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1. 发明授权

US5271940A Transdermal delivery device having delayed onset 失效
标题翻译：具有延迟发作的透皮递送装置
公开(公告)号：US5271940A
公开(公告)日：1993-12-21
申请号：US860300
申请日：1992-03-27
申请人： Gary W. Cleary , Kenneth J. Colley , Jesus Miranda
发明人： Gary W. Cleary , Kenneth J. Colley , Jesus Miranda
IPC分类号： A61F13/00 , A61F13/02 , A61K9/70
CPC分类号： A61K9/703 , A61F13/0206 , A61F13/0223 , A61F13/0226 , A61F13/0259 , A61K9/7069 , A61K9/7084 , A61F2013/00906
摘要： A transdermal delivery device has a reservoir containing an active compound, which is kept separate from the delivery layers of the device until administration. At the time of administration, the reservoir is laminated to the delivery layers, or is ruptured to place the active compound, vehicle, and/or permeation enhancers in contact with the delivery layers, which results in administration of the active compound to the skin after a delay period.
摘要翻译：透皮递送装置具有含有活性化合物的储存器，其保持与装置的递送层分开直到给药。在施用时，将储存器层压到递送层上，或者破裂以使活性化合物，载体和/或渗透促进剂与递送层接触，这导致活性化合物向皮肤施用后进入皮肤延迟期。

2. 发明授权

US5091186A Biphasic transdermal drug delivery device 失效
标题翻译： BIPHASIC TRANSDERMAL DRUG DELIVERY DEVICE
公开(公告)号：US5091186A
公开(公告)日：1992-02-25
申请号：US394096
申请日：1989-08-15
申请人： Jesus Miranda , Gary W. Cleary
发明人： Jesus Miranda , Gary W. Cleary
IPC分类号： A61K9/70
CPC分类号： A61K9/7069
摘要： A transdermal drug delivery system in which drug delivery is biphasic is provided. Drug is delivered at a therapeutically effective rate during an initial, delivery phase, typically of about 10 to 14 hours, followed by a subsequent, secondary phase during which virtually no drug is delivered. Substantially all of the drug initially loaded into the device is delivered within the initial, delivery phase.

3. 发明授权

US4915950A Printed transdermal drug delivery device 失效
标题翻译：印刷透皮药物输送装置
公开(公告)号：US4915950A
公开(公告)日：1990-04-10
申请号：US215074
申请日：1988-07-05
申请人： Jesus Miranda , Gary W. Cleary
发明人： Jesus Miranda , Gary W. Cleary
IPC分类号： A61F13/02 , A61K9/70
CPC分类号： A61K9/7084 , A61F2013/0296
摘要： A method for making transdermal drug delivery devices is provided which includes: laminating an adsorbent source layer to a pressure-sensitive, pharmaceutically acceptable contact adhesive; depositing a drug in liquid form on one face of the source layer; laminating an anchor adhesive layer to the opposing face of the source layer; and applying a drug-impermeable backing layer to the anchor adhesive, which backing layer then defines the upper surface of the device. The invention also encompasses transdermal drug delivery devices having a source layer in contact with and contained between anchor and contact adhesive layers, with a backing layer adjacent the anchor adhesive defining the upper surface of the device.
摘要翻译：提供了一种制备透皮药物递送装置的方法，其包括：将吸附剂源层层压到压敏的药学上可接受的接触粘合剂上; 将液体形式的药物沉积在源层的一个面上; 将锚粘合剂层层压到源层的相对面; 以及将药物不可渗透的背衬层施加到所述锚定粘合剂上，所述背衬层然后限定所述装置的上表面。本发明还包括具有与锚定和接触粘合剂层接触并包含在锚定和接触粘合剂层之间的源层的透皮药物递送装置，邻近锚定粘合剂的背衬层限定了装置的上表面。

