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1. 发明申请

WO2009052438A3 DEVICES FOR TERMINATION OF TETHERS 审中-公开
标题翻译：用于终止四舍五入的设备
公开(公告)号：WO2009052438A3
公开(公告)日：2009-07-02
申请号：PCT/US2008080381
申请日：2008-10-17
申请人： GUIDED DELIVERY SYSTEMS INC , SERINA EUGENE , CALHOUN TENNY C , MEIER STEPHEN , FABRO MARIEL , MIRCHANDANI TIFFANY HUYNH , TO JOHN , TANG BRIAN
发明人： SERINA EUGENE , CALHOUN TENNY C , MEIER STEPHEN , FABRO MARIEL , MIRCHANDANI TIFFANY HUYNH , TO JOHN , TANG BRIAN
IPC分类号： A61B17/04
CPC分类号： A61B17/0487 , A61B17/0467 , A61B17/0485 , A61B2017/00243 , A61B2017/00783 , A61B2017/0448 , A61B2017/045 , A61B2017/0454 , A61B2017/0456 , A61B2017/048 , A61B2017/0488 , A61B2017/0496 , A61B2017/320052
摘要： Devices and methods for locking and/or cutting tethers during a tissue modification procedure are described. In some variations, a tether may be used to tighten or compress tissue by bringing two pieces or sections of the tissue together. The tether, which may be under tension, may be locked to maintain the tension, and excess tether may be severed, using one or more of the devices and/or methods. The devices and/or methods may be used, for example, in minimally invasive procedures.
摘要翻译：描述了在组织修改过程中锁定和/或切割系绳的装置和方法。在一些变型中，系绳可以用于通过将组织的两个或多个部分组合在一起来收紧或压缩组织。可能处于张力下的系绳可以被锁定以保持张力，并且可以使用一种或多种装置和/或方法来切断多余的系绳。装置和/或方法可以用于例如微创程序。

2. 发明申请

WO2008048626A3 METHODS AND DEVICES FOR CATHETER ADVANCEMENT AND DELIVERY OF SUBSTANCES THERETHROUGH 审中-公开
标题翻译：用于导管器推进和递送物质的方法和装置
公开(公告)号：WO2008048626A3
公开(公告)日：2008-06-26
申请号：PCT/US2007022122
申请日：2007-10-16
申请人： GUIDED DELIVERY SYSTEMS INC , STARKSEN NIEL F , IM KARL S , FABRO MARIEL , MEIER STEPHEN , SERINA EUGENE
发明人： STARKSEN NIEL F , IM KARL S , FABRO MARIEL , MEIER STEPHEN , SERINA EUGENE
IPC分类号： A61M25/01
CPC分类号： A61M25/01 , A61B17/0401 , A61B17/0485 , A61B17/0644 , A61B17/068 , A61B17/3468 , A61B2017/00243 , A61B2017/00783 , A61B2017/0496 , A61B2017/06019 , A61F2/2466
摘要： Methods and devices for successively advancing a plurality of catheters over a guide element to a body tissue are described. In some of the methods, the guide element may be attached to the body tissue, which may be accessible minimally invasively. In certain variations, the guide element may not be detached from the body tissue after the catheters have been advanced over the guide element. The methods may further comprise deploying at least one implant from at least one of the plurality of catheters. In some variations, a method may comprise advancing a first delivery catheter to a first region of a body tissue, deploying a first anchor from the first delivery catheter, where the first anchor is attached to a guide element, proximally withdrawing the first delivery catheter, advancing a second delivery catheter over the guide element, and deploying a second anchor from the second delivery catheter.
摘要翻译：描述了将引导元件上的多个导管连续前进到身体组织的方法和装置。在一些方法中，引导元件可以附接到身体组织，其可以被最小程度地侵入。在某些变型中，在导管已经推进导引元件之后，引导元件可能不会与身体组织分离。所述方法还可以包括从所述多个导管中的至少一个导管部署至少一个植入物。在一些变型中，方法可以包括将第一递送导管推进到身体组织的第一区域，从第一递送导管展开第一锚定件，其中第一锚固件附接到引导元件，向近侧抽出第一递送导管，将第二输送导管推入导引元件上，并从第二输送导管展开第二锚定器。

