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1. 发明专利

ZA201502430B ADHESIVE FUNCTIONAL STRIP FOR TRANSCUTANEOUS FLUORESCENCE MEASUREMENT 未知
公开(公告)号：ZA201502430B
公开(公告)日：2021-09-29
申请号：ZA201502430
申请日：2015-04-10
申请人： LOHMANN GMBH & CO KG , GRETZ NORBERT , SCHOCK KUSCH DANIEL
发明人： GRETZ NORBERT , SCHOCK-KUSCH DANIEL , HERBERTZ MICHAEL , NITTENWILM RALF
摘要： The present invention pertains to a functional patch to be affixed to the skin, with the aim of measuring metabolic disruptions to organs, and general organ functions, of kidneys, liver, heart, pancreas and muscles (lactate), for example—more particularly it concerns the measurement of the glomerular filtration rate (GFR)—and also to a method for producing a functional patch of this kind.

2. 发明申请

WO2006032441A3 STOICHIOMETRICALLY DEFINED DYE-LABELED SUBSTANCES FOR MEASURING GLOMERULAR FILTRATION RATE 审中-公开
标题翻译：化学计量DEFINED染料标记的物质用于测量肾小球滤过率
公开(公告)号：WO2006032441A3
公开(公告)日：2007-02-01
申请号：PCT/EP2005010093
申请日：2005-09-20
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , PILL JOHANNES , KRAEMER UWE , GRETZ NORBERT , DEUS CARSTEN , HAGENBRUCH BERND , KLOETZER HANS-MARTIN
发明人： PILL JOHANNES , KRAEMER UWE , GRETZ NORBERT , DEUS CARSTEN , HAGENBRUCH BERND , KLOETZER HANS-MARTIN
IPC分类号： A61K49/00 , A61K47/48
CPC分类号： A61K49/0052 , A61K49/0043
摘要： The invention relates to novel chemical compounds that can be used as tracers in renal diagnosis, to the production and use thereof, and to renal diagnostic reagent containing them.
摘要翻译：本发明涉及一种可以用作肾诊断含有它们的肾诊断标记物的物质，其制备和用途，和组合物的新化合物。

3. 发明专利

AU2008213452B2 Color-marked oligosaccharides or polysaccharides 未知
公开(公告)号：AU2008213452B2
公开(公告)日：2012-09-27
申请号：AU2008213452
申请日：2008-01-23
申请人： GRETZ NORBERT
发明人： HAUSMANNS STEPHAN , ROSE THOMAS , GRETZ NORBERT , SADICK MALIHA , WALTER THOMAS , KOWALCZYK JORG , SCHOCK DANIEL , WACH WOLFGANG
IPC分类号： A61K47/48 , A61K49/00 , C13B50/00
摘要： The invention relates to color-marked oligosaccharides or polysaccharides, a method for the production of these color-marked oligosaccharides or polysaccharides, and the use thereof for the determination of kidney function.

4. 发明专利

CA3044891A1 MEANS AND METHODS FOR VISUALIZATION OF TISSUE STRUCTURES 未知
公开(公告)号：CA3044891A1
公开(公告)日：2018-06-07
申请号：CA3044891
申请日：2017-11-30
申请人： GRETZ NORBERT , RUDOLF RUDIGER , WEINFURTER STEFANIE , BRENNA CINZIA , HUANG JIAGUO , KHAN ARIF UL MAULA
发明人： GRETZ NORBERT , RUDOLF RUDIGER , WEINFURTER STEFANIE , BRENNA CINZIA , HUANG JIAGUO , KHAN ARIF UL MAULA
IPC分类号： G01N33/50 , C08G73/02 , G01N33/52
摘要： The present invention relates to a chemical compound comprising (i) a polycationic polymer, coupled to (ii) a dye. The present invention further relates to a method for visualizing a glycosamine-containing structure in a biological sample comprising a) contacting an inner lumen of said biological sample with a dye-conjugated polycationic polymer, preferably with the chemical compound according to the present invention; b) tissue-clearing said biological sample; and, thereby, c) visualizing an internal glycosamine-containing structure in said biological sample. The present invention also relates to a method for determining the number and/or size of glomeruli in a kidney or a sample thereof making use of the method for visualizing a glycosamine-containing structure; and also relates to kits and uses related to said chemical compounds and said methods.

