专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06082364A Pluripotential bone marrow cell line and methods of using the same 失效
标题翻译：多能骨髓细胞系及其使用方法
公开(公告)号：US06082364A
公开(公告)日：2000-07-04
申请号：US990746
申请日：1997-12-15
申请人： Gary Balian , Gwo-Jaw Wang , David Diduch , Chang Hahn
发明人： Gary Balian , Gwo-Jaw Wang , David Diduch , Chang Hahn
IPC分类号： A61F2/28 , A61F2/30 , A61K35/12 , A61K38/00 , A61K48/00 , A61L27/38 , C12N5/077 , C12N5/0775 , A61B19/00
CPC分类号： A61L27/3821 , A61L27/3804 , A61L27/3817 , A61L27/3847 , A61L27/3852 , C12N5/0663 , A61F2/30756 , A61F2002/2817 , A61F2002/30677 , A61K2035/124 , A61K38/00 , A61K48/00 , C12N2501/39 , C12N2510/00
摘要： Pluripotent stem-like cells obtained from bone marrow differentiate into osteocytes, chondrocytes and adipocytes, depending on the environment encountered and treatment. If systemically administered, the cells "home", that is migrate, to bone marrow. The cells may be transformed with recombinant DNA for the expression of both reporter genes, and biological factors, such as growth factors. The cells may be systemically administered to treat osteoporosis, osteolysis, improve bone implant adherence, augment bone growth or bone repair, augment cartilage repair, augment fat production for, e.g., breast augmentation, and the like.
摘要翻译：从骨髓获得的多能干细胞样细胞分化为骨细胞，软骨细胞和脂肪细胞，这取决于遇到的环境和治疗。如果系统地施用，细胞“回家”，即迁移到骨髓。可以用重组DNA转化细胞以表达两种报告基因，以及生物因子，如生长因子。可以将细胞全身施用以治疗骨质疏松症，骨质溶解，改善骨植入物粘附，增加骨生长或骨修复，增强软骨修复，增加例如隆胸等的脂肪产生。

2. 发明申请

US20050221284A1 Heteropolymer complexes and methods for their use 审中-公开
标题翻译：杂聚物复合物及其使用方法
公开(公告)号：US20050221284A1
公开(公告)日：2005-10-06
申请号：US10484374
申请日：2002-07-17
申请人： Ronald Taylor , Maria Craig , Chang Hahn
发明人： Ronald Taylor , Maria Craig , Chang Hahn
IPC分类号： A61K39/00 , A61K39/395 , A61K47/48 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/02 , A61P35/00 , C07K1/113 , C07K16/08 , C07K16/10 , C07K16/12 , C07K16/28 , C07K16/30 , C07K19/00 , C12P21/08 , C12Q1/70 , G01N33/569 , G01N33/86
CPC分类号： C07K16/2896 , A61K47/6851 , A61K2039/505 , C07K16/08 , C07K16/1081 , C07K16/12 , C07K16/1214 , C07K16/1232 , C07K2317/31 , C07K2317/52 , C07K2317/55 , G01N33/569 , G01N33/86 , G01N2333/4716 , Y02A50/386 , Y02A50/403 , Y02A50/53
摘要： The present invention relates to an improved heteropolymer complex. The improved heteropolymer complex comprises a first monoclonal antibody specific for a C3b-like receptor (known as complement receptor (CR1) or CD35 in primates and Factor H in other mammals, e.g., dog, mouse, rat, pig, rabbit) site chemically crosslinked (covalently linked) to a second monoclonal antibody, in which the isotype of at least the second monoclonal antibody is the isotype having the highest affinity for the Fc receptor, e.g., in humans, IgG1 or IgG3. The present invention also relates to methods for immune clearance of an antigen in a mammal via the C3b-like receptor comprising administering to said mammal an improved heteropolymer complex of the invention. The present invention also relates to methods for treating or preventing viral infection or microbial infection in a mammal comprising administering to said mammal an improved heteropolymer complex of the invention. The present invention also relates to methods for treating or preventing septic shock in a mammal comprising administering to said mammal an improved heteropolymer complex of the invention. The present invention also relates to methods for treating cancer in a mammal comprising administering to said mammal an improved heteropolymer complex of the invention. The present invention further relates to pharmaceutical compositions for the treatment or prevention of viral infection, microbial infection, septic shock, and cancer comprising an improved heteropolymer complex of the invention.
摘要翻译：本发明涉及一种改进的异源聚合物复合物。改进的杂合聚合物复合物包含对C3b样受体（称为补体受体（CR1））或灵长类动物中的CD35和其它哺乳动物（例如狗，小鼠，大鼠，猪，兔）中的因子H特异的第一单克隆抗体（共价连接）第二单克隆抗体，其中至少第二单克隆抗体的同种型是对Fc受体具有最高亲和力的同种型，例如在人IgG1或IgG3中。本发明还涉及通过C3b样受体免疫清除哺乳动物中抗原的方法，包括向所述哺乳动物施用改进的本发明的杂合聚合物复合物。本发明还涉及用于治疗或预防哺乳动物的病毒感染或微生物感染的方法，其包括向所述哺乳动物施用改进的本发明的杂合聚合物复合物。本发明还涉及用于治疗或预防哺乳动物感染性休克的方法，其包括向所述哺乳动物施用改进的本发明的杂合聚合物复合物。本发明还涉及用于治疗哺乳动物癌症的方法，包括向所述哺乳动物施用改进的本发明的杂合聚合物复合物。本发明还涉及用于治疗或预防病毒感染，微生物感染，败血性休克和包含本发明的改进的杂合聚合物复合物的癌症的药物组合物。

