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2. 发明专利

GB189608924A An Improved Adjustable Bicycle Support. 未知
公开(公告)号：GB189608924A
公开(公告)日：1896-11-28
申请号：GB189608924D
申请日：1896-04-28
申请人： GOODMAN MARK
发明人： GOODMAN MARK

3. 发明申请

WO2012097223A3 OLIGOSACCHARIDE CONJUGATES FOR TARGETING BACTERIA AND USES RELATED THERETO 审中-公开
标题翻译：用于靶向细菌的低聚糖结合物及其相关用途
公开(公告)号：WO2012097223A3
公开(公告)日：2013-01-10
申请号：PCT/US2012021202
申请日：2012-01-13
申请人： UNIV EMORY , GEORGIA TECH RES FOUNDATION , GEORGIA STATE RES FOUNDATION , MURTHY NIREN , GILBERT ERIC SETH , NING XINGHAI , LEE SEUNGJUN , GOODMAN MARK , TZENG YIH-LING , DICKSON ROBERT M
发明人： MURTHY NIREN , GILBERT ERIC SETH , NING XINGHAI , LEE SEUNGJUN , GOODMAN MARK , TZENG YIH-LING , DICKSON ROBERT M
IPC分类号： A61K47/48 , A61K31/135 , A61K47/36 , A61P31/00
CPC分类号： A61K47/61 , A61K31/496 , A61K45/06 , A61K47/4823 , A61K49/0021 , A61K49/0032 , A61K49/0054 , A61K51/06 , A61K51/065 , C08B31/00 , C08L3/04
摘要： This disclosure relates to conjugates for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria comprising mixing bacteria with a non-naturally occurring conjugate under conditions such that the conjugate is transported across the bacterial cell wall. Typically, the conjugate comprises an oligosaccharide and a molecule of interest. In certain embodiments, the molecule of interest may be a tracer or an antibiotic.
摘要翻译：本公开涉及用于靶向细菌和相关用途的缀合物。在某些实施方案中，本公开涉及将感兴趣的分子转移到细菌中的方法，包括在使缀合物跨过细菌细胞壁传输的条件下将细菌与非天然存在的缀合物混合。通常，缀合物包含寡糖和感兴趣的分子。在某些实施方案中，感兴趣的分子可以是示踪剂或抗生素。

4. 发明申请

WO2011008985A3 CONJUGATES COMPRISING DNA-BINDING AGENT FOR TARGETED DELIVERY OF THERAPEUTIC AGENTS 审中-公开
标题翻译：包含用于定向递送治疗药物的DNA结合剂的结合
公开(公告)号：WO2011008985A3
公开(公告)日：2011-04-14
申请号：PCT/US2010042175
申请日：2010-07-15
申请人： GEORGIA TECH RES INST , UNIV EMORY , MURTHY NIREN , DAVIS MICHAEL E , KIM DONGIN , DASARI MADHURI , LEE SUNGMUN , LEE SEUNGJUN , SY JAY , GOODMAN MARK
发明人： MURTHY NIREN , DAVIS MICHAEL E , KIM DONGIN , DASARI MADHURI , LEE SUNGMUN , LEE SEUNGJUN , SY JAY , GOODMAN MARK
IPC分类号： A61K47/48
CPC分类号： A61K47/545
摘要： Among other things, this disclosure provides for compounds having a targeting moiety linked to a therapeutic moiety and/or a diagnostic moiety; the synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and, methods for treating or diagnosing disorders. Some of the compounds include a linker which can be cleaved under physiological conditions, including linkers comprising an amide or disulfide bond. Examples of targeting moieties are derivatives of DNA binding agents, which may comprise derivatives of Hoechst 33258. Examples of therapeutic moieties are compounds useful for treating a cancer, which may comprise derivatives of nucleotides and nucleosides such as gemcitabine. This abstract is intended to be used as a scanning tool for the purposes of searching in the particular art and is not intended to limiting of the present disclosure.
摘要翻译：除此之外，本公开提供了具有连接到治疗部分和/或诊断部分的靶向部分的化合物; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及治疗或诊断疾病的方法。一些化合物包括可以在生理条件下切割的接头，包括包含酰胺或二硫键的接头。靶向部分的实例是DNA结合剂的衍生物，其可以包含Hoechst 33258的衍生物。治疗性部分的实例是可用于治疗癌症的化合物，其可以包含核苷酸和核苷的衍生物，例如吉西他滨。该摘要旨在用作扫描工具，用于在特定技术中进行搜索，并不意图限制本公开。

5. 发明申请

WO2011094389A2 CXCR4 ANTAGONISTS FOR IMAGING OF CANCER AND INFLAMMATORY DISORDERS 审中-公开
标题翻译：用于癌症和炎性疾病成像的CXCR4拮抗剂
公开(公告)号：WO2011094389A2
公开(公告)日：2011-08-04
申请号：PCT/US2011022696
申请日：2011-01-27
申请人： UNIV EMORY , SHIM HYUNSUK , LIOTTA DENNIS C , ZHU AIZHI , GOODMAN MARK
发明人： SHIM HYUNSUK , LIOTTA DENNIS C , ZHU AIZHI , GOODMAN MARK
IPC分类号： A61K31/506 , A61K31/495 , A61K31/505 , A61P29/00 , A61P35/00
CPC分类号： A61K31/505 , A61K31/506 , A61K31/5377
摘要： The invention provides radiolabeled CXCR4 antagonists, compositions and methods of use for imaging of chemokine CXCR4 receptors and biological conditions associated with the expression of CXCR4 receptors, including cancer, metastasis, and inflammatory disorders.
摘要翻译：本发明提供放射性标记的CXCR4拮抗剂，用于成像趋化因子CXCR4受体的组合物和方法以及与CXCR4受体表达相关的生物学病症，包括癌症，转移和炎性病症。