5. 发明专利

CA2901813A1 PORTABLE ILLUMINATING DEVICE FOR MANIPULATING THE CIRCADIAN CLOCK OF A SUBJECT 未知
公开(公告)号：CA2901813A1
公开(公告)日：2014-08-28
申请号：CA2901813
申请日：2014-02-20
申请人： GRETZ NORBERT
发明人： GRETZ NORBERT , SHULHEVICH YURY
IPC分类号： A61N5/06 , H05B44/00
摘要： The present invention relates to a portable illuminating device (110) comprising at least one illuminating light source (112) emitting light of a wavelength comprised in the range of 450 to 495 nm, preferably, comprising at least one further illuminating light source (112) emitting light of a wavelength comprised in the range of 620 nm to 750 nm; a diffuser (113) scattering the light of said illuminating light source (112) at least in part in the direction of at least one eye, preferably at least one cornea and/or retina, of said subject; and a mounting mechanism (114) for fixing the portable illuminating device (110) to the body of a subject. Preferably, said diffuser (113) scatters the light of said illuminating light source (112) at least in part in the direction of at least one eye and in the direction of at least a part of the facial skin of a subject. Preferably, the portable illuminating device (110) further comprises a sensor for determining if illumination is advisable, preferably a melatonin sensor, and/or comprises an oxygen and/or pulse sensor. The present invention further relates to the portable illuminating device (110) for use in preventing and/or treating a disease or disorder caused by or associated with a distorted circadian rhythm; and to a method of improving physical and/or mental performance of a healthy subject, comprising the step of illuminating at least one cornea of said subject with light comprising light of a wavelength of 450 to 495 nm for at least 15 min, thereby improving physical and/or mental performance of a healthy subject. Preferably, the invention relates to a method of improving physical and/or mental performance of a healthy subject, comprising illuminating at least one eye and/or at least a part of the facial skin of said subject with light comprising light of a wavelength of 450 nm to 495 nm and/or illuminating said subject with light comprising light of a wavelength of 620 nm to 750 nm, thereby improving physical and/or mental performance of a healthy subject.

6. 发明专利

DE102014107342A1 Vorrichtung und Verfahren zur Erkennung von Krebstumoren und anderen Gewebeveränderungen 未知
公开(公告)号：DE102014107342A1
公开(公告)日：2015-11-26
申请号：DE102014107342
申请日：2014-05-24
申请人： BRAUN FRANK , GRETZ NORBERT , RÄDLE MATTHIAS
发明人： RÄDLE MATTHIAS , GRETZ NORBERT , BRAUN FRANK
IPC分类号： G01N21/63 , G01N21/64 , G01N21/65
摘要： Es wird eine multispektrale Analysensonde zur Analyse verschiedener Spektralbereiche einer Probe vorgestellt. Die Analysensonde umfasst eine Kanüle an einer Probenseite der multispektralen Analysensonde zur Umhäusung von optischen Leitern eine Messspitze an der Probenseite der multispektralen Analysensonde einen ersten Lichtwellenleiter zum Transport eines ersten Lichtpulses, einen zweiten Lichtwellenleiter zum Transport eines zweiten Lichtpulses, der von dem ersten Lichtpuls verschiedenartig ist, wobei der erste und der zweite Lichtpuls durch die Kanüle an die Messspitze geleitet werden, um eine Spektralantwort an oder in der Probe zu erzeugen.

7. 发明专利

CA2734936A1 TRANSCUTANEOUS ORGAN FUNCTION MEASUREMENT 未知
公开(公告)号：CA2734936A1
公开(公告)日：2010-02-25
申请号：CA2734936
申请日：2009-08-20
申请人： GRETZ NORBERT
发明人： GRETZ NORBERT , HESSER JUERGEN , PILL JOHANNES , SCHOCK-KAUSCH DANIEL , WALTER THOMAS , SADICK MALIHA , EICKEMEYER FELIX , HWANG JAE HYUUG , SCHILDKNECHT CHRISTIAN , WATANABE SOICHI , WACH WOLFGANG , ROSE THOMAS
IPC分类号： A61B5/00 , A61K49/00 , C08B37/00 , G01N33/487 , G01N33/52 , G01N33/58
摘要： The invention relates to a sensor plaster (116) for the transcutaneous measurement of the functioning of an organ, particularly the functioning of a kidney. The sensor plaster (116) has at least one flexible support element (134) with at least one adhesive surface (138) which can adhere to a body surface. The sensor plaster (116) also has at least one radiation source, particularly a light source (142), wherein the radiation source is set up to irradiate the body surface with at least one interrogation light (162). The sensor plaster (116) also has at least one detector (146) which is set up to detect at least one response light (176) radiating from the direction of the body surface.

