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1. 发明申请

WO2004046319A2 BACTERIOPHAGE HAVING MODIFIED HOLIN AND USES THEREOF 审中-公开
标题翻译：具有改性肛门的细菌及其用途
公开(公告)号：WO2004046319A2
公开(公告)日：2004-06-03
申请号：PCT/US2003/036400
申请日：2003-11-14
申请人： GANGAGEN, INC. , RAMACHANDRAN, Janakiraman , PADMANABHAN, Sriram , SRIRAM, Bharathi
发明人： RAMACHANDRAN, Janakiraman , PADMANABHAN, Sriram , SRIRAM, Bharathi
IPC分类号： C12N
CPC分类号： C12N7/00 , A61K35/76 , C07K14/005 , C12N2795/10022 , C12N2795/10032 , C12N2795/10051 , Y02A50/475 , Y02A50/481
摘要： The present invention features composition and methods for treating a bacterial infection using therapeutic bacteriophage having a modified holin gene. The modified holin inactivates the bacterial host prior to production of bacteriophage, so that the bacteriophage infection is non-productive, e.g., few or no bacteriophage are produced as a result of infection of the bacterial host. Thus, holin-modified bacteriophage invade the bacterial host, and cause inactivation of the bacterial host prior to production of a detectable or significant number of phage. Holin-modified phage inhibit the spread of bacterial infection without production of a significant or detectable number of phage progeny. By avoiding the release of phage progeny, the potential for generation of immune responses against the phage is reduced.
摘要翻译：本发明的特征在于使用具有修饰的穴蛋白基因的治疗性噬菌体治疗细菌感染的组合物和方法。修饰的穴蛋白在产生噬菌体之前使细菌宿主失活，从而噬菌体感染是非生产性的，例如由于细菌宿主的感染而产生很少或不产生噬菌体。因此，穴蛋白修饰的噬菌体侵入细菌宿主，并在产生可检测或显着数量的噬菌体之前导致细菌宿主失活。 Holin修饰的噬菌体抑制细菌感染的扩散而不产生显着或可检测数量的噬菌体后代。通过避免噬菌体后代的释放，减少对噬菌体产生免疫应答的可能性。

2. 发明申请

WO2005046579A2 DEFINED DOSE THERAPEUTIC PHAGE 审中-公开
标题翻译：定义剂量治疗药
公开(公告)号：WO2005046579A2
公开(公告)日：2005-05-26
申请号：PCT/US2004/033224
申请日：2004-10-06
申请人： GANGAGEN, INC. , JAYASHEELA, M. , SRIRAM, Bharathi , PADMANABHAN, Sriram
发明人： JAYASHEELA, M. , SRIRAM, Bharathi , PADMANABHAN, Sriram
IPC分类号： A61K
CPC分类号： C12N7/00 , A61K35/76 , C12N15/1075 , C12N2795/00032 , C12N2795/00061
摘要： The invention provides therapeutic, defined-dose anti-bacterial phage preparations, methods to make such preparations, methods to treat bacterial infections using such preparations and methods to diagnose bacterial infections using such preparations.
摘要翻译：本发明提供治疗性定义剂量的抗细菌噬菌体制剂，制备这种制剂的方法，使用这种制剂治疗细菌感染的方法和使用这种制剂诊断细菌感染的方法。

3. 发明公开

EP1438066A1 INCAPACITATED WHOLE-CELL IMMUNOGENIC BACTERIAL COMPOSITIONS 有权
标题翻译：灭活免疫原性细菌全细胞组合物
公开(公告)号：EP1438066A1
公开(公告)日：2004-07-21
申请号：EP02763771.9
申请日：2002-09-27
申请人： Gangagen, Inc.
发明人： RAMACHANDRAN, Janakiraman , PADMANABHAN, Sriram , SRIRAM, Bharathi
IPC分类号： A61K39/00 , A61K39/02 , C12N1/00 , C12N1/20
CPC分类号： A61K39/092 , A61K2039/522 , A61K2039/523
摘要： The invention features incapacitated whole cell bacterial immunogenic compositions produced by infecting a bacterium with Lys minus bacteriophage, which are deficient in the lysin protein. Lys minus bacteriophage retain activity in infection of its appropriate bacterial host, destruction of the bacterial genome, and replication, which are sufficient to inhibit bacterial growth and replication. The resulting, Lys minus-infected bacterium is provided in a state of bacteriostasis, and is not capable of replicating further (e.g., is "incapacitated"). The incapacitated bacterium can then be used as to elicit an immune response for prophylactic and/or therapeutic purposes. The invention thus also features incapacitated bacteria formulated appropriately for use in immunogenic compositions for eliciting an immune response, e.g., for production of antibodies in a non-human host or in a whole cell bacterial vaccine.