3. 发明申请

US20070166696A1 Adenovirus-transfected primary cells and methods of pathway mapping 审中-公开
标题翻译：腺病毒转染的原代细胞和途径作图方法
公开(公告)号：US20070166696A1
公开(公告)日：2007-07-19
申请号：US10595944
申请日：2004-12-01
申请人： Chang Hahn , Li Li
发明人： Chang Hahn , Li Li
IPC分类号： C12Q1/68 , C12Q1/00
CPC分类号： C12N15/86 , C12N7/00 , C12N2710/10343 , C12N2830/002
摘要： A primary cell culture is transfected with a vector comprising a reporter gene operatively linked to a cis-element. Expression of a candidate regulatory protein is induced in the cell culture and its effects on the cis-element are assayed.
摘要翻译：用包含可操作地连接到顺式元件的报告基因的载体转染原代细胞培养物。在细胞培养物中诱导候选调节蛋白的表达，并测定其对顺式元件的影响。

4. 发明授权

US07202073B2 Human analogs of murine deubiquitinating proteases 有权
标题翻译：鼠类泛素化蛋白酶的人类类似物
公开(公告)号：US07202073B2
公开(公告)日：2007-04-10
申请号：US10371905
申请日：2003-02-20
申请人： Chang Hahn , Hong Liu
发明人： Chang Hahn , Hong Liu
IPC分类号： C12N9/64
CPC分类号： C12N9/16 , A61K38/00
摘要： The present invention is directed to human analogs of murine hematopoetic-specific, cytokine-inducible deubiquinating proteases (“DUBs”) clustered on chromosomes 4 and 8 and their respective regulatory regions. The nucleotides or proteins encoded thereby my be used in assays to identify inhibitors of human DUBs.
摘要翻译：本发明涉及在染色体4和8上聚集的鼠造血特异性，细胞因子诱导性脱蛋白酶（“DUB”）及其各自调节区的人类类似物。由此编码的核苷酸或蛋白质可用于测定人类DUBs的抑制剂。

5. 发明申请

US20110301125A1 Method for Treating Macular Degeneration 审中-公开
标题翻译：治疗黄斑变性的方法
公开(公告)号：US20110301125A1
公开(公告)日：2011-12-08
申请号：US13140799
申请日：2009-12-18
申请人： Chang Hahn
发明人： Chang Hahn
IPC分类号： A61K31/675 , A61P37/02 , A61K31/506 , A61P27/02 , A61K31/4985 , A61K31/505
CPC分类号： A61K31/505 , Y02A50/395
摘要： Provided herein are novel and useful methods for preventing, treating, or ameliorating a macular degeneration such as dry macular degeneration, wet macular degeneration and age related macular degeneration in a patient.
摘要翻译：本文提供了用于预防，治疗或改善黄斑变性的新颖和有用的方法，例如患者的黄斑变性，湿性黄斑变性和年龄相关性黄斑变性。

6. 发明申请

US20070166297A1 HUMAN ANALOGS OF MURINE DEUBIQUITINATING PROTEASE 审中-公开
标题翻译：人类免疫蛋白质的人类模拟
公开(公告)号：US20070166297A1
公开(公告)日：2007-07-19
申请号：US11685860
申请日：2007-03-14
申请人： Chang Hahn , Hong Liu
发明人： Chang Hahn , Hong Liu
IPC分类号： A61K38/48 , C12Q1/68 , C12N9/64
CPC分类号： C12N9/16 , A61K38/00
摘要： The present invention is directed to human analogs of murine hematopoetic-specific, cytokine-inducible deubiquinating proteases (“DUBs”) clustered on chromosomes 4 and 8 and their respective regulatory regions. The nucleotides or proteins encoded thereby my be used in assays to identify inhibitors of human DUBs.
摘要翻译：本发明涉及在染色体4和8上聚集的鼠造血特异性，细胞因子诱导性脱蛋白酶（“DUB”）及其各自调节区的人类类似物。由此编码的核苷酸或蛋白质可用于测定人类DUBs的抑制剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式