8. 发明申请

WO2008095603A3 COLOR-MARKED OLIGOSACCHARIDES OR POLYSACCHARIDES 审中-公开
标题翻译： COLOR注明寡糖或多糖
公开(公告)号：WO2008095603A3
公开(公告)日：2009-04-16
申请号：PCT/EP2008000479
申请日：2008-01-23
申请人： SUEDZUCKER AG , KOWALCZYK JOERG , ROSE THOMAS , HAUSMANNS STEPHAN , WALTER THOMAS , WACH WOLFGANG , GRETZ NORBERT , SADICK MALIHA , SCHOCK DANIEL
发明人： KOWALCZYK JOERG , ROSE THOMAS , HAUSMANNS STEPHAN , WALTER THOMAS , WACH WOLFGANG , GRETZ NORBERT , SADICK MALIHA , SCHOCK DANIEL
IPC分类号： A61K47/48 , A61K49/00 , C13B50/00
CPC分类号： A61K49/0054 , A61K47/549 , A61K49/0032 , A61K49/0052
摘要： The invention relates to color-marked oligosaccharides or polysaccharides, a method for the production of these color-marked oligosaccharides or polysaccharides, and the use thereof for the determination of kidney function.
摘要翻译：本发明涉及标记的寡糖或多糖的颜色，用于生产这些彩色标记的寡糖或多糖和其对肾功能的确定的用途。

9. 发明申请

WO2010020673A3 TRANSCUTANEOUS ORGAN FUNCTION MEASUREMENT 审中-公开
标题翻译：经皮器官功能测量
公开(公告)号：WO2010020673A3
公开(公告)日：2010-06-17
申请号：PCT/EP2009060785
申请日：2009-08-20
申请人： BASF SE , GRETZ NORBERT , HESSER JUERGEN
发明人： GRETZ NORBERT , HESSER JUERGEN
IPC分类号： A61B5/00 , A61K49/00 , C08B37/00 , G01N33/487 , G01N33/58
CPC分类号： A61B5/201 , A61B5/0002 , A61B5/0071 , A61B5/0082 , A61B5/145 , A61B5/14546 , A61B5/1455 , A61B5/6832 , A61B5/6833 , A61B90/39 , A61B2090/3941 , A61B2560/0219 , A61B2560/0412 , A61K49/0043 , G01N33/582 , G01N2800/065 , G01N2800/28 , G01N2800/347
摘要： The invention relates to a sensor plaster (116) for the transcutaneous measurement of the functioning of an organ, particularly the functioning of a kidney. The sensor plaster (116) has at least one flexible support element (134) with at least one adhesive surface (138) which can adhere to a body surface. The sensor plaster (116) also has at least one radiation source, particularly a light source (142), wherein the radiation source is set up to irradiate the body surface with at least one interrogation light (162). The sensor plaster (116) also has at least one detector (146) which is set up to detect at least one response light (176) radiating from the direction of the body surface.
摘要翻译：有一个传感器补丁（116），用于器官功能的经皮测量，特别是肾功能已经被提出。该传感器补丁（116）包括至少一个柔性支撑元件（134）的身体表面上的条形粘表面（138）的至少一个。此外，传感器补丁（116）包括至少一个辐射源，特别是光源（142），其中所述辐射源布置成与至少一个询问光（162）来照射所述主体的表面。此外，传感器补丁（116）包括被配置成检测至少一个从所述身体表面的光的响应（176）的方向上照射至少一个检测器（146）。

10. 发明专利

ES2834955T3 Tira funcional adhesiva para medición de fluorescencia transcutánea 未知
公开(公告)号：ES2834955T3
公开(公告)日：2021-06-21
申请号：ES13789701
申请日：2013-09-04
申请人： LOHMANN GMBH & CO KG , GRETZ NORBERT , MEDIBEACON
发明人： GRETZ NORBERT , SCHOCK-KUSCH DANIEL , HERBERTZ MICHAEL , NITTENWILM RALF
IPC分类号： A61B5/20 , C09J7/22 , C09J7/38
摘要： Tira funcional adhesiva para la medición de fluorescencia transcutánea de funciones orgánicas generales o trastornos orgánicos metabólicos con la ayuda de un cabezal de sensor fijado a la tira, que está equipado con luz LED y un fotodiodo, constando la tira fundamentalmente de un laminado de las siguientes capas: - tira adhesiva de transferencia transparente sin soporte o cinta adhesiva transparente (2) sensible a la presión de doble cara y adecuada para aplicaciones sobre la piel - lámina transparente (3) - al menos una capa adhesiva sensible a la presión (4-6) absorbente de luz con al menos una escotadura (13), a través de la cual se posibilita el contacto directo de la luz con la piel tanto del cabezal de sensor equipado con luz LED como del fotodiodo, - cubierta transparente (7) estabilizadora, sobre la cual, en el lado de la tira funcional opuesto a la piel, está montado un marco de sellado circunferencial que comprende cuatro tiras de sellado (8-11), que es un componente integrante del esparadrapo funcional.

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