授权

US5863922A Pain-alleviating drug composition and method for alleviating pain 失效
标题翻译：减轻疼痛的药物组合物和减轻疼痛的方法
公开(公告)号：US5863922A
公开(公告)日：1999-01-26
申请号：US889041
申请日：1997-07-07
申请人： David J. Mayer , Donald D. Price , Jianren Mao , John W. Lyle
发明人： David J. Mayer , Donald D. Price , Jianren Mao , John W. Lyle
IPC分类号： A61K45/06 , A61K31/00 , A61K31/485 , A61K31/505 , A61K31/513 , A61K31/515 , A61K31/519 , A61K31/529 , A61K31/54 , A61P25/04 , A61K31/165 , A61K31/445
CPC分类号： A61K31/485 , A61K31/515
摘要： The analgesic effectiveness of a combination drug containing at least one analgesic is significantly enhanced by the addition of a nontoxic N-methyl-D-aspartate (NMDA) receptor antagonist thereto.
摘要翻译：通过向其中加入无毒的N-甲基-D-天冬氨酸（NMDA）受体拮抗剂，显着增强含有至少一种止痛剂的组合药物的镇痛作用。

6. 发明授权

US5502058A Method for the treatment of pain 失效
标题翻译：治疗疼痛的方法
公开(公告)号：US5502058A
公开(公告)日：1996-03-26
申请号：US246184
申请日：1994-05-19
申请人： David J. Mayer , Donald D. Price , Jianren Mao , John W. Lyle
发明人： David J. Mayer , Donald D. Price , Jianren Mao , John W. Lyle
IPC分类号： A61K9/08 , A61K31/00 , A61K31/135 , A61K31/17 , A61K31/445 , A61K31/47 , A61K31/485 , A61K31/54 , A61K31/55 , A61K45/00 , A61K45/06 , A61P25/02 , A61P25/04 , A61P29/00 , A61P43/00
CPC分类号： A61K45/06 , A61K31/00 , A61K31/135 , A61K31/485 , Y10S514/886
摘要： A method of alleviating pain such as neuropathic pain or acute inflammatory pain is provided which comprises administering to a mammal that is either exhibiting pain or is about to be subjected to a pain-causing event a pain alleviating/pain suppressing amount of at least one nontoxic antagonist for the N-methyl-D-aspartate receptor, e.g., dextrorphan, or metabolic precursor of such antagonist, e.g., dextromethorphan, or at least one nontoxic substance that blocks a major intracellular consequence of N-methyl-D-aspartate receptor activation, e.g., a phenothiazine such as trifluoperazine.
摘要翻译：提供减轻疼痛的方法，例如神经性疼痛或急性炎症性疼痛，其包括对表现出疼痛或将要经历疼痛事件的哺乳动物施用至少一种无毒的疼痛缓解/疼痛抑制量 N-甲基-D-天冬氨酸受体的拮抗剂，例如右旋芳族或这种拮抗剂的代谢前体，例如右美沙芬或至少一种阻止N-甲基-D-天冬氨酸受体活化的主要细胞内后果的无毒物质，例如吩噻嗪如三氟拉嗪。

7. 发明授权

US06406716B2 Anticonvulsant containing composition for treating neuropathic pain 失效
标题翻译：用于治疗神经性疼痛的含抗惊厥药的组合物
公开(公告)号：US06406716B2
公开(公告)日：2002-06-18
申请号：US09780858
申请日：2001-02-09
申请人： Frank S. Caruso , Fredrick L. Minn , John W. Lyle
发明人： Frank S. Caruso , Fredrick L. Minn , John W. Lyle
IPC分类号： A61K922
CPC分类号： A61K45/06
摘要： The effectiveness of an anticonvulsant such as gabapentin for alleviating neuropathic pain is potentiated by a nontoxic antagonist for the N-methyl-D-aspartate receptor or nontoxic substance that blocks a major intracellular consequence of N-methyl-D-aspartate receptor activation.
摘要翻译：抗惊厥药如加巴喷丁对减轻神经性疼痛的有效性由N-甲基-D-天冬氨酸受体或无毒物质的无毒拮抗剂加强，其阻断N-甲基-D-天冬氨酸受体活化的主要细胞内后果。

