专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06380408B1 Non-calcemic, antiproliferative, transcriptionally active sulfur-containing analogs of 1&agr;, 25-dihydroxy vitamin D3 有权
标题翻译： 1α，25-二羟维生素D3的非钙，抗增殖，转录活性含硫类似物
公开(公告)号：US06380408B1
公开(公告)日：2002-04-30
申请号：US09541060
申请日：2000-03-31
申请人： Gary H. Posner , Jae-Kyoo Lee , Qiang Wang , Kenneth R. Crawford , Gyoonhee Han
发明人： Gary H. Posner , Jae-Kyoo Lee , Qiang Wang , Kenneth R. Crawford , Gyoonhee Han
IPC分类号： C07C40100
CPC分类号： C07C401/00
摘要： Novel sulfur-containing analogs of 1&agr;,25-dihydroxy vitamin D3 are provided. These analogs are synthesized in a convergent manner by joining A-ring and C,D ring fragments. Each analog with 1&agr;,3&bgr;-substituent stereochemistry shows a pharmacologically desirable combination of high antiproliferative and high transcriptional activities in vitro and also low calcemic activity in vivo.
摘要翻译：提供了1α，25-二羟基维生素D3的新型含硫类似物。这些类似物通过连接A环和C，D环片段以收敛方式合成。每个具有1alpha，3beta取代基立体化学的类似物都显示体外高抗增殖和高转录活性以及体内低钙活性的药理学上希望的组合。

2. 发明授权

US08106035B2 25-SO2-substituted analogs of 1μ,25-dihydroxyvitamin D3 有权
标题翻译： 25-SO 2取代的1μ，25-二羟基维生素D3的类似物
公开(公告)号：US08106035B2
公开(公告)日：2012-01-31
申请号：US10738248
申请日：2003-12-18
申请人： Gary H. Posner , Jae Kyoo Lee , Qiang Wang , Kenneth R. Crawford , Hong Woon Yang , Steven M. Silverman , Byung-Chul Suh , Jay A. White , Glenville Jones , Uttam Saha , Heung Bae Jeon
发明人： Gary H. Posner , Jae Kyoo Lee , Qiang Wang , Kenneth R. Crawford , Hong Woon Yang , Steven M. Silverman , Byung-Chul Suh , Jay A. White , Glenville Jones , Uttam Saha , Heung Bae Jeon
IPC分类号： A61K31/59 , C07C401/00
CPC分类号： C07C401/00 , C07B2200/07 , C07C2601/02 , C07C2601/04
摘要： The present invention provides novel D-ring and side-chain analogs of 1α,25-dihydroxyvitamin D3, compositions comprising these compounds and methods of using these compounds as selective inhibitors of CYP24. In particular, the compounds of the invention are useful for treating diseases which benefit from a modulation of the levels of 1α,25-dihydroxyvitamin D3, for example, cell-proliferative disorders.
摘要翻译：本发明提供了1α，25-二羟基维生素D 3的新型D环和侧链类似物，包含这些化合物的组合物和使用这些化合物作为CYP24选择性抑制剂的方法。特别地，本发明的化合物可用于治疗受益于1α，25-二羟基维生素D 3水平的调节的疾病，例如细胞增殖性疾病。

3. 发明授权

US6043386A Non-calcemic, antiproliferative, transcriptionally active 24-fluorinated hybrid analogs of 1.alpha.,-25-dihydroxy vitamin D.sub.3 有权
标题翻译： 1α，-25-二羟维生素D3的非钙血症，抗增殖，转录活性的24-氟化杂合类似物
公开(公告)号：US6043386A
公开(公告)日：2000-03-28
申请号：US323106
申请日：1999-06-01
申请人： Gary H. Posner , Jae Kyoo Lee , Qiang Wang
发明人： Gary H. Posner , Jae Kyoo Lee , Qiang Wang
IPC分类号： A61K31/59 , C07C401/00
CPC分类号： A61K31/59
摘要： Fluorinated analogs of 1.alpha.,25-dihydroxyvitamin D.sub.3. These analogs are synthesized in a convergent manner by joining A-ring and C,D-ring fragments. Each hybrid analog, having a calcemia-lowering 1-hydroxymethyl group and a potentiating 16-ene-24,24-difluorinated C,D-ring and side chain, is designed to be lipophilic and inert toward 24-hydroxylase enzyme catabolism. Each hybrid analog with 1.beta.,3.alpha.-substituent stereochemistry shows a pharmacologically desirable combination of high antiproliferative and high transcriptional activities in vitro and also low calcemic activity in vivo.
摘要翻译： 1α，25-二羟基维生素D3的氟化类似物。这些类似物通过连接A环和C，D环片段以收敛方式合成。具有降钙素1-羟甲基和增强的16-烯-2,24,24-二氟化C，D-环和侧链的每种杂合类似物被设计为亲脂性并且对24-羟化酶分解代谢是惰性的。具有1β，3α-取代立体化学的每种杂合类似物在体外显示高度抗增殖和高转录活性的药理学上期望的组合，并且还体内低钙活性。