3. 发明申请

WO2005025644A3 DELIVERY DEVICES AND MEHODS FOR HEART VALVE REPAIR 审中-公开
标题翻译：输送装置和心脏瓣膜修复
公开(公告)号：WO2005025644A3
公开(公告)日：2007-05-03
申请号：PCT/US2004028431
申请日：2004-09-01
申请人： GUIDED DELIVERY SYSTEMS INC , STARKSEN NIEL F , TO JOHN , FABRO MARIEL , WEI MICHAEL F , MORALES RODOLFO A
发明人： STARKSEN NIEL F , TO JOHN , FABRO MARIEL , WEI MICHAEL F , MORALES RODOLFO A
IPC分类号： A61B17/04 , A61B17/00 , A61B17/06 , A61B17/064 , A61B17/068 , A61B17/10 , A61B17/12 , A61F2/24 , A61M20060101
CPC分类号： A61F2/2436 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0643 , A61B17/0644 , A61B17/068 , A61B17/0682 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61B2017/0443 , A61B2017/0496 , A61B2017/2905 , A61F2/2427 , A61F2/2442 , A61F2/2445 , A61F2/2454 , A61F2/2466
摘要： Devices, systems and methods facilitate positioning of a cardiac valve annulus treatment device, thus enhancing treatment of the annulus. Methods generally involve advancing an anchor delivery device through vasculature of the patient to a location in the heart for treating the valve annulus, contacting the anchor delivery device with a length of the valve annulus, delivering a plurality of coupled anchors from the anchor delivery device to secure the anchors to the annulus, and drawing the anchors together to circumferentially tighten the valve annulus. Devices generally include an elongate catheter having at least one tensioning member and at least one tensioning actuator for deforming a distal portion of the catheter to help it conform to a valve annulus. The catheter device may be used to navigate a subannular space below a mitral valve to facilitate positioning of an anchor delivery device.
摘要翻译：装置，系统和方法便于心脏瓣膜环空处理装置的定位，从而增强环空处理。方法通常涉及将锚定器输送装置通过患者的脉管系统推进到心脏中的位置以处理瓣膜环，使锚定器输送装置与一段长度的瓣膜环接触，将多个联接的锚定器从锚定器输送装置输送到将锚固件固定到环形空间，并将锚固件拉紧在一起以周向地紧固阀环。装置通常包括具有至少一个张紧构件和至少一个张紧致动器的细长导管，用于使导管的远端部分变形以帮助其符合瓣膜环。导管装置可用于导航二尖瓣下方的子宫下空间，以便锚定器输送装置的定位。

4. 发明专利

AU2014278600A1 Multi-lumen-catheter retractor system for a minimally-invasive, operative gastrointestinal treatment 未知
公开(公告)号：AU2014278600A1
公开(公告)日：2016-01-21
申请号：AU2014278600
申请日：2014-06-01
申请人： FABRO MARIEL , KANTSEVOY SERGEY , MACROPLATA INC , PISKUN GREGORY , TANG BRIAN , TO JOHN
发明人： PISKUN GREGORY , TO JOHN , FABRO MARIEL , TANG BRIAN , KANTSEVOY SERGEY
IPC分类号： A61B1/00 , A61B1/018 , A61B1/31 , A61B1/32 , A61B17/00 , A61B17/02 , A61B17/34
摘要： A system for performing minimally invasive procedures in a body lumen of a patient including a flexible catheter having a first lumen configured and dimensioned to receive an endoscope therethrough and a second lumen configured and dimensioned to receive a first flexible tube therethrough. The first flexible tube is movable through the second lumen and has a distal portion including a first curve extending in a first direction with respect to the longitudinal axis and a second curve extending in a second different direction with respect to the longitudinal axis. A retractor system is positioned at a distal portion of the catheter and is movable from a non-expanded insertion position to an expanded position forming an expanded cage to form a larger working space. The distal portion of the first flexible tube is movable within the expanded cage.

5. 发明专利

AU2013277448A1 Multi-lumen-catheter retractor system for a minimally-invasive, operative gastrointestinal treatment 未知
公开(公告)号：AU2013277448A1
公开(公告)日：2015-01-22
申请号：AU2013277448
申请日：2013-06-17
申请人： FABRO MARIEL , KANTSEVOY SERGEY , MACROPLATA INC , PISKUN GREGORY , TANG BRIAN , TO JOHN
发明人： PISKUN GREGORY , TO JOHN , FABRO MARIEL , TANG BRIAN , KANTSEVOY SERGEY
IPC分类号： A61B1/00 , A61B1/018 , A61B17/02 , A61B17/34
摘要： Improved methods and devices for performing an endoscopic surgery are provided. Systems are taught for operatively treating gastrointestinal disorders endoscopically in a stable, yet dynamic operative environment, and in a minimally-invasive manner. Such systems include, for example, an endoscopic surgical suite. The surgical suite can have a reversibly-expandable retractor that expands to provide a stable, operative environment within a subject. The expansion can be asymmetric around a stabilizer subsystem to maximize space for a tool and an endoscope to each be maneuvered independently to visualize a target tissue and treat the target tissue from outside the patient in a minimally invasive manner.

