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1. 发明申请

US20090286860A1 Method of using adenoviral vectors to induce an immune response 审中-公开
标题翻译：使用腺病毒载体诱导免疫应答的方法
公开(公告)号：US20090286860A1
公开(公告)日：2009-11-19
申请号：US12477712
申请日：2009-06-03
申请人： Gary J. Nabel , Cheng Cheng , Wing-Pui Kong , Jason G. D. Gall , C. Richter King
发明人： Gary J. Nabel , Cheng Cheng , Wing-Pui Kong , Jason G. D. Gall , C. Richter King
IPC分类号： A61K31/711 , A61P37/02
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/57 , C12N7/00 , C12N15/86 , C12N2710/10343 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234
摘要： The invention provides a method of inducing an immune response against a human immunodeficiency virus (HIV) in a mammal. The method comprises administering to the mammal an adenoviral vector composition comprising one or more adenoviral vectors encoding two or more different HIV antigens, the production of which induces an immune response against HIV in the mammal. The invention also provides an adenoviral vector composition comprising four adenoviral vectors encoding an HIV clade A Env protein, an HIV clade B Env protein, an V clade C Env protein, and a fusion protein comprising an HIV clade B Gag protein and Pol protein, respectively.
摘要翻译：本发明提供一种在哺乳动物中诱导针对人类免疫缺陷病毒（HIV）的免疫应答的方法。该方法包括向哺乳动物施用腺病毒载体组合物，其包含编码两种或更多种不同HIV抗原的一种或多种腺病毒载体，其产生在哺乳动物中诱导针对HIV的免疫应答。本发明还提供一种腺病毒载体组合物，其包含分别编码HIV进化枝A Env蛋白，HIV进化枝B Env蛋白，V进化枝C Env蛋白和包含HIV进化枝B Gag蛋白和Pol蛋白的融合蛋白的四种腺病毒载体。

2. 发明授权

US08323961B2 HIV vaccines based on adenoviral vectors encoding Env from multiple clades of HIV 失效
标题翻译：基于编码Env的腺病毒载体的HIV疫苗来自HIV的多个进化枝
公开(公告)号：US08323961B2
公开(公告)日：2012-12-04
申请号：US13086884
申请日：2011-04-14
申请人： Gary J. Nabel , Bimal Chakrabarti , Wing-Pui Kong , Yue Huang , Zengguang Wang, legal representative , Zhi-Yong Yang , Jason G. D. Gall , C. Richter King
发明人： Gary J. Nabel , Bimal Chakrabarti , Wing-Pui Kong , Yue Huang , Zhi-Yong Yang , Jason G. D. Gall , C. Richter King
IPC分类号： C12N15/63 , A61K39/21
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N2710/10343 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234
摘要： The invention provides a composition comprising four adenoviral vectors, each comprising a nucleic acid sequence encoding a clade A HIV Env protein, a clade B HIV Env protein, a clade C HIV Env protein, and a clade B HIV Gag-Pol fusion protein, respectively. The invention also provides a method of inducing an immune response against HIV-1 in an animal comprising administering the composition to the animal.
摘要翻译：本发明提供包含四种腺病毒载体的组合物，每种腺病毒载体分别包含编码进化枝A HIV Env蛋白，进化枝B HIV Env蛋白，进化枝C HIV Env蛋白和进化枝B HIV Gag-Pol融合蛋白的核酸序列。本发明还提供了一种在动物中诱导针对HIV-1的免疫应答的方法，其包括向所述动物施用所述组合物。

3. 发明授权

US08454972B2 Method for inducing a multiclade immune response against HIV utilizing a multigene and multiclade immunogen 失效
标题翻译：使用多基因和多重免疫原诱导针对HIV的多重免疫应答的方法
公开(公告)号：US08454972B2
公开(公告)日：2013-06-04
申请号：US13010141
申请日：2011-01-20
申请人： Gary J. Nabel , Ling Xu , Bimal Chakrabarti , Lan Wu , Zhi-yong Yang , Jason G. D. Gall , C. Richter King , Zengguang Wang
发明人： Gary J. Nabel , Yue Huang , Ling Xu , Bimal Chakrabarti , Lan Wu , Zhi-yong Yang , Jason G. D. Gall , C. Richter King
IPC分类号： A61K39/21 , A61K39/295 , C07H21/04
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/57 , A61K2039/70 , C07K14/005 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12N2740/16222 , C12N2740/16234 , C12N2740/16271 , C12N2740/16322 , C12N2740/16334 , C12N2740/16371
摘要： The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided.
摘要翻译：本公开提供了针对人类免疫缺陷病毒引发免疫应答（包括预防性免疫应答）的组合物。该组合物包括编码多个进化枝或菌株的HIV抗原多肽的核酸构建体。还提供了通过将受试者施用组合物引起免疫应答的方法。

