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    • 5. 发明申请
    • VACCINES FOR MALARIA
    • 疟疾疫苗
    • WO2008009652A3
    • 2008-05-08
    • PCT/EP2007057301
    • 2007-07-16
    • GLAXOSMITHKLINE BIOLOG SAUS ARMYCOHEN JOSEPH DMARCHAND MARTINEOCKENHOUSE CHRISTIAN FYADAVA ANJALI
    • COHEN JOSEPH DMARCHAND MARTINEOCKENHOUSE CHRISTIAN FYADAVA ANJALI
    • A61K39/015A61K39/29
    • A61K39/015A61K2039/6075C07K14/445C07K2319/40
    • The present invention relates to a hybrid/ fusion protein derived from the CS protein of Plasmodium vivax (P. vivax), methods for preparing and purifying the same, its use in medicine, particularly in the prevention of malarial infections, for example those caused by P. vivax, compositions/vaccines containing the protein or antibodies against the protein such as monoclonal or polyclonal antibodies and use of the same, particularly in therapy. The invention also extends to lipoprotein particles of said hybrid protein and formulations/vaccines comprising the same and use thereof. In particular it relates to an immunogenic hybrid fusion protein comprising: a. at least one repeat unit derived from the repeating region of a type I circumsporozoite protein of P. vivax, b. at least one repeat unit derived from the repeating region of a type II circumsporozoite protein of P. vivax, and surface antigen S derived from Hepatitis B virus, or a fragment thereof
    • 本发明涉及来自间日疟原虫(间日疟原虫)的CS蛋白质的杂合体/融合蛋白,其制备和纯化方法,其在医学中的用途,特别是在预防疟疾感染方面的用途,例如由 间日疟原虫,含有针对蛋白质的蛋白质或抗体的单克隆或多克隆抗体的组合物/疫苗,以及其用途,特别是在治疗中。 本发明还延伸到所述杂合蛋白质的脂蛋白颗粒和包含其的制剂/疫苗及其用途。 特别地,其涉及免疫原性杂合融合蛋白,其包含:a。 至少一个源自间日疟原虫的I型环子孢子蛋白的重复区的重复单元,b。 源自间日疟原虫的II型环子孢子蛋白的重复区域的至少一个重复单元和源自乙型肝炎病毒的表面抗原S或其片段