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    • 3. 发明申请
    • Apparatus and method for enhanced hemodialysis performance
    • 增强血液透析性能的装置和方法
    • US20070119781A1
    • 2007-05-31
    • US11540705
    • 2006-10-02
    • Zhongping HuangWilliam Van Geertruyden
    • Zhongping HuangWilliam Van Geertruyden
    • B01D61/00
    • B01D71/024A61M1/16A61M1/1627B01D63/02B01D63/021B01D63/06B01D63/061B01D67/0065B01D2313/08B01D2313/086B01D2323/08
    • A dialyzer module utilizing a nano-porous ceramic membrane for enhanced hemodialysis performance, and a method for manufacturing the same, are provided. The dialyzer module may be utilized in an extracorporeal blood circuit together with pumps, monitors, and/or other components used for dialysis therapy. The one or more nano-porous ceramic tubes that serve as the hemodialysis membrane may comprise aluminum oxide (alumina) or titanium oxide (titania) tubes manufactured by the anodization of aluminum (Al) or titanium (Ti) tubes in an appropriate acid solution. The nano-porous ceramic tubes may be produced with a nano-porous wall structure having an average pore diameter of approximately five to ten nanometers (run). The nano-porous ceramic tubes exhibit a uniform pore size, uniform pore distribution, high porosity, and high hydraulic conductivity, enabling the removal of more middle and large molecular weight solutes to achieve a performance more comparable to that of an actual kidney while, at the same time, reducing the undesirable loss of important macromolecules such as albumin.
    • 提供一种利用纳米多孔陶瓷膜提高血液透析性能的透析器组件及其制造方法。 透析器模块可以与用于透析治疗的泵,监视器和/或其他部件一起用于体外血液回路中。 用作血液透析膜的一个或多个纳米多孔陶瓷管可以包括通过在合适的酸溶液中阳极氧化铝(Al)或钛(Ti)管而制造的氧化铝(氧化铝)或氧化钛(二氧化钛)管。 纳米多孔陶瓷管可以用具有大约5至10纳米(运行)的平均孔径的纳米多孔壁结构制备。 纳米多孔陶瓷管显示均匀的孔径,均匀的孔分布,高孔隙率和高水力传导性,能够除去更多的中等和大分子量溶质,以达到与实际肾脏相当的性能,而在 同时减少重要大分子如白蛋白的不良损失。