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1. 发明专利

JPS53142592A STABILIZATION OF UROKINASE HEATING 失效
公开(公告)号：JPS53142592A
公开(公告)日：1978-12-12
申请号：JP5589477
申请日：1977-05-13
申请人： GREEN CROSS CORP
发明人： NAITOU RIYOUICHI , KAWANO TAKEHIKO , NISHIDA MASAYUKI , TAJIMA MASAKAZU , MORIMOTO KAZUO
IPC分类号： C12N9/72
摘要： PURPOSE:To inactivate viruses in t urokinase-containing solution, by heating the solution in the presence of albumin originated from human serum or human placenta.

2. 发明专利

JPS56127308A BLOOD-COAGULATION FACTOR 8 PHARMACEUTICAL 失效
公开(公告)号：JPS56127308A
公开(公告)日：1981-10-06
申请号：JP3069580
申请日：1980-03-11
申请人： GREEN CROSS CORP
发明人： YOKOYAMA KAZUMASA , FUKUSHIMA TSUNEKAZU , SHIYOUJI TAKASHI , SUYAMA TADAKAZU , NAITOU RIYOUICHI
IPC分类号： A61K9/10 , A61K9/107 , A61K38/37 , A61K38/43 , A61P7/00
摘要： PURPOSE:The titled pharmaceutical, which is in a liquid or freeze-dried form with a lasting activity in blood, consists of blood coagulation factor VIII, soybean oil, phospholipid and water, and further contains a fatty acid, cholesterol or phosphatidic acid or stabilizer optionally. CONSTITUTION:A fatty emulsion pharmaceutical or a freeze-dried pharmaceutical thereof consisting of blood coagulation factor VIII (F-VIII) in an effective amount, 5- 50%(W/V) soybean oil, phospholipid at a weight ratio of the phospholipid to the soybean oil, phospholipid at a weight ratio of the phospholipid to the soybean oil, or 2:100-50:100, 0.5%(W/V) or less cholesterol or 5.0%(W/V) or less phosphatidic acid, a stabilizing amount of albumin or dextran as a stabilizer for the F-VIII and the balance of water. The pharmaceutical is effective for the remedy of hemophilia A and administrable by any of the parenteral and oral routes, and has a lasting activity in blood. The pharmaceutical may contain a 12-20C fatty acid as an isotonizing agent and an emulsifying assistant in an amount up to 0.3%(W/V).

3. 发明专利

JPS5464688A THERMAL STABILIZATION OF UROKINASE 失效
公开(公告)号：JPS5464688A
公开(公告)日：1979-05-24
申请号：JP13187077
申请日：1977-11-02
申请人： GREEN CROSS CORP
发明人： NAITOU RIYOUICHI , KAWANO TAKEHIKO , NISHIDA MASAYUKI , TAJIMA MASAKAZU , MORIMOTO KAZUO
IPC分类号： C12N9/72 , A61K38/17 , C12N9/96
摘要： PURPOSE:To inactivate viruses existing in a urokinase-containing solution by heating in the presence of gelatine. CONSTITUTION:A urokinase-containing solution is heated at 50-70 deg.C, pref. 55- 65 deg.C, for 8-12 hours, in the presence of gelatine. EFFECT:Contamination of the urokinase preparation with an antigenic substance is minimized.

4. 发明专利

JPS5459343A FOOD ADDITIVES FOR SUPPLYNG FOOD AND FEED BEING DEFFICIENT FROM FIBER SUBSTANCE 失效
公开(公告)号：JPS5459343A
公开(公告)日：1979-05-12
申请号：JP12624577
申请日：1977-10-20
申请人： GREEN CROSS CORP
发明人： NAITOU RIYOUICHI , INAHARA HIROHISA , SHIINO SATORU
IPC分类号： A23L1/30 , A23L1/308 , A23L29/00 , A61K36/00 , A61K36/8965

5. 发明专利

JPS52151723A LLASPARAGINASE PREPARATIONS AND CONTAINER FOR SAME 失效
公开(公告)号：JPS52151723A
公开(公告)日：1977-12-16
申请号：JP6902776
申请日：1976-06-12
申请人： GREEN CROSS CORP , KYOWA HAKKO KOGYO KK
发明人： NAITOU RIYOUICHI , INADA YUUJI , MIYAKE SHIYOUICHI
IPC分类号： A61K38/46 , A61J1/00 , A61K9/00 , A61M1/36
摘要： PURPOSE:An enzyme preparation incorporated in an external circulating circuit outside the body and used for treating leukemia by contact with blood, in which the enzyme is embedded in a fibrin membrane immobilized on a heat-resistant base cloth, whereby the fibrin membrane is reinforced and sterilization can be easily conducted.

