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1. 发明申请

US20130274209A1 SPRAYABLE PHARMACEUTICAL COMPOSITIONS FOR TOPICAL APPLICATION COMPRISING SUCRALFATE GEL 审中-公开
标题翻译：用于包含酸性凝胶的局部应用的可喷涂药物组合物
公开(公告)号：US20130274209A1
公开(公告)日：2013-10-17
申请号：US13996780
申请日：2011-12-21
申请人： Gaia Colombo , Paolo Colombo , Laura Gallina , Alessandra Scagliarini , Fabio Sonvico
发明人： Gaia Colombo , Paolo Colombo , Laura Gallina , Alessandra Scagliarini , Fabio Sonvico
IPC分类号： A61K47/32
CPC分类号： A61K47/32 , A61K31/7016 , A61L26/0014 , A61L26/0066 , A61L26/0076 , A61L26/008 , A61L2300/232 , C08L29/04
摘要： A pharmaceutical composition is described comprising sucralfate gel, PVA and optionally a vegetable product comprising tocotrienols and tocopherols. In particular, this composition proved to be suitable for being sprayed, and is advantageously used in the treatment of skin lesions, even deep lesions, such as second-degree burns.
摘要翻译：描述了包含硫糖铝凝胶，PVA和任选的包含生育三烯酚和生育酚的植物产品的药物组合物。特别地，该组合物被证明适合于喷雾，并且有利地用于治疗皮肤损伤，甚至深度损伤，例如二度烧伤。

2. 发明申请

US20100233276A1 COMPOSITIONS IN POWDER FORM MADE OF SOFT AGGLOMERATES OF A MICRONIZED DRUG AND OF A TWO-COMPONENTS EXCIPIENT, AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：一种微量药物和两种组分的软组合粉末形式的组合物及其制备方法
公开(公告)号：US20100233276A1
公开(公告)日：2010-09-16
申请号：US12734300
申请日：2007-10-26
申请人： Renata Raffin , Paolo Colombo , Fabio Sonvico , Gaia Colombo , Alessandra Rossi , Francesca Buttini
发明人： Renata Raffin , Paolo Colombo , Fabio Sonvico , Gaia Colombo , Alessandra Rossi , Francesca Buttini
IPC分类号： A61K9/14 , A61K9/50 , A61K9/58 , A61K9/60 , A61K9/62 , A61K9/64
CPC分类号： A61K9/1617 , A61K9/1623
摘要： The described agglomeration of drug microparticles blended with excipient microparticles is a technique for the size enlargement of micronized products that could be damaged by granulation or compaction techniques. These agglomerates can be used as oral prompt or delayed-release dosage forms administered as they are or dispersed in a liquid. The composition and quantity of the excipient microparticles resulted to be the crucial factors for the agglomerate quality. Therefore, adjusting the content of surface-active agent between 8-20%, of the excipient microparticles it is possible to agglomerate microparticles of drugs that could not be agglomerated per se. Increasing the surfactant concentration in the spray-dried excipient microparticles or increasing the fraction of these excipient microparticles in the blend, the agglomeration was improved. The spray drying technique concentrates the surface-active agent on the microparticle surface. By tumbling, the surface-active agent present on microparticles excipient surface was spread to fill the inter-particle interstices of drug particles giving rise to more resistant agglomerates. This phenomenon occurred also by vibration; the production in this case was quicker.
摘要翻译：与赋形剂微粒混合的药物微粒的所述团聚是用于通过造粒或压实技术损坏的微粉化产品的尺寸增大的技术。这些附聚物可以作为口服或缓释剂型使用，或者分散在液体中。赋形剂微粒的组成和数量是聚集质量的关键因素。因此，调整表面活性剂的含量在8〜20％之间，赋形剂微粒可能聚集本身不能团聚的药物微粒。增加喷雾干燥的赋形剂微粒中的表面活性剂浓度或增加共混物中这些赋形剂微粒的分数，聚集得到改善。喷雾干燥技术将表面活性剂浓缩在微粒表面上。通过翻滚，存在于微粒赋形剂表面上的表面活性剂被扩散以填充药物颗粒的颗粒间隙，从而产生更多的抗凝结物质。这种现象也是由振动引起的。在这种情况下的生产更快。