4. 发明申请

WO2003026767A2 LYSIN-DEFICIENT BACTERIOPHAGES HAVING REDUCED IMMUNOGENICITY 审中-公开
标题翻译：赖氨酸缺陷性细菌的免疫原性降低
公开(公告)号：WO2003026767A2
公开(公告)日：2003-04-03
申请号：PCT/US2002/030846
申请日：2002-09-27
申请人： GANGAGEN, INC. , RAMACHANDRAN, Janakiraman , PADMANABHAN, Sriram , SRIRAM, Bharathi
发明人： RAMACHANDRAN, Janakiraman , PADMANABHAN, Sriram , SRIRAM, Bharathi
IPC分类号： A81K
CPC分类号： C12N7/00 , A61K35/76 , C12N2795/10111 , C12N2795/10132 , C12N2795/10161 , Y02A50/475
摘要： The present invention features therapeutic bacteriophage deficient in the lysin protein ("Lys minus" phage). Lys minus bacteriophage are incapable of facilitating efficient lysis of the bacterial host since the enzymatic activity of the lysin of the phage is needed for breaking down the peptidoglycan layer of the bacterial cell wall. Lys minus bacteriophage retain activity in invasion of its appropriate bacterial host, destruction of the bacterial genome, and replication, which are sufficient to inhibit bacterial growth and replication. Therefore, the therapeutic Lys minus phage stops the spread of infection by the bacterial pathogen without lysis of the bacterium. This approach is attractive as it also prevents the release of the phage progeny, thus reducing or eliminating the potential for generation of immune responses against the phage. The incapacitated bacterial pathogen is then removed by the normal defense systems such as phagocytes and macrophages.
摘要翻译：本发明的特征在于溶素蛋白中缺乏的治疗性噬菌体（“Lys minus”噬菌体）。 Lys减噬菌体不能促进细菌宿主的有效裂解，因为需要噬菌体溶素的酶活性来分解细菌细胞壁的肽聚糖层。 Lys减噬菌体在侵入其合适的细菌宿主，破坏细菌基因组和复制时保持活性，其足以抑制细菌生长和复制。因此，Lys minus噬菌体治疗剂可以在不裂解细菌的情况下阻止细菌病原体的感染扩散。这种方法是有吸引力的，因为它也阻止了噬菌体后代的释放，从而减少或消除了产生针对噬菌体的免疫应答的可能性。然后通过诸如吞噬细胞和巨噬细胞的正常防御系统去除无能力的细菌病原体。

5. 发明授权

EP1435788B1 LYSIN-DEFICIENT BACTERIOPHAGES HAVING REDUCED IMMUNOGENICITY 有权
标题翻译：免疫原性降低缺乏赖氨酸噬菌体
公开(公告)号：EP1435788B1
公开(公告)日：2015-10-21
申请号：EP02776032.1
申请日：2002-09-27
申请人： Gangagen, Inc.
发明人： RAMACHANDRAN, Janakiraman , PADMANABHAN, Sriram , SRIRAM, Bharathi
IPC分类号： A01N63/00 , C12N7/00 , C12Q1/70
CPC分类号： C12N7/00 , A61K35/76 , C12N2795/10111 , C12N2795/10132 , C12N2795/10161 , Y02A50/475
摘要： The present invention features therapeutic bacteriophage deficient in the lysin protein ("Lys minus" phage). Lys minus bacteriophage are incapable of facilitating efficient lysis of the bacterial host since the enzymatic activity of the lysin of the phage is needed for breaking down the peptidoglycan layer of the bacterial cell wall. Lys minus bacteriophage retain activity in invasion of its appropriate bacterial host, destruction of the bacterial genome, and replication, which are sufficient to inhibit bacterial growth and replication. Therefore, the therapeutic Lys minus phage stops the spread of infection by the bacterial pathogen without lysis of the bacterium. This approach is attractive as it also prevents the release of the phage progeny, thus reducing or eliminating the potential for generation of immune responses against the phage. The incapacitated bacterial pathogen is then removed by the normal defense systems such as phagocytes and macrophages.

6. 发明授权

EP1677834B1 DEFINED DOSE THERAPEUTIC PHAGE 有权
标题翻译：治疗剂量噬菌体具有确定
公开(公告)号：EP1677834B1
公开(公告)日：2014-01-08
申请号：EP04816914.8
申请日：2004-10-06
申请人： Gangagen, Inc.
发明人： JAYASHEELA, M. , SRIRAM, Bharathi , PADMANABHAN, Sriram
IPC分类号： A61K39/13
CPC分类号： C12N7/00 , A61K35/76 , C12N15/1075 , C12N2795/00032 , C12N2795/00061
摘要： The invention provides therapeutic, defined-dose anti-bacterial phage preparations, methods to make such preparations, methods to treat bacterial infections using such preparations and methods to diagnose bacterial infections using such preparations.

