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1. 发明申请

WO2004105685A2 DISPLACEABLE LINKER SOLID PHASE CHEMICAL LIGATION 审中-公开
标题翻译：可拆卸连接器固体相化学发光
公开(公告)号：WO2004105685A2
公开(公告)日：2004-12-09
申请号：PCT/US2004015435
申请日：2004-05-17
申请人： GRYPHON THERAPEUTICS INC , LOW DONALD , HU YING , BOTTI PAOLO
发明人： LOW DONALD , HU YING , BOTTI PAOLO
IPC分类号： A61K20060101 , C07K1/04 , C07K1/107 , C08B37/00 , C08F2/00 , A61K
CPC分类号： C07K1/042 , C07K1/1072
摘要： The invention is directed to methods and compositions for aqueous-compatible solid phase chemical ligation. The methods and compositions of the invention involve the chemical ligation of first and second polymers, where the first polymer is attached to a support through a displaceable linker. The displaceable linker can be cleaved or otherwise displaced under aqueous conditions compatible with subsequent removal of the ligation product from the solid support. The methods and compositions of the invention are particularly useful for ligation of peptides and polypeptides on a solid support. The ligation system of the invention is applicable to a wide variety of molecules, and thus can be exploited to generate ligated polymers including peptides, polypeptides and other amino acid containing polymers.
摘要翻译：本发明涉及用于水相容性固相化学连接的方法和组合物。本发明的方法和组合物涉及第一和第二聚合物的化学连接，其中第一聚合物通过位移连接体连接到载体上。在与固体支持物随后除去连接产物相容的水性条件下，可置换接头可以被切割或以其它方式置换。本发明的方法和组合物特别可用于在固体支持物上连接肽和多肽。本发明的连接系统可应用于各种各样的分子，因此可用于产生连接的聚合物，包括肽，多肽和其它含氨基酸的聚合物。

2. 发明公开

EP1631597A4 DISPLACEABLE LINKER SOLID PHASE CHEMICAL LIGATION 审中-公开
标题翻译：化学固相结扎互换LEFT
公开(公告)号：EP1631597A4
公开(公告)日：2007-07-11
申请号：EP04752449
申请日：2004-05-17
申请人： GRYPHON THERAPEUTICS INC
发明人： LOW DONALD , HU YING , BOTTI PAOLO
IPC分类号： C08F2/00 , A61K20060101 , C07K1/04 , C07K1/107 , C08B37/00
CPC分类号： C07K1/042 , C07K1/1072
摘要： The invention is directed to methods and compositions for aqueous-compatible solid phase chemical ligation. The methods and compositions of the invention involve the chemical ligation of first and second polymers, where the first polymer is attached to a support through a displaceable linker. The displaceable linker can be cleaved or otherwise displaced under aqueous conditions compatible with subsequent removal of the ligation product from the solid support. The methods and compositions of the invention are particularly useful for ligation of peptides and polypeptides on a solid support. The ligation system of the invention is applicable to a wide variety of molecules, and thus can be exploited to generate ligated polymers including peptides, polypeptides and other amino acid containing polymers.

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