3. 发明申请

US20100074926A1 MODULES, NEW ASSEMBLAGE KITS AND NEW ASSEMBLES FOR THE CONTROLLED RELEASE OF SUBSTANCES 审中-公开
标题翻译：用于控制释放物质的模块，新组装工具和新组件
公开(公告)号：US20100074926A1
公开(公告)日：2010-03-25
申请号：US12312831
申请日：2006-12-05
申请人： Paolo Colombo , Patrizia Santi , Ruggero Bettini , Orazio Luca Strusi , Fabio Sonvico , Gaia Colombo
发明人： Paolo Colombo , Patrizia Santi , Ruggero Bettini , Orazio Luca Strusi , Fabio Sonvico , Gaia Colombo
IPC分类号： A61K9/00 , A61J3/10
CPC分类号： A61K9/2072 , A61K9/0065
摘要： A module which is destroyed in the presence of water solution, composed of a compressed powdery mixture, the said powdery mixture comprising a matrix building component, suitable to release an optionally included active substance into a surrounding aqueous liquid, and one or more tabletting aids chosen from the group consisting of lubricants, glidants, and anti-adherent agents, the said module being provided with particular male topological features allowing its connection to a corresponding female module, giving raise to an assembly that can be safely handled on industrial scale, wherein, in the composition of the male module, the percentage ratio between the tabletting aid and the matrix building component is comprised between 1:2.5 and 1:999. The module can be employed to convey pharmaceuticals, nutraceuticals, agrochemicals or other active principles to the intended site of action.
摘要翻译：在水溶液存在下被破坏的模块，由压缩的粉末混合物组成，所述粉末混合物包含基质构建组分，其适于将任选包含的活性物质释放到周围的水性液体中，并且选择一种或多种压片助剂从由润滑剂，助流剂和抗粘附剂组成的组中，所述模块具有特定的男性拓扑特征，允许其连接到相应的阴模块，从而提高可以以工业规模安全地处理的组件，其中，在阳模组合物中，压片助剂和基质构成成分之间的百分比为1:2.5至1:9999。该模块可用于将药物，营养品，农用化学品或其他活性成分输送到预期的作用位置。

4. 发明申请

US20100008972A1 Film for active ingredients dermal and transdermal administration 审中-公开
标题翻译：用于活性成分的皮肤皮肤和透皮给药
公开(公告)号：US20100008972A1
公开(公告)日：2010-01-14
申请号：US12459361
申请日：2009-06-30
申请人： Paolo Colombo , Pier Luigi Catellani , Cristina Padula , Patrizia Santi , Gaia Colombo
发明人： Paolo Colombo , Pier Luigi Catellani , Cristina Padula , Patrizia Santi , Gaia Colombo
IPC分类号： A61K9/70 , A61P43/00
CPC分类号： A61K9/0009 , A61K9/7007 , A61K9/7015
摘要： Single-layer film for active ingredients dermal and transdermal administration containing at least an active ingredient, a film-forming agent, and a hydrophilic adhesive polymer.
摘要翻译：含有至少活性成分，成膜剂和亲水性粘合剂聚合物的用于活性成分的皮肤和透皮给药的单层膜。

5. 发明授权

US09638152B2 Electric heater, heating device and heating system 有权
公开(公告)号：US09638152B2
公开(公告)日：2017-05-02
申请号：US13508092
申请日：2010-11-02
申请人： Mauro Zorzetto , Alberto Barbano , Paolo Colombo , Mirco Arata
发明人： Mauro Zorzetto , Alberto Barbano , Paolo Colombo , Mirco Arata
IPC分类号： F24H1/10 , H05B3/08 , F02B3/00 , F02M53/02 , F02M53/06
CPC分类号： F02M53/02 , F02M53/06
摘要： An electric heater for fuel of endothermal engines, in particular for fuel systems called “common rail” and the like, includes a heating part and a terminal adapted to be associated with one end of the hollow body of a fuel feeding duct; advantageously, the terminal is at least partly made of plastic material. A fuel feeding duct to which the heater is applied, as well as to a fuel warm-up device, are also provided.

