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1. 发明专利

GB190800319A An Improved Interchangeable Heel Plate and Pad, for Boots, Shoes, and the like. 未知
公开(公告)号：GB190800319A
公开(公告)日：1908-05-28
申请号：GB190800319D
申请日：1908-01-06
申请人： GRIFFIN JOHN , HAWKINS WILLIAM JOHN
发明人： GRIFFIN JOHN , HAWKINS WILLIAM JOHN
摘要： 319. Griffin, J., and Hawkins, W. J. Jan. 6. Heels; heel protectors.-An interchangeable heel for boots and shoes consists of a pad of rubber, leather, or other material, to which a metal plate b is fastened by means of spikes. This plate is pierced with a keyhole slot d, and with a square central hole adapted to receive a metal plate a, which is screwed to the heel of the boot. The meeting edges g, h of the plates are bevelled, and the pad is held firmly in place by a screw e, which engages in the keyhole slot.

2. 发明申请

WO2006028524A2 COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE 审中-公开
标题翻译：用于抑制激素和/或HMG-COA还原的组合物和治疗
公开(公告)号：WO2006028524A2
公开(公告)日：2006-03-16
申请号：PCT/US2005014843
申请日：2005-04-29
申请人： PHARMIX CORP , GRIFFIN JOHN , MYDLOWEC WILLIAM J , LANZA GUIDO , YU JESSEN
发明人： GRIFFIN JOHN , MYDLOWEC WILLIAM J , LANZA GUIDO , YU JESSEN
IPC分类号： A23L15/00 , A61K31/506 , A61K31/4178 , A61K31/4439
CPC分类号： A61K31/4178 , A61K31/4439 , A61K31/506
摘要： The present invention provides compositions of matter, kits and methods for their use in the treatment of MAP kinase-related conditions and/or HMG-CoA reductase-related conditions. In particular, the invention provides compositions for treating inflammatory and/or cardiovascular conditions in an animal subject by inhibiting p38a MAP kinase and/or HMG-CoA reductase, as well as providing formulations and modes of administering such compositions. The invention further provides methods for the rational design of inhibitors of MAP kinase, HMG-CoA reductase, or both for use in the practice of the present invention.
摘要翻译：本发明提供了用于治疗MAP激酶相关病症和/或HMG-CoA还原酶相关病症的物质，试剂盒和方法的组合物。特别地，本发明提供了通过抑制p38a MAP激酶和/或HMG-CoA还原酶来治疗动物受试者的炎症和/或心血管疾病的组合物，以及提供施用这种组合物的制剂和模式。本发明还提供了用于实施本发明的MAP激酶，HMG-CoA还原酶抑制剂或两者的合理设计的方法。

3. 发明申请

WO2007051065A3 COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE 审中-公开
标题翻译：用于抑制激素和/或HMG-COA还原的组合物和治疗
公开(公告)号：WO2007051065A3
公开(公告)日：2007-11-08
申请号：PCT/US2006042558
申请日：2006-10-30
申请人： PHARMIX CORP , GRIFFIN JOHN , LANZA GUIDO , YU JESSEN
发明人： GRIFFIN JOHN , LANZA GUIDO , YU JESSEN
IPC分类号： A61K31/4164
CPC分类号： C07D405/14 , C07D401/04 , C07D403/04
摘要： The present invention provides compositions of matter, kits and methods for their use in the treatment of MAP kinase-related conditions and/or HMG-CoA reductase-related conditions. In particular, the invention provides compositions for treating inflammatory and/or cardiovascular conditions in an animal subject by inhibiting ?38aMAP kinase and/or HMG-CoA reductase, as well as providing formulations and modes of administering such compositions. The invention further provides methods for the rational design of inhibitors of MAP kinase, HMG-CoA reductase, or both for use in the practice of the present invention.
摘要翻译：本发明提供了用于治疗MAP激酶相关病症和/或HMG-CoA还原酶相关病症的物质，试剂盒和方法的组合物。特别地，本发明提供了通过抑制α38aMAP激酶和/或HMG-CoA还原酶来治疗动物受试者的炎性和/或心血管疾病的组合物，以及提供施用这种组合物的制剂和模式。本发明还提供了用于实施本发明的MAP激酶，HMG-CoA还原酶抑制剂或两者的合理设计的方法。

