专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009089027A1 PHOSPHODIESTERASE INHIBITORS 审中-公开
标题翻译：磷酸二酯酶抑制剂
公开(公告)号：WO2009089027A1
公开(公告)日：2009-07-16
申请号：PCT/US2009/000105
申请日：2009-01-08
申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICE, NATIONAL INSTITUTES OF HEALTH , THOMAS, Craig, J. , XIA, Menghang , SKOUMBOURDIS, Amanda, P. , LECLAIRE, Christopher, A.
发明人： THOMAS, Craig, J. , XIA, Menghang , SKOUMBOURDIS, Amanda, P. , LECLAIRE, Christopher, A.
IPC分类号： C07D487/04 , C07D513/04 , A61K31/549 , A61P11/06
CPC分类号： C07D513/04 , C07D487/04
摘要： The invention relates to compounds of formula I useful for inhibiting phosphodiesterase-4.
摘要翻译：本发明涉及可用于抑制磷酸二酯酶-4的式I化合物。

2. 发明申请

WO2004033647A3 ASSAY METHODS FOR STATE-DEPENDENT CALCIUM CHANNEL AGONISTS/ANTAGONISTS 审中-公开
公开(公告)号：WO2004033647A3
公开(公告)日：2004-04-22
申请号：PCT/US2003/031822
申请日：2003-10-09
申请人： MERCK & CO., INC. , XIA, Menghang , CONNOLLY, Thomas, M. , BENNETT, Paul, B., Jr. , COHEN, Charles, J.
发明人： XIA, Menghang , CONNOLLY, Thomas, M. , BENNETT, Paul, B., Jr. , COHEN, Charles, J.
IPC分类号： C12N5/00
摘要： Methods of identifying activators and inhibitors of voltage-gated ion channels are provided in which the methods employ cells transfected with a voltage-gated ion channel of interest and a corollary channel to control the membrane potential of the cells by changing extracellular ion concentration. This allows for more convenient, more precise experimental manipulation of these transitions, and, coupled with efficient methods of detecting the result of ion flux through the channels, provides methods that are especially suitable for high throughput screening.

3. 发明申请

WO2005035716A2 NUCLEIC ACID MOLECULES ENCODING NOVEL HUMAN LOW-VOLTAGE ACTIVATED CALCIUM CHANNEL PROTEINS, DESIGNATED - ALPHA 1I-1 AND ALPHA 1I-2, ENCODED PROTEINS AND METHODS OF USE THEREOF 审中-公开
标题翻译：编码新的人类低电压激活的钙通道蛋白的核酸分子，指定的 - ALPHA 1I-1和ALPHA 1I-2，编码的蛋白质及其使用方法
公开(公告)号：WO2005035716A2
公开(公告)日：2005-04-21
申请号：PCT/US2004/031820
申请日：2004-09-28
申请人： MERCK & CO., INC. , XIA, Menghang , WILLIAMS, Mark, E.
发明人： XIA, Menghang , WILLIAMS, Mark, E.
IPC分类号： C12N
CPC分类号： C07K14/705
摘要： Disclosed are mammalian nucleic acid sequences encoding α1I subunit isoforms of a voltage-gated calcium channel. Specifically disclosed are novel variants of the α1I subunit designated herein as α1I-1 and α1I-2. In other aspects, the disclosure relates to expression vectors which encode the novel subunits of the invention, as well as cells containing such vectors. Antibodies specific for each of the variant subunits are also provided. The nucleic acid sequences of the invention find application, for example, in screening for compounds which modulate the activity of voltage-gated calcium channels and also in diagnostic methods for diagnosing various T-type channel mediated disorders , e.g., epilepsy, cancer, pain, sleep disorders and the autoimmune disease Lambert-Eaton Syndrome. Diagnosing defects in α1I subunit genes of a patient with a neuronal disease such as epilepsy are also included. An additional application of the nucleic acid sequences of the invention is in therapeutic methods of treatment for α1I subunit mediated disorders.
摘要翻译：公开了编码电压门控钙通道的α1I亚基同种型的哺乳动物核酸序列。具体公开的是本文称为α1I-1和α1I-2的α1I亚基的新变体。在其他方面，本公开涉及编码本发明的新亚基的表达载体以及含有这些载体的细胞。还提供了针对每个变体亚单位特异性的抗体。本发明的核酸序列可用于例如筛选调节电压门控钙通道活性的化合物，以及用于诊断各种T型通道介导的病症的诊断方法，例如癫痫，癌症，疼痛，睡眠障碍和自身免疫疾病兰伯特 - 伊顿综合征。还包括诊断患有神经元疾病如癫痫患者的α1I亚基基因缺陷。本发明的核酸序列的另外应用是治疗α1I亚基介导的病症的治疗方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式