8. 发明授权

US5834479A Method and composition for alleviating pain 失效
标题翻译：减轻疼痛的方法和组合
公开(公告)号：US5834479A
公开(公告)日：1998-11-10
申请号：US746202
申请日：1996-11-06
申请人： David J. Mayer , Donald D. Price , Jianren Mao , John W. Lyle
发明人： David J. Mayer , Donald D. Price , Jianren Mao , John W. Lyle
IPC分类号： A61K31/00 , A61K31/135 , A61K31/485 , A61K45/06
CPC分类号： A61K45/06 , A61K31/00 , A61K31/135 , A61K31/485 , Y10S514/825 , Y10S514/886
摘要： The analgesic effectiveness of an NSAID is significantly enhanced by administering the NSAID prior to, with or following the administration of an analgesia enhancer which is a nontoxic NMDA receptor blocker and/or a nontoxic substance that blocks at least one major intracellular consequence of NMDA receptor activation.
摘要翻译：通过在给予镇痛增强剂之前，之后或之后施用NSAID来显着增强NSAID的镇痛作用，所述镇痛增强剂是无毒NMDA受体阻断剂和/或阻断NMDA受体激活的至少一种主要细胞内后果的无毒物质。

9. 发明授权

US5556838A Inhibiting the development of tolerance to and/or dependence on an addictive substance 失效
标题翻译：抑制对成瘾物质的耐受性和/或依赖性的发展
公开(公告)号：US5556838A
公开(公告)日：1996-09-17
申请号：US245970
申请日：1994-05-19
申请人： David J. Mayer , Donald D. Price , Jianren Mao , John W. Lyle
发明人： David J. Mayer , Donald D. Price , Jianren Mao , John W. Lyle
IPC分类号： A61K31/715 , A61K31/045 , A61K31/135 , A61K31/18 , A61K31/435 , A61K31/445 , A61K31/485 , A61K31/505 , A61K31/515 , A61K31/54 , A61K31/55 , A61K45/00 , A61K45/06 , A61P25/04 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/30 , A61P25/36 , A61P43/00 , A61K31/70 , A61K31/44
CPC分类号： A61K31/485 , A61K31/54 , Y10S514/812
摘要： Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA-receptor activation, e.g., a ganglioside such as GM.sub.1 or GT.sub.1b, a phenothiazine such as trifluoperazine or a naphthalenesulfonamide such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, inhibit the development of tolerance to and/or dependence on addictive drugs, e.g., narcotic analgesics such as morphine, codeine, etc.
摘要翻译：阻断N-甲基-D-天冬氨酸（NMDA）受体的无毒物质，例如吗啡喃如右美沙芬或右美沙芬，或阻断NMDA-受体活化的主要细胞内后果，例如神经节苷脂如GM1或GT1b，诸如三氟拉嗪或萘磺酰胺如N-（6-氨基己基）-5-氯-1-萘磺酰胺的吩噻嗪抑制了对成瘾药物的耐受性和/或依赖性的发展，例如麻醉止痛剂如吗啡，可待因，等等

10. 发明授权

US08047915B2 Character for computer game and method 有权
标题翻译：电脑游戏和方法的角色
公开(公告)号：US08047915B2
公开(公告)日：2011-11-01
申请号：US11329578
申请日：2006-01-11
申请人： John W. Lyle , Brenton Lyle , Robert S. Ellsworth
发明人： John W. Lyle , Brenton Lyle , Robert S. Ellsworth
IPC分类号： A63F13/00
CPC分类号： A63F13/79 , A63F13/12 , A63F13/65 , A63F13/822 , A63F2300/5506 , A63F2300/5546 , A63F2300/5553 , A63F2300/695
摘要： A video game character or avatar is generated using images of the player so that the on-screen avatar being controlled by the player appears like the player. Answers to a questionnaire or a psychological profile are provided by the player to determine characteristics that the player views as desirable, which are used to generate a final version of the avatar. Iterations of the avatar appearance are generated from the initial appearance to the final, more desirable appearance. Using the avatar, as play of the game proceeds the player's avatar begins as a character appearing like themselves and gradually becomes a character that is more as they would like to appear. The avatar increases the emotional impact of games by providing strong visual and psychological connections with the player. The avatar may instead begin from an initial character that does not appear similar to the player. The iterations may make the avatar gradually less appealing or with other changes in appearance, in some embodiments.
摘要翻译：使用播放器的图像生成视频游戏角色或头像，使得由玩家控制的屏幕上的头像看起来像播放器。玩家提供问卷或心理资料的答案，以确定玩家视为期望的特征，用于生成化身的最终版本。化身外观的迭代从最初的外观生成到最终的，更理想的外观。使用头像，随着游戏的进行，玩家的头像开始为像自己一样的角色，并逐渐变成更像他们想要出现的角色。头像通过与玩家提供强烈的视觉和心理联系来增加游戏的情感影响。头像可以改为从与玩家不相似的初始角色开始。在一些实施例中，迭代可以使化身逐渐变得不吸引人或外观上的其他改变。

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