4. 发明专利

CA2394075C LOAD BEARING BUILDING COMPONENT AND WALL ASSEMBLY METHOD 未知
公开(公告)号：CA2394075C
公开(公告)日：2006-07-25
申请号：CA2394075
申请日：2002-07-18
申请人： GRIFFIN JOHN
发明人： GRIFFIN JOHN
IPC分类号： E04B2/28 , E04B2/86 , E04C2/288
摘要： Disclosed is a panel building component, method of making same, and method of fabricating a load-bearing, insulating building wall using the panels and concrete pour after the panels are positioned on site. The panel includes at least one foa m core, vertical C-studs, a channel shaped foot member in engaging relationship with the bott om edge of the foam core and the bottom end of the C-studs, two siding member's, spacer s to keep the foam core centered between the siding members prior to filling the panel wit h concrete, and the concrete itself. The foam core and C-studs arc fabricated shorter th an the finished height of the panel so that rebar steel reinforcing rods can be laid horizontally such that when the panel is filled with concrete, the top portion will be a concrete a nd rebar tie bean. The method of making same is simply assembly of the foregoing components, less the concrete. The method of assembling a load-bearing wall includes fixing vertical rebar to the foundation, placing a first panel building component having a top voi d onto a foundation between vertical rebar, orienting the panel vertically so that th e vertical rebar is disposed inside outwardly facing C-studs at the edges of each panel, placing a second panel building component having a top void onto the foundation, orientingthe second panel in an upright position adjacent to the first panel between vertical rebars, positioning rebar horizontally in the top void of both panels, and filling both panels with concrete.

5. 发明专利

GB189514318A An Improved Joint for Taps, Pipes, and the like. 未知
公开(公告)号：GB189514318A
公开(公告)日：1895-09-07
申请号：GB189514318D
申请日：1895-07-27
申请人： GRIFFIN JOHN
发明人： GRIFFIN JOHN

6. 发明专利

CA2394075A1 LOAD BEARING BUILDING COMPONENT AND WALL ASSEMBLY METHOD 未知
公开(公告)号：CA2394075A1
公开(公告)日：2004-01-18
申请号：CA2394075
申请日：2002-07-18
申请人： GRIFFIN JOHN
发明人： GRIFFIN JOHN
IPC分类号： E04B2/86 , E04C2/288 , E04B2/28
摘要： Disclosed is a panel building component, method of making same, and method of fabricating a load-bearing, insulating building wall using the panels and concrete pour after the panels are positioned on site. The panel includes at least one foa m core, vertical C-studs, a channel shaped foot member in engaging relationship with the bott om edge of the foam core and the bottom end of the C-studs, two siding member's, spacer s to keep the foam core centered between the siding members prior to filling the panel wit h concrete, and the concrete itself. The foam core and C-studs arc fabricated shorter th an the finished height of the panel so that rebar steel reinforcing rods can be laid horizontally such that when the panel is filled with concrete, the top portion will be a concrete a nd rebar tie bean. The method of making same is simply assembly of the foregoing components, less the concrete. The method of assembling a load-bearing wall includes fixing vertical rebar to the foundation, placing a first panel building component having a top voi d onto a foundation between vertical rebar, orienting the panel vertically so that th e vertical rebar is disposed inside outwardly facing C-studs at the edges of each panel, placing a second panel building component having a top void onto the foundation, orientingthe second panel in an upright position adjacent to the first panel between vertical rebars, positioning rebar horizontally in the top void of both panels, and filling both panels with concrete.

7. 发明专利

GB189700622A A New or Improved Device for Splitting Gut in One Operation into Two or more Strips. 未知
公开(公告)号：GB189700622A
公开(公告)日：1898-01-08
申请号：GB189700622D
申请日：1897-01-09
申请人： GRIFFIN JOHN
发明人： GRIFFIN JOHN
摘要： 622. Griffin, J. Jan. 9. Catgut.-Means are described for cutting one or more guts into three or more strips at one operation. The guts are superposed on a rod or tube E, which is then placed in front of the knives, comprising in the example shown a horizontal one c and a vertical one b held by a bolt c' to a cross-bar d. Any desired arrangement of knives may of course be used. The workman using the appliance stands behind the knives, and pulls the guts along the rod or tube towards him and against the cutting-edges of the knives.