4. 发明申请

US20080233650A1 Method for propagating adenoviral vectors encoding inhibitory gene products 审中-公开
标题翻译：繁殖编码抑制性基因产物的腺病毒载体的方法
公开(公告)号：US20080233650A1
公开(公告)日：2008-09-25
申请号：US12118008
申请日：2008-05-09
申请人： Jason G. D. Gall , Douglas E. Brough , C. Richter King
发明人： Jason G. D. Gall , Douglas E. Brough , C. Richter King
IPC分类号： C12N15/87 , C12N5/06
CPC分类号： C12N15/635 , C12N7/00 , C12N15/86 , C12N2710/10343 , C12N2710/10352 , C12N2830/006
摘要： The invention provides a method of propagating an adenoviral vector. The method comprises (a) providing a cell comprising a cellular genome comprising a nucleic acid sequence encoding a tetracycline operon repressor protein (tetR), and (b) contacting the cell with an adenoviral vector comprising a heterologous nucleic acid sequence encoding a toxic protein. The heterologous nucleic acid sequence is operably linked to a promoter and one or more tetracycline operon operator sequences (tetO), and expression of the heterologous nucleic acid sequence is inhibited in the presence of tetR, such that the adenoviral vector is propagated. The invention also provides a system comprising the aforementioned cell and adenoviral vector.
摘要翻译：本发明提供了一种繁殖腺病毒载体的方法。该方法包括（a）提供包含细胞基因组的细胞，所述细胞基因组包含编码四环素操纵子阻遏蛋白（tetR）的核酸序列，和（b）使细胞与包含编码毒性蛋白质的异源核酸序列的腺病毒载体接触。异源核酸序列可操作地连接到启动子和一个或多个四环素操纵子操纵子序列（tetO），并且异源核酸序列的表达在tetR存在下被抑制，使得腺病毒载体被繁殖。本发明还提供了包含上述细胞和腺病毒载体的系统。

5. 发明授权

US06682929B2 Adenovector complementing cells 有权
标题翻译： Adenovector补体细胞
公开(公告)号：US06682929B2
公开(公告)日：2004-01-27
申请号：US09910828
申请日：2001-07-23
申请人： Douglas E. Brough , Jason G. D. Gall , Imre Kovesdi
发明人： Douglas E. Brough , Jason G. D. Gall , Imre Kovesdi
IPC分类号： C12N510
CPC分类号： C12N15/86 , C12N7/00 , C12N2710/10343 , C12N2710/10352
摘要： The invention provides cells, particularly NCI-H460 cells and Calu-1 cells, for the propagation of replication-deficient adenoviral vectors. The cells are lung carcinomas with either a wild-type p53 gene or a heterozygous K-ras mutation. The cells comprise at least one adenoviral nucleic acid sequence, which upon expression produces a gene product that complements for at least one essential gene function of one or more regions of an adenoviral genome so as to propagate a replication-deficient adenoviral vector comprising an adenoviral genome deficient in the at least one essential gene function of the one or more regions when present in the cell.
摘要翻译：本发明提供用于增殖复制缺陷型腺病毒载体的细胞，特别是NCI-H460细胞和Calu-1细胞。细胞是具有野生型p53基因或杂合K-ras突变的肺癌。细胞包含至少一种腺病毒核酸序列，其在表达时产生补充腺病毒基因组的一个或多个区域的至少一个必需基因功能的基因产物，以便繁殖包含腺病毒基因组的复制缺陷型腺病毒载体当存在于细胞中时，一个或多个区域的至少一个必需基因功能缺陷。