4. 发明授权

US6024976A Solubility parameter based drug delivery system and method for altering drug saturation concentration 失效
标题翻译：基于溶解度参数的药物递送系统和改变药物饱和浓度的方法
公开(公告)号：US6024976A
公开(公告)日：2000-02-15
申请号：US907906
申请日：1997-08-11
申请人： Jesus Miranda , Steven Sablotsky
发明人： Jesus Miranda , Steven Sablotsky
IPC分类号： A61F13/02 , A61K9/70 , A61K47/32 , A61L15/18 , A61L15/58
CPC分类号： A61K9/7053 , A61F13/0276 , A61K47/32 , A61K9/7061 , A61K9/7069 , A61L15/18 , A61L15/58 , A61L15/585 , B26F1/384
摘要： A blend of at least two polymers, or at least one polymer and a soluble polyvinylpyrrolidone, in combination with a drug provides a pressure-sensitive adhesive composition for a transdermal drug delivery system in which the drug is delivered from the pressure-sensitive adhesive composition and through dermis when the pressure-sensitive adhesive composition is in contact with human skin. According to the invention, soluble polyvinylpyrrolidone can be used to prevent crystallization of the drug, without affecting the rate of drug delivery from the pressure-sensitive adhesive composition.
摘要翻译：至少两种聚合物或至少一种聚合物和可溶性聚乙烯吡咯烷酮与药物组合的共混物提供用于透皮药物递送系统的压敏粘合剂组合物，其中药物从压敏粘合剂组合物递送，当压敏粘合剂组合物与人的皮肤接触时通过真皮。根据本发明，可以使用可溶性聚乙烯吡咯烷酮来防止药物结晶，而不影响从压敏粘合剂组合物中药物递送的速率。

5. 发明授权

US06235306B1 Solubility parameter based drug delivery system and method for altering drug saturation concentration 有权
标题翻译：基于溶解度参数的药物递送系统和改变药物饱和浓度的方法
公开(公告)号：US06235306B1
公开(公告)日：2001-05-22
申请号：US09274886
申请日：1999-03-23
申请人： Jesus Miranda , Steven Sablotsky
发明人： Jesus Miranda , Steven Sablotsky
IPC分类号： A61F1302
CPC分类号： A61K9/7053 , A61F13/0276 , A61F2013/00646 , A61K9/7061 , A61K9/7069 , A61L15/18 , A61L15/58 , A61L15/585 , B26F1/384 , C08L83/04 , C08L33/00 , C08L31/04
摘要： The method of adjusting the saturation concentration of a drug in a transdermal composition for application to the dermis, which comprises mixing polymers having differing solubility parameters, so as to modulate the delivery of the drug. This results in the ability to achieve a predetermined permeation rate of the drug into and through the dermis. In one embodiment, a dermal composition of the present invention comprises a drug, an acrylate polymer, and a polysiloxane. The dermal compositions can be produced by a variety of methods known in the preparation of drug-containing adhesive preparations, including the mixing of the polymers, drug, and additional ingredients in solution, followed by removal of the processing solvents. The method and composition of this invention permit selectable loading of the drug into the dermal formulation and adjustment of the delivery rate of the drug from the composition through the dermis, while maintaining acceptable shear, tack, and peel adhesive properties.
摘要翻译：调节用于真皮的透皮组合物中药物的饱和浓度的方法，其包括混合具有不同溶解度参数的聚合物，以便调节药物的递送。这导致能够实现药物进入真皮和通过真皮的预定渗透速率。在一个实施方案中，本发明的皮肤组合物包含药物，丙烯酸酯聚合物和聚硅氧烷。皮肤组合物可以通过制备含药物的粘合剂制剂中已知的各种方法制备，包括将聚合物，药物和另外的成分混合在溶液中，然后除去加工溶剂。本发明的方法和组合物允许药物可选择地装载到皮肤制剂中，并且通过真皮调节药物从组合物的输送速率，同时保持可接受的剪切，粘性和剥离粘合剂性质。

