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    • 1. 发明申请
    • PROCESS FOR THE PREPARATION OF MYCOPHENOLIC ACID AND DERIVATIVES THEREOF
    • 制备麦芽酚酸及其衍生物的方法
    • WO0121607A3
    • 2001-09-07
    • PCT/HU0000099
    • 2000-09-22
    • GYOGYSZERKUTATO INTEZETBARTA ISTVANBOROS SANDORAMBRUS GABORHORVATH GYULASZABO ANTALSZABO ISTVAN MIHALYJEKKEL ANTONIAKONYA ATTILAMOZES JULIANNASALAT JANOSSOMOGYI GYOERGY
    • BARTA ISTVANBOROS SANDORAMBRUS GABORHORVATH GYULASZABO ANTALSZABO ISTVAN MIHALYJEKKEL ANTONIAKONYA ATTILAMOZES JULIANNASALAT JANOSSOMOGYI GYOERGY
    • C07D307/88C12P17/04
    • C12P17/04C07D307/88
    • The invention relates to a microbiological process for the preparation of compounds of general formula (I), wherein R1 means methyl or hydroxymethyl group and R2 stands for hydroxyl or amino group, which comprises growing a Penicillium waksmani fungal strain able to biosynthesising mycophenolic acid on a culture medium containing assimilable carbon and nitrogen sources as well as mineral salts at 22 DEG C to 30 DEG C, separating the compound of general formula (I), wherein R1 means methyl group and R2 stands for hydroxyl group, from the fermentation broth and, if desired, purifying it and, if desired, bioconverting it a) by using the cultures of Streptomyces griseoruber No. 1/6 actinomycete strain deposited at the National Collection of Agricultural and Industrial Microorganisms as Streptomyces sp. No. 1/6 under No. NCAIM (P)B 001275 to prepare a compound of general formula (I), wherein R1 means methyl group and R2 stands for amino group; or b) by using the cultures of Streptomyces resistomycificus No. 1/28 actinomycete strain deposited at the National Collection of Agricultural and Industrial Microorganisms under No. NCAIM (P)B 001276 to prepare a compound of general formula (I), wherein R1 means hydroxymethyl group and R2 stands for amino group on a culture medium containing assimilable carbon and nitrogen sources as well as mineral salts under submerged, aerated conditions up to completion of the bioconversion, then separating the compound of general formula (I) formed from the culture and, if desired, purifying it.
    • 本发明涉及制备通式(I)化合物的微生物方法,其中R1表示甲基或羟甲基,R2代表羟基或氨基,其包括生长青霉菌真菌菌株 能够在含有可同化碳源和氮源的培养基以及22℃至30℃的无机盐中生物合成霉酚酸,分离通式(I)的化合物,其中R1表示甲基,R2表示羟基 ,如果需要,对其进行纯化,如果需要,将其生物转化为a)通过使用保藏在国家农业部收集的灰霉链霉菌(Streptomyces griseoruber)1/6放线菌菌株的培养物 工业微生物作为在NCAIM(P)B 001275号下的链霉菌(Streptomyces sp。)1/6,制备通式(I)的化合物,其中R1表示甲基,R2表示氨基; 或b)通过使用在NCAIM(P)B 001276号国家农业和工业微生物收集库保藏的依赖于链霉菌链霉菌(Streptomyces)的1/28放线菌菌株的培养物来制备通式 (I)化合物,其中R1表示羟甲基,R2代表含有可同化碳源和氮源的培养基上的氨基,以及在浸没的充气条件下直至生物转化完成的矿物盐,然后将通式 I)由培养物形成,如果需要,可以纯化。