6. 发明专利

JPS58151560A KIT FOR MEASUREMENT OF HUMAN URINE CALLICREIN 失效
公开(公告)号：JPS58151560A
公开(公告)日：1983-09-08
申请号：JP3533482
申请日：1982-03-05
申请人： GREEN CROSS CORP
发明人： MORIYA HIROSHI , NAITOU RIYOUICHI , MORICHI SHIGEHIRO , SAKO EIJI
IPC分类号： G01N33/573
摘要： PURPOSE:To determine quantitatively urine callicrein in a liquid to be inspected quickly and accurately, by using a kit for quantitative determination of human urine callicrein consisting of an anti-human callicrein antibody fixing vessel, enzyme labeled human urine callicrein, standard human urine callicrein and a substrate buffer solution for enzyme activity measurement. CONSTITUTION:When incubation is carried out by adding a buffer solution of enzyme labeled human urine callicrein and a liquid to be inspected to an anti-human urine callicrein antibody fixing vessel, combined material (B material) is formed by antigen.ant ibodyreaction by reacting a fixed antibody to the enzyme labeled human urine callicrein and the callicrein in the liquid to be inspected. Incubation is carried out by adding the buffer solution for enzyme activity measurement and a substrate for oxygen activity measurement to the antibody fixing vessel carried out B/F separation. Hereafter, a product formed by enzyme reaction is determined quantitatively by using a spectrophotometer. On the other hand, a standard calibration curve is made by using various concentration of the standard human urine callicrein in stead of the liquid to be inspected and the callicrein in said liquid is determined quantitatively by com paring the value of the enzyme activity of the liquid to be inspected with said value.

7. 发明专利

JPS58109451A PERFLUOROBICYCLOHEPTANE COMPOUND 失效
公开(公告)号：JPS58109451A
公开(公告)日：1983-06-29
申请号：JP20747681
申请日：1981-12-21
申请人： GREEN CROSS CORP
发明人： YOKOYAMA KAZUMASA , FUKAYA TSUTOMU , TSUDA YOSHIO , ONO TAIZOU , ARAKAWA YOSHIO , INOUE YOSHIHISA , NAITOU YOUICHIROU , SUYAMA TADAKAZU , NAITOU RIYOUICHI
IPC分类号： C25B3/08 , A61K31/13 , A61P7/08 , C07C67/00 , C07C209/00 , C07C211/37
摘要： NEW MATERIAL:The compound of formula (R1 and R2 are lower perfluoroalkyl) which may have lower perfluoroalkyl substituent group at an arbitrary position on the cycloaliphatic ring. EXAMPLE:Perfluoro-N-ethyl-N-methyl-2-norbornylamine. USE:The oxygen-transporting component for blood substitute, oxygen transporting liquid, etc. PROCESS:The compound of formula is prepared by fluorinating the perhydro compound corresponding to the compound of formula by conventional fluorination technique such as electrochemical fluorination, cobalt fluorination, electrolytic fluorination, etc. For example, anhydrous hydrogen fluoride and a perhydro compound are mixed and dissolved with each other in an electrolyzer, and electrolyzed. The compound of formula is separated and purified from the precipitate at the bottom of the electrolyzer.