6. 发明授权

US5656286A Solubility parameter based drug delivery system and method for altering drug saturation concentration 失效
标题翻译：基于溶解度参数的药物递送系统和改变药物饱和浓度的方法
公开(公告)号：US5656286A
公开(公告)日：1997-08-12
申请号：US178558
申请日：1994-01-07
申请人： Jesus Miranda , Steven Sablotsky
发明人： Jesus Miranda , Steven Sablotsky
IPC分类号： A61F13/02 , A61K9/70 , A61K47/32 , A61L15/18 , A61L15/58
CPC分类号： A61K9/7053 , A61F13/0276 , A61K47/32 , A61K9/7061 , A61K9/7069 , A61L15/18 , A61L15/58 , A61L15/585 , B26F1/384
摘要： A blend of at least two polymers, or at least one polymer and a soluble polyvinylpyrrolidone, in combination with a drug provides a pressure-sensitive adhesive composition for a transdermal drug delivery system in which the drug is delivered from the pressure-sensitive adhesive composition and through dermis when the pressure-sensitive adhesive composition is in contact with human skin. According to the invention, soluble polyvinylpyrrolidone can be used to prevent crystallization of the drug, without affecting the rate of drug delivery from the pressure-sensitive adhesive composition.
摘要翻译：至少两种聚合物或至少一种聚合物和可溶性聚乙烯吡咯烷酮与药物组合的共混物提供用于透皮药物递送系统的压敏粘合剂组合物，其中药物从压敏粘合剂组合物递送，当压敏粘合剂组合物与人的皮肤接触时通过真皮。根据本发明，可以使用可溶性聚乙烯吡咯烷酮来防止药物结晶，而不影响从压敏粘合剂组合物中药物递送的速率。

7. 发明授权

US5474783A Solubility parameter based drug delivery system and method for altering drug saturation concentration 失效
标题翻译：基于溶解度参数的药物递送系统和改变药物饱和浓度的方法
公开(公告)号：US5474783A
公开(公告)日：1995-12-12
申请号：US722342
申请日：1991-06-27
申请人： Jesus Miranda , Steven Sablotsky
发明人： Jesus Miranda , Steven Sablotsky
IPC分类号： A61F13/02 , A61F13/00 , A61K9/70 , A61L15/00 , A61L15/16 , A61L15/18 , A61L15/26 , A61L15/58
CPC分类号： A61K9/7053 , A61F13/0276 , A61K9/7061 , A61K9/7069 , A61L15/18 , A61L15/58 , A61L15/585 , A61F2013/00646 , B26F1/384
摘要： The method of adjusting the saturation concentration of a drug in a transdermal composition for application to the dermis, which comprises mixing polymers having differing solubility parameters, so as to modulate the delivery of the drug. This results in the ability to achieve a predetermined permeation rate of the drug into and through the dermis. In one embodiment, a dermal composition of the present invention comprises a drug, an acrylate polymer, and a polysiloxane. The dermal compositions can be produced by a variety of methods known in the preparation of drug-containing adhesive preparations, including the mixing of the polymers, drug, and additional ingredients in solution, followed by removal of the processing solvents. The method and composition of this invention permit selectable loading of the drug into the dermal formulation and adjustment of the delivery rate of the drug from the composition through the dermis, while maintaining acceptable shear, tack, and peel adhesive properties.
摘要翻译：调节用于真皮的透皮组合物中药物的饱和浓度的方法，其包括混合具有不同溶解度参数的聚合物，以便调节药物的递送。这导致能够实现药物进入真皮和通过真皮的预定渗透速率。在一个实施方案中，本发明的皮肤组合物包含药物，丙烯酸酯聚合物和聚硅氧烷。皮肤组合物可以通过制备含药物的粘合剂制剂中已知的各种方法制备，包括将聚合物，药物和另外的成分混合在溶液中，然后除去加工溶剂。本发明的方法和组合物允许药物可选择地装载到皮肤制剂中，并且通过真皮调节药物从组合物的输送速率，同时保持可接受的剪切，粘性和剥离粘合剂性质。