8. 发明专利

GB189523024A An Improved Waste Preventer for Use in Drawing Off Beer, Water, and other Liquids. 未知
公开(公告)号：GB189523024A
公开(公告)日：1896-01-25
申请号：GB189523024D
申请日：1895-12-02
申请人： GRIFFIN JOHN , PINCHBECK WILLIAM ERNEST CAPNE
发明人： GRIFFIN JOHN , PINCHBECK WILLIAM ERNEST CAPNE

9. 发明申请

WO2012078519A2 3-ACYLIDENE-2-OXOINDOLE DERIVATIVES FOR INHIBITION OF TRANSGLUTAMINASE 2 审中-公开
标题翻译：用于抑制转谷氨酰胺酶2的3-亚乙烯基-2-氧杂吲哚衍生物
公开(公告)号：WO2012078519A2
公开(公告)日：2012-06-14
申请号：PCT/US2011063312
申请日：2011-12-05
申请人： NUMERATE INC , UNIV LELAND STANFORD JUNIOR , GRIFFIN JOHN , RAIMUNDO BRIAN , MADRID PETER , KHOSLA CHAITAN , JIN XI , KLOECK CORNELIUS
发明人： GRIFFIN JOHN , RAIMUNDO BRIAN , MADRID PETER , KHOSLA CHAITAN , JIN XI , KLOECK CORNELIUS
IPC分类号： C07D209/34 , A61K31/403 , A61K31/4725 , A61P25/00 , C07D401/04 , C07D401/12 , C07D401/14
CPC分类号： C07D209/34 , C07D401/06 , C07D401/12 , C07D401/14
摘要： Provided herein are acylidene oxoindole derivatives, compositions including them, and methods of inhibiting transglutaminase 2 and treating diseases mediated by transglutaminase 2 by administering such derivatives and compositions.
摘要翻译：本文提供酰基氧代吲哚衍生物，包含它们的组合物，以及通过施用此类衍生物和组合物来抑制转谷氨酰胺酶2和治疗由转谷氨酰胺酶2介导的疾病的方法。

10. 发明申请

WO2005115397A3 COMPOSITIONS AND TREATMENTS FOR MODULATING KINASE AND/OR HMG-COA REDUCTASE 审中-公开
标题翻译：用于调节激酶和/或HMG-COA还原酶的组合物和治疗剂
公开(公告)号：WO2005115397A3
公开(公告)日：2006-07-13
申请号：PCT/US2005014833
申请日：2005-04-29
申请人： PHARMIX CORP , GRIFFIN JOHN
发明人： GRIFFIN JOHN
IPC分类号： A23L15/00 , A61K31/4178 , A61K31/4439 , A61K31/506
CPC分类号： A61K31/4178 , A61K31/4439 , A61K31/506
摘要： The present invention provides compositions of matter, kits and methods for their use in the treatment of kinase-related conditions and/or HMG-CoA reductase-related conditions. In particular, the invention provides compositions for treating immuno-compromised and/or cardiovascular conditions in an animal subject by modulating one or more MAP kinase(s) and/or HMG-CoA reductase, as well as providing formulations and modes of administering such compositions. The invention further provides methods for the rational design of modulators of MAP kinases, HMG-CoA reductase, or both for use in the practice of the present invention.
摘要翻译：本发明提供了用于治疗激酶相关病症和/或HMG-CoA还原酶相关病症的物质，试剂盒和方法的组合物。特别地，本发明提供了通过调节一种或多种MAP激酶和/或HMG-CoA还原酶来治疗动物受试者的免疫受损和/或心血管病症的组合物，以及提供施用这种组合物的制剂和模式。本发明还提供了用于实施本发明的MAP激酶，HMG-CoA还原酶或两者的调节剂的合理设计的方法。

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