6. 发明专利

JP2010005422A Delivery device and method for heart valve repair 有权
标题翻译：输送装置和心脏瓣膜修复方法
公开(公告)号：JP2010005422A
公开(公告)日：2010-01-14
申请号：JP2009197009
申请日：2009-08-27
申请人： Guided Delivery Systems Inc , ガイデッドデリバリーシステムズ, インコーポレイテッド
发明人： STARKSEN NIEL F , TO JOHN , FABRO MARIEL , WEI MICHAEL F , MORALES RODOLFO A
IPC分类号： A61M25/00 , A61B17/00 , A61B17/04 , A61B17/06 , A61B17/064 , A61B17/068 , A61B17/10 , A61B17/12 , A61F2/24 , A61M20060101
CPC分类号： A61F2/2436 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0643 , A61B17/0644 , A61B17/068 , A61B17/0682 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61B2017/0443 , A61B2017/0496 , A61B2017/2905 , A61F2/2427 , A61F2/2442 , A61F2/2445 , A61F2/2454 , A61F2/2466
摘要： PROBLEM TO BE SOLVED: To improve a method, device, and system to enhance the cardiac valve annulus treatment effect. SOLUTION: The delivery device 200 is to apply connected anchors 210 to the cardiac valve annulus and has an elongated shaft 204 with a proximal end and a distal end 202, a housing 206 adjacent the distal end 202, a plurality of connected anchors 210 arranged in the housing 206, at least one anchor contact member for delivering the anchors 210 from the housing 206, and at least one actuator 208 on or near the proximal end of the shaft 204 to act on the anchor contact member so as to deliver the anchors 210 to the cardiac valve annulus. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：改进方法，装置和系统，以增强心脏瓣膜环空处理效果。解决方案：输送装置200将连接的锚定件210施加到心脏瓣膜环上并且具有细长的轴204，其具有近端和远端202，与远端202相邻的壳体206，多个连接的锚 210，其布置在壳体206中，用于从壳体206输送锚定件210的至少一个锚定接触构件以及在轴204的近端上或附近的至少一个致动器208以作用于锚定接触构件以便传递锚定件210到心脏瓣膜环。版权所有（C）2010，JPO＆INPIT

7. 发明专利

JP2010131404A Devices and methods for anchoring tissue 审中-公开
标题翻译：用于锚固组织的装置和方法
公开(公告)号：JP2010131404A
公开(公告)日：2010-06-17
申请号：JP2009296093
申请日：2009-12-25
申请人： Guided Delivery Systems Inc , ガイデッドデリバリーシステムズ, インコーポレイテッド
发明人： TO JOHN , STARKSEN NIEL F , FABRO MARIEL , PLIAM NATHAN B , IM KARL S
IPC分类号： A61B17/12 , A61B17/00 , A61B17/04 , A61B17/064 , A61B17/068 , A61B17/08 , A61B17/10 , A61F2/08 , A61F2/24 , A61L31/00
CPC分类号： A61F2/2445 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0644 , A61B17/0682 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61B2017/0443 , A61F2/0811
摘要： PROBLEM TO BE SOLVED: To provide devices and methods for anchoring tissue. SOLUTION: Anchors, anchoring systems, anchor delivery devices, and method of using anchors are described. An anchor 600 may be a flexible anchor having two curved legs 602 that cross in a single turning direction to form a loop, wherein the legs are adapted to penetrate tissue. The ends 612 and 614 of the curved legs may be blunt or sharp. The anchor can assume different configurations such as a deployed configuration and a delivery configuration, and the anchor may switch between these different configurations. In operation, the anchor may be inserted into tissue by releasing the anchor from a delivery configuration so that the anchor self-expands into the deployed configuration, so that the legs of the anchor may penetrate the tissue in a curved pathway. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供用于锚定组织的装置和方法。描述了锚，锚固系统，锚定装置以及使用锚的方法。锚固件600可以是具有两个弯曲腿部602的柔性锚固件，其在单个转动方向上交叉以形成环，其中腿部适于穿透组织。弯曲腿部的末端612和614可以是钝的或尖锐的。锚可以采取不同的配置，例如部署的配置和传送配置，并且锚可以在这些不同的配置之间切换。在操作中，锚可以通过从输送构型释放锚而插入到组织中，使得锚固体自膨胀成展开构型，使得锚的腿可以以弯曲的路径穿透组织。版权所有（C）2010，JPO＆INPIT