7. 发明授权

EP1438066B1 INCAPACITATED WHOLE-CELL IMMUNOGENIC BACTERIAL COMPOSITIONS 有权
标题翻译：灭活免疫原性细菌全细胞组合物
公开(公告)号：EP1438066B1
公开(公告)日：2007-02-21
申请号：EP02763771.9
申请日：2002-09-27
申请人： Gangagen, Inc.
发明人： RAMACHANDRAN, Janakiraman , PADMANABHAN, Sriram , SRIRAM, Bharathi
IPC分类号： A61K39/02
CPC分类号： A61K39/092 , A61K2039/522 , A61K2039/523
摘要： The invention features incapacitated whole cell bacterial immunogenic compositions produced by infecting a bacterium with Lys minus bacteriophage, which are deficient in the lysin protein. Lys minus bacteriophage retain activity in infection of its appropriate bacterial host, destruction of the bacterial genome, and replication, which are sufficient to inhibit bacterial growth and replication. The resulting, Lys minus-infected bacterium is provided in a state of bacteriostasis, and is not capable of replicating further (e.g., is "incapacitated"). The incapacitated bacterium can then be used as to elicit an immune response for prophylactic and/or therapeutic purposes. The invention thus also features incapacitated bacteria formulated appropriately for use in immunogenic compositions for eliciting an immune response, e.g., for production of antibodies in a non-human host or in a whole cell bacterial vaccine.

8. 发明公开

EP1677834A2 DEFINED DOSE THERAPEUTIC PHAGE 有权
标题翻译：治疗剂量噬菌体具有确定
公开(公告)号：EP1677834A2
公开(公告)日：2006-07-12
申请号：EP04816914.8
申请日：2004-10-06
申请人： Gangagen, Inc.
发明人： JAYASHEELA, M. , SRIRAM, Bharathi , PADMANABHAN, Sriram
IPC分类号： A61K48/00 , C12N7/00
CPC分类号： C12N7/00 , A61K35/76 , C12N15/1075 , C12N2795/00032 , C12N2795/00061
摘要： The invention provides therapeutic, defined-dose anti-bacterial phage preparations, methods to make such preparations, methods to treat bacterial infections using such preparations and methods to diagnose bacterial infections using such preparations.

9. 发明申请

WO2007130655A3 PHAGE DERIVED ANTIMICROBIAL ACTIVITIES 审中-公开
公开(公告)号：WO2007130655A3
公开(公告)日：2007-11-15
申请号：PCT/US2007/010972
申请日：2007-05-04
申请人： GANGAGEN, INC. , PADMANABHAN, Sriram , PAUL, Vivek Daniel , SARAVANAN, R. Sanjeev , SRIRAM, Bharathi
发明人： PADMANABHAN, Sriram , PAUL, Vivek Daniel , SARAVANAN, R. Sanjeev , SRIRAM, Bharathi
IPC分类号： A61K38/00 , C07K14/00
摘要： The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.

10. 发明申请

WO2003026690A1 INCAPACITATED WHOLE-CELL IMMUNOGENIC BACTERIAL COMPOSITIONS 审中-公开
标题翻译：全身细胞免疫细菌成分组成
公开(公告)号：WO2003026690A1
公开(公告)日：2003-04-03
申请号：PCT/US2002/030844
申请日：2002-09-27
申请人： GANGAGEN, INC. , RAMACHANDRAN, Janakiraman , PADMANABHAN, Sriram , SRIRAM, Bharathi
发明人： RAMACHANDRAN, Janakiraman , PADMANABHAN, Sriram , SRIRAM, Bharathi
IPC分类号： A61K39/00
CPC分类号： A61K39/092 , A61K2039/522 , A61K2039/523
摘要： The invention features incapacitated whole cell bacterial immunogenic compositions produced by infecting a bacterium with Lys minus bacteriophage, which are deficient in the lysin protein. Lys minus bacteriophage retain activity in infection of its appropriate bacterial host, destruction of the bacterial genome, and replication, which are sufficient to inhibit bacterial growth and replication. The resulting, Lys minus-infected bacterium is provided in a state of bacteriostasis, and is not capable of replicating further (e.g., is "incapacitated"). The incapacitated bacterium can then be used as to elicit an immune response for prophylactic and/or therapeutic purposes. The invention thus also features incapacitated bacteria formulated appropriately for use in immunogenic compositions for eliciting an immune response, e.g., for production of antibodies in a non-human host or in a whole cell bacterial vaccine.
摘要翻译：本发明的特征在于，通过用Lys减噬细菌感染细菌而产生的无细胞的全细胞免疫原性组合物，其缺乏赖氨酸蛋白质。 Lys减噬菌在其适当的细菌宿主感染中保留活性，破坏细菌基因组和复制，这足以抑制细菌生长和复制。所得到的Lys减感细菌以抑菌状态提供，并且不能进一步复制（例如，“丧失能力”）。然后可以使用失能能力的细菌来引发用于预防和/或治疗目的的免疫应答。因此，本发明还特征在于适用于免疫原性组合物中配制用于引发免疫应答的丧失能力的细菌，例如用于在非人宿主或全细胞细菌疫苗中产生抗体。

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