6. 发明申请

WO2010096426A8 COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT 审中-公开
标题翻译：化合物，组合物，合成方法和治疗方法
公开(公告)号：WO2010096426A8
公开(公告)日：2011-12-22
申请号：PCT/US2010024393
申请日：2010-03-12
申请人： UNIV EMORY , STEHOUWER JEFF , GOODMAN MARK , KILTS CLINT , NEMEROFF CHARLES
发明人： STEHOUWER JEFF , GOODMAN MARK , KILTS CLINT , NEMEROFF CHARLES
IPC分类号： C07D487/04 , A61K49/06 , C07D403/04 , C07D487/14
CPC分类号： C07F7/2208 , A61K51/0459 , A61K51/0468 , A61K51/0472 , C07D471/04 , C07D471/14 , C07D471/16 , C07D487/04
摘要： Briefly described, embodiments of this disclosure include compounds as described herein, labeled compounds as described herein, pharmaceutical composition including compounds described herein, methods of imaging, method of forming a compound as described herein, and the like. In particular, embodiments of the disclosure include a series of triamino-pyridine derivatives and labeled triamino-pyridine derivatives, methods of synthesizing these compounds, intermediate compounds, methods of treatment using these compounds, methods of imaging, diagnosing, localizing, monitoring, and/or assessing a condition (e.g., corticotropin releasing factor type-1 (CRF1)) and/or related biological events, using triamino-pyridine derivatives, and the like. In addition, the present disclosure includes compositions (e.g., labeled triamino-pyridine derivatives that are ligands for the CRF1 receptor) used in and methods relating to non-invasive imaging (e.g., positron emission tomography (PET) imaging or SPECT imaging).
摘要翻译：简要描述，本公开的实施方案包括本文所述的化合物，本文所述的标记化合物，包含本文所述化合物的药物组合物，成像方法，形成本文所述的化合物的方法等。特别地，本公开的实施方案包括一系列三氨基 - 吡啶衍生物和标记的三氨基 - 吡啶衍生物，合成这些化合物的方法，中间体化合物，使用这些化合物的治疗方法，成像，诊断，定位，监测和/ 或使用三氨基 - 吡啶衍生物评估病症（例如促肾上腺皮质激素释放因子1型（CRF1））和/或相关的生物学事件等。此外，本公开内容包括组合物（例如，用作CRF1受体的配体的标记的三氨基 - 吡啶衍生物）和与非侵入性成像（例如正电子发射断层摄影（PET）成像或SPECT成像）有关的方法和方法。

7. 发明申请

WO2010096426A3 COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT 审中-公开
标题翻译：化合物，组合物，合成方法和治疗方法
公开(公告)号：WO2010096426A3
公开(公告)日：2011-01-27
申请号：PCT/US2010024393
申请日：2010-03-12
申请人： UNIV EMORY , STEHOUWER JEFF , GOODMAN MARK , KILTS CLINT , NEMEROFF CHARLES
发明人： STEHOUWER JEFF , GOODMAN MARK , KILTS CLINT , NEMEROFF CHARLES
IPC分类号： C07D487/04 , A61K49/06 , C07D403/04 , C07D487/14
CPC分类号： C07F7/2208 , A61K51/0459 , A61K51/0468 , A61K51/0472 , C07D471/04 , C07D471/14 , C07D471/16 , C07D487/04
摘要： Briefly described, embodiments of this disclosure include compounds as described herein, labeled compounds as described herein, pharmaceutical composition including compounds described herein, methods of imaging, method of forming a compound as described herein, and the like. In particular, embodiments of the disclosure include a series of triamino-pyridine derivatives and labeled triamino-pyridine derivatives, methods of synthesizing these compounds, intermediate compounds, methods of treatment using these compounds, methods of imaging, diagnosing, localizing, monitoring, and/or assessing a condition (e.g., corticotropin releasing factor type-1 (CRF1)) and/or related biological events, using triamino-pyridine derivatives, and the like. In addition, the present disclosure includes compositions (e.g., labeled triamino-pyridine derivatives that are ligands for the CRF1 receptor) used in and methods relating to non-invasive imaging (e.g., positron emission tomography (PET) imaging or SPECT imaging).
摘要翻译：简而言之，本公开的实施方案包括如本文所述的化合物，如本文所述的标记的化合物，包括本文所述的化合物的药物组合物，成像方法，形成如本文所述的化合物的方法等。特别地，本公开的实施方案包括一系列三氨基吡啶衍生物和标记的三氨基吡啶衍生物，合成这些化合物的方法，中间体化合物，使用这些化合物的治疗方法，成像，诊断，定位，监测和/ 或使用三氨基吡啶衍生物等评估病症（例如促肾上腺皮质素释放因子-1型（CRF1））和/或相关生物学事件。另外，本公开内容包括在非侵入性成像（例如，正电子发射断层摄影（PET）成像或SPECT成像）中使用的组合物（例如，标记为CRF1受体的配体的三氨基 - 吡啶衍生物）和方法。

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