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1. 发明申请

WO2006020425A1 BIOABSORBABLE SELF-EXPANDING ENDOLUMENAL DEVICES 审中-公开
标题翻译：可生物自扩张内镜装置
公开(公告)号：WO2006020425A1
公开(公告)日：2006-02-23
申请号：PCT/US2005/026892
申请日：2005-07-29
申请人： GORE ENTERPRISE HOLDINGS, INC. , ARMSTRONG, Joseph, R. , BEGOVAC, Paul, C. , CLEEK, Robert, L. , CULLY, Edward, H. , FLYNN, Charles , HAYES, Byron, K. , PETERSON, Ray, V. , VONESH, Michael, J. , WHITE, Charles, F.
发明人： ARMSTRONG, Joseph, R. , BEGOVAC, Paul, C. , CLEEK, Robert, L. , CULLY, Edward, H. , FLYNN, Charles , HAYES, Byron, K. , PETERSON, Ray, V. , VONESH, Michael, J. , WHITE, Charles, F.
IPC分类号： A61F2/06
CPC分类号： A61F2/01 , A61B17/12022 , A61B17/12118 , A61B17/1214 , A61B2017/1205 , A61F2/91 , A61F2/915 , A61F2002/016 , A61F2002/018 , A61F2002/30062 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155 , A61F2210/0004 , A61F2210/0076 , A61F2220/0016 , A61F2230/005 , A61F2230/0054 , A61F2230/0069 , A61F2230/008 , A61F2250/003 , A61L31/06 , A61L31/148 , C08L67/04
摘要： The present invention is directed to bioabsorbable self-expanding medical devices for use inside or outside body conduits that self-expand at, or below, normal human body temperature without requisite for a polymeric thermal transition.
摘要翻译：本发明涉及用于在正常人体温度下或在正常人体温度下自膨胀而不在聚合物热转变条件下自身膨胀的身体导管内部或外部的生物可吸收自扩张医疗装置。

2. 发明申请

WO1997046266A1 IMPROVED BLOOD CONTACT SURFACES USING EXTRACELLULAR MATRIX SYNTHESIZED IN VITRO HAVING BIOACTIVE SPECIES IMMOBILIZED THERETO 审中-公开
标题翻译：改进的血液接触表面使用合成有生物活性物质的体外细胞基质合成
公开(公告)号：WO1997046266A1
公开(公告)日：1997-12-11
申请号：PCT/US1997009633
申请日：1997-06-02
申请人： GORE ENTERPRISE HOLDINGS, INC.
发明人： GORE ENTERPRISE HOLDINGS, INC. , BRUCHMAN, William, C. , BEGOVAC, Paul, C. , FOSTER, Nancy, L.
IPC分类号： A61L27/00
CPC分类号： A61L27/507 , A61F2/06
摘要： This invention is directed to improved blood contact devices such as vascular prostheses rendered substantially nonthrombogenic through addition of a preserved layer of extracellular subendothelial matrix. The preserved subendothelial matrix layer, which serves as the blood interface of the device, is analogous to the subendothelial matrix layer beneath the endothelium of native vascular surfaces. The device consists of a permanent synthetic base material, preferably porous expanded polytetrafluoroethylene, on which this biologic layer of subendothelial matrix is grown in situ. The biologic layer is produced using in vitro tissue culture methods whereby living cells synthesize and deposit extracellular matrix components, after which the cells are killed and/or removed and the subendothelial matrix layer preserved before implantation. Bioactive species are then attached to the subendothelial matrix layer to enhance the patency performance of the matrix layer or as a mechanism through which a therapeutical treatment is administered to a patient. This invention results in vascular prostheses that are particularly useful for arterial bypass requiring a diameter of 6 mm of less.
摘要翻译：本发明涉及通过添加细胞外内皮下基质的保留层而改进的血液接触装置，例如基本上不引起血管假体的血液假体。用作装置血液界面的保留的内皮下基质层类似于天然血管表面内皮下面的内皮下基质层。该装置由永久性合成基础材料，优选多孔膨胀聚四氟乙烯组成，该生物层内皮下基质在其上原位生长。使用体外组织培养方法产生生物层，其中活细胞合成并沉积细胞外基质组分，之后细胞被杀死和/或去除，并且内皮下基质层在植入前保留。然后将生物活性物质连接到内皮下基质层以增强基质层的通畅性能，或作为向患者施用治疗性治疗的机制。本发明导致血管假体特别适用于需要6mm直径的动脉旁路。

3. 发明公开

EP1773250A1 BIOABSORBABLE SELF-EXPANDING ENDOLUMENAL DEVICES 有权
标题翻译：生物可吸收自膨胀ENDOLUMINALVORRICHTUNGEN
公开(公告)号：EP1773250A1
公开(公告)日：2007-04-18
申请号：EP05777220.4
申请日：2005-07-29
申请人： Gore Enterprise Holdings, Inc.
发明人： ARMSTRONG, Joseph, R. , BEGOVAC, Paul, C. , CLEEK, Robert, L. , CULLY, Edward, H. , FLYNN, Charles , HAYES, Byron, K. , PETERSON, Ray, V. , VONESH, Michael, J. , WHITE, Charles, F.
IPC分类号： A61F2/06
CPC分类号： A61F2/01 , A61B17/12022 , A61B17/12118 , A61B17/1214 , A61B2017/1205 , A61F2/91 , A61F2/915 , A61F2002/016 , A61F2002/018 , A61F2002/30062 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155 , A61F2210/0004 , A61F2210/0076 , A61F2220/0016 , A61F2230/005 , A61F2230/0054 , A61F2230/0069 , A61F2230/008 , A61F2250/003 , A61L31/06 , A61L31/148 , C08L67/04
摘要： The present invention is directed to bioabsorbable self-expanding medical devices for use inside or outside body conduits that self-expand at, or below, normal human body temperature without requisite for a polymeric thermal transition.

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