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1. 发明专利

HU197025B PROCESS FOR PRODUCING 21-BENZOYLOXY-PREGNENE DERIVATIVES 未知
公开(公告)号：HU197025B
公开(公告)日：1989-02-28
申请号：HU343685
申请日：1985-09-12
申请人： GYOGYSZERKUTATO INTEZET
发明人： SOLYOM SANDOR , SZILAGYI GEZANE , TOLDY LAJOS
IPC分类号： C07J5/00

2. 发明专利

HU172949B PROCESS FOR PREPARING NEW DERIVATIVES OF SULPHONAMIDE-BENZOIC ACID 未知
公开(公告)号：HU172949B
公开(公告)日：1979-01-28
申请号：HUGO001334
申请日：1976-03-18
申请人： GYOGYSZERKUTATO INTEZET
发明人： KOSARY JUDIT , KASZTREINER ENDRE , HUSZTI ZSUZSA , KENESSEY AGNES , CSEH GYOERGY , SZILAGYI GEZANE , STVERTETZKY GYOERGYNE , SZTROKAY JUDIT
IPC分类号： C07C20060101 , C07D295/08 , C07D295/14 , C07D295/16 , C07D413/10 , C07C143/80

3. 发明专利

HU214331B METHODS FOR PRODUCING PIPERAZINE AND HOMOPIPERAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 未知
公开(公告)号：HU214331B
公开(公告)日：1998-03-02
申请号：HU9202021
申请日：1992-06-17
申请人： GYOGYSZERKUTATO INTEZET
发明人： ZUBOVICS ZOLTAN , GOLDSCHMIDTNE DR HORVATH KATAL , SZILAGYI GEZANE , ANDRASI FERENC , HODULANE DR SZENTKUTI ESZTER , TOLDY LAJOS , SUTKA KLARA , FITTLER ZSUZSANNA , SEBESTYEN LASZLO , GOERGENYI AKOSNE , SZIRAKI ISTVAN , GYIMESI JOZSEF , VITKOCZINE KARDOS VALERIA
IPC分类号： A61K31/50 , A61K31/496 , A61K31/505 , A61K31/517 , A61K31/519 , A61P1/04 , A61P1/16 , A61P3/00 , A61P3/10 , A61P9/00 , A61P9/08 , A61P9/10 , A61P11/08 , A61P13/12 , A61P29/00 , A61P37/06 , C07D237/20 , C07D239/48 , C07D239/50 , C07D239/94 , C07D239/95 , C07D403/06 , C07D475/00 , C07D475/06 , C07D475/08 , C07D403/14 , C07D403/04 , C07D237/22 , A61K31/495
摘要： The lipid peroxidation inhibiting piperazine and homopiperazine derivatives of the general formula (I) and the pharmaceutically acceptable acid addition salts thereof, Lip stands for hydrogen; C15-20 alkyl; C10-20 alkanoyl or C10-20 alkenoyl; trityl optionally substituted by halogen; adamantyl; 1- or 2-naphthyloxy or oxo-substituted tetrahydronaphthyloxy; or an amine protective group commonly used e.g. in the peptide chemistry; A and A are selected independently from the group consisting of a single bond and C2-3 alkylene optionally substituted by hydroxy or oxo; n is 1 or 2; and Het represents a group of the general formula (a), wherein R is amino or 1-pyrrolidinyl; or a 4-chloro-3-oxo-2,3-dihydro-5-pyridazinyl group of the formula (b); or a 4-amino-6,7-dimethoxy-2-quinazolinyl group of the formula (c); or a 4,7-diamino-6-phenyl-2-pteridinyl group of the formula (d); or a 2,7-diamino-6-phenyl-4-pteridinyl group of the formula (e); or a 2,4,7-triamino-6-pteridinylcarbonyl group of the ormula (f);

4. 发明专利

HU9503012D0 NEW PYRIMIDINE DERIVATIVES 未知
公开(公告)号：HU9503012D0
公开(公告)日：1995-12-28
申请号：HU9503012
申请日：1995-10-19
申请人： GYOGYSZERKUTATO INTEZET
发明人： MORAVCSIK IMRE , ZUBOVICS ZOLTAN , FEHER GABOR , ANDRASI FERENC , MATYUS PETER , ZARA DENESNE , SUTKA KLARA , SZILAGYI GEZANE , SEBESTYEN LASZLO , HODULANE DR SZENTKUTI ESZTER , HORVATH EDIT , TOLDY LAJOS , VIDANE DR ERDOE FRANCISKA , SZEKERES TIBOR , SZABO HILDA
IPC分类号： C07D239/50 , C07D295/13