4. 外观设计

USD1047900S1 Charging socket 有权
公开(公告)号：USD1047900S1
公开(公告)日：2024-10-22
申请号：US29954540
申请日：2024-07-26
申请人： Qiang Wang
设计人： Qiang Wang
摘要： FIG. 1 is a perspective view of a charging socket showing the new design;
FIG. 2 is another perspective view thereof;
FIG. 3 is a front elevation view thereof;
FIG. 4 is a back elevation view thereof;
FIG. 5 is a left-side elevation view thereof;
FIG. 6 is a right-side elevation view thereof;
FIG. 7 is a top plan view thereof; and
FIG. 8 is a bottom plan view thereof.
FIG. 9 is an enlarged partial view of area ‘9’ in FIG. 1.
FIG. 10 is an enlarged partial view of area ‘10’ in FIG. 2; and,
FIG. 11 is an enlarged partial view of area ‘11’ in FIG. 2.
The dash-dash broken lines in the drawings illustrate portions of the charging socket that form no part of the claimed design. The dash-dot broken lines illustrate the boundaries of the portions shown enlarged and form no part of the claimed design.

5. 外观设计

USD962692S1 Chair back 有权
公开(公告)号：USD962692S1
公开(公告)日：2022-09-06
申请号：US29790419
申请日：2021-11-25
申请人： Qiang Wang
设计人： Qiang Wang

6. 外观设计

USD935465S1 Docking unit for computer 有权
公开(公告)号：USD935465S1
公开(公告)日：2021-11-09
申请号：US29714765
申请日：2019-11-26
申请人： Qiang Wang
设计人： Qiang Wang

7. 发明申请

US20210303819A1 FAST SIGNATURE SCAN 有权
公开(公告)号：US20210303819A1
公开(公告)日：2021-09-30
申请号：US17343694
申请日：2021-06-09
申请人： Qiang Wang
发明人： Qiang Wang
IPC分类号： G06K9/00 , G06F16/28 , G06F16/903 , G06F21/56 , G06K9/62 , H04L29/06
摘要： Systems and methods for scanning signatures in a string field. In one implementation, the invention provides a method for signature scanning. The method includes receiving a particular string field, scanning the particular string field for a plurality of signatures using a larger scan step size, scanning the particular string field for the remaining signatures that are shorter than what can be scanned by the larger scan step size separately either using the same scanning method but a smaller scan step size or using a different scan method and the same or a smaller scan step size, and outputting any identified signatures in the particular string field.

8. 发明申请

US20210196211A9 METHODS AND APPARATUS FOR IMPROVING THE IMAGE RESOLUTION AND SENSITIVITY OF WHOLE-BODY POSITRON EMISSION TOMOGRAPHY (PET) IMAGING 有权
公开(公告)号：US20210196211A9
公开(公告)日：2021-07-01
申请号：US16697722
申请日：2019-11-27
申请人： Yuan-Chuan Tai , Joseph O'Sullivan , Ke Li , Qiang Wang
发明人： Yuan-Chuan Tai , Joseph O'Sullivan , Ke Li , Qiang Wang
IPC分类号： A61B6/03 , G01T1/29 , A61B6/00
摘要： A positron emission tomography (PET) technique that can enhance the image resolution and system sensitivity of a clinical PET/CT scanner for imaging a whole body or a target region of a subject is provided. The system includes a detector array and a detector panel. The detector array includes an array of gamma ray detectors defining a field of view of a scanner and configured to detect at least one coincidence event. The detector panel includes an array of gamma ray detectors having a higher intrinsic spatial resolution than the detector array and positioned in closer proximity to a patient table than the detector array. The detector panel is positioned outside the field of view defined by the detector array during at least a portion of scanning by the PET system. The detector panel is configured to detect at least one coincidence event in cooperation with the detector array. The control unit is configured to control the detector array, the detector panel, and the patient bed to operate in cooperation with each other.

9. 发明申请

US20210049339A1 FAST SIGNATURE SCAN 有权
公开(公告)号：US20210049339A1
公开(公告)日：2021-02-18
申请号：US17086960
申请日：2020-11-02
申请人： Qiang Wang
发明人： Qiang Wang
IPC分类号： G06K9/00 , G06F16/28 , G06F16/903 , G06F21/56 , G06K9/62 , H04L29/06
摘要： Systems and methods for scanning signatures in a string field. In one implementation, the invention provides a method for signature scanning. The method includes receiving a particular string field, scanning the particular string field for a plurality of signatures using a larger scan step size, scanning the particular string field for the remaining signatures that are shorter than what can be scanned by the larger scan step size separately either using the same scanning method but a smaller scan step size or using a different scan method and the same or a smaller scan step size, and outputting any identified signatures in the particular string field.

10. 外观设计

USD893174S1 Sports waist pack 有权
公开(公告)号：USD893174S1
公开(公告)日：2020-08-18
申请号：US29682834
申请日：2019-03-08
申请人： Qiang Wang
设计人： Qiang Wang
摘要： FIG. 1 is a front and side perspective view of a sports waist pack showing my design.
FIG. 2 is a rear and side perspective view thereof.
FIG. 3 is a front elevation view thereof.
FIG. 4 is a rear elevation view thereof.
FIG. 5 is a left side elevation view thereof.
FIG. 6 is a right side elevation view thereof.
FIG. 7 is a top plan view thereof.
FIG. 8 is a bottom plan view thereof; and,
FIG. 9 is an enlarged view of a circle labeled 9 in FIG. 7 of the sports waist pack.
The broken lines are for environmental structure, boundaries, or illustrative purposes only and form no part of the claimed designs to be patented.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式