6. 发明授权

US09109938B2 Level sensor and associated control circuit, in particular for a filter for vehicles 有权
标题翻译：液位传感器和相关的控制电路，特别是用于车辆的过滤器
公开(公告)号：US09109938B2
公开(公告)日：2015-08-18
申请号：US13322411
申请日：2010-05-25
申请人： Marco Molinaro , Mauro Zorzetto , Paolo Colombo
发明人： Marco Molinaro , Mauro Zorzetto , Paolo Colombo
IPC分类号： G01F23/24
CPC分类号： G01F23/244 , G01F23/242
摘要： A sensing device includes at least one electrode pair (2, 3, 4) and one sensing circuit (140) connected to the electrode pair (2, 3, 4). The sensing circuit (140) switches the value of its own output voltage when a substance establishes contact across the electrodes (2, 3, 4). The device further includes one output circuit (180) connected to the output of the sensing circuit (140) and adapted to provide an output signal (s7) representative of the presence of a substance across the electrode pair (2, 3, 4). The device also allows the output signal to take different voltage and/or current and/or frequency values, in particular such that values can be discerned which are representative of the presence or level of substances and/or representative of faults of the device.
摘要翻译：感测装置包括连接到电极对（2,3,4）的至少一个电极对（2,3,4）和一个感测电路（140）。当物质在电极（2,3,4）之间建立接触时，感测电路（140）切换其自身输出电压的值。该装置还包括连接到感测电路（140）的输出的一个输出电路（180），并且适于提供表示跨过电极对（2,3,4）的物质的存在的输出信号（s7）。该装置还允许输出信号采取不同的电压和/或电流和/或频率值，特别是使得可以识别代表物质的存在或水平和/或代表装置的故障的值。

7. 发明授权

US08988209B2 Device for monitoring a vehicle wheel 有权
标题翻译：用于监控车轮的装置
公开(公告)号：US08988209B2
公开(公告)日：2015-03-24
申请号：US13514844
申请日：2010-12-10
申请人： Domenico Cantarelli , Paolo Colombo
发明人： Domenico Cantarelli , Paolo Colombo
IPC分类号： B60Q1/00 , B60C23/02 , G01L27/00 , G01M17/02 , B60C23/00 , B60C23/04
CPC分类号： B60C23/0408 , B60C23/0452 , B60C23/0494
摘要： A monitoring device (20) of a vehicle wheel (11) is configured for detecting and transmitting, by a wireless connection, information relating to at least one characteristic quantity of the status of the wheel (11), such as the inflating pressure of a tire thereof. The device (20) has a casing (21-22) housing a circuit (30) adapted to transmit said information, the casing (21-22) being designed for coupling to an end portion (3a) of electrically conductive body (3) of a tire valve (2) of the wheel (11). The casing (21-22) includes a casing body (21) integrating interconnection means (28, 29, 40) prearranged to obtain both an electric connection of the circuit (30) to the end portion (3a) of the electrically conductive body (3) of the valve (2; 2′; 2″), and a mechanical coupling of the casing (21-22) to the end portion (3a) of the electrically conductive body (3) of the valve (2; 2′; 2″).
摘要翻译：车轮（11）的监视装置（20）被配置为通过无线连接来检测和发送与轮（11）的状态的至少一个特征量有关的信息，例如，其轮胎。设备（20）具有容纳适于传输所述信息的电路（30）的壳体（21-22），所述壳体（21-22）被设计成耦合到导电体（3）的端部（3a）的轮胎（11）的轮胎气门（2）。壳体（21-22）包括集成互连装置（28,29,40）的壳体（21），该互连装置预先布置成获得电路（30）到导电体的端部（3a）的电连接的阀（2; 2'; 2“）的导电体（3）的端部（3a）的机械联接， ; 2“）。

8. 发明授权

US08545883B2 Modular systems for the controlled release of a substance with space and time control 有权
标题翻译：用于控制释放具有空间和时间控制的物质的模块化系统
公开(公告)号：US08545883B2
公开(公告)日：2013-10-01
申请号：US13410560
申请日：2012-03-02
申请人： Paolo Colombo , Ruggero Bettini , Patrizia Santi , Pier Luigi Catellani
发明人： Paolo Colombo , Ruggero Bettini , Patrizia Santi , Pier Luigi Catellani
IPC分类号： A61K9/20
CPC分类号： A61K9/0065 , A61K9/2009 , A61K9/2054 , A61K9/2072 , A61K9/2086
摘要： An innovative pharmaceutical form for controlled drug release relates to systems obtained by the assembly of individual release modules, of which the capacity to release the drug in time and in space depends on the way in which the modules have been assembled. The modular structure offers high reproducibility of manufacture and flexibility of release.
摘要翻译：用于受控药物释放的创新药物形式涉及通过组装各个释放模块获得的系统，其中在时间和空间中释放药物的能力取决于模块组装的方式。模块化结构提供了很高的制造再现性和释放的灵活性。