8. 发明授权

US06974588B1 Transdermal patch for delivering volatile liquid drugs 失效
标题翻译：用于输送挥发性液体药物的透皮贴剂
公开(公告)号：US06974588B1
公开(公告)日：2005-12-13
申请号：US09456278
申请日：1999-12-07
申请人： Jesus Miranda , Charles J. Betlach, II
发明人： Jesus Miranda , Charles J. Betlach, II
IPC分类号： A61F13/00 , A61F13/02 , A61K9/70 , A61K31/167 , A61K31/465 , A61L15/16
CPC分类号： A61K9/7061 , A61K9/7069 , A61K9/7092 , A61K31/167 , A61K31/465 , A61K2300/00
摘要： A transdermal patch for administering a volatile liquid drug, such as nicotine, transdermally to a patient comprising a four-layer laminated composite of: a top drug impermeable backing layer; a pressure sensitive silicone adhesive layer containing the drug; a pressure sensitive acrylic adhesive layer also containing the drug; and a removable siliconized release liner layer. Also disclosed is a method for treating a person for nicotine dependence and particularly for treating a woman for nicotine dependence.
摘要翻译：一种经皮贴片，用于经皮给予患者的挥发性液体药物，例如尼古丁，包括四层层压复合物：顶部药物不可渗透背衬层; 含有药物的压敏硅胶粘合剂层; 还含有药物的压敏丙烯酸粘合剂层; 和可移除的硅化剥离衬垫层。还公开了一种治疗人的尼古丁依赖性，特别是治疗女性尼古丁依赖的方法。

9. 发明申请

US20180076758A1 Three-Dimensional Elongated Photovoltaic Cell Assemblies 审中-公开
公开(公告)号：US20180076758A1
公开(公告)日：2018-03-15
申请号：US15263094
申请日：2016-09-12
申请人： Jesus Miranda
发明人： Jesus Miranda
IPC分类号： H02S30/10 , H01L31/043 , H01L31/049 , H01L31/14 , H01L31/0203 , H02S40/22 , H02S40/34 , H02S40/32 , H02S40/38
CPC分类号： H02S30/10 , H01L31/042 , H02S20/10 , H02S40/36 , Y02E10/52
摘要： Three-dimensional photovoltaic assemblies capable of greater electric power output and more consistent power profiles than flat photovoltaic systems of the prior art with the same footprint are disclosed. The assemblies are comprised of a plurality of elongated photovoltaic modules arranged to project radially outward from a central trunk. In some embodiments, elongated photovoltaic modules comprise an elongated prismatic body having a multi-sided polygonal cross-section, wherein the lateral sides of the elongated body define non-parallel rectangular panels and photovoltaic cells are mounted on at least two of the lateral sides or panels of the elongated body. The photovoltaic cells on the plurality of elongated photovoltaic modules can be exposed to the radiant energy of the sun at a plurality of angles of incidence at any given point in time of day.

10. 发明授权

US06221383B1 Solubility parameter based drug delivery system and method for altering drug saturation concentration 有权
标题翻译：基于溶解度参数的药物递送系统和改变药物饱和浓度的方法
公开(公告)号：US06221383B1
公开(公告)日：2001-04-24
申请号：US09318121
申请日：1999-05-25
申请人： Jesus Miranda , Steven Sablotsky
发明人： Jesus Miranda , Steven Sablotsky
IPC分类号： A61F1302
CPC分类号： A61K9/7053 , A61F13/0276 , A61K9/7061 , A61K9/7069 , A61K47/32 , A61L15/18 , A61L15/58 , A61L15/585 , B26F1/384 , C08L33/00 , C08L31/04
摘要： A blend of at least two polymers, or at least one polymer and a soluble polyvinylpyrrolidone, in combination with a drug provides a pressure-sensitive adhesive composition for a transdermal drug delivery system in which the drug is delivered from the pressure-sensitive adhesive composition and through dermis when the pressure-sensitive adhesive composition is in contact with human skin. According to the invention, soluble polyvinylpyrrolidone can be used to prevent crystallization of the drug, without affecting the rate of drug delivery from the pressure-sensitive adhesive composition.
摘要翻译：至少两种聚合物或至少一种聚合物和可溶性聚乙烯吡咯烷酮与药物组合的共混物提供用于透皮药物递送系统的压敏粘合剂组合物，其中药物从压敏粘合剂组合物递送，当压敏粘合剂组合物与人的皮肤接触时通过真皮。根据本发明，可以使用可溶性聚乙烯吡咯烷酮来防止药物结晶，而不影响从压敏粘合剂组合物中药物递送的速率。

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