5. 发明专利

HU9202021D0 METHOD FOR PRODUCING NEW PIPERAZINE AND HOMOPIPERAZINE DERIVATIVES 未知
公开(公告)号：HU9202021D0
公开(公告)日：1992-09-28
申请号：HU9202021
申请日：1992-06-17
申请人： GYOGYSZERKUTATO INTEZET
发明人： ZUBOVICS ZOLTAN , GOLDSCHMIDTNE DR HORVATH KATAL , SZILAGYI GEZANE , ANDRASI FERENC , HODULANE DR SZENTKUTI ESZTER , TOLDY LAJOS , SUTKA KLARA , FITTLER ZSUZSANNA , SEBESTYEN LASZLO , GOERGENYI AKOSNE , SZIRAKI ISTVAN , VITKOCZINE KARDOS VALERIA , GYIMESI JOZSEF
IPC分类号： A61K31/50 , A61K31/496 , A61K31/505 , A61K31/517 , A61K31/519 , A61P1/04 , A61P1/16 , A61P3/00 , A61P3/10 , A61P9/00 , A61P9/08 , A61P9/10 , A61P11/08 , A61P13/12 , A61P29/00 , A61P37/06 , C07D237/20 , C07D239/48 , C07D239/50 , C07D239/94 , C07D239/95 , C07D403/06 , C07D475/00 , C07D475/06 , C07D475/08
摘要： The lipid peroxidation inhibiting piperazine and homopiperazine derivatives of the general formula (I) and the pharmaceutically acceptable acid addition salts thereof, Lip stands for hydrogen; C15-20 alkyl; C10-20 alkanoyl or C10-20 alkenoyl; trityl optionally substituted by halogen; adamantyl; 1- or 2-naphthyloxy or oxo-substituted tetrahydronaphthyloxy; or an amine protective group commonly used e.g. in the peptide chemistry; A and A are selected independently from the group consisting of a single bond and C2-3 alkylene optionally substituted by hydroxy or oxo; n is 1 or 2; and Het represents a group of the general formula (a), wherein R is amino or 1-pyrrolidinyl; or a 4-chloro-3-oxo-2,3-dihydro-5-pyridazinyl group of the formula (b); or a 4-amino-6,7-dimethoxy-2-quinazolinyl group of the formula (c); or a 4,7-diamino-6-phenyl-2-pteridinyl group of the formula (d); or a 2,7-diamino-6-phenyl-4-pteridinyl group of the formula (e); or a 2,4,7-triamino-6-pteridinylcarbonyl group of the ormula (f);

6. 发明专利

HUT34763A PROCESS FOR PRODUCTION OF NEW STEROID-SPIRO-LACTONS 未知
公开(公告)号：HUT34763A
公开(公告)日：1985-04-28
申请号：HU298883
申请日：1983-08-26
申请人： GYOGYSZERKUTATO INTEZET
发明人： SZILAGYI GEZANE , SOLYOM SANDOR , TOLDY LAJOS , SCHAEFER INGE , NAGYNE IVOCS JUDIT , NAGYNE BALOGH MARIA
IPC分类号： C07J1/00 , C07J21/00 , C07J31/00
摘要： Novel steroidal-spiro-lactones of general formula (I) and their salts obtd. by opening the lactone ring, are prepd. by reacting a cpd. of general formula (IV) in the presence of a base with a malonic-acid-dialkyl-ester with 1-3 carbons. In the formulae R1 is hydrogen or methyl, R2 is alkyl with 1-3 carbons, R3 is hydrogen or 1-3C alkyl-thio gp. or 2-4C alkanoyl-thio gp. Z is a gp. of formula (II) or (III), X is H or 2-4C alkoxy-carbonyl with 2-4 carbons. M is metal. The dotted line between carbons 6 and 7 can mean an additional valency bond, with the proviso, that if the dotted line does stand for an additional bond, R3 can only be hydrogen. - If in the prod. of formula (I) resulting from the reaction X is an alkoxy-carbonyl gp. and Z is a gp. of formula (II), the cpd. of formula (I) is opt. heated in the presence of water. If in the resulting cpd. of formula (I) R3 is hydrogen, the dotted line between carbons 6 and 7 does not mean an additional bond, Z stands for a gp. of formula (II) with X meaning hydrogen, a further valency bond can opt. be produced in the 6(7) position of the stern structure using a benzo-quinone deriv. Alternatively an alkyl-mercaptan with 1-3 carbons or a thiol-carboxylic-acid with 2-4 carbons can be opt. additioned to the double bond in position 6(7), and/or salt can opt. be formed with the equiv. amt. of alkali from cpds. of formula (I) when Z means a gp. of formula (II) and X stands for hydrogen.