9. 发明授权

US08505386B2 Pressure sensor device 有权
标题翻译：压力传感器装置
公开(公告)号：US08505386B2
公开(公告)日：2013-08-13
申请号：US13000287
申请日：2009-06-17
申请人： Paolo Colombo , Domenico Cantarelli , Marco Bigliati , Mauro Zorzetto , Fabio Nebbia , Giorgio Martinengo
发明人： Paolo Colombo , Domenico Cantarelli , Marco Bigliati , Mauro Zorzetto , Fabio Nebbia , Giorgio Martinengo
IPC分类号： G01L19/14 , G01L19/04
CPC分类号： G01L19/0084 , G01L19/0038 , G01L19/0092 , G01L19/06 , G01L19/0609 , G01L19/141
摘要： A pressure sensor device comprises a casing (2a, 3 a) defining a chamber (20) and an inlet passage (14a, 14b) of the chamber. Accommodated in the chamber (20) is a pressure sensor (17) having a sensor body with a cavity and a membrane capable of deformation under pressure action of a fluid present in the inlet passage (14a, 14b). The device further comprises a circuit arrangement (26, 27, 30) to which the pressure sensor (17) is electrically connected, the circuit arrangement including a circuit support at least partially accommodated in the chamber (20). The sensor body is not rigidly associated to the casing (2a, 3 a) and/or to other parts of the device (26, 27, 30, 35), i.e. it is mounted elastically or in a moveable manner with respect to the casing (2a, 3 a) and/or to said other parts (26, 27, 30, 35) inside the chamber (20).
摘要翻译：压力传感器装置包括限定腔室（20）和腔室的入口通道（14a，14b）的壳体（2a，3a）。容纳在腔室（20）中的是一个压力传感器（17），该压力传感器（17）具有一个具有空腔的传感器主体和能够在入口通道（14a，14b）中存在的流体的压力作用下变形的膜。该装置还包括一个电路装置（26,27,30），压力传感器（17）被电连接到该电路装置上，电路装置包括至少部分地容纳在腔室（20）中的电路支架。传感器体不与壳体（2a，3a）和/或与装置（26,27,30,35）的其它部分刚性地相关联，即其相对于壳体弹性地或以可移动的方式安装（2a，3a）和/或所述室（20）内的所述其它部分（26,27,30,35）。

10. 发明申请

US20120011937A1 Pressure-sensor device 有权
标题翻译：压力传感器装置
公开(公告)号：US20120011937A1
公开(公告)日：2012-01-19
申请号：US13200323
申请日：2011-09-23
申请人： Marco Bigliati , Paolo Colombo , Giorgio Martinengo , Daniel Verner Mueller , Mauro Zorzetto
发明人： Marco Bigliati , Paolo Colombo , Giorgio Martinengo , Daniel Verner Mueller , Mauro Zorzetto
IPC分类号： G01L7/00
CPC分类号： G01L9/0052 , G01L19/0672 , G01L19/143 , G01L19/147
摘要： A pressure-sensor device (1) comprises: —a pressure-sensitive component (9) having a body, defined in which is a blind cavity, and having a membrane portion (9a), operatively associated to which is a detection element (R); and —a connection structure (2), which has a duct in communication with the cavity of the pressure-sensitive component (9) and is to receive a fluid, a pressure of which is to be detected. The connection structure (2) comprises a supporting body (2a) of the pressure-sensitive component (9), which defines a respective passage (2b), and a compressible element (12, 18) that is designed to be in contact with the fluid and is configured for compensating possible variations of volume thereof. The compressible element (12, 18) is positioned at least in part within the cavity (11) of the pressure-sensitive component (9) and/or in a stretch of the passage (2b) of the supporting body (2a) that is close to the cavity (11) of the pressure-sensitive component (9).
摘要翻译：一种压力传感器装置（1）包括： - 具有主体的压敏部件（9），其限定为盲腔，并且具有膜部分（9a），其可操作地与检测元件（R ）; 和 - 连接结构（2），其具有与压敏部件（9）的空腔连通的管道，并且接收要被检测的压力的流体。连接结构（2）包括限定相应通道（2b）的压敏部件（9）的支撑体（2a）和设计成与所述压力敏感部件（9）接触的可压缩元件（12,18）并且被配置为补偿其体积的可能变化。可压缩元件（12,18）至少部分地位于压敏部件（9）的空腔（11）内和/或定位在支撑体（2a）的通道（2b）靠近压敏部件（9）的空腔（11）。

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