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1. 发明公开

EP0710654A4 TRIAZOLE DERIVATIVE AND PHARMACEUTICAL USE THEREOF 失效
标题翻译： TRIAZOLDERIVAT UND SEINE PHARMAZEUTISCHE VERWENDUNG
公开(公告)号：EP0710654A4
公开(公告)日：1996-08-28
申请号：EP94921804
申请日：1994-07-22
申请人： GREEN CROSS CORP
发明人： AKAHOSHI FUMIHIKO , OKADA TAKEHIRO , TAKEDA SHINJI , NAITO YOUICHIRO , FUKAYA CHIKARA , KUWAHARA SHIGEKI , KAJII MASAHIKO , NISHIMURA HIROKO , SUGIURA MASANORI
IPC分类号： C07D249/14 , C07D487/04 , A61K31/41 , A61K31/53
CPC分类号： C07D487/04 , C07D249/14
摘要： Prophylactic or therapeutic agents for immune-related diseases, in particular, immunosuppressant, prophylactic or therapeutic agent for allergic diseases, prophylactic or therapeutic agent for eosinocyte-related diseases and eosinophilia inhibitor, said agents containing a novel mono- or bicyclic triazole derivative represented by general formula (I) or (III) or a pharmaceutically acceptable salt thereof as the active ingredient, wherein X represents O or S; and W represents -NR?4R5 or -SR6¿. The derivatives have excellent activities of inhibiting eosinophilia and lymphocyte activation, low toxicity and persistent effect, and are particularly efficacious in treating accumulation and activation of eosinocytes and lymphocytes, inflammatory respiratory tract diseases, eosinocyte-related diseases such as eosinophilia, and immune-related diseases.
摘要翻译：用于预防和治疗免疫相关疾病的药剂，特别是免疫抑制剂，用于预防和治疗过敏性疾病的药物，用于预防和治疗嗜酸性粒细胞相关疾病的药物和嗜酸性粒细胞减少症抑制剂，其包含作为活性成分，一系列下式（I）的三唑衍生物或下式（III）其中每个符号如说明书中所定义，或其药学上可接受的盐。新型单环或双环三唑衍生物。用于预防和治疗免疫相关疾病的药物，特别是免疫抑制剂，用于预防和治疗过敏性疾病的药物，用于预防和治疗嗜酸性粒细胞相关疾病的药物，嗜酸性粒细胞增多抑制剂和新型三唑衍生物本发明的全部具有优良的嗜酸性粒细胞增多抑制作用和淋巴细胞活化抑制作用。它们是低毒性和持续性的。它们在治疗嗜酸性粒细胞和淋巴细胞的积累和活化，炎性呼吸道疾病，嗜酸性粒细胞相关疾病如嗜酸性粒细胞增多和免疫相关疾病方面特别有效。

2. 发明专利

FR2532309A1 未知
公开(公告)号：FR2532309A1
公开(公告)日：1984-03-02
申请号：FR8301448
申请日：1983-01-31
申请人： GREEN CROSS CORP
发明人： YOKOYAMA KAZUMASA , FUKAYA CHIKARA , TSUDA YOSHIO , ONO TAIZO , ARAKAWA YOSHIO , INOUE YOSHIHISA , NAITO YOUICHIRO , SUYAMA TADAKAZU
IPC分类号： A61K9/107 , A61K31/40 , A61P7/08 , C07D207/10 , C09K23/14
摘要： A perfluorocycloamine emulsion preparation having oxygen carrying ability containing a perfluorocycloamine of the general formula: wherein any position may optionally be substituted with a perfluoromethyl group as an oxygen carrying component.

3. 发明专利

AT41867T 未知
公开(公告)号：AT41867T
公开(公告)日：1989-04-15
申请号：AT85113334
申请日：1985-10-21
申请人： GREEN CROSS CORP
发明人： FUKAYA CHIKARA , NAITO YOUICHIRO , HANADA SHUICHI , WATANABE MASAHIRO , YOKOYAMA KAZUMASA
IPC分类号： A61K31/405 , A61K31/40 , A61P25/04 , A61P29/00 , C07D209/26
摘要： 1-(fluoro- or perfluoro lower alkyl-substituted benzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid carboxymethyl ester is found to have antiinflammatory and analgestic activity with less side effects on gastrointestinal traces than its homologue, acemetacin or indometacin.

4. 发明专利

CA1189079A PERFLUOROTRICYCLIC AMINE COMPOUNDS 未知
公开(公告)号：CA1189079A
公开(公告)日：1985-06-18
申请号：CA424874
申请日：1983-03-30
申请人： GREEN CROSS CORP
发明人： YOKOYAMA KAZUMASA , FUKAYA CHIKARA , TSUDA YOSHIO , ONO TAIZO , ARAKAWA YOSHIO , INOUE YOSHIHISA , NAITO YOUICHIRO , SUYAMA TADAKAZU
IPC分类号： C07D209/56 , C07D221/22
摘要： A perfluorotricyclic amine compound which is usable as an oxygen carrier in an artificial blood, represented by the general formula wherein R denotes a perfluoroalkyl group having 1 - 4 carbon atoms; the ring A denotes a five- or sixmembered ring, the ring B denotes a five-, sixor seven-membered ring, the ring C denotes a fiveor six-membered ring any one of the rings A, B and C optionary being substituted by one or more lower perfluoroalkyl group in addition to the abovementioned substituent R; and further f, g, h, i, j and k denote integers appropriately selected to construct the above-mentioned size of rings A, B, and C; is prepared by reacting the corresponding perhydrotricyclic amine with fluorine.