7. 发明专利

HUT64333A METHODS FOR PRODUCING NEW PIPERAZINE AND HOMOPIPERAZINE DERIVATIVES CONTAINING THEM 未知
公开(公告)号：HUT64333A
公开(公告)日：1993-12-28
申请号：HU9202021
申请日：1992-06-17
申请人： GYOGYSZERKUTATO INTEZET
发明人： ZUBOVICS ZOLTAN , GOLDSCHMIDTNE DR HORVATH KATAL , SZILAGYI GEZANE , ANDRASI FERENC , HODULANE DR SZENTKUTI ESZTER , TOLDY LAJOS , SUTKA KLARA , FITTLER ZSUZSANNA , SEBESTYEN LASZLO , GOERGENYI AKOSNE , SZIRAKI ISTVAN , VITKOCZINE KARDOS VALERIA , GYIMESI JOZSEF
IPC分类号： A61K31/50 , A61K31/496 , A61K31/505 , A61K31/517 , A61K31/519 , A61P1/04 , A61P1/16 , A61P3/00 , A61P3/10 , A61P9/00 , A61P9/08 , A61P9/10 , A61P11/08 , A61P13/12 , A61P29/00 , A61P37/06 , C07D237/20 , C07D239/48 , C07D239/50 , C07D239/94 , C07D239/95 , C07D403/06 , C07D475/00 , C07D475/06 , C07D475/08 , C07D403/14 , A61K31/495 , C07D237/22 , C07D403/04
摘要： The lipid peroxidation inhibiting piperazine and homopiperazine derivatives of the general formula (I) and the pharmaceutically acceptable acid addition salts thereof, Lip stands for hydrogen; C15-20 alkyl; C10-20 alkanoyl or C10-20 alkenoyl; trityl optionally substituted by halogen; adamantyl; 1- or 2-naphthyloxy or oxo-substituted tetrahydronaphthyloxy; or an amine protective group commonly used e.g. in the peptide chemistry; A and A are selected independently from the group consisting of a single bond and C2-3 alkylene optionally substituted by hydroxy or oxo; n is 1 or 2; and Het represents a group of the general formula (a), wherein R is amino or 1-pyrrolidinyl; or a 4-chloro-3-oxo-2,3-dihydro-5-pyridazinyl group of the formula (b); or a 4-amino-6,7-dimethoxy-2-quinazolinyl group of the formula (c); or a 4,7-diamino-6-phenyl-2-pteridinyl group of the formula (d); or a 2,7-diamino-6-phenyl-4-pteridinyl group of the formula (e); or a 2,4,7-triamino-6-pteridinylcarbonyl group of the ormula (f);

8. 发明专利

HUT41364A PROCESS FOR PREPARING TRIPHENYL-ALKENES BY MEANS OF THE DEHYDRATATION OF TRIPHENYL-ALKANOLS 未知
公开(公告)号：HUT41364A
公开(公告)日：1987-04-28
申请号：HU414285
申请日：1985-10-29
申请人： GYOGYSZERKUTATO INTEZET
发明人： ABRAHAM GIZELLA , HORVATH TIBOR , SOLYOM SANDOR , SZILAGYI GEZANE , TOLDY LAJOS
IPC分类号： C07C1/24 , C07C31/10 , C07C31/12 , C07C31/125
摘要： During the prepn. of triphenyl-alkenes:(I) dehydration of alkanols takes place by a reaction between triphenylalkanols and N,N'-sulphinyl-diimidazole. In (I) X is a halogen atom or 1-4C atom contg. alkoxy group and R is an alkyl group of 1-6C atoms.

9. 发明专利

HU188017B PROCESS FOR THE PRODUCTION OF NEW STEROID-17-SPIRO-OXASOLIDINON-DERIVATIVES 未知
公开(公告)号：HU188017B
公开(公告)日：1986-03-28
申请号：HU159783
申请日：1983-05-10
申请人： GYOGYSZERKUTATO INTEZET
发明人： SOLYOM SANDOR , TOLDY LAJOS , SZILAGYI GEZANE , SCHAEFER INGE , SZONDY ELEONORA
IPC分类号： C07J31/00 , C07J43/00 , C07J53/00

10. 发明专利

HUT34221A PROCESS FOR THE PRODUCTION OF NEW STEROID-17-SPIRO-OXASOLIDINON-DERIVATIVES 未知
公开(公告)号：HUT34221A
公开(公告)日：1985-02-28
申请号：HU159783
申请日：1983-05-10
申请人： GYOGYSZERKUTATO INTEZET
发明人： SOLYOM SANDOR , TOLDY LAJOS , SZILAGYI GEZANE , SCHAEFER INGE , SZONDY ELEONORA
IPC分类号： C07J31/00 , C07J43/00 , C07J53/00
摘要： Steroido-17-spiro-oxazolidone derivs. of general formula (I) are prepd. by reacting a cpd. of general formulae (II) or (III) either with (a) a sulphur-ilide or (b) with diazo-methane. The spiro-pyrazolin type intermediary resulting from the diazo-methane reaction is destroyed by acid treatment or heating. Into the cpds. of general formula (I) resulting from method (a) or (b) further double bonds are introduced in positions 1(2) or 6(7) and/or an alkyl-mercaptan with 1-3 carbons or a thiol-carboxylic acid with 2-4 carbons is added on to the double bond in position 6(7). - In the formulae, R1 = H or methyl; R2 = 1-3C alkyl; R3 = H or 1-3C alkyl; R4 = H or 1-3C alkyl-thio gp., or 2-4C acyl-thio gp.; X and Y mean methylene methine or cyclo-propylidene, at least one of X and Y means cyclo-propylidene. If X or Y = methine, then the dotted line in the formula between carbons 1 and 2, or between carbons 6 and 7 means an additional double bond. If R4 is different from H, Y must be methylene. In formulae (II) and (III), R4 is only H. The dotted line between carbons 6 and 7 in formula (II) may mean a further valency bond.

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