8. 发明专利

JP2012101094A Delivery device and method for heart valve repair 审中-公开
标题翻译：输送装置和心脏瓣膜修复方法
公开(公告)号：JP2012101094A
公开(公告)日：2012-05-31
申请号：JP2011280284
申请日：2011-12-21
申请人： Guided Delivery Systems Inc , ガイデッドデリバリーシステムズ, インコーポレイテッド
发明人： STARKSEN NIEL F , TO JOHN , FABRO MARIEL , WEI MICHAEL F , MORALES RODOLFO A
IPC分类号： A61M25/00 , A61B17/00 , A61F2/24
摘要： PROBLEM TO BE SOLVED: To provide methods, devices and systems for enhancing heart valve annulus treatment procedures.SOLUTION: The device 200 for applying a coupled anchor 210 to a heart valve annulus includes: an elongate shaft 204 having a proximal end and a distal end 202; a housing 206 adjacent to the distal end 202; a plurality of coupled anchors 210 disposed within the housing 206; at least one anchor contacting member for delivering the anchor 210 from the housing 206; and at least one actuator 208, at or near the proximal end of the shaft 204, for acting on the anchor 210 contacting member to deliver the anchor 210 to the heart valve annulus.
摘要翻译：要解决的问题：提供用于增强心脏瓣膜环空处理程序的方法，装置和系统。解决方案：用于将联接的锚定件210施加到心脏瓣膜环的装置200包括：具有近端和远端202的细长轴204; 邻近远端202的壳体206; 设置在壳体206内的多个连接的锚定件210; 至少一个锚接触构件，用于从壳体206输送锚定件210; 以及在轴204的近端处或附近的至少一个致动器208，用于作用在锚固件210接触构件上以将锚固件210输送到心脏瓣膜环。版权所有（C）2012，JPO＆INPIT

9. 发明专利

JP2010246947A Methods and devices for deployment of tissue anchors 审中-公开
标题翻译：用于部署组织锚固件的方法和装置
公开(公告)号：JP2010246947A
公开(公告)日：2010-11-04
申请号：JP2010132033
申请日：2010-06-09
申请人： Guided Delivery Systems Inc , ガイディッドデリバリーシステムズインコーポレイテッド
发明人： TO JOHN , FABRO MARIEL , IM KARL S
IPC分类号： A61B17/00
CPC分类号： A61B17/068 , A61B17/0401 , A61B17/064 , A61B2017/00867 , A61B2017/0409 , A61F2/2445
摘要： PROBLEM TO BE SOLVED: To provide devices, methods, and kits for deployment of tissue anchors.
SOLUTION: The devices comprise a shaft defining a lumen for housing at least one anchor therein (the anchor having an eyelet) and a mechanism for deploying the anchor distally from the lumen, wherein the inner diameter of the lumen is the same size or smaller than the diameter of the eyelet of the anchor to be disposed therein when the anchor is in an expanded configuration. The methods comprise loading an anchor within a lumen of a shaft (where the anchor comprises an eyelet and the shaft has a slot therethrough), passing a linking member through the slot and through the eyelet of the anchor, and deploying the anchor. Other methods comprise loading an anchor within a lumen of a shaft, and deploying the anchor distally from the lumen.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于部署组织锚的装置，方法和试剂盒。解决方案：装置包括：轴，其限定用于容纳其中的至少一个锚固件的内腔（锚具具有孔眼）和用于将锚固件从内腔向远侧展开的机构，其中内腔的内径具有相同的尺寸或者当锚固件处于膨胀构型时，小于待设置在其中的锚固件的孔眼的直径。所述方法包括将锚固件装载在轴的腔内（其中锚固件包括孔眼并且轴具有穿过其的槽），使连接构件穿过狭槽并穿过锚固件的孔眼并且展开锚固件。其他方法包括将锚固件装载在轴的内腔内，并将锚固件从内腔远端展开。版权所有（C）2011，JPO＆INPIT

10. 发明专利

CA2702446C DEVICES AND METHODS FOR TERMINATION 未知
公开(公告)号：CA2702446C
公开(公告)日：2019-03-05
申请号：CA2702446
申请日：2008-10-17
申请人： GUIDED DELIVERY SYSTEMS INC
发明人： SERINA EUGENE , CALHOUN TENNY C , MEIER STEPHEN , FABRO MARIEL , MIRCHANDANI TIFFANY HUYNH , TO JOHN , TANG BRIAN
IPC分类号： A61B17/04
摘要： Devices and methods for locking and/or cutting tethers during a tissue modification procedure are described. In some variations, a tether may be used to tighten or compress tissue by bringing two pieces or sections of the tissue together. The tether, which may be under tension, may be locked to maintain the tension, and excess tether may be severed, using one or more of the devices and/or methods. The devices and/or methods may be used, for example, in minimally invasive procedures.

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