5. 发明专利

FR2532309B1 未知
公开(公告)号：FR2532309B1
公开(公告)日：1986-01-24
申请号：FR8301448
申请日：1983-01-31
申请人： GREEN CROSS CORP
发明人： YOKOYAMA KAZUMASA , FUKAYA CHIKARA , TSUDA YOSHIO , ONO TAIZO , ARAKAWA YOSHIO , INOUE YOSHIHISA , NAITO YOUICHIRO , SUYAMA TADAKAZU
IPC分类号： A61K9/107 , A61K31/40 , A61P7/08 , C07D207/10 , C09K23/14
摘要： A perfluorocycloamine emulsion preparation having oxygen carrying ability containing a perfluorocycloamine of the general formula: wherein any position may optionally be substituted with a perfluoromethyl group as an oxygen carrying component.

6. 发明专利

CA1192494A PERFLUOROCYCLOAMINE EMULSION PREPARATION 未知
公开(公告)号：CA1192494A
公开(公告)日：1985-08-27
申请号：CA418704
申请日：1982-12-29
申请人： GREEN CROSS CORP
发明人： YOKOYAMA KAZUMASA , FUKAYA CHIKARA , TSUDA YOSHIO , ONO TAIZO , ARAKAWA YOSHIO , INOUE YOSHIHISA , NAITO YOUICHIRO , SUYAMA TADAKAZU
IPC分类号： A61K9/107 , A61K31/40 , A61P7/08 , C07D207/10 , C09K23/14 , A01N1/02 , A61K9/10
摘要： A perfluorocycloamine emulsion preparation having oxygen carrying ability containing a perfluorocycloamine of the general formula: wherein any position may optionally be substituted with a perfluoromethyl group as an oxygen carrying component.

7. 发明专利

CA1183087A PERFLUOROBICYCLO COMPOUND EMULSION PREPARATION 未知
公开(公告)号：CA1183087A
公开(公告)日：1985-02-26
申请号：CA418703
申请日：1982-12-29
申请人： GREEN CROSS CORP
发明人： YOKOYAMA KAZUMASA , FUKAYA CHIKARA , TSUDA YOSHIO , ONO TAIZO , ARAKAWA YOSHIO , INOUE YOSHIHISA , NAITO YOUICHIRO , SUYAMA TADAKAZU
IPC分类号： A01N1/02 , A61K9/10 , A61K31/435 , A61P7/08 , C07D455/02 , C09K23/14 , A61K31/445 , A61K47/00
摘要： A perfluorobicyclo compound emulsion preparation having oxygen carrying ability containing a perfluorobicyclo compound of the general formula: wherein R represents a perfluoromethyl group or perfluoroethyl group, as an oxygen carrying component.

8. 发明专利

GB2132606A PERFLUOROBICYCLO COMPOUNDS AND EMULSION PREPARATIONS CONTAINING THEM 未知
公开(公告)号：GB2132606A
公开(公告)日：1984-07-11
申请号：GB8302397
申请日：1983-01-28
申请人： GREEN CROSS CORP
发明人： YOKOYAMA KAZUMASA , FUKAYA CHIKARA , TSUDA YOSHIO , ONO TAIZO , ARAKAWA YOSHIO , INOUE YOSHIHISA , NAITO YOUICHIRO , SUYAMA TADAKAZU
IPC分类号： A01N1/02 , A61K9/10 , A61K31/435 , A61P7/08 , C07D455/02 , C09K23/14 , C07D471/04 , B01F17/14
摘要： A perfluorobicyclo compound emulsion preparation having oxygen carrying ability containing a perfluorobicyclo compound of the general formula: wherein R represents a perfluoromethyl group or perfluoroethyl group, as an oxygen carrying component.

9. 发明专利

DE3303116A1 未知
公开(公告)号：DE3303116A1
公开(公告)日：1984-03-15
申请号：DE3303116
申请日：1983-01-31
申请人： GREEN CROSS CORP
发明人： YOKOYAMA KAZUMASA , FUKAYA CHIKARA , TSUDA YOSHIO , ONO TAIZO , ARAKAWA YOSHIO , INOUE YOSHIHISA , NAITO YOUICHIRO , SUYAMA TADAKAZU
IPC分类号： A01N1/02 , A61K9/10 , A61K31/435 , A61P7/08 , C07D455/02 , C09K23/14 , A61K31/47
摘要： A perfluorobicyclo compound emulsion preparation having oxygen carrying ability containing a perfluorobicyclo compound of the general formula: wherein R represents a perfluoromethyl group or perfluoroethyl group, as an oxygen carrying component.

10. 发明专利

DE3303151A1 未知
公开(公告)号：DE3303151A1
公开(公告)日：1984-03-01
申请号：DE3303151
申请日：1983-01-31
申请人： GREEN CROSS CORP
发明人： YOKOYAMA KAZUMASA , FUKAYA CHIKARA , TSUDA YOSHIO , ONO TAIZO , ARAKAWA YOSHIO , INOUE YOSHIHISA , NAITO YOUICHIRO , SUYAMA TADAKAZU
IPC分类号： A61K9/107 , A61K31/40 , A61P7/08 , C07D207/10 , C09K23/14
摘要： A perfluorocycloamine emulsion preparation having oxygen carrying ability containing a perfluorocycloamine of the general formula: wherein any position may optionally be substituted with a perfluoromethyl group as an oxygen carrying component.

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