8. 发明专利

JPS5892680A PERFLUOROBICYCLO COMPOUND 失效
公开(公告)号：JPS5892680A
公开(公告)日：1983-06-02
申请号：JP19135881
申请日：1981-11-27
申请人： GREEN CROSS CORP
发明人： YOKOYAMA KAZUMASA , FUKAYA TSUTOMU , TSUDA YOSHIO , ONO TAIZOU , ARAKAWA YOSHIO , SUYAMA TADAKAZU , NAITOU RIYOUICHI
IPC分类号： A61K9/00 , A61K31/40 , A61K31/435 , A61P7/08 , C07D455/02 , C07D471/04 , C07D487/04 , C25B3/08
摘要： NEW MATERIAL:A perfluorobicyclo compound shown by the formulaI(one or both of the ring A and the ring B may be substituted with a lower perfluoroalkyl group; m and n are 3-4). EXAMPLE:3-Methylperhydroindolizine shown by the formula II. USE:A blood substitute, an oxygen transporting component for oxygen transporting transfusion, etc. Capable of dissolving a large amount of oxygen, metabolically inert, and quickly discharged out of the body. Prepared as a water emulsion containing 5-50W/V%, preferably 10-40W/V% compound shown by the formulaI. PROCESS:A hydrocompound corresponding to a compound shown by the formulaI is fluorinated (e.g., electrolytic fluorination, cobalt fluorination) to give a compound shown by the formulaI. Electrolytic fluorination is the most preferable amoung them, for example, anhydrous hydrogen fluoride is blended with a perhydrocompound in an electrolytic cell, a raw material compound, dissolved, and electrolyzed.

9. 发明专利

JPS5896061A PERFLUORO-CYCLIC-AMINE 失效
公开(公告)号：JPS5896061A
公开(公告)日：1983-06-07
申请号：JP19342181
申请日：1981-11-30
申请人： GREEN CROSS CORP
发明人： YOKOYAMA KAZUMASA , FUKAYA TSUTOMU , TSUDA YOSHIO , ONO TAIZOU , ARAKAWA YOSHIO , SUYAMA TADAKAZU , NAITOU RIYOUICHI
IPC分类号： C07D207/10 , A61K31/40 , A61K31/445 , A61K31/55 , A61P7/08 , C07D211/18 , C07D223/04
摘要： NEW MATERIAL:The perfluoro-cyclic amine of formula (at least one of A ring and B ring may be substituted with lower perfluoroalkyl group; m and n are 4- 6; Z is perfluoroalkylene or single bond). EXAMPLE:Perfluoro-N-cyclohexylpyrrolidine. USE:Oxygen carrier component of blood substitute, oxygen carrying transfusion liquid, etc. for mammals (man, dog, cat, cattle, horse, rat, mouse, Genea pig, etc.). PROCESS:The perfluoro-cyclic amine of formula can be prepared by fluorinating the corresponding perhydro compound by electrolytic fluorination.

10. 发明专利

JPS5892658A PERFLUORO COMPOUND 失效
公开(公告)号：JPS5892658A
公开(公告)日：1983-06-02
申请号：JP19135781
申请日：1981-11-27
申请人： GREEN CROSS CORP
发明人： YOKOYAMA KAZUMASA , FUKAYA TSUTOMU , TSUDA YOSHIO , ONO TAIZOU , ARAKAWA YOSHIO , SUYAMA TADAKAZU , NAITOU RIYOUICHI
IPC分类号： C07D209/08 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/435 , A61K31/47 , A61K31/472 , A61K31/473 , A61P7/08 , C07D209/10 , C07D209/30 , C07D209/44 , C07D209/52 , C07D217/22 , C07D221/04 , C25B3/08
摘要： NEW MATERIAL:A perfluoro compound shown by the formula (one or both of the ring A and ring B may be substituted with a lower perfluoroalkyl; l is 3 or 4; m+n is 2 or 3; R is lower perfluoroalkyl). EXAMPLE:Perfluoro-N-methylperhydroquinoline. USE:A blood substitute, an oxygen transporting component for oxygen transporting transfusion. PROCESS:Anhydrous hydrogen fluoride is blended with a perhydro compound in an electrolytic cell, dissolved, and electrolyzed (voltage of 3-9V, anodic electrolytic density of 1-100A/dcm , at 4-10 deg.C, total electrolysis of 900-1,500Ahr), to give a compound shown by the formulaI.

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