6. 发明授权

US06913927B2 Non-adenoviral gene product-based complementing cells for adenoviral vectors 失效
标题翻译：用于腺病毒载体的非腺病毒基因产物互补细胞
公开(公告)号：US06913927B2
公开(公告)日：2005-07-05
申请号：US10695605
申请日：2003-10-28
申请人： Douglas E. Brough , Jason G. D. Gall , Imre Kovesdi
发明人： Douglas E. Brough , Jason G. D. Gall , Imre Kovesdi
IPC分类号： C12N5/08 , C12N5/10 , C12N7/00 , C12N7/01 , C12N7/02 , C12N15/63 , C12N15/64 , C12N15/861
CPC分类号： C12N7/00 , C12N2710/10051 , C12N2710/10052 , C12N2710/10351 , C12N2710/10352
摘要： The invention provides cells and methods of using the cells for the propagation of replication-deficient adenoviral vectors. The cells comprise at least one heterologous nucleic acid sequence which upon expression produces at least one non-adenoviral gene product that complements in trans for a deficiency in at least one essential gene function of one or more regions of an adenoviral genome so as to propagate a replication-deficient adenoviral vector comprising an adenoviral genome deficient in the at least one essential gene function of the one or more regions when present in the cell.
摘要翻译：本发明提供了细胞和使用细胞促进复制缺陷型腺病毒载体的方法。所述细胞包含至少一种异源核酸序列，其在表达时产生至少一种非腺病毒基因产物，所述非腺病毒基因产物在腺病毒基因组的一个或多个区域的至少一个必需基因功能缺陷中互补互补，从而传播复制缺陷型腺病毒载体，其包含存在于细胞中时所述一个或多个区域的至少一个必需基因功能缺陷的腺病毒基因组。

7. 发明授权

US06677156B2 Non-adenoviral gene product-based complementing cells for adenoviral vectors 有权
公开(公告)号：US06677156B2
公开(公告)日：2004-01-13
申请号：US09911011
申请日：2001-07-23
申请人： Douglas E. Brough , Jason G. D. Gall , Imre Kovesdi
发明人： Douglas E. Brough , Jason G. D. Gall , Imre Kovesdi
IPC分类号： C12N510
CPC分类号： C12N7/00 , C12N2710/10051 , C12N2710/10052 , C12N2710/10351 , C12N2710/10352
摘要： The invention provides cells and methods of using the cells for the propagation of replication-deficient adenoviral vectors. The cells comprise at least one heterologous nucleic acid sequence which upon expression produces at least one non-adenoviral gene product that complements in trans for a deficiency in at least one essential gene function of one or more regions of an adenoviral genome so as to propagate a replication-deficient adenoviral vector comprising an adenoviral genome deficient in the at least one essential gene function of the one or more regions when present in the cell.

8. 发明授权

US07261885B2 Adenoviral vector with replication-dependent transgene expression 有权
标题翻译：具有复制依赖性转基因表达的腺病毒载体
公开(公告)号：US07261885B2
公开(公告)日：2007-08-28
申请号：US10911957
申请日：2004-08-05
申请人： Erik S. Falck-Pedersen , Jason G. D. Gall
发明人： Erik S. Falck-Pedersen , Jason G. D. Gall
IPC分类号： A61K48/00 , C12N15/861
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/10343 , C12N2840/44
摘要： The invention provides an adenoviral vector comprising (a) at least a portion of an adenoviral genome comprising a major late transcription unit containing a terminal exon, wherein the terminal exon comprises a 5′ splice acceptor DNA sequence element and a 3′ polyadenylation signal sequence, and (b) a non-native nucleic acid sequence encoding a protein that does not contribute to the adenoviral vector entry into a host cell, wherein the non-native nucleic acid sequence is positioned within the terminal exon, such that the non-native nucleic acid sequence is selectively expressed in cells within which the adenoviral vector can replicate. The invention further provides an adenoviral vector composition and a method for treating or preventing a pathologic state in a mammal, comprising administering to the mammal the adenoviral vector composition of the invention in an amount sufficient to treat or prevent the pathologic state in the mammal.
摘要翻译：本发明提供了一种腺病毒载体，其包含（a）至少一部分腺病毒基因组，其包含含有末端外显子的主要晚期转录单位，其中所述末端外显子包含5'剪接受体DNA序列元件和3'多腺苷酸化信号序列，和（b）编码不对腺病毒载体进入宿主细胞有贡献的蛋白质的非天然核酸序列，其中非天然核酸序列位于末端外显子内，使得非天然核酸酸序列在腺病毒载体可以复制的细胞中选择性表达。本发明进一步提供了一种用于治疗或预防哺乳动物病理状态的腺病毒载体组合物和方法，其包括以足以治疗或预防哺乳动物病理状态的量向哺乳动物施用本发明的腺病毒载体组合物。

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